TIPIN

Summary

TIPIN (TIMELESS interacting protein, HGNC:30750) is a protein-coding gene on chromosome 15q22.31, encoding TIMELESS-interacting protein (Q9BVW5). Plays an important role in the control of DNA replication and the maintenance of replication fork stability. It is a common-essential gene (DepMap: required in 91.7% of cancer cell lines).

The protein encoded by this gene is part of the replisome complex, a group of proteins that support DNA replication. It binds TIM, which is involved in circadian rhythm regulation, and aids in protecting cells against DNA damage and stress. Two pseudogenes and two transcript variants encoding different isoforms have been found for this gene.

Source: NCBI Gene 54962 — RefSeq curated summary.

At a glance

• GWAS associations: 3
• Clinical variants (ClinVar): 43 total
• Cancer dependency (DepMap): dependent in 91.7% of screened cell lines (common-essential)
• MANE Select transcript: NM_017858

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:30750
Approved symbol	TIPIN
Name	TIMELESS interacting protein
Location	15q22.31
Locus type	gene with protein product
Status	Approved
Aliases	FLJ20516
Ensembl gene	ENSG00000075131
Ensembl biotype	protein_coding
OMIM	610716
Entrez	54962

Gene structure

Transcript identifiers

Ensembl transcripts: 20 — 18 protein_coding, 1 protein_coding_CDS_not_defined, 1 nonsense_mediated_decay

ENST00000261881, ENST00000561773, ENST00000562124, ENST00000566524, ENST00000568216, ENST00000570251, ENST00000851323, ENST00000851324, ENST00000912702, ENST00000912703, ENST00000912704, ENST00000912705, ENST00000912706, ENST00000912707, ENST00000912708, ENST00000912709, ENST00000912710, ENST00000912711, ENST00000955702, ENST00000955703

RefSeq mRNA: 9 — MANE Select: NM_017858 NM_001289986, NM_001398281, NM_001398282, NM_001398283, NM_001398284, NM_001398285, NM_001398286, NM_001398287, NM_017858

CCDS: CCDS10215

Canonical transcript exons

ENST00000261881 — 8 exons

Exon	Start	End
ENSE00000942662	66351525	66351600
ENSE00002219102	66356639	66356685
ENSE00002580100	66336191	66337181
ENSE00003592159	66352815	66352955
ENSE00003596351	66341150	66341356
ENSE00003598726	66352129	66352207
ENSE00003604788	66349315	66349437
ENSE00003622952	66349060	66349123

Expression profiles

Bgee: expression breadth ubiquitous, 235 present calls, max score 91.36.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 11.8387 / max 443.1959, expressed in 1719 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
150589	9.5975	1619
150590	2.2411	1086

Top tissues by expression

271 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	91.36	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	87.84	gold quality
calcaneal tendon	UBERON:0003701	85.68	gold quality
secondary oocyte	CL:0000655	85.23	gold quality
right testis	UBERON:0004534	85.04	gold quality
left testis	UBERON:0004533	84.94	gold quality
testis	UBERON:0000473	84.57	gold quality
ganglionic eminence	UBERON:0004023	83.78	gold quality
ventricular zone	UBERON:0003053	83.77	gold quality
islet of Langerhans	UBERON:0000006	83.45	gold quality
sperm	CL:0000019	83.25	gold quality
male germ cell	CL:0000015	82.19	gold quality
oocyte	CL:0000023	81.64	gold quality
cortical plate	UBERON:0005343	80.85	gold quality
embryo	UBERON:0000922	79.63	gold quality
bone marrow	UBERON:0002371	78.10	gold quality
stromal cell of endometrium	CL:0002255	78.00	gold quality
rectum	UBERON:0001052	77.79	gold quality
muscle of leg	UBERON:0001383	77.70	gold quality
gastrocnemius	UBERON:0001388	77.70	gold quality
mucosa of transverse colon	UBERON:0004991	77.49	gold quality
right adrenal gland	UBERON:0001233	77.32	gold quality
left ovary	UBERON:0002119	77.05	gold quality
adrenal tissue	UBERON:0018303	77.04	gold quality
left adrenal gland	UBERON:0001234	76.81	gold quality
pancreas	UBERON:0001264	76.61	gold quality
ovary	UBERON:0000992	76.60	gold quality
hindlimb stylopod muscle	UBERON:0004252	76.57	gold quality
right adrenal gland cortex	UBERON:0035827	76.49	gold quality
anterior cingulate cortex	UBERON:0009835	76.37	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-MTAB-6911	no	105.73
E-ANND-3	no	3.82

