THAP12

Summary

THAP12 (THAP domain containing 12, HGNC:9440) is a protein-coding gene on chromosome 11q13.5, encoding 52 kDa repressor of the inhibitor of the protein kinase (O43422). Upstream regulator of interferon-induced serine/threonine protein kinase R (PKR). It is a selective cancer dependency (DepMap: 36.8% of cell lines).

Predicted to enable several functions, including DNA binding activity; protein dimerization activity; and zinc ion binding activity. Predicted to be involved in negative regulation of cell population proliferation and signal transduction. Predicted to be located in nucleus.

Source: NCBI Gene 5612 — RefSeq curated summary.

At a glance

• Gene–disease (curated): syndromic complex neurodevelopmental disorder (Limited, GenCC)
• GWAS associations: 14
• Clinical variants (ClinVar): 11 total
• Cancer dependency (DepMap): dependent in 36.8% of screened cell lines
• MANE Select transcript: NM_004705

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:9440
Approved symbol	THAP12
Name	THAP domain containing 12
Location	11q13.5
Locus type	gene with protein product
Status	Approved
Aliases	P52rIPK, DAP4, THAP0
Ensembl gene	ENSG00000137492
Ensembl biotype	protein_coding
OMIM	607374
Entrez	5612

Gene structure

Transcript identifiers

Ensembl transcripts: 12 — 6 nonsense_mediated_decay, 3 protein_coding, 2 retained_intron, 1 protein_coding_CDS_not_defined

ENST00000260045, ENST00000525277, ENST00000528993, ENST00000529901, ENST00000531878, ENST00000682046, ENST00000682527, ENST00000682978, ENST00000683600, ENST00000684059, ENST00000684702, ENST00000937942

RefSeq mRNA: 1 — MANE Select: NM_004705 NM_004705

CCDS: CCDS8243

Canonical transcript exons

ENST00000260045 — 5 exons

Exon	Start	End
ENSE00000927649	76380748	76381132
ENSE00003569397	76349956	76352794
ENSE00003608958	76355618	76355654
ENSE00003632498	76360956	76361063
ENSE00003667726	76365852	76365972

Expression profiles

Bgee: expression breadth ubiquitous, 290 present calls, max score 96.57.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 7.0468 / max 61.1785, expressed in 1725 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
121387	6.8406	1719
121386	0.2062	70

Top tissues by expression

295 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
calcaneal tendon	UBERON:0003701	96.57	gold quality
skeletal muscle tissue of biceps brachii	UBERON:0004502	94.59	gold quality
corpus epididymis	UBERON:0004359	94.58	gold quality
mucosa of sigmoid colon	UBERON:0004993	94.18	gold quality
biceps brachii	UBERON:0001507	94.00	gold quality
trabecular bone tissue	UBERON:0002483	93.97	gold quality
caput epididymis	UBERON:0004358	93.95	gold quality
colonic mucosa	UBERON:0000317	93.92	gold quality
secondary oocyte	CL:0000655	93.83	gold quality
pigmented layer of retina	UBERON:0001782	93.83	gold quality
retina	UBERON:0000966	93.81	gold quality
ventricular zone	UBERON:0003053	93.67	gold quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	93.66	gold quality
ganglionic eminence	UBERON:0004023	93.64	gold quality
body of pancreas	UBERON:0001150	93.53	gold quality
cauda epididymis	UBERON:0004360	93.52	gold quality
adrenal tissue	UBERON:0018303	93.39	gold quality
oocyte	CL:0000023	93.22	gold quality
mammary duct	UBERON:0001765	93.14	gold quality
epithelium of nasopharynx	UBERON:0001951	93.06	gold quality
tendon	UBERON:0000043	92.94	gold quality
superficial temporal artery	UBERON:0001614	92.91	gold quality
pancreas	UBERON:0001264	92.89	gold quality
rectum	UBERON:0001052	92.81	gold quality
skin of hip	UBERON:0001554	92.80	gold quality
leukocyte	CL:0000738	92.78	gold quality
mononuclear cell	CL:0000842	92.72	gold quality
monocyte	CL:0000576	92.68	gold quality
embryo	UBERON:0000922	92.64	gold quality
germinal epithelium of ovary	UBERON:0001304	92.59	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	6.56

Regulation

Is transcription factor: yes

Downstream targets (CollecTRI)

2 targets.

