TLE6

Summary

TLE6 (TLE family member 6, subcortical maternal complex member, HGNC:30788) is a protein-coding gene on chromosome 19p13.3, encoding Transducin-like enhancer protein 6 (Q9H808). Component of the subcortical maternal complex (SCMC), a multiprotein complex that plays a key role in early embryonic development.

This gene encodes a member of the Groucho/ transducin-like Enhancer of split family of transcriptional co-repressors. The encoded protein is a component of the mammalian subcortical maternal complex, which is required for preimplantation development. In mouse, knock out of this gene results in cleavage-stage embryonic arrest resulting from defective cytoplasmic F-actin meshwork formation and asymmetric cell division. In human, an allelic variant in this gene is associated with preimplantation embryonic lethality. Alternative splicing results in multiple transcript variants.

Source: NCBI Gene 79816 — RefSeq curated summary.

At a glance

• Gene–disease (curated): preimplantation embryonic lethality 1 (Strong, GenCC)
• Clinical variants (ClinVar): 167 total — 2 pathogenic, 5 likely-pathogenic
• Phenotypes (HPO): 7
• MANE Select transcript: NM_001143986

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:30788
Approved symbol	TLE6
Name	TLE family member 6, subcortical maternal complex member
Location	19p13.3
Locus type	gene with protein product
Status	Approved
Aliases	FLJ14009, GRG6
Ensembl gene	ENSG00000104953
Ensembl biotype	protein_coding
OMIM	612399
Entrez	79816

Gene structure

Transcript identifiers

Ensembl transcripts: 11 — 5 protein_coding, 3 protein_coding_CDS_not_defined, 3 retained_intron

ENST00000246112, ENST00000452088, ENST00000453329, ENST00000468176, ENST00000469572, ENST00000474207, ENST00000478073, ENST00000482627, ENST00000497878, ENST00000591953, ENST00000958788

RefSeq mRNA: 2 — MANE Select: NM_001143986 NM_001143986, NM_024760

CCDS: CCDS12100, CCDS45910

Canonical transcript exons

ENST00000246112 — 17 exons

Exon	Start	End
ENSE00001734209	2994900	2995179
ENSE00001859956	2977564	2977610
ENSE00003458283	2986829	2986891
ENSE00003465622	2989061	2989313
ENSE00003503281	2991843	2991984
ENSE00003519028	2987356	2987372
ENSE00003543514	2987724	2987790
ENSE00003562884	2978198	2978284
ENSE00003586292	2980100	2980182
ENSE00003592272	2986983	2987238
ENSE00003599405	2989535	2989785
ENSE00003615752	2987898	2987974
ENSE00003631498	2982148	2982189
ENSE00003636478	2981538	2981583
ENSE00003637196	2988091	2988128
ENSE00003650641	2994019	2994095
ENSE00003677814	2993432	2993582

Expression profiles

Bgee: expression breadth ubiquitous, 168 present calls, max score 93.27.

FANTOM5 (CAGE): breadth broad, TPM avg 0.6118 / max 42.3103, expressed in 304 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
173133	0.6118	304

Top tissues by expression

281 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
oocyte	CL:0000023	93.27	gold quality
secondary oocyte	CL:0000655	86.74	gold quality
buccal mucosa cell	CL:0002336	84.51	gold quality
right lobe of thyroid gland	UBERON:0001119	84.23	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	84.21	gold quality
left lobe of thyroid gland	UBERON:0001120	82.11	gold quality
thyroid gland	UBERON:0002046	81.23	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	77.49	gold quality
decidua	UBERON:0002450	76.74	gold quality
apex of heart	UBERON:0002098	74.03	gold quality
parotid gland	UBERON:0001831	73.99	gold quality
right lobe of liver	UBERON:0001114	73.69	gold quality
right lung	UBERON:0002167	73.67	gold quality
mucosa of transverse colon	UBERON:0004991	73.53	gold quality
pancreatic ductal cell	CL:0002079	73.35	silver quality
descending thoracic aorta	UBERON:0002345	72.47	gold quality
metanephros cortex	UBERON:0010533	72.18	gold quality
ventricular zone	UBERON:0003053	71.45	gold quality
islet of Langerhans	UBERON:0000006	71.31	gold quality
left uterine tube	UBERON:0001303	71.26	gold quality
body of uterus	UBERON:0009853	71.07	gold quality
hypothalamus	UBERON:0001898	70.99	gold quality
upper lobe of left lung	UBERON:0008952	70.88	gold quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	70.82	gold quality
endocervix	UBERON:0000458	70.65	gold quality
adenohypophysis	UBERON:0002196	70.49	gold quality
thoracic aorta	UBERON:0001515	70.03	gold quality
ascending aorta	UBERON:0001496	69.92	gold quality
ectocervix	UBERON:0012249	69.91	gold quality
right testis	UBERON:0004534	69.81	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	2.80

