THBS3-AS1

Summary

THBS3-AS1 (THBS3 antisense RNA 1, HGNC:40582) is a long non-coding RNA gene on chromosome 1q22.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:40582
Approved symbol	THBS3-AS1
Name	THBS3 antisense RNA 1
Location	1q22
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000231064
Ensembl biotype	lncRNA
Entrez	105371450
RNAcentral	URS000261799E — lncRNA, 1481 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 55 — 55 lncRNA

ENST00000422665, ENST00000430312, ENST00000436772, ENST00000447623, ENST00000453136, ENST00000454348, ENST00000685687, ENST00000686282, ENST00000687157, ENST00000690090, ENST00000701341, ENST00000701421, ENST00000702000, ENST00000702269, ENST00000702355, ENST00000702425, ENST00000702560, ENST00000702699, ENST00000702879, ENST00000702887, ENST00000702905, ENST00000730286, ENST00000730287, ENST00000730288, ENST00000730289, ENST00000730290, ENST00000730291, ENST00000730292, ENST00000730293, ENST00000730294, ENST00000730295, ENST00000730296, ENST00000730297, ENST00000730298, ENST00000730299, ENST00000730300, ENST00000730301, ENST00000730302, ENST00000730303, ENST00000730304, ENST00000730305, ENST00000730306, ENST00000730307, ENST00000730308, ENST00000730309, ENST00000730310, ENST00000730311, ENST00000730312, ENST00000730313, ENST00000730314, ENST00000730315, ENST00000730316, ENST00000730317, ENST00000730318, ENST00000730319

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000422665 — 6 exons

Exon	Start	End
ENSE00001610748	155200700	155200826
ENSE00001633913	155198403	155198618
ENSE00001736289	155200172	155200311
ENSE00003927055	155196899	155197017
ENSE00003930512	155205035	155205489
ENSE00003980808	155194997	155195372

Expression profiles

Bgee: expression breadth ubiquitous, 171 present calls, max score 97.33.

FANTOM5 (CAGE): breadth broad, TPM avg 3.8470 / max 92.9019, expressed in 820 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
5582	3.2206	654
5583	0.6264	351

Top tissues by expression

241 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right uterine tube	UBERON:0001302	97.33	gold quality
adenohypophysis	UBERON:0002196	92.63	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	92.21	gold quality
amygdala	UBERON:0001876	91.12	gold quality
nucleus accumbens	UBERON:0001882	90.57	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	90.55	gold quality
hypothalamus	UBERON:0001898	90.29	gold quality
caudate nucleus	UBERON:0001873	90.20	gold quality
anterior cingulate cortex	UBERON:0009835	89.78	gold quality
putamen	UBERON:0001874	89.56	gold quality
right frontal lobe	UBERON:0002810	89.56	gold quality
pituitary gland	UBERON:0000007	89.46	gold quality
sural nerve	UBERON:0015488	88.08	gold quality
ventricular zone	UBERON:0003053	88.05	gold quality
left uterine tube	UBERON:0001303	87.55	gold quality
mucosa of stomach	UBERON:0001199	87.21	gold quality
body of uterus	UBERON:0009853	87.02	gold quality
Brodmann (1909) area 9	UBERON:0013540	86.52	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	85.60	gold quality
tibial nerve	UBERON:0001323	85.55	gold quality
lower esophagus muscularis layer	UBERON:0035833	85.11	gold quality
lower esophagus	UBERON:0013473	85.07	gold quality
substantia nigra	UBERON:0002038	85.02	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	84.73	gold quality
left ovary	UBERON:0002119	84.71	gold quality
right ovary	UBERON:0002118	84.19	gold quality
right coronary artery	UBERON:0001625	83.99	gold quality
right lobe of thyroid gland	UBERON:0001119	83.77	gold quality
left lobe of thyroid gland	UBERON:0001120	83.63	gold quality
prefrontal cortex	UBERON:0000451	83.39	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	6.92

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.