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TM9SF2

gene
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Also known as P76Lnc-PCIR

Summary

TM9SF2 (transmembrane 9 superfamily member 2, HGNC:11865) is a protein-coding gene on chromosome 13q32.3, encoding Transmembrane 9 superfamily member 2 (Q99805). In the intracellular compartments, may function as a channel or small molecule transporter.

This gene encodes a member of the transmembrane 9 superfamily. The encoded 76 kDa protein localizes to early endosomes in human cells. The encoded protein possesses a conserved and highly hydrophobic C-terminal domain which contains nine transmembrane domains. The protein may play a role in small molecule transport or act as an ion channel. A pseudogene associated with this gene is located on the X chromosome.

Source: NCBI Gene 9375 — RefSeq curated summary.

At a glance

  • GWAS associations: 10
  • Clinical variants (ClinVar): 71 total
  • Druggable target: yes
  • MANE Select transcript: NM_004800

Identifiers

Gene identifiers

FieldValue
HGNC IDHGNC:11865
Approved symbolTM9SF2
Nametransmembrane 9 superfamily member 2
Location13q32.3
Locus typegene with protein product
StatusApproved
AliasesP76, Lnc-PCIR
Ensembl geneENSG00000125304
Ensembl biotypeprotein_coding
OMIM604678
Entrez9375

Gene structure

Transcript identifiers

Ensembl transcripts: 20 — 16 protein_coding, 4 protein_coding_CDS_not_defined

ENST00000376387, ENST00000463709, ENST00000466555, ENST00000626308, ENST00000627052, ENST00000642146, ENST00000642475, ENST00000865264, ENST00000865265, ENST00000865266, ENST00000865267, ENST00000930902, ENST00000930903, ENST00000951398, ENST00000951399, ENST00000951400, ENST00000951401, ENST00000951402, ENST00000951403, ENST00000951404

RefSeq mRNA: 1 — MANE Select: NM_004800 NM_004800

CCDS: CCDS9493

Canonical transcript exons

ENST00000376387 — 17 exons

ExonStartEnd
ENSE000005148259954155999541667
ENSE000006857229953944699539557
ENSE000006857299954071499540793
ENSE000006857359955553699555647
ENSE000008539299953773999537863
ENSE000008539309954698599547104
ENSE000008539319954916599549222
ENSE000008539329955216799552326
ENSE000008539339955430499554455
ENSE000008539349955936399559534
ENSE000014704539950147299501777
ENSE000019439479956269199564048
ENSE000035177979953660899536737
ENSE000035292429954386399543995
ENSE000035309569952003699520129
ENSE000035451959951761499517681
ENSE000036805039952946799529594

Expression profiles

Bgee: expression breadth ubiquitous, 295 present calls, max score 99.08.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 97.0357 / max 574.8540, expressed in 1825 samples.

FANTOM5 promoters (7 alternative TSS)

Promoter IDTPM avgSamples expressed
13583238.75851820
13583131.74461811
13583012.45351775
1358299.78951767
1358283.25291563
1358331.0244628
1358340.01233

Top tissues by expression

295 total, by Bgee expression score (0-100, higher = more expressed):

TissueAnatomy IDExpression scoreQuality
mucosa of sigmoid colonUBERON:000499399.08gold quality
bronchial epithelial cellCL:000232898.95gold quality
colonic mucosaUBERON:000031798.87gold quality
jejunal mucosaUBERON:000039998.72gold quality
corpus epididymisUBERON:000435998.65gold quality
rectumUBERON:000105298.36gold quality
duodenumUBERON:000211498.35gold quality
islet of LangerhansUBERON:000000698.30gold quality
ileal mucosaUBERON:000033198.30gold quality
epithelium of bronchusUBERON:000203198.30gold quality
bronchusUBERON:000218598.25gold quality
upper leg skinUBERON:000426298.07gold quality
nasal cavity mucosaUBERON:000182698.05gold quality
palpebral conjunctivaUBERON:000181297.98gold quality
caput epididymisUBERON:000435897.94gold quality
nasal cavity epitheliumUBERON:000538497.93gold quality
adult organismUBERON:000702397.88gold quality
parotid glandUBERON:000183197.84gold quality
olfactory segment of nasal mucosaUBERON:000538697.81gold quality
monocyteCL:000057697.80gold quality
skin of hipUBERON:000155497.80gold quality
adrenal tissueUBERON:001830397.77gold quality
mononuclear cellCL:000084297.75gold quality
placentaUBERON:000198797.75gold quality
urethraUBERON:000005797.73gold quality
leukocyteCL:000073897.69gold quality
oral cavityUBERON:000016797.67gold quality
epithelium of nasopharynxUBERON:000195197.67gold quality
spermCL:000001997.66gold quality
body of pancreasUBERON:000115097.64gold quality

Single-cell (SCXA)

Detected in 3 experiment(s), a significant marker in 2.

