TMED5

Summary

TMED5 (transmembrane p24 trafficking protein 5, HGNC:24251) is a protein-coding gene on chromosome 1p22.1, encoding Transmembrane emp24 domain-containing protein 5 (Q9Y3A6). Potential role in vesicular protein trafficking, mainly in the early secretory pathway.

Involved in Golgi ribbon formation. Located in cis-Golgi network; endoplasmic reticulum exit site; and endoplasmic reticulum-Golgi intermediate compartment.

Source: NCBI Gene 50999 — RefSeq curated summary.

At a glance

• GWAS associations: 1
• Clinical variants (ClinVar): 23 total
• MANE Select transcript: NM_016040

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:24251
Approved symbol	TMED5
Name	transmembrane p24 trafficking protein 5
Location	1p22.1
Locus type	gene with protein product
Status	Approved
Aliases	CGI-100, p24g2, p24gamma2
Ensembl gene	ENSG00000117500
Ensembl biotype	protein_coding
OMIM	616876
Entrez	50999

Gene structure

Transcript identifiers

Ensembl transcripts: 10 — 8 protein_coding, 1 nonsense_mediated_decay, 1 protein_coding_CDS_not_defined

ENST00000370280, ENST00000370282, ENST00000370290, ENST00000479918, ENST00000483033, ENST00000909499, ENST00000909500, ENST00000909501, ENST00000909502, ENST00000935198

RefSeq mRNA: 3 — MANE Select: NM_016040 NM_001167830, NM_001410825, NM_016040

CCDS: CCDS53342, CCDS743, CCDS91003

Canonical transcript exons

ENST00000370282 — 4 exons

Exon	Start	End
ENSE00001285089	93180054	93180413
ENSE00001945361	93149742	93154888
ENSE00003068067	93160129	93160226
ENSE00003503514	93156300	93156483

Expression profiles

Bgee: expression breadth ubiquitous, 294 present calls, max score 98.02.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 47.7636 / max 371.8702, expressed in 1825 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
13300	45.5184	1824
13299	1.4329	777
13302	0.7519	363
13301	0.0604	11

Top tissues by expression

295 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
skeletal muscle tissue of biceps brachii	UBERON:0004502	98.02	gold quality
parietal pleura	UBERON:0002400	98.00	gold quality
biceps brachii	UBERON:0001507	97.87	gold quality
corpus epididymis	UBERON:0004359	97.83	gold quality
choroid plexus epithelium	UBERON:0003911	97.60	gold quality
pleura	UBERON:0000977	97.56	gold quality
sperm	CL:0000019	97.40	gold quality
mucosa of sigmoid colon	UBERON:0004993	97.15	gold quality
jejunal mucosa	UBERON:0000399	96.90	gold quality
visceral pleura	UBERON:0002401	96.89	gold quality
diaphragm	UBERON:0001103	96.87	gold quality
decidua	UBERON:0002450	96.87	gold quality
pigmented layer of retina	UBERON:0001782	96.86	gold quality
colonic mucosa	UBERON:0000317	96.76	gold quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	96.67	gold quality
nephron tubule	UBERON:0001231	96.36	gold quality
superficial temporal artery	UBERON:0001614	96.36	gold quality
lower lobe of lung	UBERON:0008949	96.33	gold quality
renal glomerulus	UBERON:0000074	96.30	gold quality
cartilage tissue	UBERON:0002418	96.27	gold quality
pericardium	UBERON:0002407	96.21	gold quality
heart right ventricle	UBERON:0002080	96.20	gold quality
metanephric glomerulus	UBERON:0004736	96.14	gold quality
male germ cell	CL:0000015	95.93	gold quality
cauda epididymis	UBERON:0004360	95.90	gold quality
bronchial epithelial cell	CL:0002328	95.84	gold quality
caput epididymis	UBERON:0004358	95.67	gold quality
palpebral conjunctiva	UBERON:0001812	95.60	gold quality
adrenal tissue	UBERON:0018303	95.55	gold quality
germinal epithelium of ovary	UBERON:0001304	95.48	gold quality

Single-cell (SCXA)

Detected in 3 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	13.55
E-CURD-112	no	2.55
E-MTAB-9543	no	2.36