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

17 targeting TIPIN, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-495-3P	99.96	72.81	4197
HSA-MIR-5688	99.96	73.23	4504
HSA-MIR-570-3P	99.96	72.41	4910
HSA-MIR-7-1-3P	99.91	71.53	4384
HSA-MIR-7-2-3P	99.91	71.40	4394
HSA-MIR-4328	99.57	71.06	4094
HSA-MIR-3609	99.52	69.89	2587
HSA-MIR-548AH-5P	99.52	69.73	2626
HSA-MIR-548AV-3P	99.43	68.50	1721
HSA-MIR-5695	99.41	67.48	1047
HSA-MIR-4311	99.31	70.47	3041
HSA-MIR-3606-5P	99.31	69.67	1168
HSA-MIR-3925-5P	99.21	67.90	1466
HSA-MIR-1286	99.09	66.23	1046
HSA-MIR-361-5P	98.95	70.16	1340
HSA-MIR-374A-3P	98.87	67.82	1531
HSA-MIR-4521	97.73	67.64	684

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 91.7% of screened cell lines, common-essential.

Literature-anchored findings (GeneRIF, showing 12)

• Tipin is a checkpoint mediator that cooperates with Tim and may regulate the nuclear relocation of Claspin in response to replication checkpoint (PMID:17102137)
• observation explains the similar checkpoint phenotypes observed in both Tipin- and Timeless-depleted cells (PMID:17116885)
• TIM and Tipin are functional orthologs of their replisome-associated yeast counterparts capable of coordinating replication with genotoxic stress responses, and distinguishes mammalian TIM from the circadian-specific paralogs. (PMID:17141802)
• These findings indicate that the Tim-Tipin complex mediates the UV-induced intra-S checkpoint, Tim is needed to maintain DNA replication fork movement, Tipin interacts with RPA on DNA. (PMID:17296725)
• The results suggest that Timeless-Tipin functions as a replication fork stabilizer that couples DNA replication with sister chromatid cohesion established at replication forks. (PMID:20124417)
• RPA-covered ssDNA not only supports recruitment and activation of ATR but also, through Tipin and Claspin, it plays an important role in the action of ATR on its critical downstream target Chk1 (PMID:20233725)
• We now show that cellular DNA replication fork pausing and protection factors Timeless (Tim) and Tipin (Timeless-interacting protein) accumulate at OriP during S phase of the cell cycle. (PMID:21490103)
• Tim-Tipin complex might play a role in coupling DNA unwinding and DNA synthesis by directly affecting the catalytic activities of replication fork proteins. (PMID:23359676)
• Tim-Tipin complex (or Tim alone) is able to associate with DNA polymerase epsilon bound to a 40-/80-mer DNA ligand. (PMID:23511638)
• TIPIN is important for the maintenance of DNA replication and represents a potential treatment target for the worst prognosis associated breast cancers, such as Triple-negative breast cancer. (PMID:26004086)
• the 1.85 A crystal structure of a large N-terminal segment of human Timeless, spanning amino acids 1-463, is presented and this region of human Timeless harbours a partial binding site for Tipin. (PMID:28334766)
• Germline polymorphisms in genes maintaining the replication fork predict the efficacy of oxaliplatin and irinotecan in patients with metastatic colorectal cancer. (PMID:34689170)

Cross-species orthologs

7 orthologs

Organism	Symbol	Gene ID
danio_rerio	tipin	ENSDARG00000036136
mus_musculus	Tipin	ENSMUSG00000032397
rattus_norvegicus	Tipin	ENSRNOG00000043068
rattus_norvegicus		ENSRNOG00000073563
rattus_norvegicus		ENSRNOG00000084297
drosophila_melanogaster	CG10336	FBGN0032698
caenorhabditis_elegans	tipn-1	WBGENE00017738

