TMED1

Summary

TMED1 (transmembrane p24 trafficking protein 1, HGNC:17291) is a protein-coding gene on chromosome 19p13.2, encoding Transmembrane emp24 domain-containing protein 1 (Q13445). Potential role in vesicular protein trafficking, mainly in the early secretory pathway.

This gene belongs to the TMED (transmembrane emp24 domain-containing) protein family, which is involved in the vesicular trafficking of proteins. The protein encoded by this gene was identified by its interaction with interleukin 1 receptor-like 1 (IL1RL1) and may play a role in innate immunity. This protein lacks any similarity to other interleukin 1 ligands. Alternative splicing results in multiple transcript variants of this gene.

Source: NCBI Gene 11018 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 49 total
• MANE Select transcript: NM_006858

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:17291
Approved symbol	TMED1
Name	transmembrane p24 trafficking protein 1
Location	19p13.2
Locus type	gene with protein product
Status	Approved
Aliases	ST2L, MGC1270, IL1RL1LG, Il1rl1l, p24gamma1, p24g1
Ensembl gene	ENSG00000099203
Ensembl biotype	protein_coding
OMIM	605395
Entrez	11018

Gene structure

Transcript identifiers

Ensembl transcripts: 8 — 6 protein_coding, 2 nonsense_mediated_decay

ENST00000214869, ENST00000586835, ENST00000588259, ENST00000588289, ENST00000589638, ENST00000591157, ENST00000591695, ENST00000941053

RefSeq mRNA: 1 — MANE Select: NM_006858 NM_006858

CCDS: CCDS12249

Canonical transcript exons

ENST00000214869 — 4 exons

Exon	Start	End
ENSE00000888260	10832067	10833213
ENSE00002887657	10836009	10836212
ENSE00003462337	10835256	10835353
ENSE00003475959	10834934	10835117

Expression profiles

Bgee: expression breadth ubiquitous, 281 present calls, max score 94.97.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 12.7500 / max 85.2862, expressed in 1801 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
179176	7.6978	1739
179177	5.0522	1712

Top tissues by expression

296 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
stromal cell of endometrium	CL:0002255	94.97	gold quality
apex of heart	UBERON:0002098	93.74	gold quality
hindlimb stylopod muscle	UBERON:0004252	92.57	gold quality
gastrocnemius	UBERON:0001388	92.55	gold quality
muscle of leg	UBERON:0001383	92.07	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	91.20	gold quality
adenohypophysis	UBERON:0002196	91.11	gold quality
right lobe of liver	UBERON:0001114	91.02	gold quality
right uterine tube	UBERON:0001302	90.68	gold quality
left ovary	UBERON:0002119	90.33	gold quality
pituitary gland	UBERON:0000007	90.30	gold quality
heart left ventricle	UBERON:0002084	90.30	gold quality
muscle organ	UBERON:0001630	90.27	gold quality
cardiac ventricle	UBERON:0002082	90.04	gold quality
metanephros cortex	UBERON:0010533	90.01	gold quality
right adrenal gland	UBERON:0001233	89.99	gold quality
right ovary	UBERON:0002118	89.99	gold quality
endocervix	UBERON:0000458	89.82	gold quality
right adrenal gland cortex	UBERON:0035827	89.80	gold quality
adult mammalian kidney	UBERON:0000082	89.69	gold quality
left adrenal gland	UBERON:0001234	89.66	gold quality
periodontal ligament	UBERON:0008266	89.24	gold quality
left adrenal gland cortex	UBERON:0035825	89.20	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	88.95	gold quality
adrenal cortex	UBERON:0001235	88.92	gold quality
granulocyte	CL:0000094	88.88	gold quality
right lobe of thyroid gland	UBERON:0001119	88.86	gold quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	88.82	gold quality
body of pancreas	UBERON:0001150	88.81	gold quality
heart	UBERON:0000948	88.77	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	6.17

