THAP8

Summary

THAP8 (THAP domain containing 8, HGNC:23191) is a protein-coding gene on chromosome 19q13.12, encoding THAP domain-containing protein 8 (Q8NA92).

Predicted to enable DNA binding activity and zinc ion binding activity. Located in nucleoplasm.

Source: NCBI Gene 199745 — automated summary from GO annotations (Alliance of Genome Resources).

At a glance

• Clinical variants (ClinVar): 8 total
• GTEx eGene: eQTL in 18 tissues, sQTL in 5 (q < 0.05)
• Constraint (gnomAD): pLI 0.00 (LoF-tolerant), LOEUF 1.61 (unconstrained)
• MANE Select transcript: NM_152658

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:23191
Approved symbol	THAP8
Name	THAP domain containing 8
Location	19q13.12
Locus type	gene with protein product
Status	Approved
Aliases	FLJ32891
Ensembl gene	ENSG00000161277
Ensembl biotype	protein_coding
OMIM	612536
Entrez	199745

Gene structure

Transcript identifiers

Ensembl transcripts: 11 — 7 protein_coding, 3 nonsense_mediated_decay, 1 protein_coding_CDS_not_defined

MANE Select: ENST00000292894

Transcript support level (Ensembl TSL; 1 = fully mRNA-supported): TSL 1: 1, TSL 2: 1, TSL 3: 2

ENST00000292894, ENST00000522483, ENST00000524106, ENST00000607730, ENST00000872539, ENST00000944564, ENST00000944565, ENST00001004943, ENST00001104562, ENST00001116505, ENST00001135736

RefSeq mRNA: 4 — MANE Select: NM_152658 NM_001331102, NM_001331103, NM_001331104, NM_152658

CCDS: CCDS33000

Canonical transcript exons

ENST00000292894 — 4 exons

Exon	Start	End
ENSE00001057357	36039944	36040136
ENSE00001114897	36034984	36035592
ENSE00001387660	36054135	36054285
ENSE00003669000	36039323	36039718

Expression profiles

Bgee: expression breadth ubiquitous, 179 present calls, max score 92.56.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 6.1942 / max 54.2742, expressed in 1701 samples.

Highest expression (Bgee): pancreatic ductal cell, primordial germ cell in gonad, tibialis anterior, ileal mucosa, muscle layer of sigmoid colon.

Genetic regulation across tissues (GTEx eQTL / sQTL)

THAP8 is an eGene in GTEx v10 — its expression is genetically regulated (eQTL) in 18 tissues and its splicing (sQTL) in 5 (q < 0.05). Strongest associations first; slope = normalized effect of the lead variant’s alternative allele.

showing 20 of 23 significant tissue × QTL associations:

Tissue	QTL	q-value	Slope	Lead variant
Skin Sun Exposed Lower leg	eqtl	5.1e-32	+0.26	19:36042293:A:C
Skin Not Sun Exposed Suprapubic	eqtl	8.9e-29	+0.27	19:36045178:G:C
Nerve Tibial	eqtl	2.3e-24	+0.24	19:36056717:A:G
Brain Spinal cord cervical c-1	eqtl	3.0e-14	+0.49	19:36045213:G:A
Artery Tibial	eqtl	6.0e-11	+0.17	19:36042293:A:C
Esophagus Mucosa	eqtl	5.3e-08	+0.15	19:36053863:C:G
Muscle Skeletal	eqtl	4.9e-06	-0.27	19:36116392:G:A
Cells Cultured fibroblasts	eqtl	4.5e-05	-0.14	19:36034328:CTCT:C
Brain Substantia nigra	eqtl	3.7e-04	+0.30	19:36075331:G:A
Nerve Tibial	sqtl	4.1e-04	+1.37	19:35907691:C:T
Whole Blood	eqtl	8.0e-04	-0.11	19:36101850:G:T
Heart Atrial Appendage	eqtl	1.5e-03	+0.15	19:35520093:G:T
Heart Atrial Appendage	sqtl	1.6e-03	+0.88	19:35986402:G:A
Brain Caudate basal ganglia	eqtl	4.3e-03	+0.44	19:36069797:C:T
Skin Sun Exposed Lower leg	sqtl	5.2e-03	-0.27	19:36119883:G:A
Brain Cortex	eqtl	1.4e-02	+0.83	19:35129238:T:G
Brain Hippocampus	eqtl	1.8e-02	+0.21	19:36101850:G:T
Colon Sigmoid	eqtl	2.0e-02	+0.13	19:36042293:A:C
Adipose Subcutaneous	eqtl	2.1e-02	+0.45	19:36203536:C:T
Brain Frontal Cortex BA9	eqtl	2.6e-02	+0.21	19:36079243:A:G

