THAP9-AS1

Summary

THAP9-AS1 (THAP9 antisense RNA 1, HGNC:44172) is a long non-coding RNA gene on chromosome 4q21.22.

Predicted to act upstream of or within response to wounding.

Source: NCBI Gene 100499177 — RefSeq curated summary.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:44172
Approved symbol	THAP9-AS1
Name	THAP9 antisense RNA 1
Location	4q21.22
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000251022
Ensembl biotype	lncRNA
Entrez	100499177
RNAcentral	URS000075EF75 — lncRNA, 2318 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 12 — 12 lncRNA

ENST00000503704, ENST00000504520, ENST00000504718, ENST00000504792, ENST00000504869, ENST00000505028, ENST00000507660, ENST00000508772, ENST00000509007, ENST00000511271, ENST00000512932, ENST00000513581

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000503704 — 2 exons

Exon	Start	End
ENSE00002086624	82899823	82900223
ENSE00003548294	82900334	82900569

Expression profiles

Bgee: expression breadth ubiquitous, 283 present calls, max score 96.01.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 15.0376 / max 504.2526, expressed in 1733 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
52897	15.0376	1733
52896	9.8984	1564

Top tissues by expression

294 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
calcaneal tendon	UBERON:0003701	96.01	gold quality
rectum	UBERON:0001052	95.14	gold quality
tibial nerve	UBERON:0001323	95.06	gold quality
skin of abdomen	UBERON:0001416	94.31	gold quality
left ovary	UBERON:0002119	94.13	gold quality
left lobe of thyroid gland	UBERON:0001120	93.94	gold quality
thyroid gland	UBERON:0002046	93.52	gold quality
ectocervix	UBERON:0012249	93.51	gold quality
metanephros cortex	UBERON:0010533	93.50	gold quality
minor salivary gland	UBERON:0001830	93.42	gold quality
right lung	UBERON:0002167	93.41	gold quality
epithelium of nasopharynx	UBERON:0001951	93.37	gold quality
cortical plate	UBERON:0005343	93.30	gold quality
skin of leg	UBERON:0001511	93.29	gold quality
tendon	UBERON:0000043	93.27	gold quality
monocyte	CL:0000576	93.23	gold quality
ventricular zone	UBERON:0003053	93.21	gold quality
subcutaneous adipose tissue	UBERON:0002190	93.16	gold quality
endometrium	UBERON:0001295	93.15	gold quality
right ovary	UBERON:0002118	93.13	gold quality
right lobe of thyroid gland	UBERON:0001119	93.12	gold quality
mononuclear cell	CL:0000842	93.11	gold quality
ganglionic eminence	UBERON:0004023	93.10	gold quality
body of uterus	UBERON:0009853	92.89	gold quality
zone of skin	UBERON:0000014	92.79	gold quality
cerebellar hemisphere	UBERON:0002245	92.58	gold quality
leukocyte	CL:0000738	92.57	gold quality
mouth mucosa	UBERON:0003729	92.52	gold quality
cerebellar cortex	UBERON:0002129	92.49	gold quality
right hemisphere of cerebellum	UBERON:0014890	92.49	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	5.14

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 5)

• lncRNA THAP9-AS1 Promotes Pancreatic Ductal Adenocarcinoma Growth and Leads to a Poor Clinical Outcome via Sponging miR-484 and Interacting with YAP. (PMID:31831555)
• Long Noncoding RNA THAP9-AS1 and TSPOAP1-AS1 Provide Potential Diagnostic Signatures for Pediatric Septic Shock. (PMID:33344646)
• The role of long noncoding RNA THAP9-AS1 in the osteogenic differentiation of dental pulp stem cells via the miR-652-3p/VEGFA axis. (PMID:34288157)
• LncRNA THAP9-AS1 highly expressed in tissues of hepatocellular carcinoma and accelerates tumor cell proliferation. (PMID:36170961)
• THAP9-AS1 promotes nasopharyngeal carcinoma progression through targeted regulation of the miR-185-5p/SOX13 axis. (PMID:38270621)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.