THRSP

Summary

THRSP (thyroid hormone responsive, HGNC:11800) is a protein-coding gene on chromosome 11q14.1, encoding Thyroid hormone-inducible hepatic protein (Q92748). Plays a role in the regulation of lipogenesis, especially in lactating mammary gland.

The protein encoded by this gene is similar to the gene product of S14, a rat gene whose expression is limited to liver and adipose tissue and is controlled by nutritional and hormonal factors. This gene has been shown to be expressed in liver and adipocytes, particularly in lipomatous modules. It is also found to be expressed in lipogenic breast cancers, which suggests a role in controlling tumor lipid metabolism.

Source: NCBI Gene 7069 — RefSeq curated summary.

At a glance

• GWAS associations: 2
• MANE Select transcript: NM_003251

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:11800
Approved symbol	THRSP
Name	thyroid hormone responsive
Location	11q14.1
Locus type	gene with protein product
Status	Approved
Aliases	SPOT14, Lpgp, S14, THRP
Ensembl gene	ENSG00000151365
Ensembl biotype	protein_coding
OMIM	601926
Entrez	7069

Gene structure

Transcript identifiers

Ensembl transcripts: 2 — 2 protein_coding

ENST00000281030, ENST00000881052

RefSeq mRNA: 1 — MANE Select: NM_003251 NM_003251

CCDS: CCDS8256

Canonical transcript exons

ENST00000281030 — 2 exons

Exon	Start	End
ENSE00000999180	78063861	78064341
ENSE00001286299	78067659	78068351

Expression profiles

Bgee: expression breadth ubiquitous, 171 present calls, max score 99.34.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 37.2391 / max 9217.3433, expressed in 134 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
116003	37.0256	131
116001	0.1396	35
116002	0.0739	23

Top tissues by expression

248 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
upper leg skin	UBERON:0004262	99.34	gold quality
upper arm skin	UBERON:0004263	98.17	gold quality
vena cava	UBERON:0004087	96.08	gold quality
mammalian vulva	UBERON:0000997	95.76	gold quality
right lobe of liver	UBERON:0001114	94.39	gold quality
liver	UBERON:0002107	93.98	gold quality
subcutaneous adipose tissue	UBERON:0002190	93.05	gold quality
adipose tissue	UBERON:0001013	92.72	gold quality
skin of hip	UBERON:0001554	92.45	gold quality
thoracic mammary gland	UBERON:0005200	91.39	gold quality
mammary gland	UBERON:0001911	91.24	gold quality
parotid gland	UBERON:0001831	89.62	gold quality
synovial joint	UBERON:0002217	89.58	gold quality
epithelium of mammary gland	UBERON:0003244	89.34	gold quality
mammary duct	UBERON:0001765	89.32	gold quality
pericardium	UBERON:0002407	89.10	gold quality
adipose tissue of abdominal region	UBERON:0007808	87.82	gold quality
omental fat pad	UBERON:0010414	87.17	gold quality
peritoneum	UBERON:0002358	87.11	gold quality
nipple	UBERON:0002030	86.73	gold quality
cardiac muscle of right atrium	UBERON:0003379	86.45	gold quality
myocardium	UBERON:0002349	83.79	silver quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	83.61	gold quality
oocyte	CL:0000023	82.00	gold quality
quadriceps femoris	UBERON:0001377	80.97	silver quality
deltoid	UBERON:0001476	80.84	silver quality
layer of synovial tissue	UBERON:0007616	80.66	gold quality
vastus lateralis	UBERON:0001379	80.54	silver quality
left ventricle myocardium	UBERON:0006566	80.50	silver quality
hindlimb stylopod muscle	UBERON:0004252	79.35	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): NR1H4, NR1I2, NR1I3, SREBF1, SREBF2, THRA, THRB, USF2

miRNA regulators (miRDB)