FANTOM5 promoters

4 alternative TSS:

Promoter ID	TPM avg	Samples expressed
180645	3.8996	1494
180646	1.7827	1036
180647	0.3744	176
180648	0.1375	69

Top tissues by expression

showing 100 of 237 tissues by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
pancreatic ductal cell	CL:0002079	92.56	silver quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	92.12	gold quality
tibialis anterior	UBERON:0001385	88.08	silver quality
ileal mucosa	UBERON:0000331	84.51	gold quality
muscle layer of sigmoid colon	UBERON:0035805	83.44	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	82.01	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	81.95	gold quality
left testis	UBERON:0004533	81.68	gold quality
right testis	UBERON:0004534	81.65	gold quality
apex of heart	UBERON:0002098	81.23	gold quality
hindlimb stylopod muscle	UBERON:0004252	81.20	gold quality
lower esophagus	UBERON:0013473	81.10	gold quality
lower esophagus muscularis layer	UBERON:0035833	81.06	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	80.36	gold quality
testis	UBERON:0000473	79.94	gold quality
tibial nerve	UBERON:0001323	79.50	gold quality
spinal cord	UBERON:0002240	78.90	gold quality
granulocyte	CL:0000094	78.70	gold quality
stromal cell of endometrium	CL:0002255	78.63	gold quality
anterior cingulate cortex	UBERON:0009835	78.28	gold quality
prefrontal cortex	UBERON:0000451	78.19	gold quality
ectocervix	UBERON:0012249	77.75	gold quality
muscle of leg	UBERON:0001383	77.64	gold quality
gastrocnemius	UBERON:0001388	77.64	gold quality
right frontal lobe	UBERON:0002810	77.59	gold quality
Brodmann (1909) area 9	UBERON:0013540	77.47	gold quality
right adrenal gland cortex	UBERON:0035827	77.31	gold quality
lower esophagus mucosa	UBERON:0035834	77.17	gold quality
right adrenal gland	UBERON:0001233	77.13	gold quality
esophagus	UBERON:0001043	76.72	gold quality
body of uterus	UBERON:0009853	76.68	gold quality
hypothalamus	UBERON:0001898	76.65	gold quality
cortical plate	UBERON:0005343	76.64	gold quality
ganglionic eminence	UBERON:0004023	76.55	gold quality
endocervix	UBERON:0000458	76.49	gold quality
ventricular zone	UBERON:0003053	76.28	gold quality
amygdala	UBERON:0001876	76.02	gold quality
transverse colon	UBERON:0001157	75.85	gold quality
mucosa of transverse colon	UBERON:0004991	75.81	gold quality
right lobe of liver	UBERON:0001114	75.62	gold quality
right coronary artery	UBERON:0001625	75.60	gold quality
popliteal artery	UBERON:0002250	75.56	gold quality
tibial artery	UBERON:0007610	75.54	gold quality
left uterine tube	UBERON:0001303	75.41	gold quality
right hemisphere of cerebellum	UBERON:0014890	75.27	gold quality
substantia nigra	UBERON:0002038	75.21	gold quality
right ovary	UBERON:0002118	75.18	gold quality
left coronary artery	UBERON:0001626	75.08	gold quality
left adrenal gland	UBERON:0001234	75.07	gold quality
skin of abdomen	UBERON:0001416	74.99	gold quality
muscle organ	UBERON:0001630	74.91	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	74.80	gold quality
aorta	UBERON:0000947	74.66	gold quality
left adrenal gland cortex	UBERON:0035825	74.62	gold quality
mucosa of stomach	UBERON:0001199	74.61	gold quality
cerebellar hemisphere	UBERON:0002245	74.53	gold quality
cerebellar cortex	UBERON:0002129	74.46	gold quality
metanephros cortex	UBERON:0010533	74.41	gold quality
caudate nucleus	UBERON:0001873	74.39	gold quality
heart left ventricle	UBERON:0002084	74.32	gold quality
omental fat pad	UBERON:0010414	74.32	gold quality
peritoneum	UBERON:0002358	74.23	gold quality
neocortex	UBERON:0001950	74.09	gold quality
skin of leg	UBERON:0001511	74.08	gold quality
putamen	UBERON:0001874	74.04	gold quality
body of stomach	UBERON:0001161	73.97	gold quality
smooth muscle tissue	UBERON:0001135	73.94	gold quality
thoracic aorta	UBERON:0001515	73.93	gold quality
ascending aorta	UBERON:0001496	73.88	gold quality
frontal cortex	UBERON:0001870	73.74	gold quality
cardiac ventricle	UBERON:0002082	73.60	gold quality
right atrium auricular region	UBERON:0006631	73.55	gold quality
esophagus mucosa	UBERON:0002469	73.54	gold quality
nucleus accumbens	UBERON:0001882	73.36	gold quality
colon	UBERON:0001155	73.34	gold quality
descending thoracic aorta	UBERON:0002345	73.31	gold quality
coronary artery	UBERON:0001621	73.24	gold quality
small intestine Peyer’s patch	UBERON:0003454	73.19	gold quality
adipose tissue of abdominal region	UBERON:0007808	73.17	gold quality
adenohypophysis	UBERON:0002196	73.14	gold quality
left ovary	UBERON:0002119	73.09	gold quality
leukocyte	CL:0000738	72.85	gold quality
cerebellum	UBERON:0002037	72.83	gold quality
adrenal cortex	UBERON:0001235	72.75	gold quality
decidua	UBERON:0002450	72.68	gold quality
right uterine tube	UBERON:0001302	72.66	gold quality
deltoid	UBERON:0001476	72.50	silver quality
cardiac atrium	UBERON:0002081	72.50	gold quality
monocyte	CL:0000576	72.44	gold quality
gall bladder	UBERON:0002110	72.36	gold quality
large intestine	UBERON:0000059	72.23	gold quality
kidney epithelium	UBERON:0004819	72.07	gold quality
heart	UBERON:0000948	71.96	gold quality
adrenal gland	UBERON:0002369	71.82	gold quality
cerebral cortex	UBERON:0000956	71.75	gold quality
spleen	UBERON:0002106	71.72	gold quality
intestine	UBERON:0000160	71.70	gold quality
small intestine	UBERON:0002108	71.63	gold quality
forebrain	UBERON:0001890	71.53	gold quality
zone of skin	UBERON:0000014	71.50	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.69

