THOC7

Summary

THOC7 (THO complex subunit 7, HGNC:29874) is a protein-coding gene on chromosome 3p14.1, encoding THO complex subunit 7 (Q6I9Y2). Component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. It is a common-essential gene (DepMap: required in 99.3% of cancer cell lines).

Predicted to enable RNA binding activity. Involved in mRNA export from nucleus. Located in chromosome, telomeric region; cytosol; and nuclear speck. Part of THO complex part of transcription export complex.

Source: NCBI Gene 80145 — RefSeq curated summary.

At a glance

• GWAS associations: 17
• Clinical variants (ClinVar): 3 total
• Cancer dependency (DepMap): dependent in 99.3% of screened cell lines (common-essential)
• MANE Select transcript: NM_025075

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:29874
Approved symbol	THOC7
Name	THO complex subunit 7
Location	3p14.1
Locus type	gene with protein product
Status	Approved
Aliases	NIF3L1BP1, FLJ23445, fSAP24
Ensembl gene	ENSG00000163634
Ensembl biotype	protein_coding
OMIM	611965
Entrez	80145

Gene structure

Transcript identifiers

Ensembl transcripts: 7 — 3 protein_coding, 2 protein_coding_CDS_not_defined, 1 nonsense_mediated_decay, 1 retained_intron

ENST00000295899, ENST00000464327, ENST00000469153, ENST00000469584, ENST00000473141, ENST00000487570, ENST00000498422

RefSeq mRNA: 3 — MANE Select: NM_025075 NM_001285387, NM_001285404, NM_025075

CCDS: CCDS2900, CCDS74957

Canonical transcript exons

ENST00000295899 — 8 exons

Exon	Start	End
ENSE00001348935	63863772	63863805
ENSE00001874756	63833870	63834199
ENSE00003461528	63835154	63835223
ENSE00003465617	63838372	63838499
ENSE00003556677	63835324	63835390
ENSE00003560576	63836301	63836358
ENSE00003615881	63839656	63839773
ENSE00003638247	63837976	63838062

Expression profiles

Bgee: expression breadth ubiquitous, 287 present calls, max score 98.55.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 37.4318 / max 1263.1084, expressed in 1809 samples.

FANTOM5 promoters (8 alternative TSS)

Promoter ID	TPM avg	Samples expressed
42829	32.3701	1805
42833	1.9695	802
42834	1.2978	600
42827	0.5161	256
42832	0.3788	163
42828	0.3214	119
42831	0.2979	127
42826	0.2801	107

Top tissues by expression

288 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
calcaneal tendon	UBERON:0003701	98.55	gold quality
oocyte	CL:0000023	98.01	gold quality
rectum	UBERON:0001052	97.11	gold quality
hindlimb stylopod muscle	UBERON:0004252	97.03	gold quality
islet of Langerhans	UBERON:0000006	97.01	gold quality
anterior cingulate cortex	UBERON:0009835	96.97	gold quality
muscle layer of sigmoid colon	UBERON:0035805	96.93	gold quality
body of pancreas	UBERON:0001150	96.91	gold quality
cingulate cortex	UBERON:0003027	96.91	gold quality
lower esophagus	UBERON:0013473	96.91	gold quality
lower esophagus muscularis layer	UBERON:0035833	96.91	gold quality
tibial artery	UBERON:0007610	96.76	gold quality
popliteal artery	UBERON:0002250	96.75	gold quality
esophagus	UBERON:0001043	96.73	gold quality
gastrocnemius	UBERON:0001388	96.68	gold quality
muscle of leg	UBERON:0001383	96.64	gold quality
caudate nucleus	UBERON:0001873	96.62	gold quality
amygdala	UBERON:0001876	96.62	gold quality
esophagus mucosa	UBERON:0002469	96.62	gold quality
pancreas	UBERON:0001264	96.60	gold quality
nucleus accumbens	UBERON:0001882	96.54	gold quality
heart left ventricle	UBERON:0002084	96.51	gold quality
gingival epithelium	UBERON:0001949	96.46	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	96.46	gold quality
cardiac ventricle	UBERON:0002082	96.44	gold quality
left coronary artery	UBERON:0001626	96.43	gold quality
monocyte	CL:0000576	96.40	gold quality
gingiva	UBERON:0001828	96.39	gold quality
mononuclear cell	CL:0000842	96.34	gold quality
heart right ventricle	UBERON:0002080	96.30	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 2.