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

220 targeting TMED5, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4795-3P	100.00	74.62	4024
HSA-MIR-3646	100.00	73.56	5283
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-340-5P	100.00	72.50	4437
HSA-MIR-5692A	100.00	74.40	6850
HSA-MIR-3924	100.00	72.09	2394
HSA-MIR-450A-1-3P	100.00	69.33	1837
HSA-MIR-4282	99.99	75.36	6408
HSA-MIR-548C-3P	99.99	74.01	7587
HSA-MIR-548AW	99.99	72.57	3559
HSA-MIR-371B-5P	99.99	75.34	4759
HSA-MIR-186-5P	99.99	70.83	3707
HSA-MIR-511-3P	99.99	68.85	1467
HSA-MIR-3662	99.99	73.82	5684
HSA-MIR-4500	99.99	72.72	2367
HSA-MIR-4775	99.98	75.00	6394
HSA-MIR-373-5P	99.98	75.36	4753
HSA-MIR-616-5P	99.98	75.58	4775
HSA-MIR-5696	99.98	72.36	4487
HSA-MIR-520D-5P	99.98	73.34	4883
HSA-MIR-524-5P	99.98	73.43	4882
HSA-MIR-433-3P	99.98	69.37	1203
HSA-MIR-8068	99.98	73.85	2376
HSA-MIR-607	99.97	73.62	5593
HSA-MIR-590-3P	99.96	74.34	6478
HSA-MIR-3658	99.96	73.87	4379
HSA-MIR-1468-3P	99.96	72.74	3797
HSA-MIR-1250-3P	99.96	70.04	4038
HSA-MIR-23A-3P	99.95	74.24	3163
HSA-MIR-23B-3P	99.95	74.24	3163

Literature-anchored findings (GeneRIF, showing 4)

• Expression of cgi-100 mRNA decreased in a dose- and time-dependent manner in the K562 cells treated with matrine and over-expression of cgi-100 elevates the proliferation and the immaturity level of K562 cells. (PMID:18549622)
• The luminal alpha-helical but not GOLD domain of p24gamma2 was required for efficient GPI-AP transport. (PMID:24778190)
• Identification of a novel circ_0018289/miR-183-5p/TMED5 regulatory network in cervical cancer development. (PMID:34404391)
• Silencing of TMED5 inhibits proliferation, migration and invasion, and enhances apoptosis of hepatocellular carcinoma cells. (PMID:36530030)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	tmed5	ENSDARG00000008765
mus_musculus	Tmed5	ENSMUSG00000063406
rattus_norvegicus	Tmed5	ENSRNOG00000000073
drosophila_melanogaster	p24-1	FBGN0030341
caenorhabditis_elegans		WBGENE00011606

Paralogs (8): TMED2 (ENSG00000086598), TMED1 (ENSG00000099203), TMED7 (ENSG00000134970), TMED6 (ENSG00000157315), TMED4 (ENSG00000158604), TMED3 (ENSG00000166557), TMED10 (ENSG00000170348), TMED9 (ENSG00000184840)

Protein

Protein identifiers

Transmembrane emp24 domain-containing protein 5 — Q9Y3A6 (reviewed: Q9Y3A6)

Alternative names: p24 family protein gamma-2, p28

All UniProt accessions (3): B1AKT3, M0R072, Q9Y3A6

UniProt curated annotations — full annotation on UniProt →

Function. Potential role in vesicular protein trafficking, mainly in the early secretory pathway. Required for the maintenance of the Golgi apparatus; involved in protein exchange between Golgi stacks during assembly. Probably not required for COPI-vesicle-mediated retrograde transport.

Subunit / interactions. Interacts with TMED9 and TMED10.

Subcellular location. Endoplasmic reticulum membrane. Golgi apparatus. cis-Golgi network membrane. Endoplasmic reticulum-Golgi intermediate compartment membrane.

Similarity. Belongs to the EMP24/GP25L family.

Isoforms (2)

UniProt ID	Names	Canonical?
Q9Y3A6-1	1	yes
Q9Y3A6-2	2

RefSeq proteins (3): NP_001161302, NP_001397754, NP_057124* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR009038	GOLD_dom	Domain
IPR015720	Emp24-like	Family
IPR036598	GOLD_dom_sf	Homologous_superfamily

Pfam: PF01105

UniProt features (8 total): topological domain 2, signal peptide 1, chain 1, transmembrane region 1, domain 1, splice variant 1, sequence variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9Y3A6-F1	82.83	0.57

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-3238698	WNT ligand biogenesis and trafficking

