TIMM10

Summary

TIMM10 (translocase of inner mitochondrial membrane 10, HGNC:11814) is a protein-coding gene on chromosome 11q12.1, encoding Mitochondrial import inner membrane translocase subunit Tim10 (P62072). Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. It is a common-essential gene (DepMap: required in 95.8% of cancer cell lines).

The mitochondrial protein encoded by this gene belongs to a family of evolutionarily conserved proteins that are organized in heterooligomeric complexes in the mitochondrial intermembrane space. These proteins mediate the import and insertion of hydrophobic membrane proteins into the mitochondrial inner membrane, functioning as intermembrane space chaperones for the highly insoluble carrier proteins.

Source: NCBI Gene 26519 — RefSeq curated summary.

At a glance

• GWAS associations: 1
• Clinical variants (ClinVar): 9 total
• Druggable target: yes
• Cancer dependency (DepMap): dependent in 95.8% of screened cell lines (common-essential)
• MANE Select transcript: NM_012456

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:11814
Approved symbol	TIMM10
Name	translocase of inner mitochondrial membrane 10
Location	11q12.1
Locus type	gene with protein product
Status	Approved
Aliases	TIM10, TIM10A, TIMM10A
Ensembl gene	ENSG00000134809
Ensembl biotype	protein_coding
OMIM	602251
Entrez	26519

Gene structure

Transcript identifiers

Ensembl transcripts: 17 — 17 protein_coding

ENST00000257245, ENST00000525158, ENST00000525587, ENST00000910400, ENST00000927513, ENST00000927514, ENST00000927515, ENST00000927516, ENST00000927517, ENST00000927518, ENST00000927519, ENST00000927520, ENST00000927521, ENST00000927522, ENST00000927523, ENST00000927524, ENST00000927525

RefSeq mRNA: 1 — MANE Select: NM_012456 NM_012456

CCDS: CCDS7959

Canonical transcript exons

ENST00000257245 — 3 exons

Exon	Start	End
ENSE00000916206	57528464	57528918
ENSE00000916207	57530119	57530234
ENSE00001027295	57530658	57530754

Expression profiles

Bgee: expression breadth ubiquitous, 274 present calls, max score 95.37.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 34.3433 / max 173.1241, expressed in 1819 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
119794	33.0002	1818
119793	1.3432	838

Top tissues by expression

285 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
gingival epithelium	UBERON:0001949	95.37	gold quality
prefrontal cortex	UBERON:0000451	95.21	gold quality
hindlimb stylopod muscle	UBERON:0004252	94.65	gold quality
islet of Langerhans	UBERON:0000006	94.63	gold quality
gastrocnemius	UBERON:0001388	94.38	gold quality
anterior cingulate cortex	UBERON:0009835	94.24	gold quality
apex of heart	UBERON:0002098	94.23	gold quality
cingulate cortex	UBERON:0003027	94.21	gold quality
gingiva	UBERON:0001828	94.19	gold quality
muscle of leg	UBERON:0001383	94.17	gold quality
tendon of biceps brachii	UBERON:0008188	94.12	gold quality
right lobe of liver	UBERON:0001114	93.99	gold quality
biceps brachii	UBERON:0001507	93.97	gold quality
nucleus accumbens	UBERON:0001882	93.77	gold quality
heart left ventricle	UBERON:0002084	93.75	gold quality
cardiac ventricle	UBERON:0002082	93.60	gold quality
skeletal muscle tissue of biceps brachii	UBERON:0004502	93.54	gold quality
right frontal lobe	UBERON:0002810	93.48	gold quality
putamen	UBERON:0001874	93.42	gold quality
amygdala	UBERON:0001876	93.42	gold quality
right coronary artery	UBERON:0001625	93.37	gold quality
caudate nucleus	UBERON:0001873	93.37	gold quality
stromal cell of endometrium	CL:0002255	93.35	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	93.34	gold quality
right atrium auricular region	UBERON:0006631	93.13	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	93.10	gold quality
neocortex	UBERON:0001950	93.00	gold quality
Brodmann (1909) area 9	UBERON:0013540	92.99	gold quality
frontal cortex	UBERON:0001870	92.97	gold quality
muscle organ	UBERON:0001630	92.94	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	10.78

