TLX1NB

Summary

TLX1NB (TLX1 neighbor, HGNC:37183) is a long non-coding RNA gene on chromosome 10q24.31.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:37183
Approved symbol	TLX1NB
Name	TLX1 neighbor
Location	10q24.31
Locus type	RNA, long non-coding
Status	Approved
Aliases	TD1, TDI, APT-B7
Ensembl gene	ENSG00000236311
Ensembl biotype	lncRNA
OMIM	612734
Entrez	100038246
RNAcentral	URS00008121F1 — lncRNA, 1925 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 7 — 7 lncRNA

ENST00000425505, ENST00000445873, ENST00000747503, ENST00000747504, ENST00000747505, ENST00000747506, ENST00000747507

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000425505 — 3 exons

Exon	Start	End
ENSE00001733617	101126960	101127098
ENSE00004089376	101090308	101090702
ENSE00004089382	101130757	101131161

Expression profiles

Bgee: expression breadth broad, 39 present calls, max score 68.24.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.0053 / max 5.5619, expressed in 1 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
111084	0.0053	1

Top tissues by expression

39 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
spleen	UBERON:0002106	68.24	gold quality
tonsil	UBERON:0002372	60.97	silver quality
duodenum	UBERON:0002114	59.64	gold quality
cerebral cortex	UBERON:0000956	59.44	gold quality
prefrontal cortex	UBERON:0000451	53.41	gold quality
blood	UBERON:0000178	53.12	silver quality
liver	UBERON:0002107	52.64	gold quality
right lobe of liver	UBERON:0001114	52.41	gold quality
small intestine	UBERON:0002108	52.37	gold quality
saliva-secreting gland	UBERON:0001044	52.13	gold quality
small intestine Peyer’s patch	UBERON:0003454	51.84	gold quality
minor salivary gland	UBERON:0001830	50.91	gold quality
islet of Langerhans	UBERON:0000006	49.33	gold quality
intestine	UBERON:0000160	48.78	gold quality
multicellular organism	UBERON:0000468	48.18	gold quality
muscle of leg	UBERON:0001383	47.66	gold quality
vermiform appendix	UBERON:0001154	46.15	gold quality
muscle layer of sigmoid colon	UBERON:0035805	45.90	gold quality
colon	UBERON:0001155	45.77	gold quality
gastrocnemius	UBERON:0001388	45.40	silver quality
transverse colon	UBERON:0001157	45.15	gold quality
esophagus mucosa	UBERON:0002469	44.35	gold quality
heart left ventricle	UBERON:0002084	44.24	gold quality
stomach	UBERON:0000945	44.20	gold quality
heart	UBERON:0000948	44.09	gold quality
body of stomach	UBERON:0001161	44.06	gold quality
rectum	UBERON:0001052	44.01	gold quality
mucosa of transverse colon	UBERON:0004991	43.71	silver quality
right atrium auricular region	UBERON:0006631	42.91	silver quality
adult mammalian kidney	UBERON:0000082	41.94	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.98

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• The long non-coding RNA T cell leukemia homeobox 1 neighbor enhances signal transducer and activator of transcription 5A phosphorylation to promote colon cancer cell invasion, migration, and metastasis. (PMID:35502613)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.