TMCC1

Summary

TMCC1 (transmembrane and coiled-coil domain family 1, HGNC:29116) is a protein-coding gene on chromosome 3q22.1, encoding Transmembrane and coiled-coil domains protein 1 (O94876). Endoplasmic reticulum membrane protein that promotes endoplasmic reticulum-associated endosome fission.

Enables identical protein binding activity. Involved in several processes, including endosome fission; endosome membrane tubulation; and membrane fission. Located in cytosol; endoplasmic reticulum-endosome membrane contact site; and rough endoplasmic reticulum.

Source: NCBI Gene 23023 — RefSeq curated summary.

At a glance

• GWAS associations: 31
• Clinical variants (ClinVar): 52 total
• MANE Select transcript: NM_001017395

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:29116
Approved symbol	TMCC1
Name	transmembrane and coiled-coil domain family 1
Location	3q22.1
Locus type	gene with protein product
Status	Approved
Aliases	KIAA0779
Ensembl gene	ENSG00000172765
Ensembl biotype	protein_coding
OMIM	616242
Entrez	23023

Gene structure

Transcript identifiers

Ensembl transcripts: 46 — 38 protein_coding, 6 protein_coding_CDS_not_defined, 2 retained_intron

ENST00000393238, ENST00000426664, ENST00000432054, ENST00000503256, ENST00000505616, ENST00000505924, ENST00000508729, ENST00000508869, ENST00000509440, ENST00000510323, ENST00000510521, ENST00000512902, ENST00000513411, ENST00000515024, ENST00000648771, ENST00000698214, ENST00000698215, ENST00000858270, ENST00000858271, ENST00000858272, ENST00000858273, ENST00000858274, ENST00000858275, ENST00000858276, ENST00000915954, ENST00000915955, ENST00000915956, ENST00000915957, ENST00000915958, ENST00000915959, ENST00000915960, ENST00000955168, ENST00000955169, ENST00000955170, ENST00000955171, ENST00000955172, ENST00000955173, ENST00000955174, ENST00000955175, ENST00000955176, ENST00000955177, ENST00000955178, ENST00000955179, ENST00000955180, ENST00000955181, ENST00000955182

RefSeq mRNA: 16 — MANE Select: NM_001017395 NM_001017395, NM_001128224, NM_001349263, NM_001349264, NM_001349265, NM_001349266, NM_001349268, NM_001349269, NM_001349270, NM_001349271, NM_001349272, NM_001349273, NM_001349274, NM_001349275, NM_001349276, NM_015008

CCDS: CCDS33855, CCDS93382, CCDS93383

Canonical transcript exons

ENST00000393238 — 7 exons

Exon	Start	End
ENSE00001194452	129654968	129655103
ENSE00001322029	129647792	129651795
ENSE00001404015	129832774	129832826
ENSE00001428379	129880309	129880559
ENSE00002216878	129827803	129828508
ENSE00003617457	129670330	129671264
ENSE00003920315	129893494	129893711

Expression profiles

Bgee: expression breadth ubiquitous, 292 present calls, max score 98.17.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 11.7358 / max 498.3795, expressed in 1756 samples.

FANTOM5 promoters (21 alternative TSS)

Promoter ID	TPM avg	Samples expressed
44569	8.0738	1719
44570	0.6079	293
44553	0.5500	159
44566	0.3172	113
44560	0.2792	126
44558	0.2199	92
44550	0.1915	38
44567	0.1828	73
44554	0.1767	98
44557	0.1759	76

