TMEM100

Summary

TMEM100 (transmembrane protein 100, HGNC:25607) is a protein-coding gene on chromosome 17q22, encoding Transmembrane protein 100 (Q9NV29). Plays a role during embryonic arterial endothelium differentiation and vascular morphogenesis through the ACVRL1 receptor-dependent signaling pathway upon stimulation by bone morphogenetic proteins, such as GDF2/BMP9 and BMP10.

Involved in BMP signaling pathway. Located in several cellular components, including endoplasmic reticulum; perikaryon; and perinuclear region of cytoplasm.

Source: NCBI Gene 55273 — RefSeq curated summary.

At a glance

• GWAS associations: 5
• Clinical variants (ClinVar): 23 total
• MANE Select transcript: NM_018286

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:25607
Approved symbol	TMEM100
Name	transmembrane protein 100
Location	17q22
Locus type	gene with protein product
Status	Approved
Aliases	FLJ10970, FLJ37856
Ensembl gene	ENSG00000166292
Ensembl biotype	protein_coding
OMIM	616334
Entrez	55273

Gene structure

Transcript identifiers

Ensembl transcripts: 32 — 29 protein_coding, 2 protein_coding_CDS_not_defined, 1 retained_intron

ENST00000424486, ENST00000570586, ENST00000571679, ENST00000575685, ENST00000575734, ENST00000575806, ENST00000893789, ENST00000893790, ENST00000893791, ENST00000893792, ENST00000893793, ENST00000893794, ENST00000893795, ENST00000893796, ENST00000893797, ENST00000893798, ENST00000893799, ENST00000893800, ENST00000893801, ENST00000893802, ENST00000893803, ENST00000893804, ENST00000893805, ENST00000893806, ENST00000893807, ENST00000893808, ENST00000893809, ENST00000893810, ENST00000893811, ENST00000893812, ENST00000948271, ENST00000948272

RefSeq mRNA: 2 — MANE Select: NM_018286 NM_001099640, NM_018286

CCDS: CCDS11587

Canonical transcript exons

ENST00000424486 — 2 exons

Exon	Start	End
ENSE00002651774	55722619	55722864
ENSE00002683681	55719627	55721135

Expression profiles

Bgee: expression breadth ubiquitous, 242 present calls, max score 99.63.

FANTOM5 (CAGE): breadth broad, TPM avg 1.8414 / max 244.6875, expressed in 411 samples.

FANTOM5 promoters (8 alternative TSS)

Promoter ID	TPM avg	Samples expressed
167085	1.5916	382
167092	0.1386	63
167090	0.0400	21
167089	0.0377	18
167088	0.0144	5
167091	0.0084	3
167093	0.0056	2
167084	0.0050	1

Top tissues by expression

276 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right lung	UBERON:0002167	99.63	gold quality
upper lobe of left lung	UBERON:0008952	98.04	gold quality
upper lobe of lung	UBERON:0008948	97.92	gold quality
adult organism	UBERON:0007023	97.83	gold quality
mucosa of stomach	UBERON:0001199	96.46	gold quality
lower lobe of lung	UBERON:0008949	96.36	gold quality
lung	UBERON:0002048	95.84	gold quality
synovial joint	UBERON:0002217	95.07	gold quality
seminal vesicle	UBERON:0000998	94.45	gold quality
corpus epididymis	UBERON:0004359	94.28	gold quality
adipose tissue of abdominal region	UBERON:0007808	91.98	gold quality
omental fat pad	UBERON:0010414	91.85	gold quality
peritoneum	UBERON:0002358	91.77	gold quality
caput epididymis	UBERON:0004358	91.66	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	91.40	gold quality
adipose tissue	UBERON:0001013	90.55	gold quality
visceral pleura	UBERON:0002401	90.53	gold quality
layer of synovial tissue	UBERON:0007616	89.97	gold quality
left ovary	UBERON:0002119	89.85	gold quality
connective tissue	UBERON:0002384	89.36	gold quality
pericardium	UBERON:0002407	89.17	gold quality
subcutaneous adipose tissue	UBERON:0002190	89.14	gold quality
right atrium auricular region	UBERON:0006631	89.10	gold quality
right ovary	UBERON:0002118	88.31	gold quality
fundus of stomach	UBERON:0001160	87.96	gold quality
cardiac atrium	UBERON:0002081	87.76	gold quality
tibial nerve	UBERON:0001323	87.58	gold quality
pleura	UBERON:0000977	87.55	gold quality
endocervix	UBERON:0000458	87.15	gold quality
ovary	UBERON:0000992	87.10	gold quality