Experiment	Marker?	Max mean expression
E-MTAB-10042	yes	13.30
E-ANND-3	yes	9.13

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

31 targeting THOC7, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4262	100.00	73.26	3931
HSA-MIR-181A-5P	99.99	72.96	2995
HSA-MIR-181B-5P	99.99	72.97	2996
HSA-MIR-181C-5P	99.99	72.95	2996
HSA-MIR-181D-5P	99.99	73.04	2997
HSA-MIR-1250-3P	99.96	70.04	4038
HSA-MIR-548E-5P	99.89	72.73	4486
HSA-MIR-6783-3P	99.89	67.92	2059
HSA-MIR-1343-3P	99.89	66.78	1815
HSA-MIR-153-5P	99.89	73.86	6317
HSA-MIR-4503	99.85	71.45	1869
HSA-MIR-4517	99.76	69.19	1867
HSA-MIR-4422	99.72	72.07	2908
HSA-MIR-12124	99.68	69.17	2700
HSA-MIR-586	99.65	70.40	2051
HSA-MIR-5700	99.64	69.88	2280
HSA-MIR-4762-5P	99.57	68.54	1424
HSA-MIR-516A-3P	99.46	67.96	1378
HSA-MIR-516B-3P	99.46	67.96	1378
HSA-MIR-7162-5P	99.46	68.08	1368
HSA-MIR-4797-5P	99.39	68.01	1354
HSA-MIR-6507-5P	99.36	70.46	2524
HSA-MIR-3125	99.14	68.49	2269
HSA-MIR-3916	98.99	68.04	2155
HSA-MIR-6859-5P	98.99	68.07	2049
HSA-MIR-4477A	98.83	69.75	2952
HSA-MIR-1-5P	98.70	68.66	1017
HSA-MIR-1255B-2-3P	97.80	67.04	880
HSA-MIR-335-5P	97.10	68.12	1022
HSA-MIR-541-3P	96.07	66.11	1271

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 99.3% of screened cell lines, common-essential.

Literature-anchored findings (GeneRIF, showing 3)

• THOC7 (50-137, amino acid numbers) binds to the N-terminal portion (1-199) of FMIP directly. (PMID:19059247)
• THOC7 negatively regulates type I IFN production by promoting TBK1 proteasomal degradation in Sendai virus infection (PMID:30769920)
• Human THO maintains the stability of repetitive DNA. (PMID:32065701)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	thoc7	ENSDARG00000015394
mus_musculus	Thoc7	ENSMUSG00000053453
rattus_norvegicus	Thoc7	ENSRNOG00000007701
drosophila_melanogaster	thoc7	FBGN0035110
caenorhabditis_elegans		WBGENE00007195

Protein

Protein identifiers

THO complex subunit 7 — Q6I9Y2 (reviewed: Q6I9Y2)

Alternative names: Functional spliceosome-associated protein 24, Ngg1-interacting factor 3-like protein 1-binding protein 1, hTREX30

All UniProt accessions (4): Q6I9Y2, A0A5S6STF9, F8WF22, H7C5E3

UniProt curated annotations — full annotation on UniProt →

Function. Component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. Required for efficient export of polyadenylated RNA. Plays a key structural role in the oligomerization of the THO-DDX39B complex. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5’ end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NXF1 pathway. (Microbial infection) The TREX complex is essential for the export of Kaposi’s sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production.

Subunit / interactions. Tetramer; as part of a THO-DDX39B complex. Component of the THO subcomplex, which is composed of THOC1, THOC2, THOC3, THOC5, THOC6 and THOC7. Component of the transcription/export (TREX) complex at least composed of ALYREF/THOC4, DDX39B, SARNP/CIP29, CHTOP and the THO subcomplex; in the complex interacts with THOC1, THOC2 and THOC5; forms a coiled-coil dimer with THOC5; together with THOC5 and THOC6, plays a key structural role in the oligomerization of the THO-DDX39B complex. TREX seems to have a dynamic structure involving ATP-dependent remodeling. Interacts with NIF3L1.

