THRIL

Summary

THRIL (TNF and HNRNPL related immunoregulatory long non-coding RNA, HGNC:49503) is a long non-coding RNA gene on chromosome 12q24.31.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:49503
Approved symbol	THRIL
Name	TNF and HNRNPL related immunoregulatory long non-coding RNA
Location	12q24.31
Locus type	RNA, long non-coding
Status	Approved
Aliases	Linc1992, TCONS_00020260, BRI3BP-AS1
Ensembl gene	ENSG00000280634
Ensembl biotype	lncRNA
OMIM	615622
Entrez	102659353
RNAcentral	URS000075D66B — lncRNA, 1981 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000627370

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000627370 — 1 exons

Exon	Start	End
ENSE00003775406	125025434	125027410

Expression profiles

Bgee: expression breadth broad, 56 present calls, max score 76.42.

Top tissues by expression

56 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	76.42	silver quality
islet of Langerhans	UBERON:0000006	74.99	gold quality
rectum	UBERON:0001052	74.72	gold quality
pancreas	UBERON:0001264	74.53	gold quality
bone marrow cell	CL:0002092	73.25	gold quality
colonic epithelium	UBERON:0000397	72.56	gold quality
zone of skin	UBERON:0000014	72.51	gold quality
liver	UBERON:0002107	70.83	gold quality
prefrontal cortex	UBERON:0000451	70.20	gold quality
duodenum	UBERON:0002114	70.10	gold quality
lymph node	UBERON:0000029	69.99	gold quality
small intestine	UBERON:0002108	69.83	gold quality
bone marrow	UBERON:0002371	69.12	gold quality
endometrium	UBERON:0001295	68.13	gold quality
cerebral cortex	UBERON:0000956	67.54	gold quality
intestine	UBERON:0000160	67.34	gold quality
esophagus	UBERON:0001043	67.22	gold quality
uterine cervix	UBERON:0000002	66.98	silver quality
brain	UBERON:0000955	66.35	gold quality
vermiform appendix	UBERON:0001154	66.08	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	65.48	gold quality
colon	UBERON:0001155	65.33	gold quality
tonsil	UBERON:0002372	65.12	gold quality
fallopian tube	UBERON:0003889	63.70	gold quality
monocyte	CL:0000576	63.65	gold quality
ganglionic eminence	UBERON:0004023	63.43	gold quality
myometrium	UBERON:0001296	63.29	gold quality
thyroid gland	UBERON:0002046	61.97	gold quality
stomach	UBERON:0000945	61.65	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	60.88	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 14)

• THRIL has a role in regulating TNFalpha expression through its interaction with hnRNPL (PMID:24371310)
• We found a significantly decreased risk of precancerous cervical lesions for the THRIL rs7133268 AG genotype (odds ratio adjusted = 0.63, 95% confidence interval: 0.42-0.94, p = 0.025).Our results suggest that the rs7133268 polymorphism of the lncRNA THRIL gene can reduce the genetic susceptibility of precancerous cervical lesions and in turn reduce the risk of HPV infection. (PMID:30188187)
• THRIL expression correlates with increased risk of with acute respiratory distress syndrome (ARDS) and positively correlates with disease severity, inflammation, and mortality in sepsis patients. (PMID:31257645)
• elevated levels in T-cells of rheumatoid arthritis patients (PMID:31346885)
• Up-regulation of long non-coding RNA THRIL in coronary heart disease: Prediction for disease risk, correlation with inflammation, coronary artery stenosis, and major adverse cardiovascular events. (PMID:31944373)
• Analysis of the expression profile of long non-coding RNAs MALAT1 and THRIL in children with immune thrombocytopenia. (PMID:32563217)
• THRIL mediates endothelial progenitor cells autophagy via AKT pathway and FUS. (PMID:32907536)
• The expression patterns of MALAT-1, NEAT-1, THRIL, and miR-155-5p in the acute to the post-acute phase of COVID-19 disease. (PMID:35500644)
• lnc-THRIL and miR-125b relate to disease risk, severity, and imbalance of Th1 cells/Th2 cells in allergic rhinitis. (PMID:35527652)
• Expression profile of serum LncRNA THRIL and MiR-125b in inflammatory bowel disease. (PMID:36206229)
• Long noncoding RNA THRIL promotes foam cell formation and inflammation in macrophages. (PMID:36229925)
• Inter-correlation of lncRNA THRIL with microRNA-34a and microRNA-125b and their relationship with childhood asthma risk, severity, and inflammation. (PMID:36617839)
• LncRNA THRIL, transcriptionally activated by AP-1 and stabilized by METTL14-mediated m6A modification, accelerates LPS-evoked acute injury in alveolar epithelial cells. (PMID:37543013)
• Association of lncRNA THRIL, HOTAIR genes variations and expression levels with pulmonary tuberculosis. (PMID:38087305)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.