TMEM109-DT

Summary

TMEM109-DT (TMEM109 divergent transcript, HGNC:55487) is a long non-coding RNA gene on chromosome 11q12.2.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:55487
Approved symbol	TMEM109-DT
Name	TMEM109 divergent transcript
Location	11q12.2
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000256944
Ensembl biotype	lncRNA
Entrez	105369323
RNAcentral	URS000233C4B3 — lncRNA, 416 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 4 — 4 lncRNA

ENST00000543275, ENST00000725383, ENST00000725384, ENST00000725385

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000543275 — 2 exons

Exon	Start	End
ENSE00002286233	60913166	60913477
ENSE00004048927	60913960	60914095

Expression profiles

Bgee: expression breadth ubiquitous, 125 present calls, max score 93.30.

Top tissues by expression

125 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	93.30	gold quality
right testis	UBERON:0004534	86.21	gold quality
left testis	UBERON:0004533	85.55	gold quality
testis	UBERON:0000473	85.02	gold quality
skeletal muscle tissue	UBERON:0001134	78.06	gold quality
muscle of leg	UBERON:0001383	72.80	gold quality
gastrocnemius	UBERON:0001388	72.36	gold quality
right coronary artery	UBERON:0001625	72.10	gold quality
descending thoracic aorta	UBERON:0002345	70.52	gold quality
popliteal artery	UBERON:0002250	70.48	gold quality
tibial artery	UBERON:0007610	70.45	gold quality
calcaneal tendon	UBERON:0003701	69.89	gold quality
smooth muscle tissue	UBERON:0001135	69.64	gold quality
thoracic aorta	UBERON:0001515	69.47	gold quality
ascending aorta	UBERON:0001496	69.25	gold quality
granulocyte	CL:0000094	69.05	gold quality
islet of Langerhans	UBERON:0000006	68.78	gold quality
ventricular zone	UBERON:0003053	68.38	gold quality
stromal cell of endometrium	CL:0002255	68.35	gold quality
hindlimb stylopod muscle	UBERON:0004252	67.54	gold quality
urinary bladder	UBERON:0001255	67.14	gold quality
myometrium	UBERON:0001296	66.14	gold quality
left coronary artery	UBERON:0001626	65.91	gold quality
heart left ventricle	UBERON:0002084	65.85	gold quality
ganglionic eminence	UBERON:0004023	65.84	gold quality
esophagus	UBERON:0001043	65.55	gold quality
lower esophagus	UBERON:0013473	65.55	gold quality
lower esophagus muscularis layer	UBERON:0035833	65.50	gold quality
esophagus mucosa	UBERON:0002469	65.47	gold quality
right lung	UBERON:0002167	64.96	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.67

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.