TMC3-AS1

Summary

TMC3-AS1 (TMC3 antisense RNA 1, HGNC:51424) is a long non-coding RNA gene on chromosome 15q25.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:51424
Approved symbol	TMC3-AS1
Name	TMC3 antisense RNA 1
Location	15q25.1
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000259343
Ensembl biotype	lncRNA
Entrez	101929655
RNAcentral	URS000075EE99 — lncRNA, 1077 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 60 — 60 lncRNA

ENST00000558086, ENST00000558141, ENST00000558153, ENST00000559277, ENST00000559781, ENST00000560851, ENST00000560973, ENST00000612811, ENST00000642113, ENST00000654210, ENST00000654536, ENST00000662589, ENST00000664001, ENST00000665273, ENST00000665567, ENST00000667509, ENST00000667513, ENST00000667849, ENST00000669758, ENST00000685783, ENST00000687585, ENST00000701482, ENST00000829087, ENST00000829088, ENST00000829089, ENST00000829090, ENST00000829091, ENST00000829092, ENST00000829093, ENST00000829094, ENST00000829095, ENST00000829096, ENST00000829097, ENST00000829098, ENST00000829099, ENST00000829100, ENST00000829101, ENST00000829102, ENST00000829103, ENST00000829104, ENST00000829105, ENST00000829106, ENST00000829107, ENST00000829108, ENST00000829109, ENST00000829110, ENST00000829111, ENST00000829112, ENST00000829113, ENST00000829114, ENST00000829115, ENST00000829116, ENST00000829117, ENST00000829118, ENST00000829119, ENST00000829120, ENST00000829121, ENST00000829122, ENST00000829596, ENST00000829597

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000558086 — 2 exons

Exon	Start	End
ENSE00002545103	81410696	81411267
ENSE00002556329	81410517	81410602

Expression profiles

Bgee: expression breadth ubiquitous, 164 present calls, max score 87.47.

FANTOM5 (CAGE): breadth broad, TPM avg 0.9307 / max 42.3341, expressed in 494 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
148090	0.9307	494

Top tissues by expression

246 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
bone marrow cell	CL:0002092	87.47	gold quality
oocyte	CL:0000023	87.08	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	86.39	gold quality
right lobe of liver	UBERON:0001114	81.72	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	80.14	gold quality
secondary oocyte	CL:0000655	79.50	silver quality
buccal mucosa cell	CL:0002336	77.87	silver quality
colonic epithelium	UBERON:0000397	77.39	gold quality
body of pancreas	UBERON:0001150	74.93	gold quality
liver	UBERON:0002107	74.33	gold quality
cortical plate	UBERON:0005343	73.47	gold quality
stromal cell of endometrium	CL:0002255	72.18	gold quality
endocervix	UBERON:0000458	71.24	gold quality
tonsil	UBERON:0002372	70.97	gold quality
left ovary	UBERON:0002119	70.07	gold quality
right ovary	UBERON:0002118	69.63	gold quality
pancreas	UBERON:0001264	69.57	gold quality
uterine cervix	UBERON:0000002	68.95	gold quality
bone marrow	UBERON:0002371	68.68	gold quality
sural nerve	UBERON:0015488	68.35	gold quality
cerebellar cortex	UBERON:0002129	68.33	gold quality
cerebellar hemisphere	UBERON:0002245	68.33	gold quality
right hemisphere of cerebellum	UBERON:0014890	67.73	gold quality
cerebellum	UBERON:0002037	67.70	gold quality
ganglionic eminence	UBERON:0004023	67.28	gold quality
ovary	UBERON:0000992	67.27	gold quality
rectum	UBERON:0001052	67.13	gold quality
mucosa of transverse colon	UBERON:0004991	67.08	gold quality
vena cava	UBERON:0004087	66.86	gold quality
gingival epithelium	UBERON:0001949	66.54	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	5.52

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• LPS-Inducible lncRNA TMC3-AS1 Negatively Regulates the Expression of IL-10. (PMID:32774335)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.