THUMPD3-AS1

Summary

THUMPD3-AS1 (THUMPD3 antisense RNA 1, HGNC:44478) is a long non-coding RNA gene on chromosome 3p25.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:44478
Approved symbol	THUMPD3-AS1
Name	THUMPD3 antisense RNA 1
Location	3p25.3
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000206573
Ensembl biotype	lncRNA
Entrez	440944
RNAcentral	URS00008E3988 — lncRNA, 1877 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 79 — 79 lncRNA

ENST00000467069, ENST00000468186, ENST00000469846, ENST00000480904, ENST00000481221, ENST00000489616, ENST00000494680, ENST00000498199, ENST00000518437, ENST00000519043, ENST00000520396, ENST00000520447, ENST00000520629, ENST00000521267, ENST00000521609, ENST00000521708, ENST00000522221, ENST00000522525, ENST00000523354, ENST00000524210, ENST00000654392, ENST00000657509, ENST00000660127, ENST00000660363, ENST00000661342, ENST00000661714, ENST00000664273, ENST00000664441, ENST00000664877, ENST00000665171, ENST00000665983, ENST00000667458, ENST00000668063, ENST00000685076, ENST00000685952, ENST00000687342, ENST00000689821, ENST00000702536, ENST00000702696, ENST00000741671, ENST00000741672, ENST00000741673, ENST00000741674, ENST00000741675, ENST00000741676, ENST00000741677, ENST00000741678, ENST00000741679, ENST00000741680, ENST00000741681, ENST00000741682, ENST00000741683, ENST00000741684, ENST00000741685, ENST00000741686, ENST00000741687, ENST00000741688, ENST00000741689, ENST00000741690, ENST00000741691, ENST00000741692, ENST00000741693, ENST00000741694, ENST00000741695, ENST00000741696, ENST00000741697, ENST00000741698, ENST00000741699, ENST00000741700, ENST00000741701, ENST00000741702, ENST00000741703, ENST00000741704, ENST00000741705, ENST00000741706, ENST00000741707, ENST00000741708, ENST00000741709, ENST00000741710

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000467069 — 4 exons

Exon	Start	End
ENSE00001853605	9390290	9390497
ENSE00001870613	9391679	9391826
ENSE00004079106	9388845	9389796
ENSE00004079147	9397424	9397495

Expression profiles

Bgee: expression breadth ubiquitous, 235 present calls, max score 94.76.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 5.4019 / max 215.3217, expressed in 1560 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
40968	3.1212	1186
40969	0.9642	570
40970	0.7018	267
40971	0.6146	248

Top tissues by expression

247 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adenohypophysis	UBERON:0002196	94.76	gold quality
left lobe of thyroid gland	UBERON:0001120	94.16	gold quality
right lobe of thyroid gland	UBERON:0001119	93.78	gold quality
thyroid gland	UBERON:0002046	93.38	gold quality
adrenal tissue	UBERON:0018303	93.38	gold quality
pituitary gland	UBERON:0000007	93.33	gold quality
right uterine tube	UBERON:0001302	93.30	gold quality
minor salivary gland	UBERON:0001830	93.30	gold quality
body of pancreas	UBERON:0001150	92.90	gold quality
bone marrow cell	CL:0002092	92.32	gold quality
rectum	UBERON:0001052	91.69	gold quality
right testis	UBERON:0004534	91.44	gold quality
metanephros cortex	UBERON:0010533	91.41	gold quality
small intestine Peyer’s patch	UBERON:0003454	91.35	gold quality
left ovary	UBERON:0002119	91.06	gold quality
right ovary	UBERON:0002118	90.87	gold quality
right lobe of liver	UBERON:0001114	90.78	gold quality
left testis	UBERON:0004533	90.66	gold quality
tibial nerve	UBERON:0001323	90.59	gold quality
transverse colon	UBERON:0001157	90.40	gold quality
body of uterus	UBERON:0009853	90.29	gold quality
vermiform appendix	UBERON:0001154	90.28	gold quality
lower esophagus mucosa	UBERON:0035834	90.25	gold quality
gastrocnemius	UBERON:0001388	90.03	gold quality
endocervix	UBERON:0000458	89.85	gold quality
body of stomach	UBERON:0001161	89.85	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	89.85	gold quality
left adrenal gland cortex	UBERON:0035825	89.83	gold quality
epithelial cell of pancreas	CL:0000083	89.82	gold quality
monocyte	CL:0000576	89.71	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	7.40

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 4)

• LncRNA THUMPD3-AS1 enhances the proliferation and inflammatory response of chondrocytes in osteoarthritis. (PMID:34509934)
• THUMPD3-AS1 facilitates cell growth and aggressiveness by the miR-218-5p/SKAP1 axis in colorectal cancer. (PMID:35538197)
• THUMPD3-AS1 Is Correlated with Gastric Cancer and Regulates Cell Function through miR-1252-3p and CXCL17. (PMID:36017917)
• THUMPD3-AS1 inhibits ovarian cancer cell apoptosis through the miR-320d/ARF1 axis. (PMID:38963337)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.