ExperimentMarker?Max mean expression
E-CURD-112yes14.67
E-MTAB-7303no470.35
E-ANND-3no0.00

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): AP1, NFKB

miRNA regulators (miRDB)

101 targeting TM9SF2, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNAMax scoreAvg scoremiRNA target_count
HSA-MIR-1277-5P100.0073.955056
HSA-MIR-5011-5P100.0083.465820
HSA-MIR-5692B100.0071.322622
HSA-MIR-5692C100.0071.322622
HSA-MIR-4668-3P100.0068.742635
HSA-MIR-5193100.0067.261744
HSA-MIR-340-5P100.0072.504437
HSA-MIR-6870-5P99.9968.552115
HSA-MIR-1213699.9872.815713
HSA-MIR-477599.9875.006394
HSA-MIR-520D-5P99.9873.344883
HSA-MIR-524-5P99.9873.434882
HSA-MIR-3688-3P99.9772.022834
HSA-MIR-4723-5P99.9768.702034
HSA-MIR-569899.9768.492029
HSA-MIR-7111-5P99.9768.482062
HSA-MIR-6888-3P99.9765.951170
HSA-MIR-568899.9673.234504
HSA-MIR-495-3P99.9672.814197
HSA-MIR-590-3P99.9674.346478
HSA-MIR-548AT-5P99.9670.832666
HSA-MIR-128-3P99.9571.172484
HSA-MIR-216A-3P99.9571.192505
HSA-MIR-452599.9464.38675
HSA-MIR-5010-5P99.9464.11705
HSA-MIR-6508-5P99.9270.672465
HSA-MIR-7-1-3P99.9171.534384
HSA-MIR-7-2-3P99.9171.404394
HSA-MIR-10523-5P99.9169.222038
HSA-MIR-374A-5P99.9071.342923

Literature-anchored findings (GeneRIF, showing 5)

  • Among the genes enriched in this screening, the authors found that TM9SF2 is critical for N-sulfation of heparan sulfate and therefore for chikungunya virus infection because it is involved in the proper localization and stability of NDST1. (PMID:28404855)
  • TM9SF2 is identified as novel oncogene in colorectal cancer (CRC). TM9SF2 is potentially regulated by the Ets-family transcription factor ELF1, and TM9SF2 is upregulated in approximately one-third of human CRC samples. Transcriptome analysis of TM9SF2 knockout cells revealed a potential role for TM9SF2 in cell cycle progression, oxidative phosphorylation, and ceramide signaling. (PMID:30333512)
  • Study validated EXT1, TM9SF2, and TMED10 as important host factors for vaccinia virus infection. (PMID:30996093)
  • LINC01232 exerts oncogenic activities in pancreatic adenocarcinoma via regulation of TM9SF2. (PMID:31541081)
  • Identification of sulfur metabolism-related gene signature in osteoarthritis and TM9SF2’s sustenance effect on M2 macrophages’ phagocytic activity. (PMID:38218914)

Cross-species orthologs

4 orthologs

OrganismSymbolGene ID
danio_reriotm9sf2ENSDARG00000003866
mus_musculusTm9sf2ENSMUSG00000025544
rattus_norvegicusTm9sf2ENSRNOG00000012751
drosophila_melanogasterTM9SF2FBGN0032880

Paralogs (3): TM9SF3 (ENSG00000077147), TM9SF1 (ENSG00000100926), TM9SF4 (ENSG00000101337)

Protein

Protein identifiers

Transmembrane 9 superfamily member 2 — Q99805 (reviewed: Q99805)

Alternative names: p76

All UniProt accessions (3): Q99805, A0A024QYR8, A0A2R8Y4S7

UniProt curated annotations — full annotation on UniProt →

Function. In the intracellular compartments, may function as a channel or small molecule transporter.

Subcellular location. Endosome membrane. Golgi outpost. Cytoplasm. Cytoskeleton. Microtubule organizing center.