50 targeting THRSP, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-5692A	100.00	74.40	6850
HSA-MIR-4500	99.99	72.72	2367
HSA-MIR-6870-5P	99.99	68.55	2115
HSA-LET-7A-5P	99.98	72.29	1790
HSA-LET-7B-5P	99.98	72.31	1790
HSA-LET-7C-5P	99.98	72.29	1790
HSA-LET-7E-5P	99.98	72.29	1790
HSA-LET-7F-5P	99.98	72.56	1784
HSA-LET-7G-5P	99.98	72.37	1784
HSA-LET-7I-5P	99.98	72.37	1788
HSA-MIR-98-5P	99.98	72.33	1787
HSA-MIR-4723-5P	99.97	68.70	2034
HSA-MIR-5698	99.97	68.49	2029
HSA-MIR-7111-5P	99.97	68.48	2062
HSA-LET-7D-5P	99.96	71.76	1632
HSA-MIR-4458	99.96	71.64	1650
HSA-MIR-3140-3P	99.88	68.47	2069
HSA-MIR-544A	99.84	68.66	1965
HSA-MIR-202-3P	99.84	71.41	1290
HSA-MIR-6763-5P	99.76	64.68	1767
HSA-MIR-3934-3P	99.76	65.51	1351
HSA-MIR-3150A-3P	99.76	64.44	1640
HSA-MIR-3175	99.65	66.30	2031
HSA-MIR-1290	99.59	69.90	2079
HSA-MIR-5004-3P	99.54	68.27	1371
HSA-MIR-6740-3P	99.48	68.49	1392
HSA-MIR-4316	99.37	65.75	1360
HSA-MIR-3064-5P	99.26	66.13	1497
HSA-MIR-3085-3P	99.26	66.16	1490
HSA-MIR-6504-5P	99.26	65.95	1487

Literature-anchored findings (GeneRIF, showing 9)

• significantly greater thyroid hormone response for the human promoter, compared with the rat. (PMID:12960053)
• These findings provide a molecular rationale for the role of hS14 in TR-dependent transcriptional activation of the expression of specific genes. (PMID:17418816)
• human Spot 14 protein might regulate the p53 target gene, p21(WAF1/Cip1), via its direct interaction with the thyroid receptor or other p53 coactivators, such as Zac1. (PMID:18299245)
• N-terminally truncated human Thrsp and its selenomethionyl derivative were collected to 4.0, 3.0 and 3.6 A resolution (PMID:21821901)
• In human breast cancer cell lines, S14 expression was highest in those representing the luminal subtype compared to those cell lines with basal characteristics. (PMID:25472762)
• The results of the present study indicated that Spot14/S14R were differently expressed in MSC adipogenesis in AIS patients, and they may be important in the abnormal adipogenic differentiation in AIS. (PMID:27082501)
• miR-451a might participate in the free fatty acid-induced hepatic steatosis by regulating the expression of the THRSP gene. (PMID:29604329)
• THRSP identified as a potential hepatocellular carcinoma marker by integrated bioinformatics analysis and experimental validation. (PMID:35196258)
• Insulin-inducible THRSP maintains mitochondrial function and regulates sphingolipid metabolism in human adipocytes. (PMID:35715726)

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
		ENSDARG00000099399
mus_musculus	Thrsp	ENSMUSG00000035686
rattus_norvegicus	Thrsp	ENSRNOG00000012404
drosophila_melanogaster	CG2765	FBGN0035087

Paralogs (1): MID1IP1 (ENSG00000165175)

Protein

Protein identifiers

Thyroid hormone-inducible hepatic protein — Q92748 (reviewed: Q92748)

Alternative names: Spot 14 protein

All UniProt accessions (1): Q92748

UniProt curated annotations — full annotation on UniProt →

Function. Plays a role in the regulation of lipogenesis, especially in lactating mammary gland. Important for the biosynthesis of triglycerides with medium-length fatty acid chains. May modulate lipogenesis by interacting with MID1IP1 and preventing its interaction with ACACA. May function as transcriptional coactivator. May modulate the transcription factor activity of THRB.

Subunit / interactions. Homodimer. Heterodimer with MID1IP1. Interacts with THRB and PLAGL1.

Subcellular location. Nucleus. Cytoplasm.

Tissue specificity. Mainly expressed in tissues that synthesize triglycerides.

Similarity. Belongs to the SPOT14 family.

RefSeq proteins (1): NP_003242* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR009786	Spot_14	Family
IPR053719	Lipogen_MT_Stabilize_sf	Homologous_superfamily

Pfam: PF07084

UniProt features (3 total): chain 1, region of interest 1, compositionally biased region 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q92748-F1	75.64	0.38

Function

Pathways and Gene Ontology

Reactome pathways

10 pathways

ID	Pathway
R-HSA-200425	Carnitine shuttle
R-HSA-9841922	MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
R-HSA-1430728	Metabolism
R-HSA-212165	Epigenetic regulation of gene expression
R-HSA-556833	Metabolism of lipids
R-HSA-74160	Gene expression (Transcription)
R-HSA-8978868	Fatty acid metabolism
R-HSA-9818564	Epigenetic regulation of gene expression by MLL3 and MLL4 complexes
R-HSA-9851695	Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes
R-HSA-9917777	Epigenetic regulation by WDR5-containing histone modifying complexes