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

17 targeting TIMM10, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-190A-3P	100.00	80.35	5520
HSA-MIR-5011-5P	100.00	83.46	5820
HSA-MIR-8485	100.00	77.57	4731
HSA-MIR-4789-5P	99.98	70.76	2721
HSA-MIR-3065-5P	99.97	71.56	3281
HSA-MIR-3941	99.86	70.54	2735
HSA-MIR-466	99.67	70.85	2863
HSA-MIR-7159-5P	99.53	72.12	2472
HSA-MIR-4441	99.49	66.56	3216
HSA-MIR-505-3P	99.19	69.71	896
HSA-MIR-4504	99.10	69.14	1328
HSA-MIR-4796-3P	99.08	68.38	1681
HSA-MIR-4270	99.02	66.26	1987
HSA-MIR-4635	98.74	67.63	1339
HSA-MIR-6754-5P	98.60	65.54	1627
HSA-MIR-4733-3P	98.35	65.20	994
HSA-MIR-4704-3P	98.28	69.33	1300

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 95.8% of screened cell lines, common-essential.

Literature-anchored findings (GeneRIF, showing 3)

• in contrast to yeast, only a small fraction of Tim9-Tim10a-Tim10b complex is in a stable association with Tim22 (PMID:14726512)
• The crystal structure of TIM9.10 described here reveals a previously undescribed alpha-propeller topology in which helical “blades” radiate from a narrow central pore lined with polar residues. (PMID:16387659)
• Marked differences in the expression of PTMA and Tim10 were observed during the differentiation of human primary skeletal muscle cells. (PMID:16669873)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	timm10	ENSDARG00000069116
mus_musculus	Timm10	ENSMUSG00000027076
rattus_norvegicus	Timm10	ENSRNOG00000007883
drosophila_melanogaster	Tim10	FBGN0027360
caenorhabditis_elegans		WBGENE00006573

Protein

Protein identifiers

Mitochondrial import inner membrane translocase subunit Tim10 — P62072 (reviewed: P62072)

All UniProt accessions (1): P62072

UniProt curated annotations — full annotation on UniProt →

Function. Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. May also be required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.

Subunit / interactions. Heterohexamer; composed of 3 copies of TIMM9 and 3 copies of TIMM10/TIM10A, named soluble 70 kDa complex. The complex forms a 6-bladed alpha-propeller structure and associates with the TIMM22 component of the TIM22 complex. Interacts with multi-pass transmembrane proteins in transit. Also forms a complex composed of TIMM9, TIMM10/TIM10A and FXC1/TIM10B.

Subcellular location. Mitochondrion inner membrane.

Tissue specificity. Ubiquitous, with highest expression in heart, kidney, liver and skeletal muscle.

Domain organisation. The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. However, during the transit of TIMM10 from cytoplasm into mitochondrion, the Cys residues probably coordinate zinc, thereby preventing folding and allowing its transfer across mitochondrial outer membrane.

Similarity. Belongs to the small Tim family.

RefSeq proteins (1): NP_036588* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR004217	Tim10-like	Domain
IPR035427	Tim10-like_dom_sf	Homologous_superfamily

Pfam: PF02953

UniProt features (10 total): helix 4, disulfide bond 2, chain 1, short sequence motif 1, turn 1, strand 1

Structure

Experimental structures (PDB)

2 structures.

PDB	Method	Resolution (Å)
2BSK	X-RAY DIFFRACTION	3.3
7CGP	ELECTRON MICROSCOPY	3.7

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-P62072-F1	93.80	0.90

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (2): 29–54, 33–50

Function

Pathways and Gene Ontology

Reactome pathways

2 pathways

ID	Pathway
R-HSA-1268020	Mitochondrial protein import
R-HSA-9837999	Mitochondrial protein degradation

MSigDB gene sets: 193 (showing top): BUYTAERT_PHOTODYNAMIC_THERAPY_STRESS_DN, GOBP_SENSORY_PERCEPTION_OF_MECHANICAL_STIMULUS, GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN, GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_DN, GOBP_PROTEIN_TARGETING, GOBP_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_ORGANELLE, USF_C, WEI_MYCN_TARGETS_WITH_E_BOX, AMIT_EGF_RESPONSE_480_MCF10A, GOBP_INNER_MITOCHONDRIAL_MEMBRANE_ORGANIZATION, MYCMAX_01, GOBP_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_MEMBRANE, GOCC_MITOCHONDRIAL_ENVELOPE, GARCIA_TARGETS_OF_FLI1_AND_DAX1_DN, DODD_NASOPHARYNGEAL_CARCINOMA_UP