HPA expression

RNA tissue specificity: Low tissue specificity

showing 60 of 76 HPA tissues / cells by nTPM:

Tissue / cell	Axis	nTPM	Protein (IHC)
Corpus callosum	tissue	16.7
Cerebellum	tissue	12.8	low
Amygdala	tissue	12.7
Spinal cord	tissue	12.6
Cerebral cortex	tissue	12.1	medium
Retrosplenial cortex	tissue	12.1
Insular cortex	tissue	12.1
Ventral pallidum	tissue	11.6
Locus coeruleus	tissue	11.4
Olfactory bulb	tissue	11.4
Medulla oblongata	tissue	11.2
Cingulate cortex	tissue	11.2
Basal ganglia	tissue	11.1	medium
Periaqueductal gray	tissue	11.1
Hippocampal formation	tissue	10.9
Septum	tissue	10.8
Temporal cortex	tissue	10.8
Midbrain	tissue	10.7
Hypothalamus	tissue	10.3
Substantia nigra	tissue	10.3
Prefrontal cortex	tissue	9.9
Superior colliculi	tissue	9.9
Occipital cortex	tissue	9.9
Motor cortex	tissue	9.7
Skeletal muscle	tissue	9.5	low
Entorhinal cortex	tissue	9.5
Somatosensory cortex	tissue	9.4
Putamen	tissue	9.3
Pons	tissue	8.6
Thalamus	tissue	8.6
Hippocampus	tissue	7.7	not detected
Nucleus accumbens	tissue	6.5
Postcentral gyrus	tissue	6.2
Vagina	tissue	6.0	high
Skin 1	tissue	5.0	medium
Testis	tissue	5.0	medium
Pituitary gland	tissue	4.8
Ovary	tissue	4.6	medium
Retina	tissue	4.2
Smooth muscle	tissue	4.1	not detected
Choroid plexus	tissue	4.1
Seminal vesicle	tissue	4.0	not detected
Thymus	tissue	3.8
Fallopian tube	tissue	3.6	medium
Duodenum	tissue	3.5	high
Parathyroid gland	tissue	3.4	not detected
Gallbladder	tissue	3.3	medium
Heart muscle	tissue	3.2	not detected
Endometrium 1	tissue	3.2	low
Epididymis	tissue	3.2	high
Spleen	tissue	3.2	not detected
Small intestine	tissue	3.1	high
Prostate	tissue	3.1	not detected
Cervix	tissue	3.0	high
Adipose tissue	tissue	3.0	not detected
Tongue	tissue	3.0
Adrenal gland	tissue	3.0	high
Lymph node	tissue	2.9	medium
Esophagus	tissue	2.9	high
Thyroid gland	tissue	2.9	medium

