TIMM9

Summary

TIMM9 (translocase of inner mitochondrial membrane 9, HGNC:11819) is a protein-coding gene on chromosome 14q23.1, encoding Mitochondrial import inner membrane translocase subunit Tim9 (Q9Y5J7). Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. It is a selective cancer dependency (DepMap: 68.4% of cell lines).

TIMM9 belongs to a family of evolutionarily conserved proteins that are organized in heterooligomeric complexes in the mitochondrial intermembrane space. These proteins mediate the import and insertion of hydrophobic membrane proteins into the mitochondrial inner membrane.

Source: NCBI Gene 26520 — RefSeq curated summary.

At a glance

• GWAS associations: 1
• Clinical variants (ClinVar): 16 total
• Druggable target: yes
• Cancer dependency (DepMap): dependent in 68.4% of screened cell lines
• MANE Select transcript: NM_012460

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:11819
Approved symbol	TIMM9
Name	translocase of inner mitochondrial membrane 9
Location	14q23.1
Locus type	gene with protein product
Status	Approved
Aliases	TIM9A
Ensembl gene	ENSG00000100575
Ensembl biotype	protein_coding
OMIM	607384
Entrez	26520

Gene structure

Transcript identifiers

Ensembl transcripts: 36 — 34 protein_coding, 2 protein_coding_CDS_not_defined

ENST00000216463, ENST00000395159, ENST00000555061, ENST00000555097, ENST00000555404, ENST00000555593, ENST00000555930, ENST00000556007, ENST00000556367, ENST00000557397, ENST00000871598, ENST00000871599, ENST00000871600, ENST00000871601, ENST00000871602, ENST00000871603, ENST00000922994, ENST00000922995, ENST00000922996, ENST00000922997, ENST00000922998, ENST00000922999, ENST00000923000, ENST00000923001, ENST00000923002, ENST00000923003, ENST00000923004, ENST00000923005, ENST00000923006, ENST00000923007, ENST00000923008, ENST00000923009, ENST00000923010, ENST00000923011, ENST00000923012, ENST00000941474

RefSeq mRNA: 8 — MANE Select: NM_012460 NM_001304485, NM_001304486, NM_001304487, NM_001304488, NM_001304489, NM_001304490, NM_001304491, NM_012460

CCDS: CCDS76685, CCDS86393, CCDS86394, CCDS9735

Canonical transcript exons

ENST00000395159 — 6 exons

Exon	Start	End
ENSE00001520754	58408495	58409168
ENSE00001520773	58424008	58424095
ENSE00001520774	58427054	58427242
ENSE00002452592	58427392	58427531
ENSE00003655999	58410843	58410938
ENSE00003804185	58411907	58411971

Expression profiles

Bgee: expression breadth ubiquitous, 283 present calls, max score 97.32.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 23.9392 / max 288.0773, expressed in 1807 samples.

FANTOM5 promoters (6 alternative TSS)

Promoter ID	TPM avg	Samples expressed
143434	20.3951	1797
143433	1.4184	892
143436	1.3266	686
143437	0.3239	139
207236	0.2777	122
143435	0.1975	53

Top tissues by expression

287 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
body of pancreas	UBERON:0001150	97.32	gold quality
ganglionic eminence	UBERON:0004023	95.63	gold quality
hindlimb stylopod muscle	UBERON:0004252	95.52	gold quality
pancreas	UBERON:0001264	94.83	gold quality
colonic epithelium	UBERON:0000397	94.77	gold quality
ventricular zone	UBERON:0003053	94.77	gold quality
gastrocnemius	UBERON:0001388	94.57	gold quality
left ovary	UBERON:0002119	94.36	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	94.31	gold quality
muscle of leg	UBERON:0001383	94.30	gold quality
muscle layer of sigmoid colon	UBERON:0035805	93.82	gold quality
right ovary	UBERON:0002118	93.69	gold quality
cortical plate	UBERON:0005343	93.69	gold quality
omental fat pad	UBERON:0010414	93.47	gold quality
peritoneum	UBERON:0002358	93.41	gold quality
islet of Langerhans	UBERON:0000006	93.36	gold quality
popliteal artery	UBERON:0002250	93.34	gold quality
tibial artery	UBERON:0007610	93.34	gold quality
endocervix	UBERON:0000458	93.03	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	93.01	gold quality
ovary	UBERON:0000992	92.98	gold quality
lower esophagus muscularis layer	UBERON:0035833	92.96	gold quality
body of uterus	UBERON:0009853	92.94	gold quality
lower esophagus	UBERON:0013473	92.94	gold quality
body of stomach	UBERON:0001161	92.92	gold quality
mucosa of stomach	UBERON:0001199	92.91	gold quality
right adrenal gland cortex	UBERON:0035827	92.87	gold quality
left adrenal gland	UBERON:0001234	92.77	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	92.77	gold quality
left adrenal gland cortex	UBERON:0035825	92.76	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	11.00