Single-cell (SCXA)

Detected in 7 experiment(s), a significant marker in 7.

Experiment	Marker?	Max mean expression
E-MTAB-6308	yes	4101.68
E-MTAB-6653	yes	2491.06
E-GEOD-114530	yes	1201.22
E-GEOD-124472	yes	933.85
E-HCAD-10	yes	644.93
E-MTAB-8205	yes	362.15
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

83 targeting TMEM100, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-4795-3P	100.00	74.62	4024
HSA-MIR-3925-3P	100.00	69.95	1237
HSA-MIR-548C-3P	99.99	74.01	7587
HSA-MIR-3662	99.99	73.82	5684
HSA-MIR-499A-5P	99.98	70.79	1323
HSA-MIR-548N	99.98	71.94	4170
HSA-MIR-3658	99.96	73.87	4379
HSA-MIR-548AA	99.96	70.64	3753
HSA-MIR-548AP-3P	99.96	70.64	3753
HSA-MIR-548T-3P	99.96	70.64	3753
HSA-MIR-302E	99.96	70.74	2669
HSA-MIR-7153-5P	99.94	68.89	1006
HSA-MIR-539-5P	99.93	70.30	2855
HSA-MIR-497-5P	99.92	71.83	2674
HSA-MIR-15A-5P	99.90	72.80	2787
HSA-MIR-15B-5P	99.90	72.78	2798
HSA-MIR-16-5P	99.90	72.80	2780
HSA-MIR-195-5P	99.90	72.81	2805
HSA-MIR-374A-5P	99.90	71.34	2923
HSA-MIR-8087	99.90	69.55	1351
HSA-MIR-424-5P	99.89	71.90	2641
HSA-MIR-6838-5P	99.89	71.94	2690
HSA-MIR-380-3P	99.89	70.18	1978
HSA-MIR-302A-3P	99.89	71.23	1777
HSA-MIR-302B-3P	99.89	71.23	1777
HSA-MIR-302C-3P	99.89	71.20	1778
HSA-MIR-302D-3P	99.89	71.25	1777
HSA-MIR-30A-3P	99.87	69.74	2928
HSA-MIR-30D-3P	99.87	69.92	2917

Literature-anchored findings (GeneRIF, showing 12)

• Loss of TMEM100 is associated with lung adenocarcinoma. (PMID:22223368)
• This study demonistrated that TMEM100 is a novel, membrane-associated marker for enteric nerves and is as effective as PGP9.5 for identifying neuronal structures in the gastrointestinal tract. (PMID:23485812)
• The current findings suggest that TMEM100 functions as a tumor suppressor in hepatocellular carcinoma metastasis and proliferation. (PMID:25978032)
• experiments using another type of ER stress inducer demonstrated that calcium signaling was more important than ER stress in the regulation of TMEM100 expression (PMID:29690857)
• TMEM100 is critical for inflammatory cytokines secretion and is regulated by MAPK (ERK/JNK) signaling pathway in hepatic stellate cells. (PMID:30639579)
• TMEM100 expression suppresses metastasis and enhances sensitivity to chemotherapy in gastric cancer. (PMID:31188741)
• TMEM100 induces cell death in nonsmall cell lung cancer via the activation of autophagy and apoptosis. (PMID:34184748)
• TMEM100 negatively regulated by microRNA106b facilitates cellular apoptosis by suppressing survivin expression in NSCLC. (PMID:34278505)
• Functional expression of TRPA1 channel, TRPV1 channel and TMEM100 in human odontoblasts. (PMID:34514518)
• Histone deacetylase 6-mediated downregulation of TMEM100 expedites the development and progression of non-small cell lung cancer. (PMID:34687431)
• Upregulation of DRG protein TMEM100 facilitates dry-skin-induced pruritus by enhancing TRPA1 channel function. (PMID:36514220)
• Role of TMEM100 in mechanically insensitive nociceptor un-silencing. (PMID:37019973)

