TILRLS

Summary

TILRLS (TCL1A interacting lncRNA, retroperitoneal liposarcoma associated, HGNC:53077) is a long non-coding RNA gene on chromosome 5q12.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:53077
Approved symbol	TILRLS
Name	TCL1A interacting lncRNA, retroperitoneal liposarcoma associated
Location	5q12.3
Locus type	RNA, long non-coding
Status	Approved
Aliases	PILRLS
Ensembl gene	ENSG00000251206
Ensembl biotype	lncRNA
Entrez	123706549
RNAcentral	URS000043B0C1 — lncRNA, 509 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000515077

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000515077 — 3 exons

Exon	Start	End
ENSE00002033545	67270070	67270182
ENSE00002034240	67268022	67268173
ENSE00002047079	67269293	67269536

Expression profiles

Bgee: expression breadth broad, 94 present calls, max score 60.83.

Top tissues by expression

94 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
colonic epithelium	UBERON:0000397	60.83	silver quality
sural nerve	UBERON:0015488	57.23	silver quality
lymph node	UBERON:0000029	54.68	gold quality
monocyte	CL:0000576	54.22	gold quality
placenta	UBERON:0001987	54.16	gold quality
smooth muscle tissue	UBERON:0001135	53.72	gold quality
myometrium	UBERON:0001296	53.70	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	53.63	gold quality
islet of Langerhans	UBERON:0000006	52.82	gold quality
vermiform appendix	UBERON:0001154	52.43	gold quality
corpus callosum	UBERON:0002336	51.42	silver quality
tonsil	UBERON:0002372	51.42	gold quality
calcaneal tendon	UBERON:0003701	51.37	gold quality
cortex of kidney	UBERON:0001225	51.33	gold quality
lower esophagus	UBERON:0013473	50.71	gold quality
lower esophagus muscularis layer	UBERON:0035833	50.69	gold quality
left uterine tube	UBERON:0001303	50.46	gold quality
blood	UBERON:0000178	50.16	silver quality
esophagogastric junction muscularis propria	UBERON:0035841	49.73	gold quality
endometrium	UBERON:0001295	49.31	gold quality
primary visual cortex	UBERON:0002436	49.27	gold quality
ovary	UBERON:0000992	49.15	gold quality
descending thoracic aorta	UBERON:0002345	48.94	gold quality
left ovary	UBERON:0002119	48.77	gold quality
tibial nerve	UBERON:0001323	48.69	gold quality
muscle of leg	UBERON:0001383	48.64	gold quality
temporal lobe	UBERON:0001871	48.58	gold quality
esophagus	UBERON:0001043	48.33	gold quality
gastrocnemius	UBERON:0001388	48.15	gold quality
right ovary	UBERON:0002118	47.86	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.47

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• In our study, we found a novel lncRNA PILRLS (Proliferation Interacting LncRNA in Retroperitoneal Liposarcoma), which as an oncogene significantly overexpressed in retroperitoneal liposarcoma (PMID:28129655)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.