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): FOXG1, HLF, PAX6, TCF3

miRNA regulators (miRDB)

4 targeting TLE6, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4481	100.00	66.42	1669
HSA-MIR-6887-5P	98.56	68.49	1295
HSA-MIR-5187-5P	98.54	67.94	952
HSA-MIR-6795-5P	98.52	68.51	1277

Literature-anchored findings (GeneRIF, showing 6)

• Expression of Tle6-like in colon cancer cells increased cell proliferation, colony-formation, cell migration, and xenograft tumorgenicity. (PMID:18551179)
• transcriptional programmes regulated by FOXG1 and Groucho/TLE are important for BTIC-initiated brain tumour growth, implicating FOXG1 and Groucho/TLE in GBM tumourigenesis (PMID:24356439)
• In this first report of a human defect in a member of the subcortical maternal subcritical maternal complex, we show that the TLE6 mutation is gender-specific and leads to the earliest known human embryonic lethality phenotype (PMID:26537248)
• Expanding the genetic and phenotypic spectrum of female infertility caused by TLE6 mutations. (PMID:31897846)
• Two novel mutations in PADI6 and TLE6 genes cause female infertility due to arrest in embryonic development. (PMID:34036456)
• A novel TLE6 mutation, c.541+1G>A, identified using whole-exome sequencing in a Chinese family with female infertility. (PMID:34264011)

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Tle6	ENSMUSG00000034758
rattus_norvegicus	Tle6	ENSRNOG00000006350

Paralogs (6): TLE2 (ENSG00000065717), TLE5 (ENSG00000104964), TLE4 (ENSG00000106829), TLE3 (ENSG00000140332), TLE1 (ENSG00000196781), TLE7 (ENSG00000260734)

Protein

Protein identifiers

Transducin-like enhancer protein 6 — Q9H808 (reviewed: Q9H808)

All UniProt accessions (3): Q9H808, C9J532, K7ENW8

UniProt curated annotations — full annotation on UniProt →

Function. Component of the subcortical maternal complex (SCMC), a multiprotein complex that plays a key role in early embryonic development. The SCMC complex is a structural constituent of cytoplasmic lattices, which consist in fibrous structures found in the cytoplasm of oocytes and preimplantation embryos. They are required to store maternal proteins critical for embryonic development, such as proteins that control epigenetic reprogramming of the preimplantation embryo, and prevent their degradation or activation. Also required for spermatogenesis: regulates spermatogonia proliferation and cell cycle progression, potentially via regulation of cell cycle regulatory genes such as; CEBPB, CEBPA, CSF3, PCNA, and CDK4. Suppresses FOXG1/BF-1-mediated transcriptional repression by inhibiting interaction of the transcriptional corepressor TLE1 with FOXG1 which promotes cortical neuron differentiation. Acts as a transcriptional corepressor of NFATC1-mediated gene expression by contributing to PAX6-mediated repression. Component of the subcortical maternal complex (SCMC), a multiprotein complex that plays a key role in early embryonic development.