MSigDB gene sets: 202 (showing top): HORIUCHI_WTAP_TARGETS_DN, RODRIGUES_THYROID_CARCINOMA_POORLY_DIFFERENTIATED_UP, GOBP_INTRACELLULAR_PROTEIN_TRANSPORT, GRAESSMANN_APOPTOSIS_BY_SERUM_DEPRIVATION_UP, GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_UP, GOBP_VESICLE_MEDIATED_TRANSPORT, WEI_MYCN_TARGETS_WITH_E_BOX, GOBP_ENDOPLASMIC_RETICULUM_TO_GOLGI_VESICLE_MEDIATED_TRANSPORT, LI_WILMS_TUMOR_VS_FETAL_KIDNEY_1_UP, GOCC_COATED_VESICLE, GOBP_ENDOMEMBRANE_SYSTEM_ORGANIZATION, SCHLOSSER_SERUM_RESPONSE_DN, GOBP_GOLGI_RIBBON_FORMATION, CHARAFE_BREAST_CANCER_LUMINAL_VS_BASAL_DN, FLECHNER_BIOPSY_KIDNEY_TRANSPLANT_REJECTED_VS_OK_DN

GO Biological Process (4): intracellular protein transport (GO:0006886), endoplasmic reticulum to Golgi vesicle-mediated transport (GO:0006888), Golgi ribbon formation (GO:0090161), protein transport (GO:0015031)

GO Molecular Function (1): protein binding (GO:0005515)

GO Cellular Component (9): endoplasmic reticulum (GO:0005783), endoplasmic reticulum membrane (GO:0005789), endoplasmic reticulum-Golgi intermediate compartment (GO:0005793), Golgi apparatus (GO:0005794), cis-Golgi network (GO:0005801), COPII-coated ER to Golgi transport vesicle (GO:0030134), endoplasmic reticulum-Golgi intermediate compartment membrane (GO:0033116), endoplasmic reticulum exit site (GO:0070971), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Signaling by WNT	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cytoplasm	4
intracellular membrane-bounded organelle	4
intracellular protein localization	2
intracellular transport	2
endomembrane system	2
cellular anatomical structure	2
protein transport	1
intercellular transport	1
Golgi vesicle transport	1
Golgi organization	1
transport	1
establishment of protein localization	1
binding	1
organelle membrane	1
nuclear outer membrane-endoplasmic reticulum membrane network	1
endoplasmic reticulum subcompartment	1
Golgi apparatus	1
coated vesicle	1
endoplasmic reticulum-Golgi intermediate compartment	1
bounding membrane of organelle	1
endoplasmic reticulum	1

Protein interactions and networks

STRING

898 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
TMED5	TMED9	Q9BVK6	944
TMED5	TMED10	P49755	876
TMED5	TMED2	Q15363	738
TMED5	TMED4	Q7Z7H5	689
TMED5	PIGC	Q92535	543
TMED5	GRSF1	Q12849	448
TMED5	OMA1	Q96E52	416
TMED5	THAP6	Q8TBB0	394
TMED5	TM9SF4	Q92544	383
TMED5	MYSM1	Q5VVJ2	377
TMED5	METTL13	Q8N6R0	371
TMED5	MTF2	Q9Y483	368
TMED5	SYPL1	Q16563	362
TMED5	PGAP1	Q75T13	358
TMED5	PLAGL2	Q9UPG8	353
TMED5	HCK	P08631	353

IntAct

77 interactions, top by confidence:

A	B	Type	Score
CDK5RAP3	UFL1	psi-mi:“MI:0914”(association)	0.870
TMED10	TMED1	psi-mi:“MI:0914”(association)	0.730
TMED9	TMED10	psi-mi:“MI:0914”(association)	0.730
DDRGK1	UFL1	psi-mi:“MI:0914”(association)	0.710
TMED2	ATP9A	psi-mi:“MI:0914”(association)	0.640
CHST8	CANX	psi-mi:“MI:0914”(association)	0.640
CXCL9	TMED5	psi-mi:“MI:0915”(physical association)	0.560
LIPG	NRP1	psi-mi:“MI:0914”(association)	0.530
	UBXN8	psi-mi:“MI:0914”(association)	0.530
CDK5RAP3	PLD2	psi-mi:“MI:0914”(association)	0.530
CD70	METTL15	psi-mi:“MI:0914”(association)	0.530
TMED5	PRMT6	psi-mi:“MI:0915”(physical association)	0.510
TMED5		psi-mi:“MI:0915”(physical association)	0.370
TMED5	iglC2	psi-mi:“MI:0915”(physical association)	0.370
DNAJC30	TMED5	psi-mi:“MI:0915”(physical association)	0.370
Tmed10	TARS3	psi-mi:“MI:0914”(association)	0.350
Tmed2		psi-mi:“MI:0914”(association)	0.350
KSR1	DDX39A	psi-mi:“MI:0914”(association)	0.350
KSR1	FBLL1	psi-mi:“MI:0914”(association)	0.350
KSR1		psi-mi:“MI:0914”(association)	0.350
Prdm16	ESYT2	psi-mi:“MI:0914”(association)	0.350
Mecom	ESYT2	psi-mi:“MI:0914”(association)	0.350
PEBP1	ANXA2P2	psi-mi:“MI:0914”(association)	0.350
G	TMED5	psi-mi:“MI:0914”(association)	0.350
LHX1	AIFM1	psi-mi:“MI:0914”(association)	0.350

