TMBIM4

Summary

TMBIM4 (transmembrane BAX inhibitor motif containing 4, HGNC:24257) is a protein-coding gene on chromosome 12q14.3, encoding Protein lifeguard 4 (Q9HC24). Anti-apoptotic protein which can inhibit apoptosis induced by intrinsic and extrinsic apoptotic stimuli.

Predicted to enable calcium channel activity. Involved in negative regulation of apoptotic process and regulation of calcium-mediated signaling. Located in Golgi stack and endoplasmic reticulum membrane.

Source: NCBI Gene 51643 — RefSeq curated summary.

At a glance

• GWAS associations: 2
• Clinical variants (ClinVar): 46 total
• MANE Select transcript: NM_016056

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:24257
Approved symbol	TMBIM4
Name	transmembrane BAX inhibitor motif containing 4
Location	12q14.3
Locus type	gene with protein product
Status	Approved
Aliases	CGI-119, S1R, ZPRO, LFG4, GAAP
Ensembl gene	ENSG00000155957
Ensembl biotype	protein_coding
OMIM	616874
Entrez	51643

Gene structure

Transcript identifiers

Ensembl transcripts: 12 — 6 protein_coding, 4 nonsense_mediated_decay, 1 retained_intron, 1 protein_coding_CDS_not_defined

ENST00000286424, ENST00000358230, ENST00000398033, ENST00000534930, ENST00000535812, ENST00000538217, ENST00000542072, ENST00000542724, ENST00000544599, ENST00000545407, ENST00000545504, ENST00000633367

RefSeq mRNA: 4 — MANE Select: NM_016056 NM_001282606, NM_001282609, NM_001282610, NM_016056

CCDS: CCDS41805, CCDS61187, CCDS81710

Canonical transcript exons

ENST00000358230 — 7 exons

Exon	Start	End
ENSE00002324150	66135846	66138166
ENSE00003595865	66153340	66153448
ENSE00003603695	66147908	66147941
ENSE00003607620	66145841	66145958
ENSE00003660034	66152271	66152376
ENSE00003788466	66138724	66138769
ENSE00003903456	66169855	66169996

Expression profiles

Bgee: expression breadth ubiquitous, 292 present calls, max score 99.07.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 76.0934 / max 709.6131, expressed in 1822 samples.

FANTOM5 promoters (6 alternative TSS)

Promoter ID	TPM avg	Samples expressed
131932	63.8351	1822
131933	10.2001	1776
131934	1.4047	1033
131931	0.5388	69
206774	0.0718	11
131930	0.0429	6

Top tissues by expression

294 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
buccal mucosa cell	CL:0002336	99.07	gold quality
monocyte	CL:0000576	98.97	gold quality
mononuclear cell	CL:0000842	98.91	gold quality
leukocyte	CL:0000738	98.88	gold quality
calcaneal tendon	UBERON:0003701	98.80	gold quality
body of pancreas	UBERON:0001150	98.70	gold quality
left adrenal gland	UBERON:0001234	98.58	gold quality
right lung	UBERON:0002167	98.58	gold quality
left testis	UBERON:0004533	98.58	gold quality
right adrenal gland	UBERON:0001233	98.57	gold quality
right testis	UBERON:0004534	98.57	gold quality
right adrenal gland cortex	UBERON:0035827	98.56	gold quality
gall bladder	UBERON:0002110	98.53	gold quality
left adrenal gland cortex	UBERON:0035825	98.50	gold quality
rectum	UBERON:0001052	98.49	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	98.48	gold quality
endocervix	UBERON:0000458	98.46	gold quality
mucosa of stomach	UBERON:0001199	98.43	gold quality
descending thoracic aorta	UBERON:0002345	98.38	gold quality
tendon of biceps brachii	UBERON:0008188	98.34	silver quality
tendon	UBERON:0000043	98.29	gold quality
left lobe of thyroid gland	UBERON:0001120	98.29	gold quality
adrenal cortex	UBERON:0001235	98.28	gold quality
body of uterus	UBERON:0009853	98.28	gold quality
adenohypophysis	UBERON:0002196	98.19	gold quality
body of stomach	UBERON:0001161	98.17	gold quality
minor salivary gland	UBERON:0001830	98.16	gold quality
left uterine tube	UBERON:0001303	98.15	gold quality
thoracic aorta	UBERON:0001515	98.15	gold quality
peritoneum	UBERON:0002358	98.15	gold quality

Single-cell (SCXA)

Detected in 3 experiment(s), a significant marker in 3.