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

33 targeting TIMM9, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4795-3P	100.00	74.62	4024
HSA-MIR-4282	99.99	75.36	6408
HSA-MIR-4482-3P	99.98	72.50	3147
HSA-MIR-3605-5P	99.96	67.12	932
HSA-MIR-144-3P	99.94	73.98	2698
HSA-MIR-182-5P	99.87	74.03	2589
HSA-MIR-576-5P	99.84	70.46	2582
HSA-MIR-4420	99.82	70.08	1624
HSA-MIR-181B-2-3P	99.81	70.06	1646
HSA-MIR-181B-3P	99.81	70.06	1646
HSA-MIR-4320	99.75	65.80	793
HSA-MIR-132-3P	99.73	70.56	1424
HSA-MIR-212-3P	99.73	70.65	1424
HSA-MIR-4729	99.69	72.18	4233
HSA-MIR-587	99.64	70.86	2611
HSA-MIR-1827	99.63	68.57	3265
HSA-MIR-4753-5P	99.54	68.51	1356
HSA-MIR-7159-3P	99.51	70.17	1920
HSA-MIR-766-3P	99.47	65.24	1811
HSA-MIR-8070	99.07	69.30	1303
HSA-MIR-1304-5P	98.90	68.58	1054
HSA-MIR-3145-3P	98.85	69.07	2031
HSA-MIR-6894-5P	98.70	63.78	809
HSA-MIR-299-5P	98.56	71.14	1140
HSA-MIR-4766-3P	98.48	67.94	1347
HSA-MIR-1910-3P	98.44	67.51	1695
HSA-MIR-4704-3P	98.28	69.33	1300
HSA-MIR-4450	98.26	68.35	725
HSA-MIR-1263	98.13	69.18	459
HSA-MIR-6511A-5P	98.13	67.47	1770

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 68.4% of screened cell lines.

Literature-anchored findings (GeneRIF, showing 3)

• in contrast to yeast, only a small fraction of Tim9-Tim10a-Tim10b complex is in a stable association with Tim22 (PMID:14726512)
• The crystal structure of TIM9.10 described here reveals a previously undescribed alpha-propeller topology in which helical “blades” radiate from a narrow central pore lined with polar residues. (PMID:16387659)
• in gastric cancer patients, a borderline association was found between overexpression of TIMM9 and vascular invasion; patients with high expression levels of TIMM9 achieved a significantly lower disease-free survival rate compared with those with low expression levels (PMID:27720672)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	timm9	ENSDARG00000043865
mus_musculus	Timm9	ENSMUSG00000021079
rattus_norvegicus	Timm9	ENSRNOG00000008222
drosophila_melanogaster	Tim9a	FBGN0030480
caenorhabditis_elegans		WBGENE00006572

Protein

Protein identifiers

Mitochondrial import inner membrane translocase subunit Tim9 — Q9Y5J7 (reviewed: Q9Y5J7)

All UniProt accessions (5): Q9Y5J7, A0A1W2PQS5, A0A1W2PRH9, G3V2F3, G3V502

UniProt curated annotations — full annotation on UniProt →

Function. Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. May also be required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.

Subunit / interactions. Heterohexamer; composed of 3 copies of TIMM9 and 3 copies of TIMM10/TIM10A, named soluble 70 kDa complex. The complex forms a 6-bladed alpha-propeller structure and associates with the TIMM22 component of the TIM22 complex. Interacts with multi-pass transmembrane proteins in transit. Also forms a complex composed of TIMM9, TIMM10/TIM10A and FXC1/TIM10B.

Subcellular location. Mitochondrion inner membrane.

Tissue specificity. Ubiquitous, with highest expression in heart, kidney, liver and skeletal muscle.

Domain organisation. The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. However, during the transit of TIMM9 from cytoplasm into mitochondrion, the Cys residues probably coordinate zinc, thereby preventing folding and allowing its transfer across mitochondrial outer membrane.

Similarity. Belongs to the small Tim family.