Brain sub-regions (HPA Brain Atlas): detected in 191; highest nTPM — White matter (16.7), Parieto-temporal junction (white matter) (13.7), Temporal white matter (12.6), Ventral spinal cord (12.6), Nucleus raphe pallidus (12.5).

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

Targeting THAP8 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific).

22 miRNAs:

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-150-5P	99.99	66.69	1976
HSA-MIR-185-3P	99.95	67.01	1743
HSA-MIR-6499-3P	99.90	66.38	1212
HSA-MIR-629-3P	99.85	67.99	1875
HSA-MIR-3663-3P	99.84	70.39	798
HSA-MIR-4713-5P	99.78	67.80	1794
HSA-MIR-518A-5P	99.70	69.01	2209
HSA-MIR-527	99.70	69.01	2209
HSA-MIR-5697	99.39	67.74	1249
HSA-MIR-1911-3P	99.15	66.17	528
HSA-MIR-485-5P	99.10	64.78	1889
HSA-MIR-6884-5P	99.10	64.50	1987
HSA-MIR-4651	99.06	67.57	2002
HSA-MIR-608	98.93	67.83	2013
HSA-MIR-6846-5P	98.81	65.86	1121
HSA-MIR-6848-5P	98.81	65.49	1126
HSA-MIR-5691	98.23	67.02	1335
HSA-MIR-6805-3P	98.23	67.02	1334
HSA-MIR-4288	97.11	67.23	1636
HSA-MIR-1226-5P	96.50	65.28	643
HSA-MIR-632	96.08	67.17	798
HSA-MIR-6853-5P	93.94	61.88	114

Functional genomics

gnomAD constraint: pLI 7.66e-10, LOEUF 1.61, missense Z -1.22 — population loss-of-function intolerance (pLI ≥ 0.9 = LoF-intolerant; lower LOEUF = more constrained). gnomAD

Regional missense constraint (gnomAD RMC): no regional variation along ENST00000292894 — one region, missense o/e 1.08.

Cross-species orthologs

1 orthologs

Organism	Symbol	Gene ID
drosophila_melanogaster	CG13894	FBGN0035157

Paralogs (7): THAP3 (ENSG00000041988), THAP1 (ENSG00000131931), ARL14EP (ENSG00000152219), THAP2 (ENSG00000173451), THAP6 (ENSG00000174796), THAP7 (ENSG00000184436), ARL14EPL (ENSG00000268223)

Additional cross-species homologs

Sequence homologs in species beyond Ensembl Compara’s model organisms, by Diamond local protein alignment (% sequence identity; best hit per species). Lower-identity rows are more distant homologs. The matched accessions’ gene symbols aren’t in biobtree yet, so each row shows the UniProt accession.

Organism	UniProt	Identity	Method
Rattus norvegicus	Q642B6	96.3%	Diamond
Mus musculus	Q6P3Z3	96.3%	Diamond
Macaca fascicularis	Q4R7M0	95.9%	Diamond
Bos taurus	Q1RMM0	83.8%	Diamond
Gallus gallus	Q5ZHN5	50.6%	Diamond
Xenopus laevis	Q0IHI7	47.7%	Diamond

Genomic neighbors (locus context)

Genes flanking this one on the chromosome (NCBI/Entrez gene neighborhood). Positional context only — some neighbors share regulatory elements (bidirectional promoters, antisense/overlapping transcripts), but chromosomal adjacency is not itself a functional relationship (see Interactions for that).