Top tissues by expression

295 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
secondary oocyte	CL:0000655	98.17	gold quality
oocyte	CL:0000023	97.49	gold quality
dorsal motor nucleus of vagus nerve	UBERON:0002870	95.56	gold quality
colonic epithelium	UBERON:0000397	94.42	gold quality
sperm	CL:0000019	94.22	gold quality
biceps brachii	UBERON:0001507	93.98	gold quality
Brodmann (1909) area 23	UBERON:0013554	93.90	gold quality
skeletal muscle tissue of biceps brachii	UBERON:0004502	93.58	gold quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	93.25	gold quality
cortical plate	UBERON:0005343	93.24	gold quality
sural nerve	UBERON:0015488	93.21	gold quality
male germ cell	CL:0000015	92.59	gold quality
lateral nuclear group of thalamus	UBERON:0002736	92.40	gold quality
middle temporal gyrus	UBERON:0002771	92.31	gold quality
deltoid	UBERON:0001476	92.09	silver quality
skeletal muscle tissue	UBERON:0001134	92.08	gold quality
vastus lateralis	UBERON:0001379	91.77	gold quality
corpus callosum	UBERON:0002336	91.63	gold quality
substantia nigra pars reticulata	UBERON:0001966	91.55	gold quality
quadriceps femoris	UBERON:0001377	91.37	gold quality
palpebral conjunctiva	UBERON:0001812	91.36	gold quality
pons	UBERON:0000988	91.27	gold quality
germinal epithelium of ovary	UBERON:0001304	90.86	gold quality
lateral globus pallidus	UBERON:0002476	90.78	gold quality
substantia nigra pars compacta	UBERON:0001965	90.67	gold quality
muscle tissue	UBERON:0002385	90.52	gold quality
muscle organ	UBERON:0001630	90.36	gold quality
gall bladder	UBERON:0002110	90.25	gold quality
entorhinal cortex	UBERON:0002728	90.18	gold quality
gluteal muscle	UBERON:0002000	90.15	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	6.13

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• roles of TMCC1 in ER organization (PMID:24454821)

Cross-species orthologs

6 orthologs

Organism	Symbol	Gene ID
danio_rerio	tmcc1b	ENSDARG00000060954
danio_rerio	TMCC1	ENSDARG00000076747
mus_musculus	Tmcc1	ENSMUSG00000030126
rattus_norvegicus	Tmcc1	ENSRNOG00000011614
drosophila_melanogaster	Dmtn	FBGN0037443
caenorhabditis_elegans		WBGENE00015800

Paralogs (3): TMCC3 (ENSG00000057704), TMCC2 (ENSG00000133069), TEX28 (ENSG00000278057)

Protein

Protein identifiers

Transmembrane and coiled-coil domains protein 1 — O94876 (reviewed: O94876)

All UniProt accessions (6): O94876, A0A8V8TLJ9, D6RBT7, D6RH19, E9PC87, Q6N039

UniProt curated annotations — full annotation on UniProt →

Function. Endoplasmic reticulum membrane protein that promotes endoplasmic reticulum-associated endosome fission. Localizes to contact sites between the endoplasmic reticulum and endosomes and acts by promoting recruitment of the endoplasmic reticulum to endosome tubules for fission. Endosome membrane fission of early and late endosomes is essential to separate regions destined for lysosomal degradation from carriers to be recycled to the plasma membrane.

Subunit / interactions. May form homodimers and heterodimers with TMCC2 or TMCC3 via the coiled-coil domains. Interacts with ribosomal proteins RPL4 and RPS6.

Subcellular location. Endoplasmic reticulum membrane.

Similarity. Belongs to the TEX28 family.

Isoforms (2)

UniProt ID	Names	Canonical?
O94876-1	1	yes
O94876-2	2

RefSeq proteins (16): NP_001017395, NP_001121696, NP_001336192, NP_001336193, NP_001336194, NP_001336195, NP_001336197, NP_001336198, NP_001336199, NP_001336200, NP_001336201, NP_001336202, NP_001336203, NP_001336204, NP_001336205, NP_055823 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR019394	TEX28/TMCC	Family

Pfam: PF10267

UniProt features (27 total): compositionally biased region 7, region of interest 5, modified residue 3, topological domain 2, coiled-coil region 2, transmembrane region 2, splice variant 2, sequence conflict 2, chain 1, sequence variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-O94876-F1	63.55	0.27

