THAP7-AS1

Summary

THAP7-AS1 (THAP7 antisense RNA 1, HGNC:41013) is a long non-coding RNA gene on chromosome 22q11.21.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41013
Approved symbol	THAP7-AS1
Name	THAP7 antisense RNA 1
Location	22q11.21
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000230513
Ensembl biotype	lncRNA
Entrez	439931
RNAcentral	URS000075A05E — lncRNA, 2632 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 6 — 6 lncRNA

ENST00000429962, ENST00000436079, ENST00000452284, ENST00000690091, ENST00000752741, ENST00000752742

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000429962 — 2 exons

Exon	Start	End
ENSE00004099161	21001836	21002829
ENSE00004099162	21002918	21003344

Expression profiles

Bgee: expression breadth ubiquitous, 159 present calls, max score 79.94.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 7.2580 / max 106.8144, expressed in 1696 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
191180	5.5699	1645
191181	1.6881	873

Top tissues by expression

244 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
cerebellar hemisphere	UBERON:0002245	79.94	gold quality
cerebellar cortex	UBERON:0002129	79.73	gold quality
right hemisphere of cerebellum	UBERON:0014890	78.96	gold quality
adenohypophysis	UBERON:0002196	78.91	gold quality
cerebellum	UBERON:0002037	77.59	gold quality
pituitary gland	UBERON:0000007	77.18	gold quality
right uterine tube	UBERON:0001302	76.00	gold quality
mucosa of stomach	UBERON:0001199	75.71	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	75.18	gold quality
body of uterus	UBERON:0009853	73.78	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	73.68	gold quality
right adrenal gland cortex	UBERON:0035827	73.14	gold quality
tibial nerve	UBERON:0001323	72.87	gold quality
left ovary	UBERON:0002119	72.76	gold quality
Brodmann (1909) area 9	UBERON:0013540	72.40	gold quality
right adrenal gland	UBERON:0001233	72.32	gold quality
left coronary artery	UBERON:0001626	72.32	gold quality
popliteal artery	UBERON:0002250	72.32	gold quality
tibial artery	UBERON:0007610	72.32	gold quality
anterior cingulate cortex	UBERON:0009835	72.21	gold quality
lower esophagus muscularis layer	UBERON:0035833	72.20	gold quality
lower esophagus	UBERON:0013473	72.18	gold quality
right coronary artery	UBERON:0001625	72.16	gold quality
right frontal lobe	UBERON:0002810	72.07	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	71.98	gold quality
left adrenal gland cortex	UBERON:0035825	71.75	gold quality
hypothalamus	UBERON:0001898	71.71	gold quality
left uterine tube	UBERON:0001303	71.68	gold quality
muscle layer of sigmoid colon	UBERON:0035805	71.60	gold quality
left adrenal gland	UBERON:0001234	71.59	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	2.81

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• lncRNA THAP7-AS1, transcriptionally activated by SP1 and post-transcriptionally stabilized by METTL3-mediated m6A modification, exerts oncogenic properties by improving CUL4B entry into the nucleus. (PMID:34608273)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.