BioGRID (96): TMED5 (Affinity Capture-MS), TMED5 (Affinity Capture-MS), TMED5 (Affinity Capture-MS), TMED5 (Affinity Capture-MS), TMED5 (Affinity Capture-MS), TMED5 (Affinity Capture-MS), TMED5 (Affinity Capture-MS), TMED5 (Affinity Capture-MS), TMED5 (Affinity Capture-MS), TMED5 (Proximity Label-MS), TMED5 (Affinity Capture-MS), CXCL9 (Two-hybrid), TMED5 (Affinity Capture-MS), TMED5 (Affinity Capture-MS), TMED5 (Affinity Capture-MS)

ESM2 similar proteins: A0A0G2KTI4, A0A7U2QYM2, A1CKN5, A5AAA1, A7SXK3, A8N0V8, B0CPJ0, B0WEV5, B2VVF0, F4JJJ3, O04015, O04226, O17528, P32296, P55014, P55015, P55016, P58421, P91926, Q0CNR4, Q13621, Q28BQ6, Q29N38, Q2KJ84, Q4HY20, Q5B5L5, Q5B971, Q5R809, Q69SA9, Q6AXN3, Q6AY25, Q78IS1, Q7QG73, Q870U4, Q948T9, Q949M9, Q94BV7, Q9CXE7, Q9DEB5, Q9HEK4

Diamond homologs: A7SXK3, D3ZTX0, O13770, O17528, P49020, Q13445, Q15363, Q28BQ6, Q2KJ84, Q2TBK5, Q3T133, Q3V009, Q54BN0, Q5BK85, Q5I0E7, Q5R7E6, Q5R809, Q63524, Q6AXN3, Q6AY25, Q769F9, Q78IS1, Q7Z7H5, Q99KF1, Q9BVK6, Q9CXE7, Q9R0Q3, Q9Y3A6, Q9Y3B3, Q9Y3Q3, P39704, B3MTS8, B3NZM5, B4GMC3, B4HJV5, B4JG34, B4KB41, B4LYB8, B4NKL0, B4PVC6

SIGNOR signaling

1 interactions.

A	Effect	B	Mechanism
TMED5	“up-regulates activity”	TMED10	binding

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 95 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
COPI-dependent Golgi-to-ER retrograde traffic	7	12.5×	3e-04
COPI-mediated anterograde transport	6	10.6×	2e-03
Transport of small molecules	11	4.5×	2e-03

GO biological processes:

GO term	Partners	Fold	FDR
retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	6	25.3×	3e-05
endoplasmic reticulum to Golgi vesicle-mediated transport	10	17.0×	3e-07
intracellular protein transport	10	8.1×	8e-05

Disease & clinical

Clinical variants and AI predictions

ClinVar

23 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	13
Likely benign	0
Benign	2

Top pathogenic / likely-pathogenic (0)

SpliceAI

1168 predictions. Top by Δscore:

Variant	Effect	Δscore
1:93156294:A:AC	donor_gain	1.0000
1:93156295:C:CC	donor_gain	1.0000
1:93156296:TGA:T	donor_loss	1.0000
1:93156298:ACCAG:A	donor_loss	1.0000
1:93156310:T:TA	donor_gain	1.0000
1:93156479:CTACA:C	acceptor_gain	1.0000
1:93156480:TACA:T	acceptor_gain	1.0000
1:93156482:CA:C	acceptor_gain	1.0000
1:93156484:C:CC	acceptor_gain	1.0000
1:93160123:ACTT:A	donor_loss	1.0000
1:93160125:TTACG:T	donor_loss	1.0000
1:93160126:TACGT:T	donor_loss	1.0000
1:93160127:A:AC	donor_gain	1.0000
1:93160127:A:T	donor_loss	1.0000
1:93160128:C:CA	donor_gain	1.0000
1:93160128:CG:C	donor_gain	1.0000
1:93160128:CGT:C	donor_gain	1.0000
1:93160128:CGTG:C	donor_gain	1.0000
1:93160128:CGTGT:C	donor_gain	1.0000
1:93160225:AC:A	acceptor_gain	1.0000
1:93160226:CC:C	acceptor_gain	1.0000
1:93160227:C:CC	acceptor_gain	1.0000
1:93180052:A:AC	donor_gain	1.0000
1:93180053:C:CT	donor_gain	1.0000
1:93154692:T:C	donor_gain	0.9900
1:93154794:T:A	donor_gain	0.9900
1:93156292:ATAC:A	donor_loss	0.9900
1:93156293:TACT:T	donor_loss	0.9900
1:93156294:ACT:A	donor_loss	0.9900
1:93156295:CTGA:C	donor_gain	0.9900