Experiment	Marker?	Max mean expression
E-GEOD-84465	yes	1288.31
E-GEOD-125970	yes	16.03
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

42 targeting TMBIM4, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-200B-3P	100.00	73.31	2693
HSA-MIR-200C-3P	100.00	73.35	2685
HSA-MIR-429	100.00	73.44	2698
HSA-MIR-186-5P	99.99	70.83	3707
HSA-MIR-150-5P	99.99	66.69	1976
HSA-MIR-4282	99.99	75.36	6408
HSA-MIR-4775	99.98	75.00	6394
HSA-MIR-548P	99.98	72.25	3784
HSA-MIR-12136	99.98	72.81	5713
HSA-MIR-607	99.97	73.62	5593
HSA-MIR-9-3P	99.96	70.88	2068
HSA-MIR-144-3P	99.94	73.98	2698
HSA-MIR-3143	99.93	71.96	3104
HSA-MIR-10527-5P	99.91	72.28	3754
HSA-MIR-5680	99.91	69.83	3421
HSA-MIR-380-3P	99.89	70.18	1978
HSA-MIR-4503	99.85	71.45	1869
HSA-MIR-202-3P	99.84	71.41	1290
HSA-MIR-4668-5P	99.79	70.58	3782
HSA-MIR-577	99.78	69.13	2479
HSA-MIR-5580-3P	99.70	69.41	2052
HSA-MIR-510-3P	99.54	70.06	2965
HSA-MIR-186-3P	99.51	66.24	1685
HSA-MIR-582-5P	99.47	70.79	2635
HSA-MIR-5009-3P	99.45	69.43	1341
HSA-MIR-32-3P	99.36	68.20	2517
HSA-MIR-16-2-3P	99.29	70.60	1954
HSA-MIR-195-3P	99.29	70.61	1954
HSA-MIR-194-5P	99.01	69.65	1465
HSA-MIR-513B-3P	98.76	68.12	1577

Literature-anchored findings (GeneRIF, showing 10)

• Stable expression of both viral GAAP (v-GAAP) and human GAAP (h-GAAP), which is expressed in all human tissues tested, inhibited apoptosis induced by intrinsic and extrinsic apoptotic stimuli (PMID:17319741)
• The tmbim4 may participate in cell death regulation by interacting with proteins of Bcl-2 family, promoting tumor metastasis, which is deduced from the evolutionary conservation of the membrane protein family containing multiple membrane spanning segments (PMID:18440869)
• Data demonstrate that h-GAAP modulates intracellular Ca(2+) fluxes induced by both physiological and apoptotic stimuli. (PMID:19553469)
• Data indicate that GAAP and BI-1 have a six membrane-spanning topology with cytosolic N and C termini and a C-terminal reentrant loop. (PMID:22418439)
• Taken together, the proposed interaction between Chlamydia pneumoniae protein CPn0809 and GAAP modulates bacterial growth in A549 cells. (PMID:23000903)
• GAAP can oligomerize in a pH-regulated manner, and monomeric GAAP is functional. (PMID:23508950)
• The hGAAP is a novel regulator of focal adhesion dynamics, cell adhesion, and migration by controlling localized Ca(2+)-dependent activation of calpain. (PMID:23940116)
• These results suggest that the TMBIM family has comparable functions in the maintenance of intracellular Ca(2) homeostasis in a wide variety of tissues (PMID:25764978)
• Residues contributing to the ion-conducting pore have been defined and provide the first clues about the mechanistic link between these very different functions of golgi anti-apoptotic protein (GAAP) [review]. (PMID:28469007)
• Stimulation of cell invasion by the Golgi Ion Channel GAAP/TMBIM4 via an H2O2-Dependent Mechanism. (PMID:31693977)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	tmbim4	ENSDARG00000014361
mus_musculus	Tmbim4	ENSMUSG00000020225
rattus_norvegicus	Tmbim4	ENSRNOG00000004312
drosophila_melanogaster	CG33673	FBGN0053673
caenorhabditis_elegans		WBGENE00006479