RefSeq proteins (8): NP_001291414, NP_001291415, NP_001291416, NP_001291417, NP_001291418, NP_001291419, NP_001291420, NP_036592* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR004217	Tim10-like	Domain
IPR035427	Tim10-like_dom_sf	Homologous_superfamily
IPR050673	Mito_inner_translocase_sub	Family

Pfam: PF02953

UniProt features (11 total): helix 3, disulfide bond 2, strand 2, initiator methionine 1, chain 1, short sequence motif 1, modified residue 1

Structure

Experimental structures (PDB)

2 structures.

PDB	Method	Resolution (Å)
2BSK	X-RAY DIFFRACTION	3.3
7CGP	ELECTRON MICROSCOPY	3.7

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9Y5J7-F1	91.30	0.82

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (1): 2

Disulfide bonds (2): 28–52, 32–48

Function

Pathways and Gene Ontology

Reactome pathways

2 pathways

ID	Pathway
R-HSA-1268020	Mitochondrial protein import
R-HSA-9837999	Mitochondrial protein degradation

MSigDB gene sets: 199 (showing top): GSE18804_SPLEEN_MACROPHAGE_VS_TUMORAL_MACROPHAGE_UP, RORA1_01, GOBP_SENSORY_PERCEPTION_OF_MECHANICAL_STIMULUS, GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN, GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_DN, GOBP_PROTEIN_TARGETING, TGACCTY_ERR1_Q2, GOBP_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_ORGANELLE, GGGTGGRR_PAX4_03, USF_C, FREAC3_01, SHETH_LIVER_CANCER_VS_TXNIP_LOSS_PAM4, GOBP_INNER_MITOCHONDRIAL_MEMBRANE_ORGANIZATION, MYCMAX_01, GROSS_HYPOXIA_VIA_HIF1A_UP

GO Biological Process (4): obsolete protein targeting to mitochondrion (GO:0006626), sensory perception of sound (GO:0007605), protein transport (GO:0015031), protein insertion into mitochondrial inner membrane (GO:0045039)

GO Molecular Function (7): zinc ion binding (GO:0008270), membrane insertase activity (GO:0032977), protein homodimerization activity (GO:0042803), protein-folding chaperone binding (GO:0051087), protein transporter activity (GO:0140318), protein binding (GO:0005515), metal ion binding (GO:0046872)

GO Cellular Component (6): mitochondrion (GO:0005739), mitochondrial inner membrane (GO:0005743), mitochondrial intermembrane space (GO:0005758), mitochondrial intermembrane space chaperone complex (GO:0042719), TIM22 mitochondrial import inner membrane insertion complex (GO:0042721), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-2 pathways:

Category	Pathways
Protein localization	1
Metabolism of proteins	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
sensory perception of mechanical stimulus	1
transport	1
intracellular protein localization	1
establishment of protein localization	1
inner mitochondrial membrane organization	1
mitochondrial protein import pathway	1
transition metal ion binding	1
establishment of protein localization to membrane	1
protein carrier activity	1
identical protein binding	1
protein dimerization activity	1
protein binding	1
transporter activity	1
binding	1
cation binding	1
cytoplasm	1
intracellular membrane-bounded organelle	1
organelle inner membrane	1
mitochondrial membrane	1
mitochondrial envelope	1
organelle envelope lumen	1
mitochondrial intermembrane space	1
mitochondrial protein-containing complex	1
inner mitochondrial membrane protein complex	1
cellular anatomical structure	1

Protein interactions and networks

STRING

1520 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
TIMM9	TIMM10	P62072	999
TIMM9	TIMM8A	O60220	982
TIMM9	TIMM13	P62206	981
TIMM9	TIMM23	O14925	904
TIMM9	TIMM22	Q9Y584	897
TIMM9	CHCHD4	Q8N4Q1	883
TIMM9	TIMM10B	Q9Y5J6	820
TIMM9	TIMM17A	Q99595	807
TIMM9	TIMM29	Q9BSF4	783
TIMM9	TIMM21	Q9BVV7	773
TIMM9	TOMM70	O94826	744
TIMM9	TIMM50	Q3ZCQ8	736
TIMM9	TIMM44	O43615	733
TIMM9	SLC25A12	O75746	733
TIMM9	TOMM40	O96008	733

IntAct

33 interactions, top by confidence:

A	B	Type	Score
TIMM9	TIMM10	psi-mi:“MI:0914”(association)	0.830
TIMM10	TIMM9	psi-mi:“MI:0915”(physical association)	0.830
TIMM9	TIMM10	psi-mi:“MI:0915”(physical association)	0.830
TIMM10B	TIMM10	psi-mi:“MI:0914”(association)	0.710
TIMM10	TIMM10B	psi-mi:“MI:0914”(association)	0.710
TIMM10B	TIMM10	psi-mi:“MI:0915”(physical association)	0.710
TIMM10	AGK	psi-mi:“MI:0914”(association)	0.640
rep	IDE	psi-mi:“MI:0914”(association)	0.530
ANKS6	DCAF7	psi-mi:“MI:0914”(association)	0.510
TIMM22	TIMM10	psi-mi:“MI:0914”(association)	0.350
BAD	PPP6C	psi-mi:“MI:0914”(association)	0.350
BAD	ERLIN1	psi-mi:“MI:0914”(association)	0.350
rep	CEBPZOS	psi-mi:“MI:0914”(association)	0.350
FEV	PSMB4	psi-mi:“MI:0914”(association)	0.350
FOXQ1	TIMM8A	psi-mi:“MI:0914”(association)	0.350
PRDM1	HSPD1	psi-mi:“MI:0914”(association)	0.350
FGFR3	TIMM8A	psi-mi:“MI:0914”(association)	0.350
TIMM10	DCTN6	psi-mi:“MI:0914”(association)	0.350
TIMM10	IGLL5	psi-mi:“MI:0914”(association)	0.350
AGK	RAB29	psi-mi:“MI:0914”(association)	0.350
ATF2	CLIC1	psi-mi:“MI:0914”(association)	0.350
SLC14A2	SMCHD1	psi-mi:“MI:0914”(association)	0.350
SCO1	HAX1	psi-mi:“MI:2364”(proximity)	0.270
SFXN1	HAX1	psi-mi:“MI:2364”(proximity)	0.270
PARL	HAX1	psi-mi:“MI:2364”(proximity)	0.270
KLF15	TAF4	psi-mi:“MI:2364”(proximity)	0.270
PRDM1	ZNF609	psi-mi:“MI:2364”(proximity)	0.270

BioGRID (66): COX5A (Co-fractionation), NUDC (Co-fractionation), PTGES3 (Co-fractionation), TIMM10 (Co-fractionation), TIMM13 (Co-fractionation), TIMM8A (Co-fractionation), TIMM8B (Co-fractionation), TIMM9 (Co-fractionation), TIMM9 (Affinity Capture-MS), TIMM9 (Affinity Capture-MS), TIMM9 (Affinity Capture-MS), TIMM9 (Negative Genetic), TIMM9 (Positive Genetic), TIMM9 (Positive Genetic), TIMM9 (Negative Genetic)

ESM2 similar proteins: A4QNC6, B0BN94, O74700, P0CR96, P0CR97, P0CS00, P0CS01, P30629, P62075, P62076, P62077, P62078, Q10481, Q2HJI3, Q2KIV2, Q3SZ93, Q4I6B0, Q4V7R1, Q59MI8, Q59R24, Q5ZIR8, Q616Q2, Q61TH2, Q63ZH8, Q66L32, Q6BN23, Q6BU42, Q6CM57, Q6DEM5, Q6DGJ3, Q6FK81, Q6GPY0, Q6PBU0, Q75DU7, Q7SBR3, Q8AVK1, Q90YI5, Q96C01, Q9CR98, Q9N408

Diamond homologs: O74700, P0CR96, P0CR97, P57745, Q17754, Q2KIV2, Q4IB65, Q4V7R1, Q4WIQ2, Q559H1, Q568N4, Q59R24, Q5ZIR8, Q61TH2, Q6BU42, Q6C6Z2, Q6CM57, Q6FRT3, Q757S0, Q8J1Z1, Q9P7K0, Q9VYD7, Q9W762, Q9WV97, Q9WV98, Q9XGX7, Q9XGX8, Q9XGX9, Q9Y0V2, Q9Y5J7, Q9Y8A7, Q3SZW4, Q5RDJ0, Q6CWH5, Q6GR66, Q9R1B1, Q9WV96, Q9Y0V3, Q9Y5J6, P57744

SIGNOR signaling

2 interactions.