GO Biological Process (4): obsolete protein targeting to mitochondrion (GO:0006626), sensory perception of sound (GO:0007605), protein transport (GO:0015031), protein insertion into mitochondrial inner membrane (GO:0045039)

GO Molecular Function (6): zinc ion binding (GO:0008270), membrane insertase activity (GO:0032977), protein homodimerization activity (GO:0042803), protein-folding chaperone binding (GO:0051087), protein binding (GO:0005515), metal ion binding (GO:0046872)

GO Cellular Component (7): mitochondrion (GO:0005739), mitochondrial inner membrane (GO:0005743), TIM23 mitochondrial import inner membrane translocase complex (GO:0005744), mitochondrial intermembrane space (GO:0005758), mitochondrial intermembrane space chaperone complex (GO:0042719), TIM22 mitochondrial import inner membrane insertion complex (GO:0042721), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-2 pathways:

Category	Pathways
Protein localization	1
Metabolism of proteins	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
inner mitochondrial membrane protein complex	2
sensory perception of mechanical stimulus	1
transport	1
intracellular protein localization	1
establishment of protein localization	1
inner mitochondrial membrane organization	1
mitochondrial protein import pathway	1
transition metal ion binding	1
establishment of protein localization to membrane	1
protein carrier activity	1
identical protein binding	1
protein dimerization activity	1
protein binding	1
binding	1
cation binding	1
cytoplasm	1
intracellular membrane-bounded organelle	1
organelle inner membrane	1
mitochondrial membrane	1
mitochondrial envelope	1
organelle envelope lumen	1
mitochondrial intermembrane space	1
mitochondrial protein-containing complex	1
cellular anatomical structure	1

Protein interactions and networks

STRING

1948 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
TIMM10	TIMM9	Q9Y5J7	999
TIMM10	CHCHD4	Q8N4Q1	980
TIMM10	TIMM8A	O60220	972
TIMM10	TIMM13	P62206	970
TIMM10	TIMM17A	Q99595	943
TIMM10	TIMM44	O43615	897
TIMM10	TIMM22	Q9Y584	895
TIMM10	TIMM10B	Q9Y5J6	889
TIMM10	TIMM23	O14925	882
TIMM10	TOMM70	O94826	879
TIMM10	PUS1	Q9Y606	830
TIMM10	GRPEL1	Q9HAV7	826
TIMM10	TIMM29	Q9BSF4	765
TIMM10	TIMM50	Q3ZCQ8	759
TIMM10	GFER	P55789	730

IntAct

51 interactions, top by confidence:

A	B	Type	Score
TIMM9	TIMM10	psi-mi:“MI:0914”(association)	0.830
TIMM10	TIMM9	psi-mi:“MI:0915”(physical association)	0.830
TIMM9	TIMM10	psi-mi:“MI:0915”(physical association)	0.830
TIMM10B	TIMM10	psi-mi:“MI:0914”(association)	0.710
TIMM10	TIMM10B	psi-mi:“MI:0914”(association)	0.710
TIMM10B	TIMM10	psi-mi:“MI:0915”(physical association)	0.710
CHCHD4	SSNA1	psi-mi:“MI:0914”(association)	0.640
CCDC120	AIP	psi-mi:“MI:0914”(association)	0.640
TIMM10	AGK	psi-mi:“MI:0914”(association)	0.640
AGK	HCCS	psi-mi:“MI:0914”(association)	0.620
TIMM10	SIK1	psi-mi:“MI:0915”(physical association)	0.560
TIMM10	TBC1D21	psi-mi:“MI:0915”(physical association)	0.560
TIMM10	ZNF655	psi-mi:“MI:0915”(physical association)	0.560
CTDSP1	CTDSP2	psi-mi:“MI:0914”(association)	0.530
rep	IDE	psi-mi:“MI:0914”(association)	0.530
ANKS6	DCAF7	psi-mi:“MI:0914”(association)	0.510
TIMM22	TIMM10	psi-mi:“MI:0914”(association)	0.350
ADCYAP1	CETN3	psi-mi:“MI:0914”(association)	0.350
AGK	ATP12A	psi-mi:“MI:0914”(association)	0.350
CHCHD4	HAX1	psi-mi:“MI:0914”(association)	0.350
FEV	PSMB4	psi-mi:“MI:0914”(association)	0.350
PRDM1	HSPD1	psi-mi:“MI:0914”(association)	0.350
FGFR3	TIMM8A	psi-mi:“MI:0914”(association)	0.350
TIMM10	DCTN6	psi-mi:“MI:0914”(association)	0.350
CYP2A13	CD63	psi-mi:“MI:0914”(association)	0.350
PNKD	ADD1	psi-mi:“MI:0914”(association)	0.350
FAM120AOS	TIMM10	psi-mi:“MI:0914”(association)	0.350