Paralogs (5): FAIM2 (ENSG00000135472), TMBIM1 (ENSG00000135926), TMBIM6 (ENSG00000139644), GHITM (ENSG00000165678), GRINA (ENSG00000178719)

Protein

Protein identifiers

Protein lifeguard 4 — Q9HC24 (reviewed: Q9HC24)

Alternative names: Golgi anti-apoptotic protein, Protein S1R, Transmembrane BAX inhibitor motif-containing protein 4, Z-protein

All UniProt accessions (8): Q9HC24, E7EWY5, F5GXT9, F5H1S4, G3V1M2, G3V1R8, G3XAA5, Q7Z782

UniProt curated annotations — full annotation on UniProt →

Function. Anti-apoptotic protein which can inhibit apoptosis induced by intrinsic and extrinsic apoptotic stimuli. Can modulate both capacitative Ca2+ entry and inositol 1,4,5-trisphosphate (IP3)-mediated Ca2+ release.

Subunit / interactions. Interacts with ITPR3.

Subcellular location. Golgi apparatus membrane.

Similarity. Belongs to the BI1 family. LFG subfamily.

RefSeq proteins (4): NP_001269535, NP_001269538, NP_001269539, NP_057140* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR006214	Bax_inhibitor_1-related	Family

Pfam: PF01027

UniProt features (18 total): topological domain 8, transmembrane region 6, sequence variant 2, chain 1, intramembrane region 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9HC24-F1	92.33	0.81

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 174 (showing top): GOBP_NEGATIVE_REGULATION_OF_NEURON_APOPTOTIC_PROCESS, GOBP_BEHAVIOR, GOBP_REGULATION_OF_CALCIUM_MEDIATED_SIGNALING, GOBP_RESPONSE_TO_ENDOPLASMIC_RETICULUM_STRESS, CHIANG_LIVER_CANCER_SUBCLASS_UNANNOTATED_DN, GOBP_CELLULAR_RESPONSE_TO_TOPOLOGICALLY_INCORRECT_PROTEIN, GOBP_MONOATOMIC_CATION_TRANSPORT, IRF7_01, KIM_GERMINAL_CENTER_T_HELPER_UP, IRF_Q6, GOBP_NEURON_APOPTOTIC_PROCESS, GOBP_CALCIUM_ION_TRANSMEMBRANE_TRANSPORT, GRYDER_PAX3FOXO1_ENHANCERS_IN_TADS, GOBP_TRANSMEMBRANE_TRANSPORT, GOBP_RESPONSE_TO_TOPOLOGICALLY_INCORRECT_PROTEIN

GO Biological Process (7): apoptotic process (GO:0006915), locomotory behavior (GO:0007626), endoplasmic reticulum unfolded protein response (GO:0030968), negative regulation of apoptotic process (GO:0043066), negative regulation of neuron apoptotic process (GO:0043524), regulation of calcium-mediated signaling (GO:0050848), calcium ion transmembrane transport (GO:0070588)

GO Molecular Function (2): calcium channel activity (GO:0005262), protein binding (GO:0005515)

