TMEM108-AS1

Summary

TMEM108-AS1 (TMEM108 antisense RNA 1, HGNC:50307) is a long non-coding RNA gene on chromosome 3q22.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50307
Approved symbol	TMEM108-AS1
Name	TMEM108 antisense RNA 1
Location	3q22.1
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000251011
Ensembl biotype	lncRNA
Entrez	101927455
RNAcentral	URS000075AC5F — lncRNA, 2338 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 2 — 2 lncRNA

ENST00000504993, ENST00000505721

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000504993 — 4 exons

Exon	Start	End
ENSE00002028697	133253362	133253452
ENSE00002032792	133248378	133248597
ENSE00002051655	133246106	133246475
ENSE00002067113	133257025	133257048

Expression profiles

Bgee: expression breadth broad, 66 present calls, max score 81.27.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.0571 / max 24.3211, expressed in 15 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
44639	0.0190	8
44640	0.0177	6
44637	0.0154	5
44638	0.0050	2

Top tissues by expression

174 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
bone marrow cell	CL:0002092	81.27	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	80.41	gold quality
cortical plate	UBERON:0005343	58.95	silver quality
amygdala	UBERON:0001876	57.51	gold quality
hindlimb stylopod muscle	UBERON:0004252	57.17	gold quality
adrenal tissue	UBERON:0018303	55.25	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	54.18	gold quality
skin of hip	UBERON:0001554	54.06	silver quality
epithelium of nasopharynx	UBERON:0001951	53.44	gold quality
calcaneal tendon	UBERON:0003701	52.00	silver quality
corpus callosum	UBERON:0002336	51.58	gold quality
temporal lobe	UBERON:0001871	51.49	gold quality
prefrontal cortex	UBERON:0000451	51.43	gold quality
monocyte	CL:0000576	50.90	silver quality
sperm	CL:0000019	49.93	gold quality
buccal mucosa cell	CL:0002336	49.89	gold quality
muscle of leg	UBERON:0001383	49.87	silver quality
tendon	UBERON:0000043	49.11	silver quality
testis	UBERON:0000473	48.95	gold quality
Brodmann (1909) area 9	UBERON:0013540	48.25	gold quality
islet of Langerhans	UBERON:0000006	47.86	silver quality
urinary bladder	UBERON:0001255	47.75	silver quality
anterior cingulate cortex	UBERON:0009835	46.82	gold quality
bone marrow	UBERON:0002371	46.75	silver quality
gastrocnemius	UBERON:0001388	46.57	silver quality
adrenal gland	UBERON:0002369	46.53	silver quality
olfactory segment of nasal mucosa	UBERON:0005386	46.07	silver quality
upper leg skin	UBERON:0004262	45.95	silver quality
lung	UBERON:0002048	45.90	gold quality
blood	UBERON:0000178	45.55	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	4.06

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.