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (3): 1, 382, 414

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 286 (showing top): GSE45365_NK_CELL_VS_CD8_TCELL_UP, GSE18804_SPLEEN_MACROPHAGE_VS_COLON_TUMORAL_MACROPHAGE_DN, RNGTGGGC_UNKNOWN, AP1_01, GOBP_ENDOSOME_ORGANIZATION, DACOSTA_UV_RESPONSE_VIA_ERCC3_XPCS_DN, TGCTGCT_MIR15A_MIR16_MIR15B_MIR195_MIR424_MIR497, FISCHER_G1_S_CELL_CYCLE, GOBP_VESICLE_ORGANIZATION, MORF_ATRX, IVANOVA_HEMATOPOIESIS_MATURE_CELL, TGACCTY_ERR1_Q2, GOBP_VESICLE_MEDIATED_TRANSPORT, BILD_SRC_ONCOGENIC_SIGNATURE, TTGGGAG_MIR150

GO Biological Process (5): endoplasmic reticulum organization (GO:0007029), endosomal transport (GO:0016197), membrane fission (GO:0090148), endosome membrane tubulation (GO:0097750), endosome fission (GO:0140285)

GO Molecular Function (2): identical protein binding (GO:0042802), protein binding (GO:0005515)

GO Cellular Component (7): endoplasmic reticulum membrane (GO:0005789), rough endoplasmic reticulum (GO:0005791), cytosol (GO:0005829), endomembrane system (GO:0012505), endoplasmic reticulum-endosome membrane contact site (GO:0140284), endoplasmic reticulum (GO:0005783), membrane (GO:0016020)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	3
cytoplasm	2
organelle organization	1
endomembrane system organization	1
vesicle-mediated transport	1
intracellular transport	1
membrane organization	1
endosome organization	1
membrane tubulation	1
organelle fission	1
protein binding	1
binding	1
organelle membrane	1
nuclear outer membrane-endoplasmic reticulum membrane network	1
endoplasmic reticulum subcompartment	1
endoplasmic reticulum	1
vacuole	1
plasma membrane	1
organelle membrane contact site	1
endomembrane system	1
intracellular membrane-bounded organelle	1

Protein interactions and networks

STRING

484 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
TMCC1	CFAP100	Q494V2	879
TMCC1	PODXL2	Q9NZ53	875
TMCC1	KLF15	Q9UIH9	847
TMCC1	PLXND1	Q9Y4D7	845
TMCC1	PLXNA1	Q9UIW2	688
TMCC1	CORO1C	Q9ULV4	639
TMCC1	GATA2	P23769	492
TMCC1	VSTM2B	A6NLU5	448
TMCC1	IST1	P53990	414
TMCC1	TMCO1	Q9UM00	377
TMCC1	ZFYVE27	Q5T4F4	355
TMCC1	RSRP1	Q9BUV0	327
TMCC1	SNX2	P82862	323
TMCC1	EFCAB8	A8MWE9	314
TMCC1	SPAST	Q9UBP0	313

IntAct

44 interactions, top by confidence:

A	B	Type	Score
YWHAG	BLTP3B	psi-mi:“MI:2364”(proximity)	0.640
TEX28	TMCC2	psi-mi:“MI:0914”(association)	0.640
YWHAB	BLTP3B	psi-mi:“MI:2364”(proximity)	0.610
YWHAH	BLTP3B	psi-mi:“MI:2364”(proximity)	0.570
SLC30A2	ESYT2	psi-mi:“MI:0914”(association)	0.530
ARHGEF4	TMCC1	psi-mi:“MI:0915”(physical association)	0.400
TMCC1	CBX5	psi-mi:“MI:0915”(physical association)	0.400
TMCC1	rstB	psi-mi:“MI:0915”(physical association)	0.370
TMCC1	ZDHHC17	psi-mi:“MI:0915”(physical association)	0.370
ESR1	ESYT2	psi-mi:“MI:0914”(association)	0.350
TEX28	NBAS	psi-mi:“MI:0914”(association)	0.350
HCN1	USP27X	psi-mi:“MI:0914”(association)	0.350
HCN1	POTEF	psi-mi:“MI:0914”(association)	0.350
MAPRE1	SCAMP1	psi-mi:“MI:0914”(association)	0.350
CXCR4	ESYT2	psi-mi:“MI:0914”(association)	0.350
SAAL1	TMEM223	psi-mi:“MI:0914”(association)	0.350
SLC39A4	GPR39	psi-mi:“MI:0914”(association)	0.350
TEX28	PRAF2	psi-mi:“MI:0914”(association)	0.350
TMCC1	TMCC2	psi-mi:“MI:0914”(association)	0.350
SLC19A2	TMEM223	psi-mi:“MI:0914”(association)	0.350
SLC30A5	NBAS	psi-mi:“MI:0914”(association)	0.350
SLC30A7	ESYT2	psi-mi:“MI:0914”(association)	0.350
SLC39A4	ESYT2	psi-mi:“MI:0914”(association)	0.350
SFN	BLTP3B	psi-mi:“MI:2364”(proximity)	0.270
YWHAB	E2F8	psi-mi:“MI:2364”(proximity)	0.270

BioGRID (38): TMCC1 (Two-hybrid), TMCC1 (Reconstituted Complex), TMCC1 (Affinity Capture-MS), TMCC1 (Affinity Capture-RNA), TMCC1 (Affinity Capture-MS), TMCC1 (Affinity Capture-RNA), TMCC1 (Affinity Capture-RNA), TMCC1 (Proximity Label-MS), CBX5 (Proximity Label-MS), TMCC1 (Proximity Label-MS), TMCC1 (Proximity Label-MS), TMCC1 (Proximity Label-MS), TMCC1 (Proximity Label-MS), TMCC1 (Affinity Capture-MS), TMCC1 (Proximity Label-MS)

ESM2 similar proteins: A0JNJ3, A0M8T5, A4IG66, F1Q930, F7AEX0, O00750, O15327, O48832, O94876, P35612, P97578, Q00PJ1, Q05764, Q07E15, Q07E28, Q09YG9, Q0P4J3, Q155Q3, Q1JPG0, Q2QLA2, Q2T9N1, Q2TBG9, Q2VUH7, Q3ZC62, Q4R4D7, Q4V8E4, Q5BJ78, Q5BLE2, Q5JTW2, Q5R5V7, Q5RA60, Q5T1M5, Q69ZZ6, Q6GR21, Q6INU2, Q6IP02, Q6NTW1, Q8BG50, Q8C5W4, Q8C6E0

Diamond homologs: O75069, O94876, Q69ZZ6, Q80W04, Q8R310, Q9ULS5

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 35 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Activation of BAD and translocation to mitochondria	7	213.2×	6e-14
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	7	188.1×	9e-14
SARS-CoV-1 targets host intracellular signalling and regulatory pathways	7	188.1×	9e-14
Activation of BH3-only proteins	7	139.0×	9e-13
RHO GTPases activate PKNs	7	88.8×	3e-11
Intrinsic Pathway for Apoptosis	7	82.0×	4e-11
FOXO-mediated transcription	5	67.2×	8e-08
SARS-CoV-1-host interactions	7	49.2×	1e-09

GO biological processes:

GO term	Partners	Fold	FDR
protein targeting	5	57.2×	3e-06
intracellular protein localization	8	26.2×	1e-07

Disease & clinical

Clinical variants and AI predictions

ClinVar

52 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	44
Likely benign	0
Benign	1

Top pathogenic / likely-pathogenic (0)

SpliceAI

2702 predictions. Top by Δscore:

Variant	Effect	Δscore
3:129651582:T:TA	donor_gain	1.0000
3:129654122:ATTT:A	donor_gain	1.0000
3:129654122:ATTTC:A	donor_gain	1.0000
3:129654965:AAC:A	donor_loss	1.0000
3:129654966:A:AC	donor_gain	1.0000
3:129654966:A:AT	donor_loss	1.0000
3:129654967:C:CC	donor_gain	1.0000
3:129655099:CACAT:C	acceptor_gain	1.0000
3:129655100:ACAT:A	acceptor_gain	1.0000
3:129655101:CAT:C	acceptor_gain	1.0000
3:129655101:CATC:C	acceptor_gain	1.0000
3:129655102:AT:A	acceptor_gain	1.0000
3:129655103:TCT:T	acceptor_loss	1.0000
3:129655104:C:CA	acceptor_loss	1.0000
3:129655104:C:CC	acceptor_gain	1.0000
3:129655105:T:C	acceptor_loss	1.0000
3:129671260:TCGAT:T	acceptor_gain	1.0000
3:129671261:CGAT:C	acceptor_gain	1.0000
3:129671261:CGATC:C	acceptor_gain	1.0000
3:129671263:AT:A	acceptor_gain	1.0000
3:129671264:TC:T	acceptor_loss	1.0000
3:129671265:C:CC	acceptor_gain	1.0000
3:129671265:CTAGT:C	acceptor_loss	1.0000
3:129671268:G:C	acceptor_gain	1.0000
3:129671268:G:GC	acceptor_gain	1.0000
3:129671270:G:GC	acceptor_gain	1.0000
3:129822569:T:A	donor_gain	1.0000
3:129822586:ATTT:A	donor_gain	1.0000
3:129651578:AACGT:A	donor_gain	0.9900
3:129651793:CTC:C	acceptor_gain	0.9900

AlphaMissense

4297 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
3:129651641:A:G	L601S	1.000
3:129651662:A:G	L594P	1.000
3:129651662:A:T	L594Q	1.000
3:129651752:A:G	L564P	1.000
3:129651770:C:G	R558P	1.000
3:129651788:A:G	L552P	1.000
3:129651792:C:G	A551P	1.000
3:129654978:C:G	R546P	1.000
3:129654984:C:G	R544P	1.000
3:129654994:A:G	S541P	1.000
3:129655000:A:C	Y539D	1.000
3:129655000:A:G	Y539H	1.000
3:129655026:A:G	L530P	1.000
3:129655038:A:G	L526S	1.000
3:129655056:T:G	Q520P	1.000
3:129655060:G:C	H519D	1.000
3:129655062:A:G	L518P	1.000
3:129655071:A:G	L515P	1.000
3:129655080:A:G	L512P	1.000
3:129655083:T:G	Q511P	1.000
3:129670998:A:C	F281L	1.000
3:129670998:A:T	F281L	1.000
3:129671000:A:G	F281L	1.000
3:129671053:A:G	L263S	1.000
3:129671057:A:G	Y262H	1.000
3:129651630:A:G	S605P	0.999
3:129651632:A:T	V604D	0.999
3:129651641:A:C	L601W	0.999
3:129651647:A:T	V599D	0.999
3:129651651:C:G	A598P	0.999

dbSNP variants (sampled 300 via entrez): RS1000003865 (3:129754511 C>T), RS1000010079 (3:129708526 A>G), RS1000018136 (3:129795093 A>T), RS1000022178 (3:129707271 C>A,T), RS1000034064 (3:129692188 T>A,C), RS1000049429 (3:129744837 T>C), RS1000051139 (3:129806497 T>C), RS1000070869 (3:129705604 A>C,T), RS1000071541 (3:129707029 T>C,G), RS1000073087 (3:129877244 T>C), RS1000095699 (3:129700265 C>A,T), RS1000101892 (3:129845422 A>G), RS1000102338 (3:129888269 C>A,T), RS1000110711 (3:129761440 G>A), RS1000113029 (3:129701748 C>T)

Disease associations

OMIM: gene MIM:616242 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

31 associations (top):