MSigDB gene sets: 98 (showing top): GOBP_REGULATION_OF_TRIGLYCERIDE_METABOLIC_PROCESS, YAO_HOXA10_TARGETS_VIA_PROGESTERONE_UP, GRAESSMANN_APOPTOSIS_BY_SERUM_DEPRIVATION_DN, GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN, GOBP_GLYCEROLIPID_METABOLIC_PROCESS, GOBP_REGULATION_OF_LIPID_BIOSYNTHETIC_PROCESS, MARTINEZ_RB1_TARGETS_UP, GOBP_REGULATION_OF_LIPID_METABOLIC_PROCESS, ACEVEDO_LIVER_TUMOR_VS_NORMAL_ADJACENT_TISSUE_DN, GOBP_GLYCEROLIPID_BIOSYNTHETIC_PROCESS, GOBP_NEUTRAL_LIPID_BIOSYNTHETIC_PROCESS, GOBP_LIPID_METABOLIC_PROCESS, GOBP_NEUTRAL_LIPID_METABOLIC_PROCESS, NADLER_OBESITY_DN, GOBP_LIPID_BIOSYNTHETIC_PROCESS

GO Biological Process (4): lipid metabolic process (GO:0006629), response to bacterium (GO:0009617), regulation of triglyceride biosynthetic process (GO:0010866), regulation of lipid biosynthetic process (GO:0046890)

GO Molecular Function (4): identical protein binding (GO:0042802), protein homodimerization activity (GO:0042803), molecular function inhibitor activity (GO:0140678), protein binding (GO:0005515)

GO Cellular Component (4): nucleoplasm (GO:0005654), cytosol (GO:0005829), nucleus (GO:0005634), cytoplasm (GO:0005737)

Reactome top-level categories

Rollup of top-8 pathways:

Category	Pathways
Fatty acid metabolism	1
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes	1
Gene expression (Transcription)	1
Metabolism	1
Metabolism of lipids	1
Epigenetic regulation by WDR5-containing histone modifying complexes	1
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes	1
Epigenetic regulation of gene expression	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	3
primary metabolic process	1
response to other organism	1
triglyceride biosynthetic process	1
regulation of lipid biosynthetic process	1
regulation of triglyceride metabolic process	1
lipid biosynthetic process	1
regulation of biosynthetic process	1
regulation of lipid metabolic process	1
protein binding	1
identical protein binding	1
protein dimerization activity	1
molecular function regulator activity	1
binding	1
nuclear lumen	1
cytoplasm	1
intracellular membrane-bounded organelle	1
intracellular anatomical structure	1

Protein interactions and networks

STRING

1088 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
THRSP	ELOVL6	Q9H5J4	744
THRSP	FASN	P49327	685
THRSP	ACACA	Q13085	678
THRSP	ACLY	P53396	677
THRSP	INSR	P06213	614
THRSP	ACACB	O00763	589
THRSP	SOCS3	O14543	567
THRSP	CIDEC	Q96AQ7	559
THRSP	DHCR7	Q9UBM7	555
THRSP	SREBF1	P36956	552
THRSP	DGAT2	Q96PD7	547
THRSP	PLIN1	O60240	540
THRSP	BAMBI	Q13145	536
THRSP	PNPLA3	Q9NST1	534
THRSP	NR1H4	Q96RI1	534

IntAct

45 interactions, top by confidence:

A	B	Type	Score
THRSP	THRSP	psi-mi:“MI:0915”(physical association)	0.670
THRSP	TUM1	psi-mi:“MI:0915”(physical association)	0.560
THRSP	ZMYND12	psi-mi:“MI:0915”(physical association)	0.560
INCA1	THRSP	psi-mi:“MI:0915”(physical association)	0.560
THRSP	TEPSIN	psi-mi:“MI:0915”(physical association)	0.560
Plagl1	THRSP	psi-mi:“MI:0407”(direct interaction)	0.440
THRSP	AKT1	psi-mi:“MI:0915”(physical association)	0.370
THRSP	AURKA	psi-mi:“MI:0915”(physical association)	0.370
THRSP	BAG4	psi-mi:“MI:0915”(physical association)	0.370
BCAR3	THRSP	psi-mi:“MI:0915”(physical association)	0.370
BRMS1	THRSP	psi-mi:“MI:0915”(physical association)	0.370
CDH1	THRSP	psi-mi:“MI:0915”(physical association)	0.370
THRSP	ERBB2	psi-mi:“MI:0915”(physical association)	0.370
FGFR4	THRSP	psi-mi:“MI:0915”(physical association)	0.370
THRSP	HMMR	psi-mi:“MI:0915”(physical association)	0.370
IGF1R	THRSP	psi-mi:“MI:0915”(physical association)	0.370
KRAS	THRSP	psi-mi:“MI:0915”(physical association)	0.370
THRSP	LSP1	psi-mi:“MI:0915”(physical association)	0.370
PALB2	THRSP	psi-mi:“MI:0915”(physical association)	0.370
THRSP	PARP1	psi-mi:“MI:0915”(physical association)	0.370
THRSP	PIK3CA	psi-mi:“MI:0915”(physical association)	0.370
THRSP	PTPN1	psi-mi:“MI:0915”(physical association)	0.370
RB1CC1	THRSP	psi-mi:“MI:0915”(physical association)	0.370
SMAD4	THRSP	psi-mi:“MI:0915”(physical association)	0.370
THRSP	STK11	psi-mi:“MI:0915”(physical association)	0.370
THRSP	TGFB1	psi-mi:“MI:0915”(physical association)	0.370
THRSP	TSG101	psi-mi:“MI:0915”(physical association)	0.370

BioGRID (67): THRSP (Two-hybrid), THRSP (Two-hybrid), THRSP (Two-hybrid), THRSP (Two-hybrid), THRSP (Two-hybrid), THRSP (Two-hybrid), THRSP (Two-hybrid), THRSP (Two-hybrid), THRSP (Two-hybrid), THRSP (Two-hybrid), THRSP (Two-hybrid), THRSP (Two-hybrid), THRSP (Two-hybrid), THRSP (Two-hybrid), THRSP (Two-hybrid)

ESM2 similar proteins: A1L1K1, A2AVJ5, A2BID5, A2CI97, A2RV06, A7YY97, B1A193, F1QN74, P04143, P47805, Q0KK59, Q0VDN7, Q1LUV9, Q2NL11, Q2TAA8, Q3SYZ9, Q561Q8, Q561X3, Q5BLE2, Q5E9R0, Q5EB20, Q5FWU8, Q5M8Y7, Q5PNP6, Q5PQS3, Q5XG48, Q62264, Q6AXZ5, Q6GR21, Q6MZQ0, Q6NRB7, Q6P047, Q6P7D5, Q6TNU3, Q80ZQ3, Q8AWD1, Q8BFT2, Q8CDT7, Q92748, Q96C34

Diamond homologs: P04143, P47805, Q1LUV9, Q62264, Q6P7D5, Q8AWD1, Q92748, Q9CQ20, Q9NPA3

SIGNOR signaling

1 interactions.

A	Effect	B	Mechanism
THRSP	“down-regulates activity”	MID1IP1	binding

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 34 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

GO biological processes:

GO term	Partners	Fold	FDR
insulin receptor signaling pathway	5	37.0×	7e-05
phosphatidylinositol 3-kinase/protein kinase B signal transduction	5	35.1×	7e-05
protein autophosphorylation	5	24.2×	2e-04
negative regulation of cell population proliferation	9	12.6×	2e-05
negative regulation of apoptotic process	7	8.1×	1e-03
positive regulation of gene expression	6	7.8×	4e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

0 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

260 predictions. Top by Δscore:

Variant	Effect	Δscore
11:78064278:G:GT	donor_gain	1.0000
11:78064289:G:GT	donor_gain	1.0000
11:78064290:A:T	donor_gain	1.0000
11:78064299:G:GT	donor_gain	1.0000
11:78064300:A:T	donor_gain	1.0000
11:78064315:T:G	donor_gain	1.0000
11:78064170:G:GT	donor_gain	0.9900
11:78064209:G:GT	donor_gain	0.9900
11:78064338:G:GT	donor_gain	0.9900
11:78064338:G:T	donor_gain	0.9900
11:78064339:A:T	donor_gain	0.9900
11:78064320:T:TA	donor_gain	0.9800
11:78064321:A:AA	donor_gain	0.9800
11:78067653:CCACA:C	acceptor_loss	0.9800
11:78067654:CACAG:C	acceptor_loss	0.9800
11:78067656:CA:C	acceptor_loss	0.9800
11:78067657:A:AG	acceptor_gain	0.9800
11:78067657:A:AT	acceptor_loss	0.9800
11:78067658:G:GG	acceptor_gain	0.9800
11:78064196:A:T	donor_gain	0.9700
11:78064338:GAAGG:G	donor_loss	0.9700
11:78064339:AAG:A	donor_loss	0.9700
11:78064341:GG:G	donor_loss	0.9700
11:78064342:G:T	donor_loss	0.9700
11:78067658:GATCC:G	acceptor_gain	0.9600
11:78067658:GAT:G	acceptor_gain	0.9500
11:78067658:GATC:G	acceptor_gain	0.9400
11:78064005:C:G	donor_gain	0.9300
11:78064314:G:GG	donor_gain	0.9300
11:78067651:C:G	acceptor_gain	0.9300