Subunit / interactions. Homodimers. Component of the subcortical maternal complex (SCMC), at least composed of NLRP5, KHDC3, OOEP, and TLE6. Within the complex, interacts with NLRP5, KHDC3 and OOEP. The SCMC may facilitate translocation of its components between the nuclear and cytoplasmic compartments. As part of the SCMC interacts with the SCMC-associated protein ZBED3. As part of the SCMC interacts with the SCMC-associated protein NLRP4F. As part of the SCMC interacts with the SCMC-associated protein CFL1/Cofilin-1. Interacts with FOXG1/BF-1; the interaction inhibits TLE1 interaction with FOXG1/BF-1. Interacts with NFATC1. Interacts with PAX6. Component of the subcortical maternal complex (SCMC), at least composed of NLRP5, KHDC3L, OOEP, and TLE6 isoform 1. Within the complex, interacts with NLRP5, KHDC3L and OOEP. The SCMC may facilitate translocation of its components between the nuclear and cytoplasmic compartments.

Subcellular location. Cytoplasm. Nucleus Cytoplasm Cytoplasm.

Disease relevance. Oocyte/zygote/embryo maturation arrest 15 (OZEMA15) [MIM:616814] A rare cause of female primary infertility. In affected women, ovulation proceeds normally and the retrieved oocytes appear normal, but zygote formation and division are severely impaired. Inheritance is autosomal recessive. The disease is caused by variants affecting the gene represented in this entry.

Domain organisation. Contrary to other WD repeat Groucho/TLE family members, does not contain any identifiable Q, GP, CcN or SP domains. Only the C-terminal WD-repeat domain is conserved.

Similarity. Belongs to the WD repeat Groucho/TLE family.

Isoforms (2)

UniProt ID	Names	Canonical?
Q9H808-1	1	yes
Q9H808-2	2

RefSeq proteins (2): NP_001137458, NP_079036 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001680	WD40_rpt	Repeat
IPR009146	Groucho_enhance	Family
IPR015943	WD40/YVTN_repeat-like_dom_sf	Homologous_superfamily
IPR036322	WD40_repeat_dom_sf	Homologous_superfamily

Pfam: PF00400

UniProt features (65 total): strand 32, sequence variant 13, repeat 7, turn 4, region of interest 3, helix 2, chain 1, compositionally biased region 1, modified residue 1, splice variant 1

Structure

Experimental structures (PDB)

4 structures.

PDB	Method	Resolution (Å)
8X7V	ELECTRON MICROSCOPY	3.01
8X7W	ELECTRON MICROSCOPY	3.36
9L4L	ELECTRON MICROSCOPY	3.4
9L4K	ELECTRON MICROSCOPY	3.41

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9H808-F1	66.29	0.37

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (1): 510

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 193 (showing top): GOBP_EMBRYO_DEVELOPMENT_ENDING_IN_BIRTH_OR_EGG_HATCHING, GOBP_SPINDLE_LOCALIZATION, GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN, GOBP_REGULATION_OF_WNT_SIGNALING_PATHWAY, GOBP_MALE_GAMETE_GENERATION, SHETH_LIVER_CANCER_VS_TXNIP_LOSS_PAM2, GOBP_CANONICAL_WNT_SIGNALING_PATHWAY, GOBP_ACTIN_FILAMENT_ORGANIZATION, GOBP_CILIUM_MOVEMENT, GOBP_CILIUM_OR_FLAGELLUM_DEPENDENT_CELL_MOTILITY, SCHAEFFER_PROSTATE_DEVELOPMENT_48HR_UP, GOBP_REGULATION_OF_CELL_DIVISION, GOBP_ENDOMEMBRANE_SYSTEM_ORGANIZATION, GOBP_MULTI_MULTICELLULAR_ORGANISM_PROCESS, GOBP_DEVELOPMENTAL_PROCESS_INVOLVED_IN_REPRODUCTION

GO Biological Process (15): negative regulation of transcription by RNA polymerase II (GO:0000122), actin filament organization (GO:0007015), spermatogenesis (GO:0007283), flagellated sperm motility (GO:0030317), positive regulation of embryonic development (GO:0040019), epigenetic programming in the zygotic pronuclei (GO:0044725), establishment of spindle localization (GO:0051293), regulation of cell division (GO:0051302), endoplasmic reticulum localization (GO:0051643), mitochondrion localization (GO:0051646), embryonic process involved in female pregnancy (GO:0060136), negative regulation of canonical Wnt signaling pathway (GO:0090090), protein storage (GO:0140089), regulation of DNA-templated transcription (GO:0006355), developmental process (GO:0032502)