Target	Regulation
IFNA1
TPM1

miRNA regulators (miRDB)

81 targeting THAP12, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-LET-7A-3P	100.00	74.03	3932
HSA-LET-7B-3P	100.00	74.08	3913
HSA-LET-7F-1-3P	100.00	74.02	3928
HSA-MIR-98-3P	100.00	74.08	3907
HSA-MIR-30A-5P	100.00	76.31	3233
HSA-MIR-30B-5P	100.00	76.29	3248
HSA-MIR-30C-5P	100.00	76.29	3248
HSA-MIR-30D-5P	100.00	76.32	3233
HSA-MIR-30E-5P	100.00	76.32	3242
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-340-5P	100.00	72.50	4437
HSA-MIR-1277-5P	100.00	73.95	5056
HSA-MIR-3662	99.99	73.82	5684
HSA-MIR-6077	99.99	68.04	2299
HSA-MIR-12136	99.98	72.81	5713
HSA-MIR-302C-5P	99.97	72.56	3642
HSA-MIR-551B-5P	99.96	71.28	3493
HSA-MIR-4666A-3P	99.96	71.71	3434
HSA-MIR-23A-3P	99.95	74.24	3163
HSA-MIR-23B-3P	99.95	74.24	3163
HSA-MIR-23C	99.95	73.92	3192
HSA-MIR-1-3P	99.93	72.35	1914
HSA-MIR-206	99.93	72.50	1893
HSA-MIR-381-3P	99.93	71.87	2854
HSA-MIR-300	99.92	71.76	2856
HSA-MIR-613	99.91	71.50	1710
HSA-MIR-8063	99.91	69.76	3146
HSA-MIR-3671	99.90	73.04	3897
HSA-MIR-8062	99.88	68.43	995
HSA-MIR-3919	99.87	69.45	2489

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 36.8% of screened cell lines.

Literature-anchored findings (GeneRIF, showing 2)

• role in promoting MST1-induced apoptosis by enabling colocalization of MST with p53 (PMID:12384512)
• PRKRIR provides a novel positive regulator controlling the RIG-I-IFN production system through protein stability control. (PMID:21910972)

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
danio_rerio	thap12b	ENSDARG00000020964
danio_rerio	thap12a	ENSDARG00000042489
mus_musculus	Thap12	ENSMUSG00000030753
rattus_norvegicus	Thap12	ENSRNOG00000053923

Paralogs (18): GTF2IRD1 (ENSG00000006704), ZMYM2 (ENSG00000121741), ZMYM5 (ENSG00000132950), ZMYM4 (ENSG00000146463), ZMYM3 (ENSG00000147130), ZMYM6 (ENSG00000163867), KIAA1958 (ENSG00000165185), GTF2IRD2B (ENSG00000174428), EPM2AIP1 (ENSG00000178567), GTF2IRD2 (ENSG00000196275), ZMYM1 (ENSG00000197056), QRICH1 (ENSG00000198218), FAM200C (ENSG00000221886), FAM200A (ENSG00000221909), SCAND3 (ENSG00000232040), ZBED5 (ENSG00000236287), FAM200B (ENSG00000237765), GTF2I (ENSG00000263001)

Protein

Protein identifiers

52 kDa repressor of the inhibitor of the protein kinase — O43422 (reviewed: O43422)

Alternative names: 58 kDa interferon-induced protein kinase-interacting protein, Death-associated protein 4, THAP domain-containing protein 0, THAP domain-containing protein 12

All UniProt accessions (8): O43422, A0A140VJQ7, A0A804HKN8, A0A804HKR8, A0A804HKT7, A0A804HKY5, A0A804HL83, E9PSI2

UniProt curated annotations — full annotation on UniProt →

Function. Upstream regulator of interferon-induced serine/threonine protein kinase R (PKR). May block the PKR-inhibitory function of DNAJC3, resulting in restoration of kinase activity and suppression of cell growth.

