TMEM105

Summary

TMEM105 (TMEM105 long non-coding RNA, HGNC:26794) is a long non-coding RNA gene on chromosome 17q25.3.

Predicted to be located in membrane.

Source: NCBI Gene 284186 — RefSeq curated summary.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:26794
Approved symbol	TMEM105
Name	TMEM105 long non-coding RNA
Location	17q25.3
Locus type	RNA, long non-coding
Status	Approved
Aliases	FLJ38792
Ensembl gene	ENSG00000185332
Ensembl biotype	lncRNA
Entrez	284186
RNAcentral	URS0001980FCD — lncRNA, 3326 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 7 — 7 lncRNA

ENST00000571868, ENST00000574093, ENST00000576919, ENST00000577027, ENST00000650606, ENST00000811483, ENST00000811484

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000571868 — 2 exons

Exon	Start	End
ENSE00002657022	81327595	81327941
ENSE00002679464	81330144	81330429

Expression profiles

Bgee: expression breadth ubiquitous, 150 present calls, max score 84.52.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.3242 / max 27.6925, expressed in 159 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
168688	0.2593	141
168687	0.0650	39

Top tissues by expression

235 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
tendon of biceps brachii	UBERON:0008188	84.52	silver quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	84.19	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	83.23	gold quality
right lobe of liver	UBERON:0001114	79.08	gold quality
nasal cavity epithelium	UBERON:0005384	78.14	gold quality
esophagus squamous epithelium	UBERON:0006920	76.07	gold quality
buccal mucosa cell	CL:0002336	75.79	gold quality
cartilage tissue	UBERON:0002418	75.66	silver quality
liver	UBERON:0002107	71.45	gold quality
parotid gland	UBERON:0001831	71.19	gold quality
tendon	UBERON:0000043	69.80	gold quality
gastrocnemius	UBERON:0001388	69.39	gold quality
vena cava	UBERON:0004087	69.20	gold quality
muscle of leg	UBERON:0001383	68.96	gold quality
myocardium	UBERON:0002349	68.82	gold quality
bone marrow	UBERON:0002371	68.44	gold quality
endothelial cell	CL:0000115	68.06	gold quality
gingival epithelium	UBERON:0001949	67.89	gold quality
gingiva	UBERON:0001828	67.87	gold quality
skeletal muscle tissue of biceps brachii	UBERON:0004502	67.66	gold quality
secondary oocyte	CL:0000655	67.13	silver quality
heart right ventricle	UBERON:0002080	67.10	gold quality
pharyngeal mucosa	UBERON:0000355	66.97	gold quality
lower esophagus mucosa	UBERON:0035834	66.68	gold quality
cortical plate	UBERON:0005343	66.67	gold quality
nipple	UBERON:0002030	66.48	gold quality
oral cavity	UBERON:0000167	66.17	gold quality
biceps brachii	UBERON:0001507	65.97	gold quality
duodenum	UBERON:0002114	65.64	gold quality
synovial joint	UBERON:0002217	65.62	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.07

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Glycolysis-related lncRNA TMEM105 upregulates LDHA to facilitate breast cancer liver metastasis via sponging miR-1208. (PMID:36737428)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.