GO Cellular Component (5): Golgi membrane (GO:0000139), endoplasmic reticulum membrane (GO:0005789), Golgi stack (GO:0005795), membrane (GO:0016020), Golgi apparatus (GO:0005794)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
programmed cell death	1
apoptotic signaling pathway	1
execution phase of apoptosis	1
behavior	1
cellular response to unfolded protein	1
response to endoplasmic reticulum stress	1
intracellular signal transduction	1
apoptotic process	1
regulation of apoptotic process	1
negative regulation of programmed cell death	1
negative regulation of apoptotic process	1
regulation of neuron apoptotic process	1
neuron apoptotic process	1
calcium-mediated signaling	1
regulation of intracellular signal transduction	1
calcium ion transport	1
monoatomic cation transmembrane transport	1
monoatomic cation channel activity	1
calcium ion transmembrane transporter activity	1
binding	1
Golgi apparatus	1
bounding membrane of organelle	1
organelle membrane	1
nuclear outer membrane-endoplasmic reticulum membrane network	1
endoplasmic reticulum subcompartment	1
Golgi apparatus subcompartment	1
cellular anatomical structure	1
cytoplasm	1
endomembrane system	1
intracellular membrane-bounded organelle	1

Protein interactions and networks

STRING

872 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
TMBIM4	PML	P29590	898
TMBIM4	SIGMAR1	Q99720	876
TMBIM4	RIGI	O95786	845
TMBIM4	TMEM97	Q5BJF2	830
TMBIM4	ITPR3	Q14573	814
TMBIM4	EIF4E	P06730	755
TMBIM4	IFIH1	Q9BYX4	745
TMBIM4	PSMB2	P31145	719
TMBIM4	SERPINA1	P01009	715
TMBIM4	GP2	P55259	678
TMBIM4	PSMB10	P40306	669
TMBIM4	ERN1	O75460	613
TMBIM4	PSMB8	P28062	602
TMBIM4	GTPBP1	O00178	601
TMBIM4	ITPR1	Q14643	586

IntAct

38 interactions, top by confidence:

A	B	Type	Score
	TMBIM4	psi-mi:“MI:0915”(physical association)	0.370
TMBIM4	SSR4	psi-mi:“MI:0915”(physical association)	0.000
TMBIM4	MFN1	psi-mi:“MI:0915”(physical association)	0.000
TMBIM4	CCDC47	psi-mi:“MI:0915”(physical association)	0.000
TMBIM4	NDUFB6	psi-mi:“MI:0915”(physical association)	0.000
TMBIM4	COX4I1	psi-mi:“MI:0915”(physical association)	0.000
TMBIM4	PPIB	psi-mi:“MI:0915”(physical association)	0.000
TMBIM4	PEBP1	psi-mi:“MI:0915”(physical association)	0.000
TMBIM4	TXN	psi-mi:“MI:0915”(physical association)	0.000
TMBIM4	MYCBP	psi-mi:“MI:0915”(physical association)	0.000
TMBIM4	OTUD4	psi-mi:“MI:0915”(physical association)	0.000
TMBIM4	RANGAP1	psi-mi:“MI:0915”(physical association)	0.000
TMBIM4	TMCO1	psi-mi:“MI:0915”(physical association)	0.000
TMBIM4	SUN2	psi-mi:“MI:0915”(physical association)	0.000
TMBIM4	RPL22	psi-mi:“MI:0915”(physical association)	0.000
TMBIM4	PRPSAP1	psi-mi:“MI:0915”(physical association)	0.000
TMBIM4	ORMDL1	psi-mi:“MI:0915”(physical association)	0.000
TMBIM4	SURF4	psi-mi:“MI:0915”(physical association)	0.000
TMBIM4	DFFA	psi-mi:“MI:0915”(physical association)	0.000
TMBIM4	SMIM11	psi-mi:“MI:0915”(physical association)	0.000
TMBIM4	HNRNPL	psi-mi:“MI:0915”(physical association)	0.000
TMBIM4	PRMT1	psi-mi:“MI:0915”(physical association)	0.000
TMBIM4	DDOST	psi-mi:“MI:0915”(physical association)	0.000
TMBIM4	HACD3	psi-mi:“MI:0915”(physical association)	0.000
TMBIM4		psi-mi:“MI:0915”(physical association)	0.000
TMBIM4	EMC1	psi-mi:“MI:0915”(physical association)	0.000
PSMB5	TMBIM4	psi-mi:“MI:0915”(physical association)	0.000
TMBIM4	SGPL1	psi-mi:“MI:0915”(physical association)	0.000
TMBIM4	RPN2	psi-mi:“MI:0915”(physical association)	0.000
TMBIM4	CMTM6	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (13): SLC27A4 (Affinity Capture-MS), RPN2 (Affinity Capture-MS), CCDC47 (Affinity Capture-MS), DDOST (Affinity Capture-MS), PPIB (Affinity Capture-MS), MTX1 (Affinity Capture-MS), PRPSAP1 (Affinity Capture-MS), DFFA (Affinity Capture-MS), COX4I1 (Affinity Capture-MS), TMBIM4 (Two-hybrid), TMBIM4 (Two-hybrid), TMBIM4 (PCA), TMBIM4 (Two-hybrid)