Subunit / interactions. Interacts with DNAJC3, probably sequestring it.

Isoforms (2)

UniProt ID	Names	Canonical?
O43422-1	Long	yes
O43422-2	Short

RefSeq proteins (1): NP_004696* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR006612	THAP_Znf	Domain
IPR008906	HATC_C_dom	Domain
IPR012337	RNaseH-like_sf	Homologous_superfamily
IPR025398	RNase-like_ZMYM1	Domain
IPR052958	IFN-induced_PKR_regulator	Family

Pfam: PF05485, PF05699, PF14291

UniProt features (10 total): sequence conflict 3, splice variant 2, chain 1, zinc finger region 1, region of interest 1, compositionally biased region 1, modified residue 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-O43422-F1	83.91	0.59

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (1): 566

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 166 (showing top): GSE45365_NK_CELL_VS_CD8A_DC_MCMV_INFECTION_DN, TGCGCANK_UNKNOWN, GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN, BROWNE_HCMV_INFECTION_16HR_UP, MEF2_02, chr11q13, PUJANA_CHEK2_PCC_NETWORK, TCF4_Q5, OCT1_06, DEBIASI_APOPTOSIS_BY_REOVIRUS_INFECTION_UP, LASTOWSKA_NEUROBLASTOMA_COPY_NUMBER_DN, FISCHER_DREAM_TARGETS, NIKOLSKY_BREAST_CANCER_11Q12_Q14_AMPLICON, DANG_BOUND_BY_MYC, BENPORATH_MYC_MAX_TARGETS

GO Biological Process (2): signal transduction (GO:0007165), negative regulation of cell population proliferation (GO:0008285)

GO Molecular Function (5): DNA binding (GO:0003677), zinc ion binding (GO:0008270), protein dimerization activity (GO:0046983), protein binding (GO:0005515), metal ion binding (GO:0046872)

GO Cellular Component (1): nucleus (GO:0005634)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
cell population proliferation	1
regulation of cell population proliferation	1
negative regulation of cellular process	1
nucleic acid binding	1
transition metal ion binding	1
protein binding	1
binding	1
cation binding	1
intracellular membrane-bounded organelle	1

Protein interactions and networks

STRING

826 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
THAP12	THAP7	Q9BT49	912
THAP12	THAP4	Q8WY91	904
THAP12	THAP11	Q96EK4	899
THAP12	THAP1	Q9NVV9	891
THAP12	THAP3	Q8WTV1	882
THAP12	DNAJC3	Q13217	874
THAP12	THAP5	Q7Z6K1	644
THAP12	EIF2AK2	P19525	627
THAP12	THAP9	Q9H5L6	607
THAP12	THAP10	Q9P2Z0	592
THAP12	THAP8	Q8NA92	583
THAP12	THAP6	Q8TBB0	473
THAP12	HSP90AB1	P08238	455
THAP12	SPATA31D3	P0C874	447
THAP12	A0A3B3IRQ3	A0A3B3IRQ3	445

IntAct

131 interactions, top by confidence:

A	B	Type	Score
THAP12	ZNF526	psi-mi:“MI:0915”(physical association)	0.670
GPR156	PLD2	psi-mi:“MI:0914”(association)	0.640
LIN28A	IGF2BP3	psi-mi:“MI:0914”(association)	0.640
THAP12	ZNF574	psi-mi:“MI:0915”(physical association)	0.620
ZNF574	THAP12	psi-mi:“MI:0914”(association)	0.620
THAP12	TACC1	psi-mi:“MI:0915”(physical association)	0.560
TACC1	THAP12	psi-mi:“MI:0915”(physical association)	0.560
SELENBP1	THAP12	psi-mi:“MI:0915”(physical association)	0.560
THAP12	SELENBP1	psi-mi:“MI:0915”(physical association)	0.560
THAP12	KIAA1958	psi-mi:“MI:0915”(physical association)	0.560
RPS14	MAGEB2	psi-mi:“MI:0914”(association)	0.560
CACNG5	ZNF316	psi-mi:“MI:0914”(association)	0.530
XAGE1A	THAP12	psi-mi:“MI:0914”(association)	0.530
IGHMBP2	THAP12	psi-mi:“MI:0914”(association)	0.530
FADD	THAP12	psi-mi:“MI:0914”(association)	0.530
TMEM171	THAP12	psi-mi:“MI:0914”(association)	0.530
LHX4	THAP12	psi-mi:“MI:0914”(association)	0.530
H2AC20	PPM1G	psi-mi:“MI:0914”(association)	0.530
RPS2	MPHOSPH10	psi-mi:“MI:0914”(association)	0.530
KRR1	MPHOSPH10	psi-mi:“MI:0914”(association)	0.530

BioGRID (133): TACC1 (Two-hybrid), PRKRIR (Affinity Capture-MS), PRKRIR (Affinity Capture-MS), PRKRIR (Affinity Capture-MS), PRKRIR (Affinity Capture-MS), PRKRIR (Affinity Capture-MS), PRKRIR (Affinity Capture-MS), PRKRIR (Affinity Capture-MS), PRKRIR (Affinity Capture-MS), MAPKAPK3 (Two-hybrid), MAPKAPK3 (Affinity Capture-Western), MAPKAPK2 (Affinity Capture-Western), EIF2AK2 (Affinity Capture-Western), PRKRIR (Affinity Capture-MS), PRKRIR (Affinity Capture-MS)

ESM2 similar proteins: A3KMX0, A4IFA3, A4IGY9, A4Z943, A4Z944, B8QB46, D2EAC2, E1C2V1, O43422, O60290, P10911, P35125, P86452, Q13075, Q2NKX8, Q3UPF5, Q49AG3, Q5FWF4, Q5SVZ6, Q5T890, Q5TKR9, Q6DJS0, Q6EKJ0, Q6R2W3, Q6YI93, Q7Z2W4, Q80WE4, Q86UP8, Q86VD1, Q8BZ21, Q8N8K9, Q8QMP8, Q8TDB6, Q8WML3, Q92794, Q96JM7, Q96JS3, Q99388, Q99NI3, Q9CUX1

Diamond homologs: O43422, Q9CUX1, A4IGQ8, A5PKF5, Q6IR68, Q6TGZ4, Q96EK4, Q9JJD0

SIGNOR signaling

1 interactions.

A	Effect	B	Mechanism
THAP12	unknown	EIF2S1	phosphorylation

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 116 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
SARS-CoV-1 modulates host translation machinery	8	32.9×	1e-09
Eukaryotic Translation Initiation	7	28.8×	5e-08
Cap-dependent Translation Initiation	7	28.8×	5e-08
Eukaryotic Translation Elongation	7	26.0×	9e-08
Peptide chain elongation	15	25.4×	2e-15
Viral mRNA Translation	15	25.4×	2e-15
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	7	25.4×	9e-08
Transport of Mature Transcript to Cytoplasm	5	25.4×	9e-06

GO biological processes:

GO term	Partners	Fold	FDR
cytoplasmic translation	16	29.1×	9e-17
translation	18	18.1×	1e-15
ribosomal small subunit biogenesis	7	15.6×	4e-05
mitochondrial translation	9	15.3×	1e-06
regulation of alternative mRNA splicing, via spliceosome	6	14.4×	3e-04
mRNA transport	5	12.9×	3e-03
negative regulation of translation	5	9.6×	1e-02
rRNA processing	6	8.3×	5e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