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Tmem100	ENSMUSG00000069763
rattus_norvegicus	Tmem100	ENSRNOG00000002434

Paralogs (1): PIRT (ENSG00000233670)

Protein

Protein identifiers

Transmembrane protein 100 — Q9NV29 (reviewed: Q9NV29)

All UniProt accessions (2): A0A0A0MTR3, Q9NV29

UniProt curated annotations — full annotation on UniProt →

Function. Plays a role during embryonic arterial endothelium differentiation and vascular morphogenesis through the ACVRL1 receptor-dependent signaling pathway upon stimulation by bone morphogenetic proteins, such as GDF2/BMP9 and BMP10. Involved in the regulation of nociception, acting as a modulator of the interaction between TRPA1 and TRPV1, two molecular sensors and mediators of pain signals in dorsal root ganglia (DRG) neurons. Mechanistically, it weakens their interaction, thereby releasing the inhibition of TRPA1 by TRPV1 and increasing the single-channel open probability of the TRPA1-TRPV1 complex.

Subunit / interactions. Interacts (via C-terminus) with TRPA1 and TRPV1. Interacts with TASOR.

Subcellular location. Cell membrane. Membrane. Perikaryon. Cytoplasm. Perinuclear region. Endoplasmic reticulum.

Tissue specificity. Expressed in neurons of the myenteric and submucosal plexuses in the gastric body, jejunum and proximal colon. Expressed in arterial endothelial cells and neurons of the central nervous system and peripheral nervous system. Expressed in umbilical artery endothelial cells (at protein level).

Induction. Up-regulated by GDF2/BMP9 and BMP10 (at protein level).

RefSeq proteins (2): NP_001093110, NP_060756* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR032536	TMEM100	Family

Pfam: PF16311

UniProt features (5 total): transmembrane region 2, chain 1, modified residue 1, sequence conflict 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9NV29-F1	66.39	0.12

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (1): 121

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 218 (showing top): GOBP_POSITIVE_REGULATION_OF_EPITHELIAL_CELL_DIFFERENTIATION, GOBP_REGULATION_OF_VASCULOGENESIS, GOBP_EMBRYO_DEVELOPMENT_ENDING_IN_BIRTH_OR_EGG_HATCHING, GOBP_EPITHELIUM_DEVELOPMENT, GOBP_REGULATION_OF_CALCIUM_MEDIATED_SIGNALING, GOBP_POSITIVE_REGULATION_OF_ENDOTHELIAL_CELL_DIFFERENTIATION, GOBP_ENDOCARDIAL_CUSHION_DEVELOPMENT, GOBP_REGULATION_OF_ENDOTHELIAL_CELL_DIFFERENTIATION, AP4_Q6, GOBP_ENDOCARDIAL_CUSHION_MORPHOGENESIS, CAGCTG_AP4_Q5, GOBP_ENDOCARDIAL_CUSHION_FORMATION, SENESE_HDAC1_AND_HDAC2_TARGETS_DN, GOBP_REGULATION_OF_EPITHELIAL_CELL_DIFFERENTIATION, GOBP_SENSORY_PERCEPTION_OF_PAIN

GO Biological Process (15): angiogenesis (GO:0001525), vasculogenesis (GO:0001570), in utero embryonic development (GO:0001701), epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198), Notch signaling pathway (GO:0007219), BMP signaling pathway (GO:0030509), positive regulation of endothelial cell differentiation (GO:0045603), regulation of calcium-mediated signaling (GO:0050848), positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction (GO:0051897), regulation of sensory perception of pain (GO:0051930), arterial endothelial cell differentiation (GO:0060842), cellular response to BMP stimulus (GO:0071773), positive regulation of vasculogenesis (GO:2001214), endocardial cushion development (GO:0003197), cell differentiation (GO:0030154)