Protein

Protein identifiers

TIMELESS-interacting protein — Q9BVW5 (reviewed: Q9BVW5)

All UniProt accessions (5): Q9BVW5, H3BQ83, H3BTH1, H3BU04, H3BVG9

UniProt curated annotations — full annotation on UniProt →

Function. Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Important for cell survival after DNA damage or replication stress. May be specifically required for the ATR-CHEK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light. Forms a complex with TIMELESS and this complex regulates DNA replication processes under both normal and stress conditions, stabilizes replication forks and influences both CHEK1 phosphorylation and the intra-S phase checkpoint in response to genotoxic stress.

Subunit / interactions. Interacts with TIMELESS (via N-terminus), which impairs TIMELESS self-association. Associates with the MCM2-7 complex. Interacts with RPA2, PRDX2.

Subcellular location. Cytoplasm. Nucleus.

Similarity. Belongs to the CSM3 family.

RefSeq proteins (9): NP_001276915, NP_001385210, NP_001385211, NP_001385212, NP_001385213, NP_001385214, NP_001385215, NP_001385216, NP_060328* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR012923	Csm3	Domain
IPR040038	TIPIN/Csm3/Swi3	Family

Pfam: PF07962

UniProt features (15 total): sequence variant 6, modified residue 4, region of interest 3, chain 1, sequence conflict 1

Structure

Experimental structures (PDB)

3 structures.

PDB	Method	Resolution (Å)
7PLO	ELECTRON MICROSCOPY	2.8
7PFO	ELECTRON MICROSCOPY	3.2
8B9D	ELECTRON MICROSCOPY	3.4

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9BVW5-F1	67.67	0.20

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (4): 194, 222, 233, 244

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-5693607	Processing of DNA double-strand break ends

MSigDB gene sets: 262 (showing top): GOBP_DNA_TEMPLATED_DNA_REPLICATION_MAINTENANCE_OF_FIDELITY, E2F_Q4_01, RODRIGUES_THYROID_CARCINOMA_POORLY_DIFFERENTIATED_UP, GOBP_REGULATION_OF_DNA_TEMPLATED_DNA_REPLICATION, GOBP_CELL_CYCLE_DNA_REPLICATION, FISCHER_G1_S_CELL_CYCLE, MODULE_151, GOBP_CELL_CYCLE_PHASE_TRANSITION, MITSIADES_RESPONSE_TO_APLIDIN_DN, GOBP_NEGATIVE_REGULATION_OF_DNA_TEMPLATED_DNA_REPLICATION, GOBP_MITOTIC_INTRA_S_DNA_DAMAGE_CHECKPOINT_SIGNALING, GOBP_REGULATION_OF_NUCLEAR_CELL_CYCLE_DNA_REPLICATION, WEI_MYCN_TARGETS_WITH_E_BOX, GOCC_NUCLEAR_REPLICATION_FORK, OSWALD_HEMATOPOIETIC_STEM_CELL_IN_COLLAGEN_GEL_UP

GO Biological Process (11): DNA replication checkpoint signaling (GO:0000076), positive regulation of cell population proliferation (GO:0008284), response to UV (GO:0009411), replication fork processing (GO:0031297), mitotic intra-S DNA damage checkpoint signaling (GO:0031573), regulation of nuclear cell cycle DNA replication (GO:0033262), replication fork arrest (GO:0043111), cell cycle phase transition (GO:0044770), cell division (GO:0051301), DNA damage checkpoint signaling (GO:0000077), DNA damage response (GO:0006974)

GO Molecular Function (2): DNA binding (GO:0003677), protein binding (GO:0005515)

