THORLNC

Summary

THORLNC (testis associated oncogenic lncRNA, HGNC:53788) is a long non-coding RNA gene on chromosome 2q14.2.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:53788
Approved symbol	THORLNC
Name	testis associated oncogenic lncRNA
Location	2q14.2
Locus type	RNA, long non-coding
Status	Approved
Aliases	THOR
Ensembl gene	ENSG00000226856
Ensembl biotype	lncRNA
OMIM	619296
Entrez	100506797
RNAcentral	URS0000A765A8 — lncRNA, 631 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 38 — 38 lncRNA

ENST00000414886, ENST00000449075, ENST00000449819, ENST00000647942, ENST00000648779, ENST00000661786, ENST00000669120, ENST00000687658, ENST00000688717, ENST00000701291, ENST00000744784, ENST00000744785, ENST00000744786, ENST00000744787, ENST00000744788, ENST00000744789, ENST00000744790, ENST00000744791, ENST00000744792, ENST00000744793, ENST00000744794, ENST00000744795, ENST00000744796, ENST00000744797, ENST00000744798, ENST00000744799, ENST00000744800, ENST00000744801, ENST00000744802, ENST00000744803, ENST00000744804, ENST00000744805, ENST00000744806, ENST00000744807, ENST00000744808, ENST00000744809, ENST00000744810, ENST00000744811

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000414886 — 4 exons

Exon	Start	End
ENSE00001635309	118183087	118183322
ENSE00001671825	118186231	118186386
ENSE00001764410	118176765	118176905
ENSE00001768414	118132128	118132372

Expression profiles

Bgee: expression breadth ubiquitous, 150 present calls, max score 95.18.

FANTOM5 (CAGE): breadth broad, TPM avg 1.1996 / max 116.3799, expressed in 531 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
30373	0.6604	287
30374	0.5391	298

Top tissues by expression

248 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	95.18	gold quality
sperm	CL:0000019	94.83	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	93.04	gold quality
left testis	UBERON:0004533	89.99	gold quality
right testis	UBERON:0004534	89.25	gold quality
testis	UBERON:0000473	87.68	gold quality
tibialis anterior	UBERON:0001385	82.24	silver quality
pancreatic ductal cell	CL:0002079	81.31	silver quality
ileal mucosa	UBERON:0000331	78.99	silver quality
endothelial cell	CL:0000115	78.89	silver quality
adult organism	UBERON:0007023	72.46	gold quality
sural nerve	UBERON:0015488	72.11	gold quality
bone marrow cell	CL:0002092	69.27	gold quality
ventricular zone	UBERON:0003053	67.94	gold quality
deltoid	UBERON:0001476	67.10	gold quality
ganglionic eminence	UBERON:0004023	65.49	gold quality
right coronary artery	UBERON:0001625	64.60	gold quality
cortical plate	UBERON:0005343	64.34	gold quality
right lobe of liver	UBERON:0001114	59.89	gold quality
monocyte	CL:0000576	59.19	gold quality
hindlimb stylopod muscle	UBERON:0004252	58.16	gold quality
layer of synovial tissue	UBERON:0007616	58.13	gold quality
islet of Langerhans	UBERON:0000006	57.90	gold quality
skin of hip	UBERON:0001554	57.50	silver quality
epithelial cell of pancreas	CL:0000083	57.24	gold quality
lymph node	UBERON:0000029	56.89	gold quality
saphenous vein	UBERON:0007318	56.80	gold quality
pancreas	UBERON:0001264	56.56	gold quality
dorsal root ganglion	UBERON:0000044	56.45	gold quality
prefrontal cortex	UBERON:0000451	56.21	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.70

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 13)

• Lnc-THOR expression is essential for human osteosarcoma cell growth. (PMID:29626476)
• THOR expression promotes renal cell carcinoma cell growth in vitro and in vivo. (PMID:29752937)
• results demonstrate that lncRNA THOR could attenuate cisplatin sensitivity of NPC cells by enhancing cells stemness through promoting YAP transcriptional activity (PMID:29959065)
• Data demonstrated that THOR expression is upregulated in hepatocellular carcinoma (HCC) tissues, and THOR siRNA silencing suppresses the growth and metastasis of HCC cells. Moreover, THOR promoted HCC cell progression by activating PTEN/AKT signaling in vitro. (PMID:30098425)
• lncRNA THOR is up-regulated in retinoblastoma, and its over-expression significantly enhances the malignant phenotype transformation of retinoblastoma cells by up-regulating c-myc and TGF2BP1 expression. (PMID:30119193)
• THOR could potentiate the stemness of gastric cancer cells via directly binding to SOX9 3’UTR. (PMID:30227327)
• THOR mediated IGF2 expression via interacting with IGF2BP1, and affected the downstream MEK-ERK signaling pathway to regulate tongue squamous cell carcinomas cells proliferation. (PMID:31220513)
• Lnc-THOR silencing inhibits human glioma cell survival by activating MAGEA6-AMPK signaling. (PMID:31727877)
• Long Non-Coding RNA THOR Enhances the Stem Cell-Like Traits of Triple-Negative Breast Cancer Cells Through Activating beta-Catenin Signaling. (PMID:32665537)
• A novel N6-methyladenosine (m6A)-dependent fate decision for the lncRNA THOR. (PMID:32792482)
• Carboxymethylated chitosan alleviated oxidative stress injury in retinal ganglion cells via IncRNA-THOR/IGF2BP1 axis. (PMID:33811613)
• LncRNA THOR promotes endometrial cancer progression through the AKT and ERK signaling pathways. (PMID:36175594)
• The lncRNA THOR interacts with and stabilizes hnRNPD to promote cell proliferation and metastasis in breast cancer. (PMID:36329124)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.