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

45 targeting TMED1, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4283	100.00	66.42	2097
HSA-MIR-3910	99.95	71.13	2227
HSA-MIR-124-3P	99.89	73.74	3043
HSA-MIR-506-3P	99.89	73.55	3057
HSA-MIR-221-5P	99.86	65.45	1052
HSA-MIR-8073	99.86	65.21	1118
HSA-MIR-4728-5P	99.85	69.39	4718
HSA-MIR-6785-5P	99.82	68.68	4428
HSA-MIR-4659A-3P	99.80	72.62	4248
HSA-MIR-4659B-3P	99.80	72.62	4248
HSA-MIR-1273H-5P	99.77	66.32	2471
HSA-MIR-4319	99.76	69.83	2586
HSA-MIR-149-3P	99.72	68.22	3963
HSA-MIR-3714	99.71	70.74	2671
HSA-MIR-6883-5P	99.69	68.05	3785
HSA-MIR-6887-3P	99.66	67.83	1778
HSA-MIR-7150	99.62	66.80	1322
HSA-MIR-8064	99.45	66.92	875
HSA-MIR-4762-3P	99.43	69.72	2363
HSA-MIR-125A-5P	99.36	70.59	1640
HSA-MIR-125B-5P	99.36	70.36	1662
HSA-MIR-128-1-5P	99.33	60.46	332
HSA-MIR-5582-5P	99.27	71.42	1879
HSA-MIR-8070	99.07	69.30	1303
HSA-MIR-4695-5P	99.06	64.87	1151
HSA-MIR-3619-5P	99.00	68.87	2308
HSA-MIR-214-3P	98.71	68.12	2128
HSA-MIR-761	98.71	68.07	2051
HSA-MIR-1227-5P	98.65	65.32	1549
HSA-MIR-12125	98.59	67.54	1044

Literature-anchored findings (GeneRIF, showing 3)

• ST2L is stably and selectively expressed on human Th2, Tc2 and NK2 lymphocyte lines and can be used as a marker for determining shifts in immune status of human diseases such as HIV infection. (PMID:11466339)
• The GOLD domain-containing protein TMED1 is involved in interleukin-33 signaling (PMID:23319592)
• Structural and thermodynamic analyses of human TMED1 (p24gamma1) Golgi dynamics. (PMID:34634369)

Cross-species orthologs

6 orthologs

Organism	Symbol	Gene ID
danio_rerio	tmed1b	ENSDARG00000017255
danio_rerio	tmed1a	ENSDARG00000031325
mus_musculus	Tmed1	ENSMUSG00000032180
rattus_norvegicus	Tmed1	ENSRNOG00000008037
drosophila_melanogaster	p24-1	FBGN0030341
caenorhabditis_elegans		WBGENE00011606

Paralogs (8): TMED2 (ENSG00000086598), TMED5 (ENSG00000117500), TMED7 (ENSG00000134970), TMED6 (ENSG00000157315), TMED4 (ENSG00000158604), TMED3 (ENSG00000166557), TMED10 (ENSG00000170348), TMED9 (ENSG00000184840)

Protein

Protein identifiers

Transmembrane emp24 domain-containing protein 1 — Q13445 (reviewed: Q13445)

Alternative names: Interleukin-1 receptor-like 1 ligand, Putative T1/ST2 receptor-binding protein, p24 family protein gamma-1

All UniProt accessions (7): Q13445, K7EIN4, K7EIR1, K7EQ63, K7ER03, K7ERK5, K7ES06

UniProt curated annotations — full annotation on UniProt →

Function. Potential role in vesicular protein trafficking, mainly in the early secretory pathway. May act as a cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and may be involved in vesicle coat formation at the cytoplasmic side. Plays a positive role in IL-33-mediated IL-8 and IL-6 production by interacting with interleukin-33 receptor IL1RL1. Also plays a role in the modulation of innate immune signaling through the cGAS-STING pathway by interacting with RNF26.

Subunit / interactions. Homodimer in endoplasmic reticulum, endoplasmic reticulum-Golgi intermediate compartment and cis-Golgi network. Interacts with IL1RL1. Interacts with RNF26; this interaction is important to modulate innate immune signaling through the cGAS-STING pathway.

Subcellular location. Cell membrane. Endoplasmic reticulum membrane. Golgi apparatus. cis-Golgi network membrane. Endoplasmic reticulum-Golgi intermediate compartment membrane.

Tissue specificity. Widely expressed.

Miscellaneous. Found only in very low concentrations in the endoplasmic reticulum, Golgi apparatus and endoplasmic reticulum-Golgi intermediate compartment compared to other members of the EMP24/GP25L family.

Similarity. Belongs to the EMP24/GP25L family.

RefSeq proteins (1): NP_006849* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR009038	GOLD_dom	Domain
IPR015720	Emp24-like	Family
IPR036598	GOLD_dom_sf	Homologous_superfamily

Pfam: PF01105

UniProt features (19 total): strand 7, mutagenesis site 2, topological domain 2, short sequence motif 2, signal peptide 1, chain 1, transmembrane region 1, domain 1, coiled-coil region 1, sequence variant 1

Structure

Experimental structures (PDB)

1 structures.

