TM4SF1-AS1

Summary

TM4SF1-AS1 (TM4SF1 antisense RNA 1, HGNC:40587) is a long non-coding RNA gene on chromosome 3q25.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:40587
Approved symbol	TM4SF1-AS1
Name	TM4SF1 antisense RNA 1
Location	3q25.1
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000240541
Ensembl biotype	lncRNA
Entrez	100874091
RNAcentral	URS0000369BBE — lncRNA, 754 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 15 — 15 lncRNA

ENST00000484046, ENST00000496491, ENST00000665408, ENST00000781305, ENST00000781306, ENST00000781307, ENST00000781308, ENST00000781309, ENST00000781310, ENST00000781311, ENST00000781312, ENST00000781313, ENST00000781314, ENST00000781315, ENST00000781316

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000484046 — 4 exons

Exon	Start	End
ENSE00001917381	149384993	149385169
ENSE00004153320	149378134	149378315
ENSE00004153321	149373970	149374029
ENSE00004153328	149386368	149386585

Expression profiles

Bgee: expression breadth ubiquitous, 113 present calls, max score 68.05.

Top tissues by expression

113 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
minor salivary gland	UBERON:0001830	68.05	gold quality
saliva-secreting gland	UBERON:0001044	67.55	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	67.15	gold quality
islet of Langerhans	UBERON:0000006	66.60	gold quality
pancreas	UBERON:0001264	65.47	gold quality
body of pancreas	UBERON:0001150	64.83	gold quality
sural nerve	UBERON:0015488	63.92	silver quality
thoracic mammary gland	UBERON:0005200	63.04	gold quality
fundus of stomach	UBERON:0001160	61.93	gold quality
gall bladder	UBERON:0002110	61.35	gold quality
stromal cell of endometrium	CL:0002255	60.70	gold quality
body of stomach	UBERON:0001161	60.56	gold quality
stomach	UBERON:0000945	60.23	gold quality
right uterine tube	UBERON:0001302	60.14	gold quality
endometrium	UBERON:0001295	60.10	gold quality
prostate gland	UBERON:0002367	57.29	gold quality
prefrontal cortex	UBERON:0000451	57.21	gold quality
skeletal muscle tissue	UBERON:0001134	56.86	gold quality
omental fat pad	UBERON:0010414	56.86	gold quality
placenta	UBERON:0001987	56.84	gold quality
duodenum	UBERON:0002114	56.64	gold quality
adipose tissue	UBERON:0001013	55.85	gold quality
esophagus mucosa	UBERON:0002469	55.77	gold quality
calcaneal tendon	UBERON:0003701	55.54	gold quality
left coronary artery	UBERON:0001626	55.26	gold quality
hindlimb stylopod muscle	UBERON:0004252	55.24	gold quality
subcutaneous adipose tissue	UBERON:0002190	55.06	gold quality
skin of leg	UBERON:0001511	54.46	gold quality
fallopian tube	UBERON:0003889	54.26	gold quality
tonsil	UBERON:0002372	54.23	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.04

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• HIF-1alpha-activated TM4SF1-AS1 promotes the proliferation, migration, and invasion of hepatocellular carcinoma cells by enhancing TM4SF1 expression. (PMID:34118595)
• Effect and mechanism of downregulating the long-chain noncoding RNA TM4SF1-AS1 on the proliferation, apoptosis and invasion of gastric cancer cells. (PMID:34330293)
• lncRNA TM4SF1-AS1 predicts dismal outcomes and promotes cholangiocarcinoma progression via modulating miR-744-3p. (PMID:35346892)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.