Subcellular location. Cytoplasm. Nucleus. Nucleus speckle.

Similarity. Belongs to the THOC7 family.

RefSeq proteins (3): NP_001272316, NP_001272333, NP_079351* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR008501	THOC7/Mft1	Family

Pfam: PF05615

UniProt features (16 total): helix 4, sequence conflict 3, region of interest 3, modified residue 3, initiator methionine 1, chain 1, coiled-coil region 1

Structure

Experimental structures (PDB)

3 structures.

PDB	Method	Resolution (Å)
7APK	ELECTRON MICROSCOPY	3.3
7ZNL	ELECTRON MICROSCOPY	3.45
7ZNK	ELECTRON MICROSCOPY	3.9

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q6I9Y2-F1	88.31	0.68

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (3): 2, 5, 36

Function

Pathways and Gene Ontology

Reactome pathways

8 pathways

ID	Pathway
R-HSA-159236	Transport of Mature mRNA derived from an Intron-Containing Transcript
R-HSA-72187	mRNA 3’-end processing
R-HSA-73856	RNA Polymerase II Transcription Termination
R-HSA-72202	Transport of Mature Transcript to Cytoplasm
R-HSA-72203	Processing of Capped Intron-Containing Pre-mRNA
R-HSA-73857	RNA Polymerase II Transcription
R-HSA-74160	Gene expression (Transcription)
R-HSA-8953854	Metabolism of RNA

MSigDB gene sets: 143 (showing top): MODULE_97, STARK_PREFRONTAL_CORTEX_22Q11_DELETION_DN, MODULE_182, GOBP_NUCLEAR_TRANSPORT, MILI_PSEUDOPODIA_HAPTOTAXIS_UP, GAZDA_DIAMOND_BLACKFAN_ANEMIA_PROGENITOR_DN, REACTOME_MRNA_3_END_PROCESSING, REACTOME_PROCESSING_OF_CAPPED_INTRON_CONTAINING_PRE_MRNA, GOBP_NUCLEOBASE_CONTAINING_COMPOUND_TRANSPORT, GOBP_RNA_SPLICING, GOBP_NUCLEAR_EXPORT, GOBP_RNA_LOCALIZATION, chr3p14, REACTOME_METABOLISM_OF_RNA, GOCC_TRANSCRIPTION_EXPORT_COMPLEX

GO Biological Process (4): mRNA processing (GO:0006397), mRNA export from nucleus (GO:0006406), RNA splicing (GO:0008380), mRNA transport (GO:0051028)

GO Molecular Function (2): RNA binding (GO:0003723), protein binding (GO:0005515)

GO Cellular Component (9): transcription export complex (GO:0000346), THO complex (GO:0000347), THO complex part of transcription export complex (GO:0000445), nucleus (GO:0005634), nucleoplasm (GO:0005654), cytoplasm (GO:0005737), cytosol (GO:0005829), nuclear speck (GO:0016607), chromosome, telomeric region (GO:0000781)

Reactome top-level categories

Rollup of top-5 pathways:

Category	Pathways
Processing of Capped Intron-Containing Pre-mRNA	2
Transport of Mature Transcript to Cytoplasm	1
RNA Polymerase II Transcription	1
Metabolism of RNA	1
Gene expression (Transcription)	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	3
RNA processing	2
nuclear protein-containing complex	2
mRNA metabolic process	1
RNA export from nucleus	1
gene expression	1
mRNA transport	1
RNA transport	1
nucleic acid binding	1
binding	1
transcription export complex	1
THO complex	1
intracellular membrane-bounded organelle	1
nuclear lumen	1
intracellular anatomical structure	1
cytoplasm	1
nuclear ribonucleoprotein granule	1
chromosomal region	1