Symbol	Type	Entrez
CLIP3	protein-coding	25999
WDR62	protein-coding	284403
POLR2I	protein-coding	5438
OVOL3	protein-coding	728361
ALKBH6	protein-coding	84964
SYNE4	protein-coding	163183
TBCB	protein-coding	1155
SDHAF1	protein-coding	644096

Protein

Protein identifiers

THAP domain-containing protein 8 — Q8NA92 (reviewed: Q8NA92)

All UniProt accessions (3): E5RHW1, Q8NA92, U3KQ16

RefSeq proteins (4): NP_001318031, NP_001318032, NP_001318033, NP_689871* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR006612	THAP_Znf	Domain
IPR052224	THAP_domain_protein	Family

Pfam: PF05485

UniProt features (8 total): sequence variant 5, chain 1, zinc finger region 1, region of interest 1

Structure

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8NA92-F1	73.06	0.42

Human Protein Atlas

Protein class: Predicted intracellular proteins, Transcription factors, Zinc-coordinating DNA-binding domains

Protein evidence: Evidence at protein level

Subcellular location (HPA, imaging): nucleoplasm

Antibody reliability (HPA): IH approved · IF enhanced

Function

Pathways and Gene Ontology

Reactome pathways

0 curated (TAS) of 0; 0 disease pathways. Curated-first; evidence = TAS (manually curated) vs IEA (electronic inference).

MSigDB gene sets: 62 (showing top): E2F_Q4, MYAATNNNNNNNGGC_UNKNOWN, E2F_Q4_01, E2F4DP1_01, MENSE_HYPOXIA_UP, E2F1DP1_01, E2F1DP2_01, E2F1_Q3, IK3_01, E2F_Q3_01, E2F_02, SGCGSSAAA_E2F1DP2_01, E2F_Q6, E2F4DP2_01, MARTENS_TRETINOIN_RESPONSE_UP

GO Molecular Function (4): DNA binding (GO:0003677), zinc ion binding (GO:0008270), protein binding (GO:0005515), metal ion binding (GO:0046872)

GO Cellular Component (1): nucleoplasm (GO:0005654)

GO top-level categories

6 GO namespaces:

Category	Terms
nucleic acid binding	1
transition metal ion binding	1
binding	1
cation binding	1
nuclear lumen	1
cellular anatomical structure	1

Experimentally-supported GO annotations

GO terms backed by direct experimental evidence (ECO experimental codes) — 1 of 5 annotations. The rest are phylogenetic / computational / electronic (IEA).

1 experimentally-supported GO terms:

GO term	NS	Evidence
nucleoplasm	CC	direct assay

Protein interactions and networks

STRING

showing 15 of 178 interactions by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
THAP8	THAP10	Q9P2Z0	773
THAP8	THAP6	Q8TBB0	570
THAP8	THAP12	O43422	547
THAP8	THAP9	Q9H5L6	547
THAP8	TTLL2	Q9BWV7	515
THAP8	OR51M1	Q9H341	470
THAP8	THAP11	Q96EK4	465
THAP8	WSCD2	Q2TBF2	440
THAP8	GAB3	Q8WWW8	421
THAP8	ANKRD18B	A2A2Z9	390
THAP8	ALPK2	Q86TB3	379
THAP8	ZFPM1	Q8IX07	365
THAP8	CHST12	Q9NRB3	365
THAP8	MEX3B	Q6ZN04	363
THAP8	ZNF628	Q5EBL2	352

IntAct

Human interaction partners of THAP8 in IntAct, one row per partner (best MIscore; records = supporting IntAct interaction records).

