TILAM

Summary

TILAM (TGF-beta induced lncRNA activating myofibroblasts, HGNC:52795) is a long non-coding RNA gene on chromosome 17q21.33.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:52795
Approved symbol	TILAM
Name	TGF-beta induced lncRNA activating myofibroblasts
Location	17q21.33
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000249406
Ensembl biotype	lncRNA
Entrez	101927230
RNAcentral	URS00004FE11E — lncRNA, 455 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 29 — 29 lncRNA

ENST00000509943, ENST00000514468, ENST00000650459, ENST00000654981, ENST00000655214, ENST00000657387, ENST00000661144, ENST00000662496, ENST00000663981, ENST00000666820, ENST00000670608, ENST00000832079, ENST00000832080, ENST00000832081, ENST00000832082, ENST00000832083, ENST00000832084, ENST00000832085, ENST00000832086, ENST00000832087, ENST00000832088, ENST00000832089, ENST00000832090, ENST00000832091, ENST00000832092, ENST00000832093, ENST00000832094, ENST00000832095, ENST00000832096

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000509943 — 7 exons

Exon	Start	End
ENSE00002042818	50214920	50214982
ENSE00002045697	50213835	50213915
ENSE00002071195	50209336	50209406
ENSE00002080974	50211946	50212121
ENSE00003856524	50215111	50215423
ENSE00003863056	50199876	50199934
ENSE00003878418	50214101	50214775

Expression profiles

Bgee: expression breadth broad, 100 present calls, max score 78.35.

Top tissues by expression

100 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	78.35	gold quality
stromal cell of endometrium	CL:0002255	68.34	gold quality
muscle tissue	UBERON:0002385	57.83	gold quality
descending thoracic aorta	UBERON:0002345	56.20	gold quality
right coronary artery	UBERON:0001625	56.00	gold quality
popliteal artery	UBERON:0002250	55.37	gold quality
tibial artery	UBERON:0007610	55.37	gold quality
smooth muscle tissue	UBERON:0001135	54.60	gold quality
right ovary	UBERON:0002118	54.14	gold quality
left ovary	UBERON:0002119	54.13	gold quality
myometrium	UBERON:0001296	54.01	gold quality
muscle layer of sigmoid colon	UBERON:0035805	53.84	gold quality
body of uterus	UBERON:0009853	53.81	gold quality
thoracic aorta	UBERON:0001515	53.75	gold quality
ovary	UBERON:0000992	53.70	gold quality
ascending aorta	UBERON:0001496	53.44	gold quality
left coronary artery	UBERON:0001626	53.31	gold quality
urinary bladder	UBERON:0001255	53.28	gold quality
fundus of stomach	UBERON:0001160	52.93	gold quality
ectocervix	UBERON:0012249	52.69	gold quality
endocervix	UBERON:0000458	51.95	gold quality
placenta	UBERON:0001987	51.81	gold quality
colon	UBERON:0001155	50.91	gold quality
lymph node	UBERON:0000029	50.59	silver quality
left uterine tube	UBERON:0001303	50.54	gold quality
mucosa of stomach	UBERON:0001199	50.26	gold quality
endometrium	UBERON:0001295	49.74	gold quality
vermiform appendix	UBERON:0001154	49.26	gold quality
stomach	UBERON:0000945	48.89	gold quality
calcaneal tendon	UBERON:0003701	48.80	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.63

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.