Tissue specificity. Ubiquitously expressed. Especially abundant in pancreas, highly expressed in kidney, lower levels in heart, brain, skeletal muscle and placenta. Lowest expression in lung and liver.

Similarity. Belongs to the nonaspanin (TM9SF) (TC 8.A.68) family.

RefSeq proteins (1): NP_004791* (*=MANE)

Domains & families (InterPro)

IDNameType
IPR004240EMP70Family

Pfam: PF02990

UniProt features (21 total): topological domain 10, transmembrane region 9, signal peptide 1, chain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

ModelpLDDTFraction very-high
AF-Q99805-F184.950.48

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 203 (showing top): GOBP_GLYCOLIPID_BIOSYNTHETIC_PROCESS, CHIANG_LIVER_CANCER_SUBCLASS_UNANNOTATED_DN, CHEOK_RESPONSE_TO_MERCAPTOPURINE_AND_LD_MTX_UP, MORF_HDAC2, GOCC_MICROTUBULE_ORGANIZING_CENTER, GOBP_CARBOHYDRATE_DERIVATIVE_METABOLIC_PROCESS, GOBP_REGULATION_OF_GLYCOPROTEIN_METABOLIC_PROCESS, ONKEN_UVEAL_MELANOMA_UP, GOBP_SPHINGOLIPID_METABOLIC_PROCESS, GOBP_AMIDE_METABOLIC_PROCESS, GOBP_HEPARAN_SULFATE_PROTEOGLYCAN_METABOLIC_PROCESS, GOBP_CARBOHYDRATE_DERIVATIVE_BIOSYNTHETIC_PROCESS, GOBP_GLYCOSPHINGOLIPID_BIOSYNTHETIC_PROCESS, MORF_PRKDC, GOBP_LIPID_METABOLIC_PROCESS

GO Biological Process (4): ceramide metabolic process (GO:0006672), glycosphingolipid biosynthetic process (GO:0006688), regulation of heparan sulfate proteoglycan biosynthetic process (GO:0010908), protein localization to membrane (GO:0072657)

GO Molecular Function (0):

GO Cellular Component (9): endosome (GO:0005768), Golgi apparatus (GO:0005794), microtubule organizing center (GO:0005815), plasma membrane (GO:0005886), endosome membrane (GO:0010008), membrane (GO:0016020), extracellular exosome (GO:0070062), cytoplasm (GO:0005737), cytoskeleton (GO:0005856)

GO top-level categories

Rollup of top GO terms by namespace:

CategoryTerms
cellular anatomical structure3
endomembrane system2
sphingolipid metabolic process1
glycosphingolipid metabolic process1
glycolipid biosynthetic process1
sphingolipid biosynthetic process1
heparan sulfate proteoglycan biosynthetic process1
regulation of protein O-linked glycosylation1
intracellular protein localization1
localization within membrane1
cytoplasmic vesicle1
cytoplasm1
intracellular membrane-bounded organelle1
microtubule cytoskeleton1
membrane1
cell periphery1
endosome1
cytoplasmic vesicle membrane1
bounding membrane of organelle1
extracellular vesicle1
intracellular anatomical structure1
intracellular membraneless organelle1

Protein interactions and networks

STRING

942 interactions, top by confidence (×1000):

Protein AProtein BPartner UniProtScore
TM9SF2LAPTM4AQ15012661
TM9SF2CLEC19AQ6UXS0624
TM9SF2TMEM165Q9HC07607
TM9SF2SPTSSAQ969W0567
TM9SF2B4GALT5O43286563
TM9SF2UNC50Q53HI1545
TM9SF2A4GALTQ9NPC4496
TM9SF2FAM234BA2RU67494
TM9SF2RIN2Q8WYP3490
TM9SF2CLYBLQ8N0X4461
TM9SF2SPTLC1O15269453
TM9SF2VPS54Q9P1Q0452
TM9SF2GPR108Q9NPR9447
TM9SF2UGCGQ16739443
TM9SF2VPS51Q9UID3438

IntAct

74 interactions, top by confidence:

ABTypeScore
IFT70BIFT56psi-mi:“MI:0914”(association)0.790
CFTRESYT2psi-mi:“MI:0914”(association)0.710
TACR1ATP5PBpsi-mi:“MI:0914”(association)0.640
CFTRHAX1psi-mi:“MI:0914”(association)0.610
SLC22A9GPR89Apsi-mi:“MI:0914”(association)0.530
TMEM9ESYT2psi-mi:“MI:0914”(association)0.530
NCEH1CLGNpsi-mi:“MI:0914”(association)0.530
LPAR1TMEM223psi-mi:“MI:0914”(association)0.530
sseJAGPSpsi-mi:“MI:0914”(association)0.460
TMEM18TM9SF2psi-mi:“MI:0915”(physical association)0.400
TM9SF2HTR2Cpsi-mi:“MI:0915”(physical association)0.370
TM9SF2SMAD4psi-mi:“MI:0915”(physical association)0.370
ESYT2psi-mi:“MI:0914”(association)0.350
MAPK6psi-mi:“MI:0914”(association)0.350
ORF47ZZEF1psi-mi:“MI:0914”(association)0.350
TSPOpsi-mi:“MI:0914”(association)0.350
Prdm16ESYT2psi-mi:“MI:0914”(association)0.350
LRRK2psi-mi:“MI:0914”(association)0.350
TMPRSS11Bpsi-mi:“MI:0914”(association)0.350
SLC22A9GPR89Apsi-mi:“MI:0914”(association)0.350
Ppsi-mi:“MI:0914”(association)0.350
Mpsi-mi:“MI:0914”(association)0.350
TMEM223psi-mi:“MI:0914”(association)0.350

BioGRID (114): TM9SF2 (Affinity Capture-MS), TM9SF2 (Proximity Label-MS), TM9SF2 (Synthetic Lethality), TM9SF2 (Affinity Capture-MS), TM9SF2 (Affinity Capture-MS), TM9SF2 (Affinity Capture-MS), TM9SF2 (Affinity Capture-MS), TM9SF2 (Two-hybrid), TM9SF2 (Affinity Capture-MS), TM9SF2 (Affinity Capture-MS), TM9SF2 (Affinity Capture-MS), TM9SF2 (Affinity Capture-MS), TM9SF2 (Affinity Capture-MS), TM9SF2 (Affinity Capture-MS), TM9SF2 (Affinity Capture-MS)

ESM2 similar proteins: A0A060LAL9, A0A097ZPE6, A0A1I9R3Y5, A2VEI2, A2XVG1, A8B479, A8WQT4, B3H7A9, F4I1L3, G1JSL4, H2E7T7, O22585, O22788, O45228, O64407, O65015, O81270, P10538, P16098, Q0KHU5, Q19337, Q28C60, Q2QRX6, Q43727, Q5QIT3, Q5R8Y6, Q5Z8Y4, Q66HG5, Q6DCK1, Q7FAX1, Q7JW12, Q8CD10, Q8IYU8, Q8VZQ4, Q95PZ2, Q99805, Q99P63, Q9CAB7, Q9CAB8, Q9D5U0

Diamond homologs: A4IFE9, A5D7E2, F4HW17, F4KIB2, O15321, P58021, Q4KLL4, Q54ZW0, Q5R8F1, Q5R8Y6, Q5RDY2, Q66HF2, Q66HG5, Q8BH24, Q8RWW1, Q92544, Q940G0, Q940S0, Q99805, Q9C5N2, Q9C720, Q9DBU0, Q9ET30, Q9FHT4, Q9HD45, Q9LIC2, Q9Y819, Q9ZPS7, F4JRE0, P32802, Q04562, Q55FP0, Q9FYQ8, Q7YTA6

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

71 variants total. Per-class counts are floors (≥ shown; pagination cap):

ClassificationCount (floor)
Pathogenic0
Likely pathogenic0
Uncertain significance45
Likely benign3
Benign0

Top pathogenic / likely-pathogenic (0)

SpliceAI

2056 predictions. Top by Δscore:

VariantEffectΔscore
13:99501774:CAAG:Cdonor_loss1.0000
13:99501775:AAG:Adonor_loss1.0000
13:99501776:AG:Adonor_loss1.0000
13:99501777:GG:Gdonor_loss1.0000
13:99501778:G:Adonor_loss1.0000
13:99501779:T:Adonor_loss1.0000
13:99517606:A:AGacceptor_gain1.0000
13:99517607:T:Gacceptor_gain1.0000
13:99517609:TTCA:Tacceptor_loss1.0000
13:99517611:CAG:Cacceptor_loss1.0000
13:99517612:A:AGacceptor_gain1.0000
13:99517612:AG:Aacceptor_gain1.0000
13:99517612:AGGCC:Aacceptor_gain1.0000
13:99517613:G:Cacceptor_loss1.0000
13:99517613:G:GAacceptor_gain1.0000
13:99517613:GG:Gacceptor_gain1.0000
13:99517613:GGCC:Gacceptor_gain1.0000
13:99517613:GGCCG:Gacceptor_gain1.0000
13:99517677:ACAGC:Adonor_gain1.0000
13:99517678:CAGC:Cdonor_gain1.0000
13:99517678:CAGCG:Cdonor_loss1.0000
13:99517679:AGC:Adonor_gain1.0000
13:99517679:AGCG:Adonor_loss1.0000
13:99517680:GC:Gdonor_gain1.0000
13:99517680:GCG:Gdonor_gain1.0000
13:99517681:CGT:Cdonor_loss1.0000
13:99517682:G:GCdonor_loss1.0000
13:99517682:G:GGdonor_gain1.0000
13:99517683:TAA:Tdonor_loss1.0000
13:99520031:CCCA:Cacceptor_loss1.0000

AlphaMissense

4376 scored. Top likely-pathogenic:

VariantProtein changeam_pathogenicity
13:99520081:T:AN95K1.000
13:99520081:T:GN95K1.000
13:99520085:G:CG97R1.000
13:99520085:G:TG97C1.000
13:99540732:T:AW283R1.000
13:99540732:T:CW283R1.000
13:99540734:G:CW283C1.000
13:99540734:G:TW283C1.000
13:99540741:A:GR286G1.000
13:99540742:G:CR286T1.000
13:99540742:G:TR286I1.000
13:99540743:A:CR286S1.000
13:99540743:A:TR286S1.000
13:99540744:T:AW287R1.000
13:99540744:T:CW287R1.000
13:99540746:G:CW287C1.000
13:99540746:G:TW287C1.000
13:99541568:T:AN306K1.000
13:99541568:T:GN306K1.000
13:99541627:T:CL326P1.000
13:99541635:G:CD329H1.000
13:99541636:A:CD329A1.000
13:99541636:A:TD329V1.000
13:99543884:G:CG347R1.000
13:99543885:G:AG347D1.000
13:99543887:T:AW348R1.000
13:99543887:T:CW348R1.000
13:99543888:G:CW348S1.000
13:99543889:G:CW348C1.000
13:99543889:G:TW348C1.000

dbSNP variants (sampled 300 via entrez): RS1000044409 (13:99560403 A>G), RS1000095799 (13:99525203 G>A), RS1000114447 (13:99561657 T>C), RS1000152260 (13:99505054 T>A,C), RS1000163514 (13:99519953 C>G), RS1000197426 (13:99524431 G>A,C), RS1000286028 (13:99512545 G>A), RS1000358540 (13:99510467 C>A,T), RS1000454223 (13:99559684 C>G,T), RS1000457357 (13:99535925 C>T), RS1000549559 (13:99524898 G>A), RS1000567275 (13:99545975 G>A), RS1000579767 (13:99529647 T>C,G), RS1000631331 (13:99504744 G>A), RS1000633574 (13:99529382 C>A,T)

Disease associations

OMIM: gene MIM:604678 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

10 associations (top):

StudyTraitp-value
GCST001762_113Obesity-related traits4.000000e-06
GCST003484_6Periodontal disease-related phenotype (Socransky)1.000000e-08
GCST007798_145Asthma5.000000e-18
GCST007799_36Asthma (adult onset)6.000000e-12
GCST007995_42Asthma (childhood onset)5.000000e-13
GCST008916_6Asthma4.000000e-13
GCST009391_105Metabolite levels3.000000e-07
GCST009391_1981Metabolite levels1.000000e-06
GCST010043_65Asthma8.000000e-20
GCST90014325_56Asthma1.000000e-16

EFO canonical traits (5, from GWAS)

EFO IDTrait name
EFO:0006336diastolic blood pressure
EFO:0007780periodontal measurement
EFO:1002011adult onset asthma
EFO:0010491glycocholate measurement
EFO:0005058tyrosine measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL6067238 (SINGLE PROTEIN)

PharmGKB: 1 entry (VIP=true, CPIC=false)

ChEMBL bioactivities

2 potent at pChembl≥5 of 2 total, top 2 by pChembl (potency: 10 = 0.1 nM, 6 = 1 µM).

pChemblTypeValueUnitMolecule
6.93Kd118.5nMCHEMBL5653589
6.93ED50118.5nMCHEMBL5653589

PubChem BioAssay actives

1 with measured affinity, of 2 total; 1 most potent distinct compounds. Largely complementary to BindingDB; screening values are coarse (µM, 4 dp), so sub-nM hits tie at the floor.

