TLR8-AS1

Summary

TLR8-AS1 (TLR8 antisense RNA 1, HGNC:40720) is a long non-coding RNA gene on chromosome Xp22.2.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:40720
Approved symbol	TLR8-AS1
Name	TLR8 antisense RNA 1
Location	Xp22.2
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000233338
Ensembl biotype	lncRNA
Entrez	349408
RNAcentral	URS000075D4A0 — lncRNA, 1660 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000451564

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000451564 — 3 exons

Exon	Start	End
ENSE00001675401	12902817	12903985
ENSE00001679823	12908216	12908333
ENSE00001769346	12906190	12906251

Expression profiles

Bgee: expression breadth broad, 36 present calls, max score 87.42.

Top tissues by expression

167 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	87.42	gold quality
secondary oocyte	CL:0000655	80.11	gold quality
oocyte	CL:0000023	78.06	gold quality
monocyte	CL:0000576	49.96	silver quality
blood	UBERON:0000178	49.84	silver quality
descending thoracic aorta	UBERON:0002345	47.79	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	47.60	gold quality
muscle of leg	UBERON:0001383	46.20	silver quality
olfactory segment of nasal mucosa	UBERON:0005386	45.66	silver quality
gall bladder	UBERON:0002110	45.09	silver quality
lymph node	UBERON:0000029	44.78	silver quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	43.37	gold quality
gastrocnemius	UBERON:0001388	42.89	silver quality
endocervix	UBERON:0000458	42.86	gold quality
right lung	UBERON:0002167	42.48	silver quality
anatomical system	UBERON:0000467	42.19	gold quality
material anatomical entity	UBERON:0000465	42.09	gold quality
right atrium auricular region	UBERON:0006631	42.08	silver quality
multicellular organism	UBERON:0000468	42.07	gold quality
left uterine tube	UBERON:0001303	41.94	gold quality
bone marrow	UBERON:0002371	41.91	gold quality
tibial artery	UBERON:0007610	41.87	silver quality
inferior vagus X ganglion	UBERON:0005363	41.75	gold quality
oviduct epithelium	UBERON:0004804	41.73	gold quality
fallopian tube	UBERON:0003889	41.70	silver quality
aorta	UBERON:0000947	41.67	silver quality
trigeminal ganglion	UBERON:0001675	41.50	gold quality
vastus lateralis	UBERON:0001379	41.41	gold quality
quadriceps femoris	UBERON:0001377	41.37	gold quality
cardiac atrium	UBERON:0002081	41.36	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.81

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• LncRNA TLR8-AS1 promotes metastasis and chemoresistance of ovarian cancer through enhancing TLR8 mRNA stability. (PMID:32278547)
• Long non-coding RNA TLR8-AS1 induces preeclampsia through increasing TLR8/STAT1 axis. (PMID:37199563)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.