PDB	Method	Resolution (Å)
7RRM	X-RAY DIFFRACTION	1.72

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q13445-F1	83.68	0.54

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Mutagenesis-validated functional residues (2):

Position	Phenotype
45	significant loss of interaction with il1rl1.
106	significant loss of interaction with il1rl1.

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 144 (showing top): GSE18804_SPLEEN_MACROPHAGE_VS_COLON_TUMORAL_MACROPHAGE_DN, GOBP_INTRACELLULAR_PROTEIN_TRANSPORT, DACOSTA_UV_RESPONSE_VIA_ERCC3_UP, AREB6_01, GOBP_VESICLE_MEDIATED_TRANSPORT, MODULE_70, GOBP_CELL_CELL_SIGNALING, GTGCCTT_MIR506, GOBP_DEFENSE_RESPONSE_TO_OTHER_ORGANISM, GOBP_ENDOPLASMIC_RETICULUM_TO_GOLGI_VESICLE_MEDIATED_TRANSPORT, GOCC_COATED_VESICLE, GOBP_ENDOMEMBRANE_SYSTEM_ORGANIZATION, GOMF_SIGNALING_RECEPTOR_BINDING, TGCCTTA_MIR124A, GOBP_GOLGI_ORGANIZATION

GO Biological Process (8): intracellular protein transport (GO:0006886), endoplasmic reticulum to Golgi vesicle-mediated transport (GO:0006888), Golgi organization (GO:0007030), signal transduction (GO:0007165), cell-cell signaling (GO:0007267), innate immune response (GO:0045087), immune system process (GO:0002376), protein transport (GO:0015031)

GO Molecular Function (2): signaling receptor binding (GO:0005102), protein binding (GO:0005515)

GO Cellular Component (8): endoplasmic reticulum (GO:0005783), endoplasmic reticulum membrane (GO:0005789), endoplasmic reticulum-Golgi intermediate compartment (GO:0005793), Golgi apparatus (GO:0005794), plasma membrane (GO:0005886), COPII-coated ER to Golgi transport vesicle (GO:0030134), endoplasmic reticulum-Golgi intermediate compartment membrane (GO:0033116), membrane (GO:0016020)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cytoplasm	4
intracellular membrane-bounded organelle	3
intracellular protein localization	2
intracellular transport	2
cell communication	2
signaling	2
endomembrane system	2
protein transport	1
intercellular transport	1
Golgi vesicle transport	1
organelle organization	1
endomembrane system organization	1
cellular process	1
regulation of cellular process	1
cellular response to stimulus	1
immune response	1
defense response to symbiont	1
biological_process	1
transport	1
establishment of protein localization	1
protein binding	1
binding	1
organelle membrane	1
nuclear outer membrane-endoplasmic reticulum membrane network	1
endoplasmic reticulum subcompartment	1
membrane	1
cell periphery	1
coated vesicle	1
endoplasmic reticulum-Golgi intermediate compartment	1
bounding membrane of organelle	1
cellular anatomical structure	1

Protein interactions and networks

STRING

582 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
TMED1	IL1RL1	Q01638	814
TMED1	TMED9	Q9BVK6	678
TMED1	TMED10	P49755	631
TMED1	TMED4	Q7Z7H5	622
TMED1	ENDOD1	O94919	550
TMED1	TMEM33	P57088	529
TMED1	C3orf18	Q9UK00	497
TMED1	IL1RN	P18510	493
TMED1	FAM8A1	Q9UBU6	490
TMED1	E9PSI1	E9PSI1	479
TMED1	GFRAL	Q6UXV0	461
TMED1	APP	P05067	459
TMED1	PRSS57	Q6UWY2	455
TMED1	RNF26	Q9BY78	451
TMED1	DENND1A	Q8TEH3	445

IntAct

93 interactions, top by confidence:

A	B	Type	Score
CDK5RAP3	UFL1	psi-mi:“MI:0914”(association)	0.870
SGF29	NDC80	psi-mi:“MI:0914”(association)	0.840
EXOC1	EXOC5	psi-mi:“MI:0914”(association)	0.730
TMED10	TMED1	psi-mi:“MI:0914”(association)	0.730
TMED9	TMED10	psi-mi:“MI:0914”(association)	0.730
DDRGK1	UFL1	psi-mi:“MI:0914”(association)	0.710
TMED2	ATP9A	psi-mi:“MI:0914”(association)	0.640
RAF1	CALU	psi-mi:“MI:0914”(association)	0.640
CHST8	CANX	psi-mi:“MI:0914”(association)	0.640
FGF3	GTPBP10	psi-mi:“MI:0914”(association)	0.530
SPPL2B	UQCRQ	psi-mi:“MI:0914”(association)	0.530
JPH4	ZSWIM8	psi-mi:“MI:0914”(association)	0.530
CD226	MEN1	psi-mi:“MI:0914”(association)	0.530
CDK5RAP3	PLD2	psi-mi:“MI:0914”(association)	0.530
CREB3	MYO9A	psi-mi:“MI:0914”(association)	0.530
EXOC3	TMED1	psi-mi:“MI:0914”(association)	0.510
JUN	NKRF	psi-mi:“MI:0914”(association)	0.460
TMED1	TMED1	psi-mi:“MI:0915”(physical association)	0.400
GPC1	SNAP23	psi-mi:“MI:0915”(physical association)	0.400
GPC1	GANAB	psi-mi:“MI:0915”(physical association)	0.400
TMED1	F2RL1	psi-mi:“MI:0915”(physical association)	0.370
TMED1	GPR37	psi-mi:“MI:0915”(physical association)	0.370
TMED1	LTB4R2	psi-mi:“MI:0915”(physical association)	0.370
SMAD3	TMED1	psi-mi:“MI:0915”(physical association)	0.370
Tmed10	TARS3	psi-mi:“MI:0914”(association)	0.350
Tmed10	NDUFS8	psi-mi:“MI:0914”(association)	0.350

BioGRID (103): TMED1 (Affinity Capture-MS), TMED1 (Affinity Capture-MS), TMED1 (Affinity Capture-MS), TMED1 (Affinity Capture-MS), TMED1 (Affinity Capture-MS), TMED1 (Affinity Capture-MS), TMED1 (Affinity Capture-MS), TMED1 (Affinity Capture-MS), TMED1 (Affinity Capture-MS), TMED1 (Affinity Capture-MS), TMED1 (Affinity Capture-MS), TMED1 (Affinity Capture-MS), TMED1 (Affinity Capture-MS), TMED1 (Affinity Capture-MS), TMED1 (Affinity Capture-MS)

ESM2 similar proteins: A5PK45, A6NDV4, B1AWJ5, O14908, O18735, O60568, O70422, O97583, P04626, P06494, P52849, P52850, P60027, P70424, Q0GA42, Q13445, Q1WIM1, Q28BQ6, Q2KJ84, Q2TBK5, Q3V009, Q5BK85, Q5R6K5, Q5R7E6, Q5R809, Q5U367, Q5ZIW1, Q60553, Q6AXN3, Q6AY25, Q6IEE7, Q78IS1, Q7Z4H8, Q812F8, Q8BRK9, Q8K297, Q8NBJ5, Q8NFZ8, Q8R464, Q92759

Diamond homologs: A7SXK3, D3ZTX0, O13770, O17528, P49020, Q13445, Q15363, Q28BQ6, Q2KJ84, Q2TBK5, Q3T133, Q3V009, Q54BN0, Q5BK85, Q5I0E7, Q5R7E6, Q5R809, Q63524, Q6AXN3, Q6AY25, Q769F9, Q78IS1, Q7Z7H5, Q99KF1, Q9BVK6, Q9CXE7, Q9R0Q3, Q9Y3A6, Q9Y3B3, Q9Y3Q3, P39704, Q12450

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 116 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

GO biological processes:

GO term	Partners	Fold	FDR
response to endoplasmic reticulum stress	7	11.0×	1e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

49 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	37
Likely benign	1
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

550 predictions. Top by Δscore:

Variant	Effect	Δscore
19:10833209:GACTC:G	acceptor_gain	1.0000
19:10833210:ACTC:A	acceptor_gain	1.0000
19:10833211:CTC:C	acceptor_gain	1.0000
19:10833211:CTCC:C	acceptor_gain	1.0000
19:10833212:TC:T	acceptor_gain	1.0000
19:10833212:TCCT:T	acceptor_gain	1.0000
19:10833213:CC:C	acceptor_gain	1.0000
19:10833213:CCTAC:C	acceptor_loss	1.0000
19:10833214:C:CC	acceptor_gain	1.0000
19:10833215:T:G	acceptor_loss	1.0000
19:10833222:C:CT	acceptor_gain	1.0000
19:10833223:A:T	acceptor_gain	1.0000
19:10834929:CACA:C	donor_loss	1.0000
19:10834930:ACACC:A	donor_loss	1.0000
19:10834931:CACC:C	donor_loss	1.0000
19:10834932:A:AC	donor_gain	1.0000
19:10834933:C:CA	donor_gain	1.0000
19:10834933:C:CC	donor_gain	1.0000
19:10834933:C:CT	donor_loss	1.0000
19:10834944:T:TA	donor_gain	1.0000
19:10834956:T:TA	donor_gain	1.0000
19:10835113:CCACC:C	acceptor_gain	1.0000
19:10835114:CACC:C	acceptor_gain	1.0000
19:10835114:CACCC:C	acceptor_gain	1.0000
19:10835116:CC:C	acceptor_gain	1.0000
19:10835117:CC:C	acceptor_gain	1.0000
19:10835118:C:CC	acceptor_gain	1.0000
19:10835118:C:T	acceptor_gain	1.0000
19:10835123:C:CT	acceptor_gain	1.0000
19:10835250:A:C	donor_gain	1.0000

AlphaMissense

1478 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
19:10835072:G:C	N109K	1.000
19:10835072:G:T	N109K	1.000
19:10833131:C:G	R183P	0.999
19:10835079:A:G	F107S	0.999
19:10835039:G:C	F120L	0.998
19:10835039:G:T	F120L	0.998
19:10835041:A:G	F120L	0.998
19:10833141:C:G	A180P	0.997
19:10835043:A:T	V119E	0.997
19:10835063:G:C	S112R	0.997
19:10835063:G:T	S112R	0.997
19:10835065:T:G	S112R	0.997
19:10835066:G:C	F111L	0.997
19:10835066:G:T	F111L	0.997
19:10835068:A:G	F111L	0.997
19:10835073:T:A	N109I	0.997
19:10835079:A:C	F107C	0.997
19:10835082:C:G	C106S	0.997
19:10835083:A:G	C106R	0.997
19:10835083:A:T	C106S	0.997
19:10835316:A:G	L74P	0.997
19:10835322:A:G	F72S	0.997
19:10836013:T:C	Y60C	0.997
19:10833137:C:G	R181P	0.996
19:10833175:G:C	S168R	0.996
19:10833175:G:T	S168R	0.996
19:10833177:T:G	S168R	0.996
19:10835064:C:A	S112I	0.996
19:10835092:A:C	Y103D	0.996
19:10835098:C:A	G101W	0.996

dbSNP variants (sampled 300 via entrez): RS1000966057 (19:10837700 G>A,T), RS1002826531 (19:10835317 G>A,C), RS1002865126 (19:10832381 C>A,T), RS1002929105 (19:10832197 C>G,T), RS1003688947 (19:10836543 G>A,T), RS1003920864 (19:10833218 A>G), RS1004411238 (19:10834639 C>A,T), RS1006130665 (19:10837166 A>G), RS1006209341 (19:10834836 G>A,T), RS1006264656 (19:10834614 G>A,C), RS1006342777 (19:10832208 C>T), RS1006887596 (19:10836996 A>C,T), RS1006938468 (19:10836777 C>A,T), RS1007247015 (19:10831653 C>T), RS1008445844 (19:10831894 G>A)

Disease associations

OMIM: gene MIM:605395 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

17 total (human), top 17 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects expression, decreases expression	3
Cadmium Chloride	decreases reaction, increases abundance, increases palmitoylation, decreases expression	2
triphenyl phosphate	affects expression	1
propionaldehyde	decreases expression	1
sodium arsenite	decreases expression	1
2-bromopalmitate	decreases reaction, increases abundance, increases palmitoylation	1
ICG 001	increases expression	1
bisphenol B	increases expression	1
abrine	increases expression	1
bisphenol S	increases expression	1
bisphenol AF	increases expression	1
4-(4-((5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl)methylene)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)benzoic acid	increases expression	1
Vorinostat	decreases expression	1
Cadmium	decreases reaction, increases abundance, increases palmitoylation	1
Cytarabine	decreases expression	1
Ivermectin	decreases expression	1
Smoke	decreases expression	1

Cellosaurus cell lines

4 cell lines: 4 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_C7YT	HAP1 TMED1 (-) 1	Cancer cell line	Male
CVCL_C7YU	HAP1 TMED1 (-) 2	Cancer cell line	Male
CVCL_C7YV	HAP1 TMED1 (-) 3	Cancer cell line	Male
CVCL_C7YW	HAP1 TMED1 (-) 4	Cancer cell line	Male

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.