GO Molecular Function (1): protein binding (GO:0005515)

GO Cellular Component (6): endoplasmic reticulum (GO:0005783), plasma membrane (GO:0005886), perikaryon (GO:0043204), perinuclear region of cytoplasm (GO:0048471), cytoplasm (GO:0005737), membrane (GO:0016020)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	4
blood vessel morphogenesis	2
cytoplasm	2
anatomical structure formation involved in morphogenesis	1
cell differentiation	1
chordate embryonic development	1
endocardial cushion formation	1
cardiac epithelial to mesenchymal transition	1
cell surface receptor signaling pathway	1
cellular response to BMP stimulus	1
transforming growth factor beta receptor superfamily signaling pathway	1
positive regulation of epithelial cell differentiation	1
endothelial cell differentiation	1
regulation of endothelial cell differentiation	1
calcium-mediated signaling	1
regulation of intracellular signal transduction	1
phosphatidylinositol 3-kinase/protein kinase B signal transduction	1
regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	1
positive regulation of intracellular signal transduction	1
sensory perception of pain	1
regulation of sensory perception	1
blood vessel endothelial cell differentiation	1
cellular response to growth factor stimulus	1
response to BMP	1
vasculogenesis	1
positive regulation of cell differentiation	1
regulation of vasculogenesis	1
heart development	1
mesenchyme development	1
cellular developmental process	1
binding	1
endomembrane system	1
intracellular membrane-bounded organelle	1
membrane	1
cell periphery	1
neuronal cell body	1
intracellular anatomical structure	1

Protein interactions and networks

STRING

732 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
TMEM100	FCN3	O75636	496
TMEM100	TRPA1	O75762	484
TMEM100	SNX15	Q9NRS6	438
TMEM100	ACVRL1	P37023	432
TMEM100	GDF2	Q9UK05	430
TMEM100	LHX1	P48742	417
TMEM100	AKAP5	P24588	415
TMEM100	PCTP	Q9UKL6	410
TMEM100	ANKS6	Q68DC2	402
TMEM100	TRPV1	Q8NER1	402
TMEM100	SIX2	Q9NPC8	391
TMEM100	TMEM63C	Q9P1W3	378
TMEM100	BMP10	O95393	370
TMEM100	ANKFN1	Q8N957	370
TMEM100	CITED1	Q99966	368

IntAct

101 interactions, top by confidence:

A	B	Type	Score
TMEM100	MEOX2	psi-mi:“MI:0915”(physical association)	0.560
CCDC57	TMEM100	psi-mi:“MI:0915”(physical association)	0.560
TMEM79	TMEM100	psi-mi:“MI:0915”(physical association)	0.560
TMEM100	CCDC57	psi-mi:“MI:0915”(physical association)	0.560
MEOX2	TMEM100	psi-mi:“MI:0915”(physical association)	0.560
TMEM100	GJA8	psi-mi:“MI:0915”(physical association)	0.560
TMEM100	HSD17B13	psi-mi:“MI:0915”(physical association)	0.560
TMEM100	STING1	psi-mi:“MI:0915”(physical association)	0.560
TMEM100	LHFPL5	psi-mi:“MI:0915”(physical association)	0.560
STX1A	TMEM100	psi-mi:“MI:0915”(physical association)	0.560
NUP93	TMEM100	psi-mi:“MI:0915”(physical association)	0.560
RNF19B	TMEM100	psi-mi:“MI:0915”(physical association)	0.560
SLC30A4	TMEM100	psi-mi:“MI:0915”(physical association)	0.560
REEP1	TMEM100	psi-mi:“MI:0915”(physical association)	0.560
FNDC9	TMEM100	psi-mi:“MI:0915”(physical association)	0.560
CLDN7	TMEM100	psi-mi:“MI:0915”(physical association)	0.560
SLC35A5	TMEM100	psi-mi:“MI:0915”(physical association)	0.560
GPR152	TMEM100	psi-mi:“MI:0915”(physical association)	0.560
EBP	TMEM100	psi-mi:“MI:0915”(physical association)	0.560
FAM209A	TMEM100	psi-mi:“MI:0915”(physical association)	0.560
IFNGR1	TMEM100	psi-mi:“MI:0915”(physical association)	0.560