GO Cellular Component (5): chromatin (GO:0000785), nucleus (GO:0005634), nucleoplasm (GO:0005654), cytoplasm (GO:0005737), replication fork protection complex (GO:0031298)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	3
DNA integrity checkpoint signaling	2
DNA-templated DNA replication maintenance of fidelity	2
cell population proliferation	1
regulation of cell population proliferation	1
positive regulation of cellular process	1
response to light stimulus	1
mitotic S phase	1
mitotic DNA damage checkpoint signaling	1
regulation of cell cycle process	1
nuclear DNA replication	1
regulation of DNA-templated DNA replication	1
negative regulation of DNA-templated DNA replication	1
cell cycle process	1
cellular process	1
signal transduction in response to DNA damage	1
cellular response to stress	1
nucleic acid binding	1
binding	1
chromosome	1
intracellular membrane-bounded organelle	1
nuclear lumen	1
intracellular anatomical structure	1
nuclear replication fork	1
nuclear protein-containing complex	1

Protein interactions and networks

STRING

2002 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
TIPIN	TIMELESS	Q9UNS1	999
TIPIN	CLSPN	Q9HAW4	997
TIPIN	WDHD1	O75717	993
TIPIN	MRC1	P22897	911
TIPIN	MCM7	P33993	870
TIPIN	CHEK1	O14757	838
TIPIN	FBXL15	Q9H469	810
TIPIN	MCM10	Q7L590	771
TIPIN	ITFG1	Q8TB96	769
TIPIN	RAD52	P43351	738
TIPIN	CDC45	O75419	735
TIPIN	CDC7	O00311	727
TIPIN	TOPBP1	Q92547	717
TIPIN	DDX11	Q96FC9	666
TIPIN	SMARCAL1	Q9NZC9	666

IntAct

43 interactions, top by confidence:

A	B	Type	Score
RPA2	RPA1	psi-mi:“MI:0914”(association)	0.960
RPA1	RPA2	psi-mi:“MI:0914”(association)	0.960
RPA3	RPA2	psi-mi:“MI:0914”(association)	0.930
MCM2	MCM4	psi-mi:“MI:0914”(association)	0.830
TIPIN	TIMELESS	psi-mi:“MI:0407”(direct interaction)	0.730
TIPIN	TIMELESS	psi-mi:“MI:0915”(physical association)	0.730
RPA2	TIPIN	psi-mi:“MI:0407”(direct interaction)	0.670
TIPIN	RPA2	psi-mi:“MI:0407”(direct interaction)	0.670
TIPIN	TEX11	psi-mi:“MI:0915”(physical association)	0.560
GSC2	TIPIN	psi-mi:“MI:0915”(physical association)	0.560
TIPIN	SPRED1	psi-mi:“MI:0915”(physical association)	0.560
TIPIN	MCM7	psi-mi:“MI:0914”(association)	0.530
GINS3	MCM7	psi-mi:“MI:0914”(association)	0.530
H2BC26	PPM1G	psi-mi:“MI:0914”(association)	0.530
PRIMPOL	RPA2	psi-mi:“MI:0914”(association)	0.510
Tipin	RPA2	psi-mi:“MI:0915”(physical association)	0.400
Timeless	RPA2	psi-mi:“MI:0915”(physical association)	0.400
TIPIN	E2	psi-mi:“MI:0915”(physical association)	0.370
Timeless	TRAPPC13	psi-mi:“MI:0914”(association)	0.350
Clspn	MCM3	psi-mi:“MI:0914”(association)	0.350
TIPIN	MCM3	psi-mi:“MI:0914”(association)	0.350
TCEAL1	PDCD5	psi-mi:“MI:0914”(association)	0.350
SSRP1	DDX39A	psi-mi:“MI:0914”(association)	0.350
S100P	PLEKHG3	psi-mi:“MI:0914”(association)	0.350
CYP2J2	NDUFS4	psi-mi:“MI:0914”(association)	0.350

BioGRID (97): TEX11 (Two-hybrid), TIPIN (Affinity Capture-MS), SUPT16H (Affinity Capture-MS), TIMELESS (Affinity Capture-MS), MCM7 (Affinity Capture-MS), MCM2 (Affinity Capture-MS), GINS1 (Affinity Capture-MS), MCM3 (Affinity Capture-MS), GINS4 (Affinity Capture-MS), TIPIN (Affinity Capture-MS), TIPIN (Affinity Capture-MS), TIMELESS (Affinity Capture-MS), TIPIN (Affinity Capture-MS), GINS4 (Affinity Capture-MS), GINS1 (Affinity Capture-MS)