GO Molecular Function (3): transcription corepressor activity (GO:0003714), structural constituent of cytoplasmic lattice (GO:0140094), protein binding (GO:0005515)

GO Cellular Component (8): nucleus (GO:0005634), transcription regulator complex (GO:0005667), cytoplasm (GO:0005737), cell cortex (GO:0005938), protein-containing complex (GO:0032991), sperm midpiece (GO:0097225), subcortical maternal complex (GO:0106333), cytoplasmic lattice (GO:0140095)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
negative regulation of DNA-templated transcription	2
embryo development	2
organelle localization	2
protein-containing complex	2
cellular anatomical structure	2
regulation of transcription by RNA polymerase II	1
transcription by RNA polymerase II	1
actin cytoskeleton organization	1
supramolecular fiber organization	1
developmental process involved in reproduction	1
male gamete generation	1
cilium-dependent cell motility	1
cilium movement involved in cell motility	1
sperm motility	1
regulation of embryonic development	1
positive regulation of developmental process	1
positive regulation of multicellular organismal process	1
epigenetic programming of gene expression	1
microtubule cytoskeleton organization	1
establishment of localization in cell	1
spindle localization	1
establishment of organelle localization	1
regulation of cellular process	1
cell division	1
endoplasmic reticulum organization	1
female pregnancy	1
embryo development ending in birth or egg hatching	1
multicellular organismal reproductive process	1
negative regulation of Wnt signaling pathway	1
canonical Wnt signaling pathway	1
regulation of canonical Wnt signaling pathway	1
nutrient storage	1
DNA-templated transcription	1
regulation of gene expression	1
regulation of RNA biosynthetic process	1
biological_process	1
transcription coregulator activity	1
structural molecule activity	1
binding	1
intracellular membrane-bounded organelle	1

Protein interactions and networks

STRING

684 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
TLE6	OOEP	A6NGQ2	999
TLE6	PADI6	Q6TGC4	950
TLE6	NLRP5	P59047	932
TLE6	KHDC3L	Q587J8	916
TLE6	NLRP2	Q9NX02	813
TLE6	HLF	Q16534	788
TLE6	ZBED3	Q96IU2	689
TLE6	PATL2	C9JE40	672
TLE6	SRPX2	O60687	668
TLE6	WEE2	P0C1S8	643
TLE6	A0A087WTN9	A0A087WTN9	640
TLE6	TCF3	P15883	639
TLE6	TLE5	Q08117	621
TLE6	TUBB8	Q3ZCM7	591
TLE6	DBP	Q10586	588

IntAct

14 interactions, top by confidence:

A	B	Type	Score
TLE6	BDNF	psi-mi:“MI:0915”(physical association)	0.560
KLK6	TLE6	psi-mi:“MI:0915”(physical association)	0.560
	TLE6	psi-mi:“MI:0915”(physical association)	0.560
KHDC3L	OOEP	psi-mi:“MI:0403”(colocalization)	0.460
TLE6	NLRP7	psi-mi:“MI:0915”(physical association)	0.400
TLE6	NUDC	psi-mi:“MI:0915”(physical association)	0.400
TLE6	RPL14	psi-mi:“MI:0915”(physical association)	0.370

BioGRID (10): TLE6 (Affinity Capture-Western), TLE6 (Reconstituted Complex), TLE6 (Affinity Capture-Western), TLE6 (Reconstituted Complex), TLE6 (Affinity Capture-MS), TLE6 (Two-hybrid), CAND1 (Cross-Linking-MS (XL-MS)), TLE6 (Proximity Label-MS), TLE6 (Proximity Label-MS), TLE6 (Two-hybrid)

