TIGD4

Summary

TIGD4 (tigger transposable element derived 4, HGNC:18335) is a protein-coding gene on chromosome 4q31.3, encoding Tigger transposable element-derived protein 4 (Q8IY51).

The protein encoded by this gene belongs to the tigger subfamily of the pogo superfamily of DNA-mediated transposons in humans. These proteins are related to DNA transposons found in fungi and nematodes, and more distantly to the Tc1 and mariner transposases. They are also very similar to the major mammalian centromere protein B. The exact function of this gene is not known.

Source: NCBI Gene 201798 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 59 total
• MANE Select transcript: NM_145720

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:18335
Approved symbol	TIGD4
Name	tigger transposable element derived 4
Location	4q31.3
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000169989
Ensembl biotype	protein_coding
Entrez	201798

Gene structure

Transcript identifiers

Ensembl transcripts: 5 — 5 protein_coding

ENST00000304337, ENST00000891947, ENST00000914394, ENST00000914395, ENST00000914396

RefSeq mRNA: 1 — MANE Select: NM_145720 NM_145720

CCDS: CCDS34079

Canonical transcript exons

ENST00000304337 — 2 exons

Exon	Start	End
ENSE00001130765	152769354	152771542
ENSE00001324732	152779482	152779730

Expression profiles

Bgee: expression breadth ubiquitous, 148 present calls, max score 88.70.

FANTOM5 (CAGE): breadth broad, TPM avg 0.9521 / max 38.4938, expressed in 470 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
54399	0.9521	470

Top tissues by expression

224 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	88.70	gold quality
sperm	CL:0000019	88.06	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	78.76	gold quality
right uterine tube	UBERON:0001302	70.14	gold quality
bronchial epithelial cell	CL:0002328	69.23	gold quality
ventricular zone	UBERON:0003053	68.94	gold quality
myocardium	UBERON:0002349	68.88	gold quality
bronchus	UBERON:0002185	68.50	gold quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	67.35	gold quality
buccal mucosa cell	CL:0002336	65.51	gold quality
islet of Langerhans	UBERON:0000006	65.20	gold quality
ganglionic eminence	UBERON:0004023	63.84	gold quality
right testis	UBERON:0004534	63.55	gold quality
left testis	UBERON:0004533	63.27	gold quality
testis	UBERON:0000473	62.66	gold quality
pigmented layer of retina	UBERON:0001782	60.97	silver quality
endothelial cell	CL:0000115	60.33	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	59.75	gold quality
adenohypophysis	UBERON:0002196	59.25	gold quality
pituitary gland	UBERON:0000007	58.59	gold quality
calcaneal tendon	UBERON:0003701	57.53	gold quality
lower lobe of lung	UBERON:0008949	57.31	silver quality
oviduct epithelium	UBERON:0004804	56.97	silver quality
fallopian tube	UBERON:0003889	56.95	gold quality
endometrium	UBERON:0001295	56.87	gold quality
superficial temporal artery	UBERON:0001614	56.05	gold quality
vastus lateralis	UBERON:0001379	55.96	gold quality
upper leg skin	UBERON:0004262	55.87	silver quality
quadriceps femoris	UBERON:0001377	55.61	gold quality
vena cava	UBERON:0004087	55.58	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.45

Regulation

Is transcription factor: yes

JASPAR motifs

Motif	Name	Family
MA2561.1	TIGD4	More than 3 adjacent zinc fingers

JASPAR matrix evidence (PMIDs): PMID:39605368

miRNA regulators (miRDB)

5 targeting TIGD4, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-374A-5P	99.90	71.34	2923
HSA-MIR-374B-5P	99.90	69.98	2734
HSA-MIR-153-5P	99.89	73.86	6317
HSA-MIR-6124	99.87	69.78	3551

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Tigd4	ENSMUSG00000047819
rattus_norvegicus	Tigd4	ENSRNOG00000010741

Paralogs (12): CENPB (ENSG00000125817), TIGD7 (ENSG00000140993), POGK (ENSG00000143157), POGZ (ENSG00000143442), TIGD6 (ENSG00000164296), TIGD3 (ENSG00000173825), TIGD5 (ENSG00000179886), TIGD2 (ENSG00000180346), JRKL (ENSG00000183340), TIGD1 (ENSG00000221944), JRK (ENSG00000234616), (ENSG00000293642)

Protein

Protein identifiers

Tigger transposable element-derived protein 4 — Q8IY51 (reviewed: Q8IY51)

All UniProt accessions (1): Q8IY51

UniProt curated annotations — full annotation on UniProt →

Subcellular location. Nucleus.