ESM2 similar proteins: A0ZWU1, A1C8Y9, A1D9E6, A3LW29, A4DA84, A4RCW0, A5DDH8, A5DWY0, B8B2G4, G0SAV1, O14350, O43088, P0CY38, P28706, P33288, P36592, Q02398, Q04659, Q09808, Q0CU66, Q0IHI4, Q0UJ25, Q1DME8, Q2H3R6, Q2UQ97, Q3ZCC4, Q4IB96, Q4QR88, Q4WP03, Q4WXD3, Q4WZJ6, Q59X26, Q5B4Q8, Q5B8U0, Q5BDI1, Q5BER4, Q5F416, Q67VW6, Q6C656, Q6CIH2

Diamond homologs: A1C8Y9, A1D9E6, A3LW29, A4DA84, A4RCW0, A5DWY0, O14350, Q0CU66, Q0IHI4, Q0UJ25, Q1DME8, Q2H3R6, Q3ZCC4, Q4QR88, Q59X26, Q5F416, Q6C656, Q6DBR4, Q75DC6, Q7SHE8, Q91WA1, Q9BVW5, Q6CIH2, Q6FU57, Q8INX3, Q04659, A5DDH8, Q9TXI0, Q61XH2

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 28 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Activation of the pre-replicative complex	8	137.4×	4e-14
Activation of ATR in response to replication stress	8	126.5×	4e-14
DNA Replication Pre-Initiation	5	83.5×	9e-08
Synthesis of DNA	5	79.1×	1e-07
DNA Replication	5	62.6×	3e-07
G1/S Transition	5	61.3×	3e-07
Mitotic G1 phase and G1/S transition	5	48.5×	8e-07
S Phase	5	47.7×	8e-07

GO biological processes:

GO term	Partners	Fold	FDR
DNA replication	10	71.8×	6e-15

Disease & clinical

Clinical variants and AI predictions

ClinVar

43 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	28
Likely benign	2
Benign	1

Top pathogenic / likely-pathogenic (0)

SpliceAI

1072 predictions. Top by Δscore:

Variant	Effect	Δscore
15:66337177:CATAT:C	acceptor_gain	1.0000
15:66337179:TAT:T	acceptor_gain	1.0000
15:66337179:TATC:T	acceptor_loss	1.0000
15:66337182:C:CC	acceptor_gain	1.0000
15:66337798:G:C	donor_gain	1.0000
15:66341176:AG:A	donor_gain	1.0000
15:66341176:AGCAG:A	donor_gain	1.0000
15:66341177:G:C	donor_gain	1.0000
15:66341353:TCATC:T	acceptor_loss	1.0000
15:66341354:CAT:C	acceptor_gain	1.0000
15:66341355:ATC:A	acceptor_loss	1.0000
15:66341356:TCT:T	acceptor_loss	1.0000
15:66341357:C:CC	acceptor_gain	1.0000
15:66341357:CTG:C	acceptor_loss	1.0000
15:66341358:T:G	acceptor_loss	1.0000
15:66349119:CAGGT:C	acceptor_gain	1.0000
15:66349122:GTC:G	acceptor_loss	1.0000
15:66349123:TCTG:T	acceptor_loss	1.0000
15:66349124:C:CC	acceptor_gain	1.0000
15:66349124:C:T	acceptor_loss	1.0000
15:66349125:T:A	acceptor_loss	1.0000
15:66349436:GCCTG:G	acceptor_loss	1.0000
15:66349437:CCT:C	acceptor_loss	1.0000
15:66349438:CT:C	acceptor_loss	1.0000
15:66349439:T:A	acceptor_loss	1.0000
15:66352124:TGTA:T	donor_loss	1.0000
15:66352125:GTAC:G	donor_loss	1.0000
15:66352126:TACCT:T	donor_loss	1.0000
15:66352127:A:T	donor_loss	1.0000
15:66352128:C:CG	donor_loss	1.0000