Protein interactions and networks

STRING

1486 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
THOC7	THOC5	Q13769	998
THOC7	THOC6	Q86W42	998
THOC7	THOC2	Q8NI27	997
THOC7	THOC1	Q96FV9	997
THOC7	THOC3	Q96J01	997
THOC7	NIF3L1	Q9GZT8	939
THOC7	DDX39B	Q13838	876
THOC7	SARNP	P82979	855
THOC7	ALYREF	Q86V81	790
THOC7	NCBP1	Q09161	740
THOC7	DDX39A	O00148	640
THOC7	CHTOP	Q9Y3Y2	638
THOC7	FYTTD1	Q96QD9	624
THOC7	NXF1	Q9UBU9	621
THOC7	NXT1	Q9UKK6	593

IntAct

104 interactions, top by confidence:

A	B	Type	Score
THOC1	THOC5	psi-mi:“MI:0914”(association)	0.930
RBM8A	CASC3	psi-mi:“MI:0914”(association)	0.900
DDX39B	THOC5	psi-mi:“MI:0915”(physical association)	0.800
THOC1	EIF4A3	psi-mi:“MI:0914”(association)	0.660
THOC7	THOC5	psi-mi:“MI:0915”(physical association)	0.650
THOC5	THOC7	psi-mi:“MI:0915”(physical association)	0.650
THOC5	THOC7	psi-mi:“MI:0914”(association)	0.650
THOC7	THOC5	psi-mi:“MI:0914”(association)	0.650
THOC7	THOC5	psi-mi:“MI:0403”(colocalization)	0.650
SF3B1	SAP18	psi-mi:“MI:0914”(association)	0.640
THOC1	DDX39A	psi-mi:“MI:0914”(association)	0.640
NDC80	THOC7	psi-mi:“MI:0915”(physical association)	0.560
THOC7	SMARCD1	psi-mi:“MI:0915”(physical association)	0.560
THOC7	MNS1	psi-mi:“MI:0915”(physical association)	0.560
THOC7	CCDC146	psi-mi:“MI:0915”(physical association)	0.560
THOC3	CLUH	psi-mi:“MI:0914”(association)	0.530
NCBP3	SAP18	psi-mi:“MI:0914”(association)	0.530
	EIF4A3	psi-mi:“MI:0915”(physical association)	0.490
CPSF6	DDX39A	psi-mi:“MI:0914”(association)	0.480
DDX21	MED19	psi-mi:“MI:2364”(proximity)	0.480
CHTOP	SAP18	psi-mi:“MI:0915”(physical association)	0.400

BioGRID (167): THOC7 (Affinity Capture-RNA), THOC7 (Affinity Capture-RNA), THOC7 (Affinity Capture-RNA), THOC7 (Affinity Capture-RNA), THOC7 (Affinity Capture-MS), THOC7 (Affinity Capture-MS), THOC1 (Co-fractionation), THOC3 (Co-fractionation), THOC7 (Co-fractionation), THOC7 (Co-fractionation), THOC7 (Co-fractionation), THOC7 (Proximity Label-MS), ADAR (Affinity Capture-MS), BCL2L2 (Affinity Capture-MS), DHX9 (Affinity Capture-MS)

ESM2 similar proteins: A4IFK9, A4IGK3, A6H6W9, A9YWH3, O54941, O70166, O93388, P13668, P16949, P21818, P31395, P54227, P55821, P63042, P63043, Q2KI04, Q32KT0, Q32M00, Q3SZ60, Q3T0C7, Q4R4N5, Q4R712, Q5BJU6, Q5R4C5, Q5R8C6, Q5RBB8, Q5RE12, Q5SQY2, Q5XIA2, Q5ZK25, Q642H2, Q6AYJ2, Q6DUB7, Q6I9Y2, Q6NXN1, Q6PH81, Q7TMY4, Q7Z422, Q8BR65, Q8CJ19

Diamond homologs: A7RX34, Q3SZ60, Q552L5, Q6DGZ3, Q6I9Y2, Q6P643, Q7SZ78, Q7TMY4, Q8IRJ8, Q8LDS5, Q9M8T6

SIGNOR signaling

1 interactions.