CompoundAssayTypeValueUnit
4-methyl-3-[(2-methyl-6-pyridin-3-ylpyrazolo[3,4-d]pyrimidin-4-yl)amino]-N-[3-(trifluoromethyl)phenyl]benzamide2149596: Binding affinity to human TM9SF2 incubated for 45 mins by Kinobead based pull down assaykd0.1185uM

CTD chemical–gene interactions

32 total (human), top 30 by PubMed support.

ChemicalActions (top 5)PubMed papers
Acetaminophendecreases expression2
Rotenoneincreases expression2
aristolochic acid Idecreases expression1
triphenyl phosphateaffects expression1
bisphenol Aincreases expression1
deoxynivalenoldecreases expression1
sodium arseniteincreases expression1
2-bromopalmitatedecreases reaction, increases abundance, increases palmitoylation1
zinc chromateincreases abundance, increases expression1
nivalenoldecreases expression1
chromium hexavalent ionincreases abundance, increases expression1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamideaffects cotreatment, decreases expression1
abrinedecreases expression1
LDN 193189affects cotreatment, decreases expression1
Temozolomidedecreases expression1
Air Pollutantsincreases abundance, decreases expression1
Bilirubindecreases expression1
Cadmiumincreases palmitoylation, decreases reaction, increases abundance1
Cannabidioldecreases expression1
Clozapinedecreases expression1
Doxorubicindecreases expression1
Haloperidoldecreases expression1
Ivermectindecreases expression1
Phenobarbitalaffects expression1
Ribonucleotidesaffects binding1
Valproic Acidincreases expression1
Cyclosporinedecreases expression1
Cadmium Chloridedecreases reaction, increases abundance, increases palmitoylation1
Thapsigarginincreases expression1
Copper Sulfatedecreases expression1

ChEMBL screening assays

1 unique, capped per target: 1 binding

Representative assays (with source publication via chembl_document):

Assay IDTypeDescriptionSource paper
CHEMBL5652638BindingBinding affinity to human TM9SF2 incubated for 45 mins by Kinobead based pull down assayNVP-BHG712: Effects of Regioisomers on the Affinity and Selectivity toward the EPHrin Family. — ChemMedChem

Cellosaurus cell lines

2 cell lines: 2 cancer cell line

First 10 cell lines (id-ordered, not curated):

CellosaurusNameCategorySex
CVCL_TS58HAP1 TM9SF2 (-) 1Cancer cell lineMale
CVCL_TS59HAP1 TM9SF2 (-) 2Cancer cell lineMale

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.

  • Disease cohort memberships (association, not causation — diseases whose associated-gene cohort lists this gene; a subset are also under Associated diseases): childhood onset asthma

About this page

Generated deterministically by Sugi Atlas from primary biomedical databases via BioBTree. Every record on this page traces to a primary source.

Generated
Atlas version
v1.1.4
BioBTree
v2.0.2

Sources 77

This page pulls from 77 datasets indexed by BioBTree:

alphafoldalphamissenseantibodybgeebgee_evidencebindingdbbiogrid_interactionbrendabrenda_kineticsccdscellosauruschembl_activitychembl_assaychembl_documentchembl_moleculechembl_targetciviccivic_evidenceclingen_dosageclingen_gene_validityclinical_trialsclinvarcollectrictd_gene_interactiondbsnpdepmapdiamond_similarityefoensemblentrezesm2_similarityexonfantom5_genefantom5_promotergenccgenerifgogoparentgtopdbgwasgwas_studyhgnchpointactinterprointogenjasparmeshmimmirdbmondomsigdborphanetorthologparalogpdbpfampharmgkb_clinicalpharmgkb_genepharmgkb_guidelinepharmgkb_variantpubchempubchem_activitypubchem_assaypubmedreactomerefseqrhearnacentralscxa_expressionscxa_gene_experimentsignorspliceaistring_interactiontranscriptufeatureuniprot