11 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	4
Likely benign	1
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

999 predictions. Top by Δscore:

Variant	Effect	Δscore
11:76352790:ATCAA:A	acceptor_gain	1.0000
11:76352791:TCAA:T	acceptor_gain	1.0000
11:76352792:CAA:C	acceptor_gain	1.0000
11:76352792:CAAC:C	acceptor_gain	1.0000
11:76352793:AA:A	acceptor_gain	1.0000
11:76352793:AACT:A	acceptor_loss	1.0000
11:76352795:C:CC	acceptor_gain	1.0000
11:76355616:A:AC	donor_gain	1.0000
11:76355617:C:CC	donor_gain	1.0000
11:76355663:C:CT	acceptor_gain	1.0000
11:76355664:A:T	acceptor_gain	1.0000
11:76361062:CT:C	acceptor_gain	1.0000
11:76361064:C:CC	acceptor_gain	1.0000
11:76361064:CT:C	acceptor_loss	1.0000
11:76365850:A:AC	donor_gain	1.0000
11:76365851:C:CC	donor_gain	1.0000
11:76365851:CAGTT:C	donor_gain	1.0000
11:76365911:G:C	donor_gain	1.0000
11:76380746:ACC:A	donor_loss	1.0000
11:76352793:A:T	acceptor_gain	0.9900
11:76352803:C:CT	acceptor_gain	0.9900
11:76352804:A:T	acceptor_gain	0.9900
11:76355611:CACTT:C	donor_loss	0.9900
11:76355612:ACTT:A	donor_loss	0.9900
11:76355613:CT:C	donor_loss	0.9900
11:76355614:T:TA	donor_loss	0.9900
11:76355615:TACTT:T	donor_loss	0.9900
11:76355616:AC:A	donor_loss	0.9900
11:76355617:C:T	donor_loss	0.9900
11:76355617:CT:C	donor_gain	0.9900

AlphaMissense

5067 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
11:76351128:A:C	F674L	1.000
11:76351128:A:T	F674L	1.000
11:76351130:A:G	F674L	1.000
11:76351203:C:A	W649C	1.000
11:76351203:C:G	W649C	1.000
11:76351204:C:G	W649S	1.000
11:76351205:A:G	W649R	1.000
11:76351205:A:T	W649R	1.000
11:76351215:C:A	W645C	1.000
11:76351215:C:G	W645C	1.000
11:76351216:C:G	W645S	1.000
11:76351217:A:G	W645R	1.000
11:76351217:A:T	W645R	1.000
11:76351218:A:C	C644W	1.000
11:76351220:A:G	C644R	1.000
11:76351225:A:G	L642P	1.000
11:76351324:G:C	P609R	1.000
11:76351324:G:T	P609H	1.000
11:76351325:G:A	P609S	1.000
11:76351325:G:T	P609T	1.000
11:76361016:A:C	F86L	1.000
11:76361016:A:T	F86L	1.000
11:76361018:A:G	F86L	1.000
11:76361026:G:C	P83R	1.000
11:76361026:G:T	P83Q	1.000
11:76361027:G:A	P83S	1.000
11:76361027:G:T	P83T	1.000
11:76361044:A:G	L77P	1.000
11:76361044:A:T	L77H	1.000
11:76365876:A:C	F62L	1.000

dbSNP variants (sampled 300 via entrez): RS1000136620 (11:76380004 T>C), RS1000180032 (11:76363034 T>C), RS1000383682 (11:76357014 C>G), RS1000402271 (11:76379750 G>A), RS1000422203 (11:76372222 G>A,C), RS1000485640 (11:76374689 G>A,T), RS1000597187 (11:76368511 G>A), RS1000682748 (11:76360531 C>A,G,T), RS1000865162 (11:76354904 T>C), RS1001009047 (11:76381104 G>C), RS1001099447 (11:76368753 A>G), RS1001177565 (11:76382926 C>T), RS1001184230 (11:76364318 T>A,G), RS1001276182 (11:76354553 T>C), RS1001290079 (11:76377258 T>A,C)