A	Effect	B	Mechanism
THOC7	“form complex”	“TREX complex”	binding

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 106 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
mRNA 3’-end processing	16	42.0×	3e-20
Transport of Mature Transcript to Cytoplasm	7	35.5×	3e-08
RNA Polymerase II Transcription Termination	12	35.1×	4e-14
Transport of Mature mRNA derived from an Intron-Containing Transcript	13	26.4×	8e-14
Processing of Capped Intron-Containing Pre-mRNA	18	19.7×	8e-17
mRNA Splicing	13	19.0×	5e-12
mRNA Splicing - Major Pathway	23	16.8×	3e-20
mRNA Polyadenylation	14	16.4×	5e-12

GO biological processes:

GO term	Partners	Fold	FDR
mRNA export from nucleus	13	40.5×	1e-15
U2-type prespliceosome assembly	5	32.9×	4e-05
mRNA splicing, via spliceosome	19	18.3×	3e-16
RNA splicing	18	16.7×	3e-15
mRNA processing	19	15.8×	1e-15
regulation of alternative mRNA splicing, via spliceosome	5	12.8×	2e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

3 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	1
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1146 predictions. Top by Δscore:

Variant	Effect	Δscore
3:63834200:C:CC	acceptor_gain	1.0000
3:63835152:A:AC	donor_gain	1.0000
3:63835152:ACTTT:A	donor_gain	1.0000
3:63835153:C:CC	donor_gain	1.0000
3:63835153:CTTTC:C	donor_gain	1.0000
3:63835156:T:A	donor_gain	1.0000
3:63835220:CCAG:C	acceptor_gain	1.0000
3:63835221:CAG:C	acceptor_gain	1.0000
3:63835221:CAGC:C	acceptor_gain	1.0000
3:63835222:AGC:A	acceptor_loss	1.0000
3:63835224:C:CC	acceptor_gain	1.0000
3:63835225:T:A	acceptor_loss	1.0000
3:63835226:G:C	acceptor_gain	1.0000
3:63835226:G:GC	acceptor_gain	1.0000
3:63835229:T:TC	acceptor_gain	1.0000
3:63835328:T:C	donor_gain	1.0000
3:63835388:TCCC:T	acceptor_loss	1.0000
3:63835389:CC:C	acceptor_gain	1.0000
3:63835390:CC:C	acceptor_gain	1.0000
3:63835391:C:A	acceptor_loss	1.0000
3:63835391:C:CC	acceptor_gain	1.0000
3:63835392:T:A	acceptor_loss	1.0000
3:63836294:CACTT:C	donor_loss	1.0000
3:63836295:ACTT:A	donor_loss	1.0000
3:63836296:CT:C	donor_loss	1.0000
3:63836297:T:TC	donor_loss	1.0000
3:63836298:T:TC	donor_loss	1.0000
3:63836299:A:AC	donor_gain	1.0000
3:63836299:AC:A	donor_loss	1.0000
3:63836300:C:CA	donor_gain	1.0000

AlphaMissense

1353 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
3:63835171:A:G	L177P	1.000
3:63835192:A:G	L170P	1.000
3:63836334:A:T	I126N	1.000
3:63836356:A:G	Y119H	1.000
3:63837981:C:G	R116P	1.000
3:63837990:C:G	R113P	1.000
3:63838003:C:G	A109P	1.000
3:63838467:A:G	L57P	1.000
3:63839684:A:G	W37R	1.000
3:63839684:A:T	W37R	1.000
3:63839704:A:G	L30P	1.000
3:63839715:T:A	R26S	1.000
3:63839715:T:G	R26S	1.000
3:63839726:C:G	D23H	1.000
3:63839728:C:T	G22E	1.000
3:63839734:C:T	G20D	1.000
3:63839735:C:A	G20C	1.000
3:63839735:C:G	G20R	1.000
3:63839740:C:A	G18V	1.000
3:63839740:C:T	G18E	1.000
3:63839741:C:G	G18R	1.000
3:63839741:C:T	G18R	1.000
3:63839744:C:G	D17H	1.000
3:63839749:A:G	L15P	1.000
3:63839752:A:G	L14P	1.000
3:63839752:A:T	L14H	1.000
3:63839755:C:G	R13P	1.000
3:63839756:G:T	R13S	1.000
3:63839761:C:G	R11P	1.000
3:63839764:A:T	I10K	1.000