BioGRID (109): TIMM10 (Co-fractionation), TIMM10 (Co-fractionation), TIMM10 (Co-fractionation), TIMM10 (Affinity Capture-MS), TIMM10 (Affinity Capture-MS), TIMM10 (Affinity Capture-MS), TIMM10 (Affinity Capture-MS), TIMM9 (Affinity Capture-MS), TIMM10 (Affinity Capture-MS), TIMM10 (Proximity Label-MS), TIMM10 (Proximity Label-MS), TIMM10 (Affinity Capture-RNA), TIMM10 (Affinity Capture-MS), TBC1D21 (Two-hybrid), ZNF655 (Two-hybrid)

ESM2 similar proteins: O45319, O74700, P0CR96, P0CR97, P0CR98, P0CR99, P57745, P62072, P62073, P62074, P62075, P62076, P87108, Q2KIV2, Q2NKR1, Q4IB65, Q4IPZ1, Q4PGT2, Q4QR62, Q4V7R1, Q4WIQ2, Q4WJX5, Q59R24, Q61BP6, Q6BHJ3, Q6BU42, Q6C6Z2, Q6CIK7, Q6CM57, Q6DI06, Q6FRT3, Q6GQ52, Q6P321, Q757S0, Q759W7, Q8J1Z1, Q9C0N3, Q9P335, Q9UTE9, Q9VTN3

Diamond homologs: P0CR98, P0CR99, P32830, P62072, P62073, P62074, P87108, Q2NKR1, Q4IPZ1, Q4QR62, Q4WJX5, Q54NZ0, Q61BP6, Q6BHJ3, Q6C6U1, Q6CIK7, Q6DI06, Q6GQ52, Q6P321, Q759W7, Q9C0N3, Q9P335, Q9UTE9, Q9W2D6, Q9Y0V6, Q9Y8A8, Q9ZW33, Q6CJX3, Q6FK81, Q6FRE1, Q9XGX7, Q9XGX8, Q9XGX9, Q9XGY4, Q6BU42, Q6C6Z2, Q9Y8C0, Q59MI8, Q6BN23, Q6CWH5

SIGNOR signaling

2 interactions.

A	Effect	B	Mechanism
TIMM10	“form complex”	“TIM22 complex”	binding

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 50 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Mitochondrial protein import	7	32.7×	3e-07

Disease & clinical

Clinical variants and AI predictions

ClinVar

9 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	8
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

380 predictions. Top by Δscore:

Variant	Effect	Δscore
11:57528917:TT:T	acceptor_gain	1.0000
11:57528919:C:CC	acceptor_gain	1.0000
11:57528914:TCATT:T	acceptor_gain	0.9900
11:57528915:CATT:C	acceptor_gain	0.9900
11:57528915:CATTC:C	acceptor_gain	0.9900
11:57528916:ATT:A	acceptor_gain	0.9900
11:57528918:TC:T	acceptor_loss	0.9900
11:57528919:C:CA	acceptor_loss	0.9900
11:57530113:CTTTA:C	donor_loss	0.9800
11:57530114:TTTA:T	donor_loss	0.9800
11:57530115:TTA:T	donor_loss	0.9800
11:57530116:TAC:T	donor_loss	0.9800
11:57530117:A:AT	donor_loss	0.9800
11:57530118:C:A	donor_loss	0.9800
11:57530232:ATC:A	acceptor_gain	0.9800
11:57530235:C:CC	acceptor_gain	0.9800
11:57530235:C:CA	acceptor_loss	0.9700
11:57530236:T:C	acceptor_loss	0.9700
11:57530657:CCA:C	donor_gain	0.9700
11:57528916:ATTC:A	acceptor_gain	0.9600
11:57528917:TTCT:T	acceptor_gain	0.9600
11:57530651:CACTT:C	donor_loss	0.9500
11:57530652:ACTTA:A	donor_loss	0.9500
11:57530653:CTTAC:C	donor_loss	0.9500
11:57530654:TTACC:T	donor_loss	0.9500
11:57530656:ACCAC:A	donor_loss	0.9500
11:57528918:TCTG:T	acceptor_gain	0.9400
11:57530231:AATC:A	acceptor_gain	0.9400
11:57530233:TC:T	acceptor_gain	0.9400
11:57530234:CC:C	acceptor_gain	0.9400