9 partners by confidence:

Partner	Interaction type	MIscore	Records
TFIP11	physical association	0.670	5
NMI	physical association	0.560	3
TMED9	physical association	0.370	1
RAB14	association	0.350	1
SNAP29	association	0.350	1
UBE2D2	association	0.350	1
DYNLL1	physical association	0.000	1
SETDB1	physical association	0.000	1
TP53	physical association	0.000	1

BioGRID (33 interactions; top human partners by supporting records): C9orf16 (Affinity Capture-MS; 3 records), PRMT7 (Affinity Capture-MS; 3 records), LASP1 (Affinity Capture-MS; 2 records), UBE2D2 (Affinity Capture-MS; 2 records), ALCAM (Affinity Capture-MS), ATPIF1 (Affinity Capture-MS), CEP44 (Affinity Capture-MS), CORO1B (Affinity Capture-MS), DAK (Affinity Capture-MS), DYNLL1 (Two-hybrid), EML3 (Affinity Capture-MS), FAM49B (Affinity Capture-MS), HNRNPH1 (Affinity Capture-RNA), MIPOL1 (Affinity Capture-MS), MRS2 (Affinity Capture-MS)

Disease & clinical

Genetic variants

Variant evidence for THAP8: 8 ClinVar records (0 pathogenic / likely pathogenic).

ClinVar

8 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	7
Likely benign	0
Benign	0

SpliceAI

Top 10 splice-impact sites by Δscore (adjacent positions with the same effect merged into one range; 37 predictions of 319):

Position(s)	Effect	Δscore	Sites
19:36039321–36039322	donor_loss	1.0000	5
19:36054133–36054134	donor_loss	0.9900	6
19:36035593–36035594	acceptor_loss	0.9800	6
19:36039942–36039943	donor_loss	0.9800	5
19:36040137–36040138	acceptor_loss	0.9800	5
19:36040137	acceptor_loss	0.9700
19:36054105	donor_gain	0.9700
19:36040811	donor_gain	0.9600
19:36039719–36039720	acceptor_loss	0.9500	6
19:36039886	donor_gain	0.9400

AlphaMissense

328 missense substitutions predicted likely pathogenic (of 1,729 scored), across 71 residues. Top 20 hotspot residues, ranked by the number of likely-pathogenic substitutions (of those reachable by a single-nucleotide change), then by mean score:

Residue	Likely-pathogenic substitutions	Mean am_pathogenicity	Max am_pathogenicity
F62	8	0.966	0.994
F67	8	0.940	0.989
F29	8	0.924	0.992
H61	8	0.910	0.979
F26	8	0.905	0.991
F85	8	0.891	0.984
S59	8	0.835	0.974
W40	7	0.966	0.986
C58	7	0.942	0.959
C10	7	0.933	0.958
C5	7	0.919	0.950
W71	7	0.883	0.956
S25	7	0.860	0.958
W69	7	0.847	0.910
W49	7	0.844	0.958
H54	7	0.737	0.894
D33	7	0.659	0.745
P30	6	0.914	0.947
P82	6	0.901	0.962
P51	6	0.888	0.961

HPA cancer prognostics

RNA cancer specificity: Low cancer specificity

Human Protein Atlas survival analysis — favorable = higher expression predicts better survival.

2 prognostic cancer types:

Cancer	Prognostic	p-value
Liver Hepatocellular Carcinoma (TCGA)	unfavorable	4.27e-07
Lung Squamous Cell Carcinoma (TCGA)	favorable	0.000313

Disease associations

OMIM: gene MIM:612536 | disease phenotypes:

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (CPIC guideline: no)

CTD chemical–gene interactions

21 total (human), top 21 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
(+)-JQ1 compound	increases expression	2
Aflatoxin B1	increases methylation, decreases expression	2
Cadmium Chloride	decreases expression, increases expression	2
TAK-243	increases sumoylation	1
sodium arsenite	decreases expression	1
S-(1,2-dichlorovinyl)cysteine	affects response to substance, increases expression	1
di-n-butylphosphoric acid	affects expression	1
2-palmitoylglycerol	increases expression	1
jinfukang	affects cotreatment, increases expression	1
Sunitinib	increases expression	1
Air Pollutants	decreases expression, increases abundance	1
Cisplatin	affects cotreatment, increases expression	1
Dichlorodiphenyl Dichloroethylene	decreases expression	1
Estradiol	decreases expression	1
Hydrogen Peroxide	affects expression	1
Lipopolysaccharides	decreases expression, affects response to substance, increases expression	1
Rotenone	increases expression	1
Tobacco Smoke Pollution	decreases expression	1
Urethane	decreases expression	1
Valproic Acid	increases methylation	1
Particulate Matter	decreases expression, increases abundance	1

Clinical trials (associated diseases)

Via MONDO — disease-level, not drug-specific.