dbSNP variants (sampled 300 via entrez): RS1000039641 (3:63856130 A>G), RS1000074512 (3:63835748 A>C), RS1000120340 (3:63848844 T>C), RS1000126641 (3:63836040 T>G), RS1000312104 (3:63861860 T>C), RS1000374389 (3:63843151 C>T), RS1000427573 (3:63860359 T>C), RS1000483033 (3:63860144 A>G), RS1000630319 (3:63844028 G>A), RS1000659857 (3:63844407 T>C), RS1000771606 (3:63847474 A>C,G), RS1000898147 (3:63853733 C>A,G,T), RS1000982902 (3:63841704 C>T), RS1001131757 (3:63834580 A>T), RS1001258430 (3:63836468 G>C)

Disease associations

OMIM: gene MIM:611965 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

17 associations (top):

Study	Trait	p-value
GCST002539_49	Schizophrenia	1.000000e-08
GCST004946_63	Schizophrenia	4.000000e-08
GCST006803_106	Schizophrenia	1.000000e-10
GCST007201_143	Schizophrenia	5.000000e-09
GCST007201_208	Schizophrenia	6.000000e-10
GCST008506_1	Stress sensitivity (neuroticism score x major depressive disorder status interaction)	2.000000e-06
GCST008506_6	Stress sensitivity (neuroticism score x major depressive disorder status interaction)	7.000000e-06
GCST008595_34	Cognitive ability, years of educational attainment or schizophrenia (pleiotropy)	2.000000e-08
GCST009600_13	Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy)	4.000000e-09
GCST010002_428	Refractive error	5.000000e-11
GCST010698_66	Subcortical volume (min-P)	1.000000e-16
GCST010699_21	Brain morphology (min-P)	9.000000e-10
GCST010701_75	Cortical surface area (MOSTest)	4.000000e-09
GCST010702_127	Subcortical volume (MOSTest)	4.000000e-09
GCST010703_71	Brain morphology (MOSTest)	3.000000e-08
GCST90002398_124	Neutrophil count	2.000000e-09
GCST90002407_49	White blood cell count	5.000000e-11

EFO canonical traits (5, from GWAS)

EFO ID	Trait name
EFO:0007660	neuroticism measurement
EFO:0004337	intelligence
EFO:0004784	self reported educational attainment
EFO:0004346	neuroimaging measurement
EFO:0004833	neutrophil count

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

31 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Particulate Matter	decreases expression, increases abundance, increases expression, affects cotreatment	3
bisphenol A	affects expression, increases abundance, decreases expression, affects cotreatment	2
sodium arsenite	decreases expression, increases abundance, increases expression	2
Air Pollutants	decreases expression, increases abundance, increases expression	2
aristolochic acid I	decreases expression	1
TAK-243	increases sumoylation	1
ginger extract	affects cotreatment, affects expression, increases abundance	1
bufotalin	decreases expression	1
methylmercuric chloride	decreases expression	1
beta-lapachone	decreases expression, increases expression	1
arsenite	affects binding, increases reaction	1
perfluorooctanoic acid	increases expression	1
perfluorooctane sulfonic acid	increases expression	1
CGP 52608	increases reaction, affects binding	1
perfluorohexanesulfonic acid	decreases expression	1
bisphenol S	affects cotreatment, increases expression	1
Acetaminophen	decreases expression	1
Ethanol	decreases expression, increases abundance, affects cotreatment	1
Arsenic	increases abundance, increases expression	1
Atrazine	decreases expression	1
Benzo(a)pyrene	affects methylation	1
Dexamethasone	affects cotreatment, increases expression	1
Diuron	decreases expression	1
Gasoline	decreases expression, increases abundance, affects cotreatment	1
Indomethacin	affects cotreatment, increases expression	1
Oils, Volatile	affects cotreatment, affects expression, increases abundance	1
Polycyclic Aromatic Hydrocarbons	affects cotreatment, decreases expression, increases abundance	1
Urethane	decreases expression	1
1-Methyl-3-isobutylxanthine	affects cotreatment, increases expression	1
Aflatoxin M1	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.