ESM2 similar proteins: A0A1B0GVX0, A2ADU8, A2ADU9, A2Y075, A6QP72, O82232, P34655, P55017, P55018, P56508, P59158, P68178, P68179, Q0DKW8, Q0VBW2, Q22701, Q3ZCB2, Q53GD3, Q54RZ2, Q5REK4, Q5RJI2, Q5TYP8, Q66I68, Q6DK93, Q6DK99, Q6E1M8, Q6E213, Q6GMG8, Q6GZQ0, Q6NUC1, Q6P828, Q6PCW6, Q6ZPD8, Q8H5T6, Q8NG11, Q8QZY6, Q8S5M8, Q91VA1, Q9ARD5, Q9BYD5

Diamond homologs: F4JIE8, O25578, O31539, O74888, O88407, P0AAC6, P0AAC7, P0DA10, P0DA11, P0DXN1, P0DXN2, P0DXN3, Q03268, Q5XDQ1, Q8K097, Q8P2D4, Q94A20, Q9A1B9, Q9DA39, Q9HC24, Q9KSA1, Q9M1V9, Q9SA63, Q9ZKT1, Q9ZQX7, Q11080, Q1LZ71, Q32L53, Q5R4I4, Q6P6R0, Q7Z429, Q9BWQ8, Q9ESF4, Q9PIQ8, Q8BJZ3, Q969X1, Q9A2A3, O51489, O84826, P0AAC4

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

46 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	30
Likely benign	3
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1415 predictions. Top by Δscore:

Variant	Effect	Δscore
12:66137962:A:AC	donor_gain	1.0000
12:66137963:C:CC	donor_gain	1.0000
12:66137979:T:TA	donor_gain	1.0000
12:66138167:C:CC	acceptor_gain	1.0000
12:66169853:A:AC	donor_gain	1.0000
12:66169853:AC:A	donor_gain	1.0000
12:66169854:C:CC	donor_gain	1.0000
12:66169854:CC:C	donor_gain	1.0000
12:66137973:A:C	donor_gain	0.9900
12:66138049:A:AC	donor_gain	0.9900
12:66138050:C:CC	donor_gain	0.9900
12:66138162:AAAAA:A	acceptor_gain	0.9900
12:66138163:AAAA:A	acceptor_gain	0.9900
12:66138164:AAA:A	acceptor_gain	0.9900
12:66138165:AA:A	acceptor_gain	0.9900
12:66138717:AACTT:A	donor_loss	0.9900
12:66138718:ACTTA:A	donor_loss	0.9900
12:66145959:C:CC	acceptor_gain	0.9900
12:66153339:CCT:C	donor_gain	0.9900
12:66153449:C:CC	acceptor_gain	0.9900
12:66169288:A:AC	donor_gain	0.9900
12:66169289:C:CC	donor_gain	0.9900
12:66169744:C:CA	donor_gain	0.9900
12:66169850:CGTA:C	donor_loss	0.9900
12:66169851:GTACC:G	donor_loss	0.9900
12:66169852:TA:T	donor_loss	0.9900
12:66169853:ACCC:A	donor_loss	0.9900
12:66169854:C:CG	donor_loss	0.9900
12:66169854:C:CT	donor_loss	0.9900
12:66169854:CCCA:C	donor_gain	0.9900