AlphaMissense

1522 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
1:93154806:C:G	R185P	1.000
1:93154816:C:G	A182P	1.000
1:93154812:C:G	R183P	0.999
1:93156441:A:C	N110K	0.999
1:93156441:A:T	N110K	0.999
1:93154697:A:C	F221L	0.998
1:93154697:A:T	F221L	0.998
1:93154698:A:C	F221C	0.998
1:93154699:A:G	F221L	0.998
1:93154743:A:C	M206R	0.998
1:93154765:A:G	S199P	0.998
1:93154809:T:A	D184V	0.998
1:93154825:C:G	A179P	0.998
1:93154850:A:C	S170R	0.998
1:93154850:A:T	S170R	0.998
1:93154852:T:G	S170R	0.998
1:93154860:A:G	L167P	0.998
1:93156408:G:C	F121L	0.998
1:93156408:G:T	F121L	0.998
1:93156410:A:G	F121L	0.998
1:93156417:C:A	K118N	0.998
1:93156417:C:G	K118N	0.998
1:93156432:G:C	S113R	0.998
1:93156432:G:T	S113R	0.998
1:93156434:T:G	S113R	0.998
1:93156442:T:A	N110I	0.998
1:93156448:A:G	F108S	0.998
1:93156451:C:G	C107S	0.998
1:93156451:C:T	C107Y	0.998
1:93156452:A:G	C107R	0.998

dbSNP variants (sampled 300 via entrez): RS1000097733 (1:93166418 C>T), RS1000173993 (1:93171555 T>C), RS1000270723 (1:93179014 C>G), RS1000439516 (1:93157742 C>T), RS1000444604 (1:93164988 G>A,C,T), RS1000479081 (1:93170371 G>A,C), RS1000506879 (1:93170528 T>C,G), RS1000749907 (1:93157051 A>G), RS1000880653 (1:93151326 A>G), RS1001120701 (1:93177099 A>T), RS1001150304 (1:93171309 A>C), RS1001188618 (1:93164090 A>G), RS1001359394 (1:93170969 G>A,C,T), RS1001473440 (1:93170796 A>C), RS1001530165 (1:93149539 C>T)

Disease associations

OMIM: gene MIM:616876 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST006005_1	High density lipoprotein cholesterol levels	1.000000e-10

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0004612	high density lipoprotein cholesterol measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

37 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	decreases methylation, affects cotreatment, increases expression	5
sodium arsenite	affects cotreatment, increases abundance, increases expression, decreases expression	3
chloropicrin	decreases expression, increases expression	2
entinostat	increases expression, affects cotreatment	2
Panobinostat	affects cotreatment, increases expression	2
Phenylmercuric Acetate	affects cotreatment, increases expression	2
Tobacco Smoke Pollution	increases expression	2
aristolochic acid I	decreases expression	1
bisphenol F	increases expression	1
TAK-243	decreases sumoylation	1
methylmercuric chloride	increases expression	1
bisphenol A	affects expression	1
titanium dioxide	affects expression	1
mono-(2-ethylhexyl)phthalate	increases expression	1
manganese chloride	increases abundance, increases expression, affects cotreatment	1
4-phenylbutyric acid	decreases expression, increases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, increases expression	1
dorsomorphin	affects cotreatment, increases expression	1
jinfukang	decreases expression	1
Vorinostat	increases expression	1
Acetaminophen	increases expression	1
Arsenic	affects cotreatment, increases abundance, increases expression	1
Cisplatin	decreases expression	1
Clorgyline	increases expression	1
Formaldehyde	decreases expression	1
Ivermectin	decreases expression	1
Manganese	affects cotreatment, increases abundance, increases expression	1
Plant Oils	increases expression	1
Dihydrotestosterone	increases expression	1
Tunicamycin	increases expression	1

Cellosaurus cell lines

2 cell lines: 2 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_TS72	HAP1 TMED5 (-) 1	Cancer cell line	Male
CVCL_XU33	HAP1 TMED5 (-) 2	Cancer cell line	Male

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.