ESM2 similar proteins: A0A140LI67, A0A1W2PR48, A0JP70, D3YYM4, F1LW30, O13034, O15040, O70173, Q15345, Q3SXM0, Q3UDP0, Q3UJB9, Q3ULW6, Q3V129, Q3ZAV8, Q58DC2, Q5F479, Q5JV73, Q5M9H0, Q5M9H1, Q5R6T6, Q5R9H2, Q68DX3, Q6IRN0, Q6NV72, Q6P2E9, Q6P4K6, Q6PCD5, Q6ZPG2, Q6ZW76, Q7TNH6, Q80TQ5, Q8BLD6, Q8C008, Q8C5V5, Q8CBW4, Q8CIK8, Q8IWE5, Q8JZL1, Q8K1C9

Diamond homologs: A0A1W2PR48, O02482, O13166, O13168, O42469, O42478, P16371, Q04724, Q04725, Q04726, Q04727, Q07141, Q08122, Q62440, Q62441, Q9H808, Q9JIT3, Q9WVB2, Q9WVB3, A2RRU3, O14435, O42470, O94365, P16520, P40066, P63002, P63003, P79083, Q08117, Q10281, Q5A7Q3, Q5GIS3, Q5REE0, Q8C7V3, Q8TED0, A6ZQL5, A8XZJ9, P47025, Q06078, Q08924

SIGNOR signaling

1 interactions.

A	Effect	B	Mechanism
PHF12	“up-regulates activity”	TLE6	binding

Disease & clinical

Clinical variants and AI predictions

ClinVar

167 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	2
Likely pathogenic	5
Uncertain significance	102
Likely benign	32
Benign	11

Top pathogenic / likely-pathogenic (7)

Variant ID	HGVS	Classification
1691503	NM_001143986.2(TLE6):c.1054G>C (p.Gly352Arg)	Pathogenic
2160860	NM_001143986.2(TLE6):c.665dup (p.Ser223fs)	Pathogenic
2064539	NM_001143986.2(TLE6):c.741-1G>C	Likely pathogenic
222026	NM_001143986.2(TLE6):c.1529C>A (p.Ser510Tyr)	Likely pathogenic
4796590	NM_001143986.2(TLE6):c.376del (p.Thr126fs)	Likely pathogenic
4849455	NM_001143986.2(TLE6):c.1147C>T (p.Gln383Ter)	Likely pathogenic
812696	NM_001143986.2(TLE6):c.805_806del (p.Lys269fs)	Likely pathogenic

SpliceAI

2258 predictions. Top by Δscore:

Variant	Effect	Δscore
19:2977615:GGGAC:G	donor_gain	1.0000
19:2977616:GGACG:G	donor_gain	1.0000
19:2977620:G:GG	donor_gain	1.0000
19:2980098:A:AG	acceptor_gain	1.0000
19:2980099:G:GA	acceptor_gain	1.0000
19:2980099:GCCTT:G	acceptor_gain	1.0000
19:2986888:GGAG:G	donor_gain	1.0000
19:2986889:GAGG:G	donor_gain	1.0000
19:2986892:G:C	donor_loss	1.0000
19:2986972:T:TA	acceptor_gain	1.0000
19:2986975:C:CA	acceptor_gain	1.0000
19:2986976:G:A	acceptor_gain	1.0000
19:2986978:GCCA:G	acceptor_loss	1.0000
19:2986980:CA:C	acceptor_loss	1.0000
19:2986981:A:AG	acceptor_gain	1.0000
19:2986981:A:C	acceptor_loss	1.0000
19:2986981:AG:A	acceptor_gain	1.0000
19:2986982:G:GG	acceptor_gain	1.0000
19:2986982:GG:G	acceptor_gain	1.0000
19:2986982:GGT:G	acceptor_gain	1.0000
19:2986982:GGTC:G	acceptor_gain	1.0000
19:2986982:GGTCT:G	acceptor_gain	1.0000
19:2987221:C:T	donor_gain	1.0000
19:2987234:CAGAC:C	donor_gain	1.0000
19:2987235:AGAC:A	donor_gain	1.0000
19:2987236:GAC:G	donor_gain	1.0000
19:2987236:GACG:G	donor_gain	1.0000
19:2987237:AC:A	donor_gain	1.0000
19:2987237:ACGT:A	donor_loss	1.0000
19:2987239:G:GA	donor_loss	1.0000