Study	Trait	p-value
GCST001585_20	Breast size	5.000000e-07
GCST005956_82	Waist-to-hip ratio adjusted for BMI	2.000000e-07
GCST005958_5	Waist-to-hip ratio adjusted for BMI (age >50)	4.000000e-10
GCST005962_16	Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test)	2.000000e-11
GCST008163_451	Height	4.000000e-07
GCST009379_134	Type 2 diabetes	4.000000e-08
GCST009379_135	Type 2 diabetes	7.000000e-06
GCST012227_1259	Hip circumference adjusted for BMI	4.000000e-12
GCST012229_48	Hip index	2.000000e-08
GCST90020024_1265	A body shape index	2.000000e-14
GCST90020024_1267	A body shape index	8.000000e-10
GCST90020025_461	Waist-to-hip ratio adjusted for BMI	5.000000e-15
GCST90020025_463	Waist-to-hip ratio adjusted for BMI	9.000000e-09
GCST90020025_465	Waist-to-hip ratio adjusted for BMI	2.000000e-22
GCST90020025_466	Waist-to-hip ratio adjusted for BMI	9.000000e-24
GCST90020026_113	Hip index	3.000000e-09
GCST90020026_114	Hip index	3.000000e-28
GCST90020026_115	Hip index	1.000000e-20
GCST90020026_116	Hip index	1.000000e-15
GCST90020026_117	Hip index	3.000000e-08
GCST90020027_302	Waist-hip index	9.000000e-09
GCST90020027_304	Waist-hip index	5.000000e-22
GCST90020027_305	Waist-hip index	5.000000e-23
GCST90020027_311	Waist-hip index	2.000000e-14
GCST90020028_1709	Hip circumference adjusted for BMI	6.000000e-29
GCST90020028_1710	Hip circumference adjusted for BMI	2.000000e-19
GCST90020028_1711	Hip circumference adjusted for BMI	8.000000e-12
GCST90020028_1856	Hip circumference adjusted for BMI	2.000000e-11
GCST90020028_1857	Hip circumference adjusted for BMI	1.000000e-08
GCST90020028_1858	Hip circumference adjusted for BMI	1.000000e-31

EFO canonical traits (5, from GWAS)

EFO ID	Trait name
EFO:0007788	BMI-adjusted waist-hip ratio
EFO:0008007	age at assessment
EFO:0008343	sex interaction measurement
EFO:0008039	BMI-adjusted hip circumference
EFO:0007789	BMI-adjusted waist circumference

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

PharmGKB variants

1 variants.

Variant	Genes	Level	Score	#Clin annots	Drugs
rs2811332	TMCC1		0.00	0

CTD chemical–gene interactions

45 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects cotreatment, decreases expression, affects expression, decreases methylation	7
Tetrachlorodibenzodioxin	affects expression, increases expression	4
Benzo(a)pyrene	affects methylation, decreases expression, increases expression, increases methylation	3
Cyclosporine	decreases expression, increases expression	3
bisphenol A	affects expression, affects cotreatment, decreases methylation	2
Estradiol	affects cotreatment, increases expression	2
Formaldehyde	decreases expression	2
Aflatoxin B1	decreases expression, decreases methylation	2
Cadmium Chloride	increases expression	2
aristolochic acid I	decreases expression	1
FR900359	increases phosphorylation	1
triphenyl phosphate	affects expression	1
trichostatin A	decreases expression	1
tris(1,3-dichloro-2-propyl)phosphate	decreases expression	1
butyraldehyde	decreases expression	1
9,10-dihydro-9,10-dihydroxybenzo(a)pyrene	increases expression	1
potassium chromate(VI)	affects cotreatment, decreases expression	1
2,3-bis(3’-hydroxybenzyl)butyrolactone	affects cotreatment, decreases expression	1
resorcinol	increases expression	1
epigallocatechin gallate	affects cotreatment, decreases expression	1
di-n-butylphosphoric acid	affects expression	1
CGP 52608	affects binding, increases reaction	1
monomethylarsonous acid	increases expression	1
K 7174	decreases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, decreases expression	1
abrine	decreases expression	1
2,2’,4,4’-tetrabromodiphenyl ether	decreases expression	1
dorsomorphin	affects cotreatment, decreases expression	1
eprenetapopt	affects expression, affects reaction	1
Zoledronic Acid	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.