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000312783 (11:57528079 T>G), RS1000339548 (11:57528119 G>A), RS1000620995 (11:57529715 G>A), RS1000956953 (11:57530097 G>A,C,T), RS1002041328 (11:57530296 A>G), RS1002452804 (11:57529950 C>T), RS1002585582 (11:57529242 C>T), RS1004117732 (11:57531863 T>A), RS1004237656 (11:57532045 T>C,G), RS1005649227 (11:57530515 C>A,G,T), RS1006693458 (11:57530418 T>C), RS1006897886 (11:57528181 C>T), RS1007156987 (11:57530118 C>A,G,T), RS1008988590 (11:57530435 G>A), RS1009090716 (11:57528399 C>T)

Disease associations

OMIM: gene MIM:602251 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST006946_8	Worry too long after an embarrassing experience	7.000000e-10

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0009589	worry measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL6067408 (SINGLE PROTEIN)

PharmGKB: 1 entry (VIP=true, CPIC=false)

ChEMBL bioactivities

2 potent at pChembl≥5 of 2 total, top 2 by pChembl (potency: 10 = 0.1 nM, 6 = 1 µM).

pChembl	Type	Value	Unit	Molecule
7.61	Kd	24.55	nM	CHEMBL3752910
7.55	ED50	27.94	nM	CHEMBL3752910

PubChem BioAssay actives

1 with measured affinity, of 2 total; 1 most potent distinct compounds. Largely complementary to BindingDB; screening values are coarse (µM, 4 dp), so sub-nM hits tie at the floor.

Compound	Assay	Type	Value	Unit
4-methyl-3-[(1-methyl-6-pyridin-3-ylpyrazolo[3,4-d]pyrimidin-4-yl)amino]-N-[3-(trifluoromethyl)phenyl]benzamide	2149953: Binding affinity to human TIMM10 incubated for 45 mins by Kinobead based pull down assay	kd	0.0245	uM

CTD chemical–gene interactions

30 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects cotreatment, increases expression, affects expression	5
sodium arsenite	decreases expression, increases abundance, increases expression	4
Acetaminophen	decreases expression	2
Arsenic	increases abundance, increases expression, affects methylation	2
alpha phellandrene	decreases expression	1
triphenyl phosphate	affects expression	1
O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate	affects expression, affects response to substance	1
tris(2-butoxyethyl) phosphate	affects expression	1
cobaltous chloride	decreases expression	1
perfluorooctanoic acid	increases expression	1
di-n-butylphosphoric acid	affects expression	1
CGP 52608	affects binding, increases reaction	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, increases expression	1
ICG 001	increases expression	1
dorsomorphin	increases expression, affects cotreatment	1
(+)-JQ1 compound	decreases expression	1
Temozolomide	decreases expression	1
Air Pollutants	decreases expression, increases abundance	1
Atrazine	decreases expression	1
Cisplatin	affects cotreatment, decreases expression	1
Dichlorodiphenyl Dichloroethylene	increases expression	1
Hydrogen Peroxide	increases expression	1
Ivermectin	decreases expression	1
Phthalic Acids	increases methylation	1
Piroxicam	affects cotreatment, decreases expression	1
Smoke	decreases expression	1
Testosterone	decreases expression	1
Thiram	decreases expression	1
Tobacco Smoke Pollution	increases expression	1
Particulate Matter	decreases expression, increases abundance	1

ChEMBL screening assays

1 unique, capped per target: 1 binding

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL5652995	Binding	Binding affinity to human TIMM10 incubated for 45 mins by Kinobead based pull down assay	NVP-BHG712: Effects of Regioisomers on the Affinity and Selectivity toward the EPHrin Family. — ChemMedChem

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.