AlphaMissense

961 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
11:78064059:T:C	F60L	0.959
11:78064061:C:A	F60L	0.959
11:78064061:C:G	F60L	0.959
11:78064293:T:G	Y138D	0.936
11:78063984:A:C	S35R	0.934
11:78063986:C:A	S35R	0.934
11:78063986:C:G	S35R	0.934
11:78064073:G:C	K64N	0.931
11:78064073:G:T	K64N	0.931
11:78063979:T:C	I33T	0.929
11:78064294:A:C	Y138S	0.922
11:78063962:G:A	M27I	0.921
11:78063962:G:C	M27I	0.921
11:78063962:G:T	M27I	0.921
11:78064219:T:C	F113S	0.919
11:78064293:T:C	Y138H	0.909
11:78064272:G:C	A131P	0.900
11:78064261:T:C	L127P	0.894
11:78063977:G:A	M32I	0.893
11:78063977:G:C	M32I	0.893
11:78063977:G:T	M32I	0.893
11:78064227:C:G	H116D	0.891
11:78063939:T:G	Y20D	0.883
11:78063991:T:A	L37Q	0.881
11:78064230:T:C	F117L	0.880
11:78064232:C:A	F117L	0.880
11:78064232:C:G	F117L	0.880
11:78064229:C:A	H116Q	0.873
11:78064229:C:G	H116Q	0.873
11:78064069:T:A	L63H	0.865

dbSNP variants (sampled 300 via entrez): RS1000334591 (11:78067295 T>C), RS1000857110 (11:78067257 G>A), RS1001234581 (11:78068512 C>T), RS1001261060 (11:78062437 C>A), RS1001308127 (11:78068678 G>A), RS1001352879 (11:78062612 C>T), RS1001603933 (11:78068733 C>T), RS1002453443 (11:78063166 T>C), RS1002485908 (11:78063622 G>A), RS1002964312 (11:78063407 C>A), RS1003031239 (11:78064079 C>A,T), RS1003273209 (11:78065552 C>A,T), RS1003486333 (11:78064952 G>A), RS1005166007 (11:78063809 C>A), RS1005367023 (11:78064850 G>A,T)

Disease associations

OMIM: gene MIM:601926 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

2 associations (top):

Study	Trait	p-value
GCST002541_88	Menarche (age at onset)	2.000000e-12
GCST007277_15	Tourette syndrome	5.000000e-06

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0004703	age at menarche

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

49 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Benzo(a)pyrene	decreases expression, increases expression, increases methylation	5
perfluorooctanoic acid	decreases expression, increases expression	4
Aflatoxin B1	decreases methylation, affects expression, decreases expression	4
Acetaminophen	decreases expression	3
Tetrachlorodibenzodioxin	decreases expression	3
lasiocarpine	decreases expression	2
methyleugenol	decreases expression	2
bisphenol A	decreases expression, increases expression	2
perfluorooctane sulfonic acid	decreases expression	2
bisphenol S	increases expression	2
Methapyrilene	decreases expression, increases expression	2
N-Nitrosopyrrolidine	decreases expression	2
Nickel	decreases expression	2
Fenofibrate	decreases expression, increases reaction	2
Cyclosporine	decreases expression	2
bisphenol F	increases expression	1
propionaldehyde	decreases expression	1
pirinixic acid	increases expression	1
sodium arsenite	decreases expression	1
sulconazole	affects expression	1
fipronil	affects cotreatment, increases expression	1
clemizole	affects expression	1
perfluoro-n-nonanoic acid	decreases expression	1
bardoxolone methyl	decreases expression	1
6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime	decreases expression	1
clothianidin	decreases expression	1
bisphenol B	increases expression	1
2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine	increases expression, increases response to substance	1
bisphenol AF	increases expression	1
Clopidogrel	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.