Disease associations

OMIM: gene MIM:607374 | disease phenotypes:

GenCC curated gene-disease

Disease	Classification	Inheritance
syndromic complex neurodevelopmental disorder	Limited	Autosomal recessive

Mondo (1): syndromic complex neurodevelopmental disorder (MONDO:0800439)

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

14 associations (top):

Study	Trait	p-value
GCST007095_2	Systolic blood pressure	4.000000e-08
GCST007095_3	Systolic blood pressure	2.000000e-07
GCST007096_56	Pulse pressure	3.000000e-08
GCST007097_104	Pulse pressure	2.000000e-10
GCST007097_105	Pulse pressure	7.000000e-11
GCST007099_14	Systolic blood pressure	4.000000e-09
GCST007564_15	Asthma or allergic disease (pleiotropy)	3.000000e-28
GCST007994_26	Asthma (age of onset)	4.000000e-15
GCST007995_34	Asthma (childhood onset)	2.000000e-39
GCST008916_101	Asthma	1.000000e-48
GCST008916_84	Asthma	8.000000e-29
GCST009798_77	Asthma	4.000000e-35
GCST012298_9	Schizophrenia, bipolar disorder or major depressive disorder x sex interaction	5.000000e-06
GCST012301_11	Schizophrenia, bipolar disorder or major depressive disorder x sex interaction	8.000000e-06

EFO canonical traits (3, from GWAS)

EFO ID	Trait name
EFO:0006335	systolic blood pressure
EFO:0005763	pulse pressure measurement
EFO:0008343	sex interaction measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

24 total (human), top 24 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	decreases expression	2
Particulate Matter	affects cotreatment, decreases expression, increases abundance	2
aristolochic acid I	decreases expression, increases expression	1
FR900359	increases phosphorylation	1
dicrotophos	decreases expression	1
triphenyl phosphate	affects expression	1
glycidyl methacrylate	decreases expression	1
sodium arsenite	decreases expression	1
perfluorooctane sulfonic acid	increases expression	1
CGP 52608	affects binding, increases reaction	1
jinfukang	decreases expression	1
Sunitinib	increases expression	1
Air Pollutants	decreases expression, increases abundance	1
Ethanol	decreases expression, increases abundance, affects cotreatment	1
Atrazine	decreases expression	1
Benzo(a)pyrene	affects methylation	1
Doxorubicin	decreases expression	1
Gasoline	affects cotreatment, decreases expression, increases abundance	1
Methyl Methanesulfonate	decreases expression	1
Polycyclic Aromatic Hydrocarbons	affects cotreatment, decreases expression, increases abundance	1
Tobacco Smoke Pollution	increases expression	1
Tretinoin	decreases expression	1
Antirheumatic Agents	increases expression	1
Cadmium Chloride	decreases expression	1

Cellosaurus cell lines

12 cell lines: 4 transformed cell line, 4 finite cell line, 4 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_C7LL	GM27988	Transformed cell line	Female
CVCL_C7LM	GM27990	Finite cell line	Female
CVCL_C7LN	GM27991	Transformed cell line	Female
CVCL_C7LP	GM27993	Finite cell line	Female
CVCL_C7LQ	GM27994	Transformed cell line	Female
CVCL_C7LR	GM27995	Finite cell line	Female
CVCL_C7LS	GM27996	Transformed cell line	Male
CVCL_C7LT	GM27997	Finite cell line	Male
CVCL_D8CE	Ubigene A-549 THAP12 KO	Cancer cell line	Male
CVCL_E2HW	HAP1 PRKRIR (-) 1	Cancer cell line	Male

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.