A	Effect	B	Mechanism
TIMM9	“form complex”	“TIM22 complex”	binding

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 34 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Mitochondrial protein import	5	36.5×	4e-05

Disease & clinical

Clinical variants and AI predictions

ClinVar

16 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	9
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1141 predictions. Top by Δscore:

Variant	Effect	Δscore
14:58410605:G:C	donor_gain	1.0000
14:58410838:CATA:C	donor_loss	1.0000
14:58410839:ATAC:A	donor_loss	1.0000
14:58410840:TA:T	donor_loss	1.0000
14:58410841:A:C	donor_loss	1.0000
14:58410842:CCT:C	donor_gain	1.0000
14:58410934:TTAAA:T	acceptor_gain	1.0000
14:58410935:TAAA:T	acceptor_gain	1.0000
14:58410936:AAA:A	acceptor_gain	1.0000
14:58410937:AA:A	acceptor_gain	1.0000
14:58410937:AAC:A	acceptor_gain	1.0000
14:58410937:AACTA:A	acceptor_loss	1.0000
14:58410938:ACT:A	acceptor_gain	1.0000
14:58410938:ACTA:A	acceptor_loss	1.0000
14:58410939:C:CC	acceptor_gain	1.0000
14:58410939:CT:C	acceptor_gain	1.0000
14:58410939:CTACA:C	acceptor_loss	1.0000
14:58410940:T:G	acceptor_gain	1.0000
14:58410859:T:TA	donor_gain	0.9900
14:58410935:TAAAC:T	acceptor_gain	0.9900
14:58410936:AAACT:A	acceptor_gain	0.9900
14:58411901:CCTTA:C	donor_loss	0.9900
14:58411902:CTTA:C	donor_loss	0.9900
14:58411903:TTAC:T	donor_loss	0.9900
14:58411904:TA:T	donor_loss	0.9900
14:58411905:ACCTG:A	donor_loss	0.9900
14:58411970:ACCTA:A	acceptor_loss	0.9900
14:58411972:CTA:C	acceptor_loss	0.9900
14:58411973:T:G	acceptor_loss	0.9900
14:58424091:CTTAC:C	acceptor_gain	0.9900

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000199336 (14:58416477 C>T), RS1000242201 (14:58409647 C>T), RS1000296070 (14:58409959 G>A), RS1000418708 (14:58428917 A>G), RS1000477156 (14:58416109 T>G), RS1000605697 (14:58411763 C>A,T), RS1000671722 (14:58422158 C>G,T), RS1000775294 (14:58428896 C>T), RS1000807956 (14:58418352 A>G), RS1000819036 (14:58425068 T>C), RS1000912350 (14:58424696 C>T), RS1001074810 (14:58418628 A>T), RS1001177257 (14:58417199 C>G), RS1001251105 (14:58411205 T>C), RS1001364294 (14:58423916 A>G)

Disease associations

OMIM: gene MIM:607384 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST010703_93	Brain morphology (MOSTest)	6.000000e-54

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0004346	neuroimaging measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL6066451 (SINGLE PROTEIN)

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

42 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Air Pollutants	decreases expression, increases abundance, increases expression	3
Cyclosporine	increases expression, increases methylation	3
Particulate Matter	decreases expression, increases abundance, increases expression	3
bisphenol A	affects expression, increases expression	2
Acetaminophen	affects response to substance, decreases expression	2
Tunicamycin	increases expression	2
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	decreases expression	2
Cadmium Chloride	decreases expression	2
aristolochic acid I	decreases expression	1
bisphenol F	increases expression, affects cotreatment	1
beauvericin	affects cotreatment, decreases expression	1
deoxynivalenol	increases expression	1
beta-lapachone	increases expression	1
sodium arsenite	decreases expression	1
perfluorooctanoic acid	increases expression	1
beta-methylcholine	affects expression	1
enniatins	affects cotreatment, decreases expression	1
perfluoro-n-nonanoic acid	increases expression	1
4-(4-((5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl)methylene)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)benzoic acid	decreases expression	1
Resveratrol	affects cotreatment, decreases expression	1
Sunitinib	increases expression	1
Vehicle Emissions	increases abundance, increases expression	1
Benzo(a)pyrene	increases methylation	1
Cannabidiol	increases expression	1
Dichlorodiphenyl Dichloroethylene	increases expression	1
Dexamethasone	affects cotreatment, increases expression	1
Doxorubicin	decreases expression	1
Indomethacin	affects cotreatment, increases expression	1
Ivermectin	decreases expression	1
Plant Extracts	affects cotreatment, decreases expression	1

ChEMBL screening assays

1 unique, capped per target: 1 binding

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL5652633	Binding	Binding affinity to human TIMM9 incubated for 45 mins by Kinobead based pull down assay	NVP-BHG712: Effects of Regioisomers on the Affinity and Selectivity toward the EPHrin Family. — ChemMedChem

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.