Similarity. Belongs to the tigger transposable element derived protein family.

RefSeq proteins (1): NP_663772* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR004875	DDE_SF_endonuclease_dom	Domain
IPR006600	HTH_CenpB_DNA-bd_dom	Domain
IPR007889	HTH_Psq	Domain
IPR009057	Homeodomain-like_sf	Homologous_superfamily
IPR050863	CenT-Element_Derived	Family

Pfam: PF03184, PF03221, PF04218

UniProt features (11 total): domain 3, sequence variant 3, DNA-binding region 2, chain 1, sequence conflict 1, region of interest 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8IY51-F1	79.02	0.38

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 32 (showing top): GGGTGGRR_PAX4_03, SP1_Q2_01, TGCTGAY_UNKNOWN, FOXO4_02, SCGGAAGY_ELK1_02, FOXO3_01, ARNT2_TARGET_GENES, DIDO1_TARGET_GENES, DLX4_TARGET_GENES, E2F2_TARGET_GENES, ELF2_TARGET_GENES, HOXB6_TARGET_GENES, ID1_TARGET_GENES, ID2_TARGET_GENES, NR1I2_TARGET_GENES

GO Biological Process (0):

GO Molecular Function (3): DNA binding (GO:0003677), nucleic acid binding (GO:0003676), protein binding (GO:0005515)

GO Cellular Component (1): nucleus (GO:0005634)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
binding	2
nucleic acid binding	1
intracellular membrane-bounded organelle	1

Protein interactions and networks

STRING

316 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
TIGD4	ARFIP1	P53367	591
TIGD4	TMEM131L	A2VDJ0	572
TIGD4	SMIM14	Q96QK8	559
TIGD4	COMMD8	Q9NX08	539
TIGD4	RNF150	Q9ULK6	530
TIGD4	OCIAD2	Q56VL3	519
TIGD4	G5EA03	G5EA03	491
TIGD4	NAIF1	Q69YI7	485
TIGD4	TIGD5	Q53EQ6	477
TIGD4	LIN37	Q96GY3	473
TIGD4	LIAS	O43766	468
TIGD4	SYNPO2	Q9UMS6	461
TIGD4	MCM3AP	O60318	460
TIGD4	ETFDH	Q16134	452
TIGD4	GABRB1	P18505	448

IntAct

8 interactions, top by confidence:

A	B	Type	Score
TIGD4	KIFBP	psi-mi:“MI:0915”(physical association)	0.590
TRAF2	TIGD4	psi-mi:“MI:0915”(physical association)	0.560
HOXD4	TIGD4	psi-mi:“MI:0915”(physical association)	0.370
S100B	PLEKHG3	psi-mi:“MI:0914”(association)	0.350
TIGD4	TRAF2	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (7): KIAA1279 (Affinity Capture-MS), KIAA1279 (Affinity Capture-MS), TIGD4 (Affinity Capture-MS), TIGD4 (Two-hybrid), TIGD4 (Affinity Capture-MS), KIAA1279 (Affinity Capture-MS), TIGD4 (Two-hybrid)

ESM2 similar proteins: A4IFA3, A4Z943, A4Z944, A4Z945, B2RRL2, D3Z4R1, F1NQJ3, O43422, O60108, O60290, O96006, P08770, P0CF97, P12258, P16320, P34601, Q09772, Q0VBL1, Q17RP2, Q3EBC8, Q3YK19, Q49AG3, Q4R6P1, Q4W5G0, Q5SVZ6, Q5SXJ3, Q6EKJ0, Q6NT04, Q6R2W3, Q7L775, Q7M3K2, Q86UP8, Q8BUZ3, Q8IY51, Q8IZ13, Q8TBB0, Q8TCP9, Q8TDG4, Q8VEH5, Q95M72

Diamond homologs: P07199, P27790, P48988, P49451, Q17RP2, Q4W5G0, Q6B0B8, Q8IY51, Q6NT04, Q8BUZ3, Q7TM95

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

59 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	55
Likely benign	1
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

410 predictions. Top by Δscore:

Variant	Effect	Δscore
4:152771550:T:C	acceptor_gain	1.0000
4:152771550:T:TC	acceptor_gain	1.0000
4:152779495:T:A	donor_gain	0.9900
4:152771543:C:CC	acceptor_gain	0.9800
4:152779484:T:A	donor_gain	0.9800
4:152779487:T:TA	donor_gain	0.9800
4:152771546:T:TC	acceptor_gain	0.9700
4:152771558:T:TC	acceptor_gain	0.9700
4:152771422:T:TG	acceptor_gain	0.9600
4:152779663:TTCG:T	donor_gain	0.9600
4:152779664:TCG:T	donor_gain	0.9600
4:152779652:T:TA	donor_gain	0.9500
4:152771558:T:C	acceptor_gain	0.9400
4:152771546:T:C	acceptor_gain	0.9100
4:152771549:T:TC	acceptor_gain	0.9100
4:152779478:TAAC:T	donor_loss	0.9100
4:152779480:AC:A	donor_loss	0.9100
4:152779481:C:CG	donor_loss	0.9100
4:152779481:CCTT:C	donor_gain	0.9100
4:152779482:C:G	donor_loss	0.9000
4:152779655:TGGAG:T	donor_gain	0.8900
4:152774551:C:G	acceptor_gain	0.8600
4:152779581:CGGT:C	donor_gain	0.8600
4:152771548:G:C	acceptor_gain	0.8500
4:152779462:C:A	donor_gain	0.8500
4:152779550:CAT:C	donor_gain	0.8500
4:152779666:G:GT	donor_gain	0.8500
4:152771423:C:A	acceptor_gain	0.8400
4:152771540:CTT:C	acceptor_gain	0.8400
4:152778764:C:CA	donor_gain	0.8300

AlphaMissense

3360 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
4:152770589:C:A	R139M	0.999
4:152770601:C:G	R135P	0.999
4:152770611:A:G	W132R	0.999
4:152770611:A:T	W132R	0.999
4:152770877:G:T	A43D	0.999
4:152770594:T:A	K137N	0.998
4:152770594:T:G	K137N	0.998
4:152770609:C:A	W132C	0.998
4:152770609:C:G	W132C	0.998
4:152770613:C:T	G131D	0.998
4:152770627:A:C	F126L	0.998
4:152770627:A:T	F126L	0.998
4:152770629:A:G	F126L	0.998
4:152770652:G:T	A118D	0.998
4:152770665:C:G	A114P	0.998
4:152770676:A:G	L110S	0.998
4:152770765:T:A	R80S	0.998
4:152770765:T:G	R80S	0.998
4:152770847:A:G	L53S	0.998
4:152770588:C:A	R139S	0.997
4:152770588:C:G	R139S	0.997
4:152770589:C:G	R139T	0.997
4:152770597:A:C	F136L	0.997
4:152770597:A:T	F136L	0.997
4:152770598:A:G	F136S	0.997
4:152770599:A:G	F136L	0.997
4:152770610:C:G	W132S	0.997
4:152770614:C:G	G131R	0.997
4:152770618:A:C	S129R	0.997
4:152770618:A:T	S129R	0.997

dbSNP variants (sampled 300 via entrez): RS1000168153 (4:152779905 T>C), RS10002433 (4:152772068 G>A), RS1000496773 (4:152769176 A>C), RS1000583628 (4:152778378 T>C), RS10008780 (4:152774102 C>G), RS1001007940 (4:152776651 T>C), RS1001465068 (4:152775886 T>C), RS1001646259 (4:152775575 A>G), RS1001995404 (4:152769644 G>C), RS1002247759 (4:152777425 A>G), RS1002404210 (4:152769765 C>G), RS10028182 (4:152780488 G>A), RS1002956082 (4:152772046 A>T), RS1003405992 (4:152771744 T>C), RS1003471102 (4:152779459 C>T)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

16 total (human), top 16 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects cotreatment, decreases expression, decreases methylation	6
methylmercuric chloride	decreases expression	1
trichostatin A	decreases expression	1
S-(1,2-dichlorovinyl)cysteine	decreases expression, decreases reaction	1
pentanal	decreases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	decreases expression, affects cotreatment	1
abrine	decreases expression	1
dorsomorphin	affects cotreatment, decreases expression	1
jinfukang	affects cotreatment, decreases expression	1
incobotulinumtoxinA	decreases expression	1
2,6-dichloro-(1,4)benzoquinone	increases expression	1
Cisplatin	affects cotreatment, decreases expression	1
Diethylhexyl Phthalate	decreases expression	1
Folic Acid	increases expression	1
Lipopolysaccharides	decreases expression, decreases reaction	1
Tobacco Smoke Pollution	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.