THRB-AS2

Summary

THRB-AS2 (THRB antisense RNA 2, HGNC:54854) is a long non-coding RNA gene on chromosome 3p24.2.

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:54854
Approved symbol	THRB-AS2
Name	THRB antisense RNA 2
Location	3p24.2
Locus type	RNA, long non-coding
Status	Approved
Entrez	101927854
RNAcentral	URS000075CD6E — lncRNA, 643 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 0

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

None — 0 exons

Expression profiles

Top tissues by expression

0 total, by Bgee expression score (0-100, higher = more expressed):

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Protein identifiers

Canonical reviewed UniProt: None (reviewed: )

All UniProt accessions (0):

RefSeq proteins (0): (*=MANE)

Domains & families (InterPro)

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 2 (showing top): chr3p24, TRAVAGLINI_LUNG_PLATELET_MEGAKARYOCYTE_CELL

GO Biological Process (0):

GO Molecular Function (0):

GO Cellular Component (0):

Protein interactions and networks

STRING

0 interactions, top by confidence (×1000):

IntAct

0 interactions, top by confidence:

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

0 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1864 predictions. Top by Δscore:

Variant	Effect	Δscore
3:24143495:CCTTA:C	donor_loss	1.0000
3:24143496:CTTAC:C	donor_loss	1.0000
3:24143497:TTA:T	donor_loss	1.0000
3:24143498:TA:T	donor_loss	1.0000
3:24143499:A:AC	donor_gain	1.0000
3:24143499:A:AG	donor_loss	1.0000
3:24143500:C:CA	donor_loss	1.0000
3:24143500:C:CC	donor_gain	1.0000
3:24143521:T:TA	donor_gain	1.0000
3:24143702:CACCA:C	acceptor_gain	1.0000
3:24143703:ACCA:A	acceptor_gain	1.0000
3:24143704:CCA:C	acceptor_gain	1.0000
3:24143704:CCAC:C	acceptor_gain	1.0000
3:24143705:CA:C	acceptor_gain	1.0000
3:24143705:CAC:C	acceptor_gain	1.0000
3:24143706:ACTG:A	acceptor_loss	1.0000
3:24143707:C:CC	acceptor_gain	1.0000
3:24143707:CTGGG:C	acceptor_loss	1.0000
3:24152489:CC:C	acceptor_gain	1.0000
3:24152490:CC:C	acceptor_gain	1.0000
3:24143494:GCCTT:G	donor_loss	0.9900
3:24143500:CCAG:C	donor_gain	0.9900
3:24146673:A:AC	donor_gain	0.9900
3:24146674:C:CC	donor_gain	0.9900
3:24146674:CA:C	donor_gain	0.9900
3:24146674:CAA:C	donor_gain	0.9900
3:24146821:CC:C	acceptor_gain	0.9900
3:24146822:CC:C	acceptor_gain	0.9900
3:24152384:AATT:A	donor_loss	0.9900
3:24152385:ATTAC:A	donor_loss	0.9900

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000010244 (3:24184800 G>A), RS1000410221 (3:24179012 C>A), RS1000508487 (3:24159500 G>A), RS1000554733 (3:24154655 A>G), RS1000566865 (3:24160733 C>T), RS1000696894 (3:24188954 A>G), RS1000778517 (3:24189755 C>A,T), RS1000867192 (3:24154137 T>C), RS1000878889 (3:24172412 G>A), RS1000902541 (3:24183321 A>G), RS1001015844 (3:24177752 T>C,G), RS1001016594 (3:24183697 T>A), RS1001103616 (3:24165925 A>G), RS1001154958 (3:24152995 A>G), RS1001176459 (3:24154923 TGA>T)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 0 entries

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.