AlphaMissense

3779 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
19:2989757:T:A	W406R	0.992
19:2989757:T:C	W406R	0.992
19:2989254:T:A	W312R	0.987
19:2989254:T:C	W312R	0.987
19:2989759:G:C	W406C	0.987
19:2989759:G:T	W406C	0.987
19:2989256:G:C	W312C	0.983
19:2989256:G:T	W312C	0.983
19:2989625:T:A	W362R	0.983
19:2989625:T:C	W362R	0.983
19:2989203:A:C	S295R	0.981
19:2989205:C:A	S295R	0.981
19:2989205:C:G	S295R	0.981
19:2989225:T:C	F302S	0.981
19:2989224:T:C	F302L	0.980
19:2989226:C:A	F302L	0.980
19:2989226:C:G	F302L	0.980
19:2989733:T:C	F398L	0.980
19:2989735:C:A	F398L	0.980
19:2989735:C:G	F398L	0.980
19:2994024:T:A	W515R	0.979
19:2994024:T:C	W515R	0.979
19:2991901:T:A	W435R	0.977
19:2991901:T:C	W435R	0.977
19:2993570:T:C	F509L	0.977
19:2993572:C:A	F509L	0.977
19:2993572:C:G	F509L	0.977
19:2989587:T:C	L349P	0.974
19:2994027:T:A	W516R	0.973
19:2994027:T:C	W516R	0.973

dbSNP variants (sampled 300 via entrez): RS1000060681 (19:2977833 G>A), RS1000080333 (19:2985228 C>T), RS1000168507 (19:2981885 T>G), RS1000205983 (19:2979823 A>G,T), RS1000394870 (19:2993921 A>C,G,T), RS1000480362 (19:2986503 C>G), RS1000646304 (19:2981891 G>C), RS1000655120 (19:2990550 G>T), RS1000681957 (19:2977664 T>G), RS1000766885 (19:2994326 C>A), RS1000818380 (19:2977465 C>T), RS1000912438 (19:2991075 G>A), RS1001127879 (19:2983188 AACC>A), RS1001201029 (19:2994177 C>CA), RS1001288665 (19:2978629 G>C)

Disease associations

OMIM: gene MIM:612399 | disease phenotypes:

GenCC curated gene-disease

Disease	Classification	Inheritance
preimplantation embryonic lethality 1	Strong	Autosomal recessive

Mondo (1): (MONDO:0014783)

Orphanet (0):

HPO phenotypes

7 total (7 of 7 shown, HPO-id order):

HPO	Term
HP:0000007	Autosomal recessive inheritance
HP:0000147	Polycystic ovaries
HP:0008222	Female infertility
HP:0008669	Abnormal spermatogenesis
HP:0020155	Abnormal oocyte morphology
HP:0031515	Abnormal meiosis
HP:0031516	Metaphase I oocyte maturation arrest

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

24 total (human), top 24 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sotorasib	affects cotreatment, decreases expression	1
ethyl-p-hydroxybenzoate	decreases expression	1
tris(1,3-dichloro-2-propyl)phosphate	decreases expression	1
sodium arsenite	decreases expression	1
cupric chloride	decreases expression	1
nutlin 3	affects cotreatment, increases expression	1
abrine	decreases expression	1
jinfukang	affects cotreatment, increases expression	1
trametinib	affects cotreatment, decreases expression	1
NVP-BKM120	affects cotreatment, decreases expression	1
Pioglitazone	increases expression	1
Benzo(a)pyrene	decreases methylation, increases methylation, affects methylation	1
Camptothecin	increases expression	1
Cisplatin	affects cotreatment, increases expression	1
Dactinomycin	affects cotreatment, increases expression	1
Dichlorodiphenyl Dichloroethylene	increases expression	1
Oxygen	increases expression	1
Phenobarbital	affects expression	1
Silicon Dioxide	decreases expression	1
Tobacco Smoke Pollution	decreases expression	1
Triclosan	decreases expression	1
Valproic Acid	increases methylation	1
Aflatoxin B1	affects methylation	1
Okadaic Acid	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.