BioGRID (35): TMEM100 (Two-hybrid), TMEM79 (Two-hybrid), CCDC57 (Two-hybrid), TMEM100 (Two-hybrid), TMEM100 (Two-hybrid), TMEM100 (Two-hybrid), TMEM100 (Two-hybrid), TMEM100 (Two-hybrid), TMEM100 (Two-hybrid), TMEM100 (Two-hybrid), TMEM100 (Two-hybrid), TMEM100 (Two-hybrid), TMEM100 (Two-hybrid), TMEM100 (Two-hybrid), TMEM100 (Two-hybrid)

ESM2 similar proteins: A0A1B0GQX3, A0A1B0GRQ0, A0A1B0GV90, A0A1B0GVT2, A0A590UK83, A4QNL6, A5D7B5, A7RYM7, B0YA61, B3DHH5, C0HJJ0, D3YUK8, G1TZA0, H3BR10, O13001, O22752, O43073, O75324, P0C2S0, P0DKX4, P47111, P57054, P58550, P59648, P59649, P61807, P61808, Q12016, Q17Q87, Q3E8L0, Q3E912, Q3T0S0, Q3URE8, Q4V921, Q4WCL2, Q5RBD8, Q5XV67, Q80ZU4, Q8BT42, Q8LBX7

Diamond homologs: Q2KIC8, Q569C0, Q9CQG9, Q9NV29

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

23 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	19
Likely benign	2
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

458 predictions. Top by Δscore:

Variant	Effect	Δscore
17:55722612:CA:C	donor_gain	1.0000
17:55722612:CACT:C	donor_gain	1.0000
17:55721136:C:CC	acceptor_gain	0.9900
17:55721734:A:AC	donor_gain	0.9900
17:55721735:C:CC	donor_gain	0.9900
17:55722615:TCACC:T	donor_loss	0.9900
17:55722616:C:CG	donor_loss	0.9900
17:55721133:AAGC:A	acceptor_loss	0.9800
17:55721134:AGC:A	acceptor_loss	0.9800
17:55721136:C:A	acceptor_loss	0.9800
17:55721731:CCCA:C	donor_gain	0.9800
17:55721131:GAAAG:G	acceptor_gain	0.9700
17:55722611:ACACT:A	donor_gain	0.9700
17:55722612:CACTC:C	donor_gain	0.9700
17:55722618:CCT:C	donor_gain	0.9700
17:55721133:AAG:A	acceptor_gain	0.9600
17:55721134:AG:A	acceptor_gain	0.9600
17:55722637:A:AC	donor_gain	0.9600
17:55722655:TG:T	donor_gain	0.9600
17:55722793:A:AC	donor_gain	0.9600
17:55722794:C:CC	donor_gain	0.9600
17:55722611:A:AC	donor_gain	0.9500
17:55722612:C:CC	donor_gain	0.9500
17:55721816:CTG:C	acceptor_gain	0.9400
17:55722617:A:AC	donor_gain	0.9400
17:55722618:C:CC	donor_gain	0.9400
17:55721132:AAAG:A	acceptor_gain	0.9300
17:55722635:CCA:C	donor_gain	0.9300
17:55722636:CA:C	donor_gain	0.9300
17:55722643:A:T	donor_gain	0.9300