AlphaMissense

1525 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
12:66153444:A:C	F34L	0.998
12:66153444:A:T	F34L	0.998
12:66153446:A:G	F34L	0.998
12:66138107:G:C	F190L	0.994
12:66138107:G:T	F190L	0.994
12:66138109:A:G	F190L	0.994
12:66153445:A:G	F34S	0.994
12:66152271:A:C	F104L	0.992
12:66152271:A:T	F104L	0.992
12:66152273:A:G	F104L	0.992
12:66138087:T:G	D197A	0.991
12:66138106:A:G	C191R	0.991
12:66138002:G:C	F225L	0.989
12:66138002:G:T	F225L	0.989
12:66138004:A:G	F225L	0.989
12:66138121:C:G	G186R	0.989
12:66138121:C:T	G186R	0.989
12:66147929:C:G	A109P	0.989
12:66138087:T:A	D197V	0.988
12:66153397:G:T	T50K	0.988
12:66169860:C:G	R31P	0.988
12:66138017:A:C	D220E	0.987
12:66138017:A:T	D220E	0.987
12:66138102:C:T	G192E	0.987
12:66147916:G:T	A113E	0.987
12:66138006:A:G	L224P	0.986
12:66138018:T:G	D220A	0.986
12:66138753:A:G	W161R	0.986
12:66138753:A:T	W161R	0.986
12:66145895:C:T	G137D	0.986

dbSNP variants (sampled 300 via entrez): RS1000082605 (12:66147570 A>G), RS1000147157 (12:66149259 A>G), RS1000286727 (12:66167609 A>C), RS1000430720 (12:66138604 T>C), RS1000431831 (12:66147163 AAG>A), RS1000483281 (12:66138225 A>C,G,T), RS1000512164 (12:66171637 C>T), RS1000534722 (12:66169984 A>C,G), RS1000568549 (12:66165960 T>C), RS1000705238 (12:66144141 G>T), RS1000729048 (12:66144941 A>T), RS1000778581 (12:66159452 T>C), RS1000849867 (12:66140058 A>G), RS1000862836 (12:66163562 C>G), RS1000927299 (12:66157436 C>T)

Disease associations

OMIM: gene MIM:616874 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

2 associations (top):

Study	Trait	p-value
GCST004387_4	Pulse pressure	8.000000e-09
GCST90020028_987	Hip circumference adjusted for BMI	9.000000e-11

EFO canonical traits (2, from GWAS)

EFO ID	Trait name
EFO:0005763	pulse pressure measurement
EFO:0008039	BMI-adjusted hip circumference

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

32 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
bisphenol A	decreases expression, affects cotreatment, increases expression	2
Quercetin	decreases expression	2
Valproic Acid	decreases expression, decreases methylation, increases expression	2
dicrotophos	decreases expression	1
triphenyl phosphate	affects expression	1
propionaldehyde	decreases expression	1
arsenite	affects binding, increases reaction	1
butyraldehyde	decreases expression	1
casticin	increases expression	1
K 7174	decreases expression	1
ICG 001	increases expression	1
Temozolomide	decreases expression	1
Sunitinib	decreases expression	1
Leflunomide	decreases expression	1
Acetaminophen	decreases expression	1
Benzo(a)pyrene	increases methylation	1
Carcinogens	decreases expression	1
Dexamethasone	affects cotreatment, increases expression	1
Diuron	decreases expression	1
Doxorubicin	decreases expression	1
Indomethacin	affects cotreatment, increases expression	1
Methyl Methanesulfonate	decreases expression	1
Mutagens	decreases expression	1
Oxygen	decreases expression	1
Phthalic Acids	decreases expression	1
Tobacco Smoke Pollution	decreases expression	1
Tretinoin	increases expression	1
Tunicamycin	increases expression	1
1-Methyl-3-isobutylxanthine	affects cotreatment, increases expression	1
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.