AlphaMissense

2003 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
15:66349398:A:G	W110R	0.999
15:66349398:A:T	W110R	0.999
15:66351598:A:G	L72S	0.998
15:66349385:A:G	L114P	0.997
15:66349396:C:A	W110C	0.997
15:66349396:C:G	W110C	0.997
15:66349395:C:G	A111P	0.996
15:66349346:A:T	V127D	0.995
15:66351583:C:T	G77E	0.995
15:66351584:C:G	G77R	0.995
15:66351584:C:T	G77R	0.995
15:66349104:C:G	R144P	0.994
15:66349319:A:T	V136D	0.994
15:66349337:A:G	L130P	0.994
15:66351580:A:G	L78P	0.993
15:66351580:A:T	L78H	0.993
15:66349110:C:G	R142P	0.992
15:66349116:A:G	L140S	0.992
15:66349334:C:T	G131E	0.992
15:66349397:C:G	W110S	0.992
15:66351580:A:C	L78R	0.992
15:66349381:G:C	F115L	0.991
15:66349381:G:T	F115L	0.991
15:66349383:A:G	F115L	0.991
15:66349394:G:T	A111E	0.991
15:66349418:A:G	L103P	0.991
15:66352141:A:T	L67Q	0.991
15:66349373:A:G	L118P	0.990
15:66349101:A:G	L145P	0.989
15:66349366:A:C	F120L	0.989

dbSNP variants (sampled 300 via entrez): RS1000010261 (15:66372530 T>C), RS1000071958 (15:66367069 A>G), RS1000098681 (15:66373334 A>T), RS1000133430 (15:66365754 T>A), RS1000176580 (15:66353300 C>A), RS1000185322 (15:66347561 T>C), RS1000229464 (15:66336815 T>C), RS1000330112 (15:66377877 C>T), RS1000342997 (15:66378360 C>T), RS1000386681 (15:66383010 G>T), RS1000391755 (15:66340542 A>G), RS1000400967 (15:66384224 C>T), RS1000498095 (15:66367649 T>C), RS1000582325 (15:66355178 C>A,G), RS1000667993 (15:66361416 C>G,T)

Disease associations

OMIM: gene MIM:610716 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

3 associations (top):

Study	Trait	p-value
GCST004635_28	Testicular germ cell tumor	8.000000e-13
GCST004713_8	Testicular germ cell tumor	1.000000e-10
GCST010988_203	Adult body size	5.000000e-08

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

61 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	decreases expression, affects cotreatment, increases abundance, increases expression	4
Valproic Acid	affects cotreatment, increases expression, affects expression	4
Cisplatin	decreases reaction, decreases expression	2
Tretinoin	decreases expression	2
Aflatoxin B1	increases expression	2
Cadmium Chloride	decreases expression, increases abundance, increases expression	2
GSK-J4	decreases expression	1
afuresertib	decreases expression	1
FR900359	increases phosphorylation	1
dicrotophos	decreases expression	1
testosterone enanthate	affects expression	1
triphenyl phosphate	affects expression	1
bisphenol A	decreases expression	1
2,2’-methylenebis(4-methyl-6-tert-butylphenol)	affects expression, affects response to substance	1
tris(2-butoxyethyl) phosphate	affects expression	1
arsenite	affects binding, increases reaction	1
afimoxifene	decreases reaction, increases expression	1
butyraldehyde	increases expression	1
manganese chloride	increases abundance, increases expression, affects cotreatment	1
2,3-bis(3’-hydroxybenzyl)butyrolactone	affects cotreatment, increases expression	1
corosolic acid	decreases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, increases expression	1
14-deoxy-11,12-didehydroandrographolide	decreases expression	1
dorsomorphin	affects cotreatment, increases expression	1
7-(benzylamino)-1,3,4,8-tetrahydropyrrolo(4,3,2-de)quinolin-8(1H)-one	decreases expression	1
NSC 689534	affects binding, decreases expression	1
(+)-JQ1 compound	decreases expression	1
4-(4-((5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl)methylene)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)benzoic acid	decreases expression	1
Dasatinib	decreases expression	1
Resveratrol	affects cotreatment, increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.