AlphaMissense

868 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
17:55720869:C:G	G68R	0.990
17:55720762:A:C	S103R	0.988
17:55720762:A:T	S103R	0.988
17:55720764:T:G	S103R	0.988
17:55720805:C:T	G89D	0.987
17:55720868:C:T	G68D	0.986
17:55720806:C:G	G89R	0.983
17:55720905:A:G	C56R	0.980
17:55720785:C:G	G96R	0.978
17:55720785:C:T	G96R	0.978
17:55720784:C:T	G96E	0.971
17:55720895:G:C	P59R	0.971
17:55720914:A:G	C53R	0.970
17:55720847:G:T	A75D	0.969
17:55720895:G:T	P59H	0.960
17:55720946:A:G	L42S	0.956
17:55720931:C:A	G47V	0.955
17:55720932:C:A	G47W	0.955
17:55720859:A:T	V71D	0.953
17:55720891:A:C	F60L	0.951
17:55720891:A:T	F60L	0.951
17:55720893:A:G	F60L	0.951
17:55720931:C:T	G47E	0.951
17:55720904:C:G	C56S	0.950
17:55720905:A:T	C56S	0.950
17:55720883:A:T	V63D	0.949
17:55720868:C:A	G68V	0.947
17:55720869:C:A	G68C	0.946
17:55720848:C:G	A75P	0.944
17:55720903:G:C	C56W	0.944

dbSNP variants (sampled 300 via entrez): RS1001051487 (17:55728160 G>T), RS1001216398 (17:55728552 A>T), RS1001393538 (17:55729726 T>A), RS1002301900 (17:55723071 A>G), RS1002352607 (17:55722694 C>G,T), RS1002898080 (17:55720342 T>C), RS1002913709 (17:55726790 T>C), RS1002929151 (17:55720760 G>A), RS1003076676 (17:55725618 C>T), RS1003265884 (17:55719165 C>T), RS1003306731 (17:55724564 A>C,G), RS1003457666 (17:55724004 C>T), RS1003519447 (17:55730128 G>A), RS1003533618 (17:55725391 A>G), RS1003809170 (17:55725431 A>G)

Disease associations

OMIM: gene MIM:616334 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

5 associations (top):

Study	Trait	p-value
GCST001290_3	Height	6.000000e-09
GCST003628_7	Clozapine-induced agranulocytosis/granulocytopenia in treatment-resistant schizophrenia	5.000000e-06
GCST007272_33	Pulse pressure	1.000000e-26
GCST90020025_1458	Waist-to-hip ratio adjusted for BMI	3.000000e-09
GCST90020027_433	Waist-hip index	1.000000e-09

EFO canonical traits (2, from GWAS)

EFO ID	Trait name
EFO:0005763	pulse pressure measurement
EFO:0007788	BMI-adjusted waist-hip ratio

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

30 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects cotreatment, increases expression, affects expression	7
Thapsigargin	decreases expression, increases expression	2
methylmercuric chloride	decreases expression	1
methyleugenol	decreases expression	1
bisphenol A	affects cotreatment, decreases methylation	1
2-methyl-4-isothiazolin-3-one	increases expression	1
trichostatin A	increases expression	1
arsenite	affects expression	1
boron nitride	decreases expression	1
beta-methylcholine	affects expression	1
CGP 52608	affects binding, increases reaction	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, increases expression	1
dorsomorphin	affects cotreatment, increases expression	1
(+)-JQ1 compound	decreases expression	1
Temozolomide	decreases expression	1
Fulvestrant	affects cotreatment, decreases methylation	1
Vorinostat	increases expression	1
Benzo(a)pyrene	increases methylation, affects methylation	1
Boron Compounds	decreases expression	1
Calcitriol	increases expression, affects cotreatment	1
Dihydrotestosterone	increases expression	1
Testosterone	affects cotreatment, increases expression	1
Tetrachlorodibenzodioxin	affects expression	1
Tretinoin	decreases expression	1
Triclosan	increases expression	1
Tunicamycin	decreases expression	1
Cyclosporine	increases expression	1
Aflatoxin B1	decreases expression	1
Tungsten Compounds	decreases expression	1
Okadaic Acid	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.