TMEM120A

Summary

TMEM120A (transmembrane protein 120A, HGNC:21697) is a protein-coding gene on chromosome 7q11.23, encoding Transmembrane protein 120A (Q9BXJ8). Multifunctional protein involved in mechanosensation, and plays an essential role in lipid metabolism and adipocyte differentiation.

Enables coenzyme A binding activity. Involved in antiviral innate immune response; fat cell differentiation; and protein complex oligomerization. Located in endoplasmic reticulum and plasma membrane.

Source: NCBI Gene 83862 — RefSeq curated summary.

At a glance

• GWAS associations: 3
• Clinical variants (ClinVar): 84 total
• Druggable target: yes
• MANE Select transcript: NM_031925

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:21697
Approved symbol	TMEM120A
Name	transmembrane protein 120A
Location	7q11.23
Locus type	gene with protein product
Status	Approved
Aliases	TMPIT, NET29, TACAN
Ensembl gene	ENSG00000189077
Ensembl biotype	protein_coding
OMIM	616550
Entrez	83862

Gene structure

Transcript identifiers

Ensembl transcripts: 24 — 15 protein_coding, 6 retained_intron, 2 nonsense_mediated_decay, 1 protein_coding_CDS_not_defined

ENST00000417509, ENST00000431867, ENST00000439537, ENST00000440632, ENST00000460127, ENST00000465494, ENST00000465989, ENST00000480538, ENST00000480899, ENST00000484946, ENST00000485200, ENST00000486865, ENST00000490656, ENST00000493111, ENST00000493251, ENST00000910815, ENST00000910816, ENST00000910817, ENST00000910818, ENST00000910819, ENST00000910820, ENST00000944815, ENST00000944816, ENST00000944817

RefSeq mRNA: 3 — MANE Select: NM_031925 NM_001317803, NM_001363462, NM_031925

CCDS: CCDS64688, CCDS83192

Canonical transcript exons

ENST00000493111 — 12 exons

Exon	Start	End
ENSE00001422203	75994490	75994595
ENSE00001685220	75986831	75987285
ENSE00003537823	75987360	75987428
ENSE00003539187	75988252	75988341
ENSE00003580820	75988083	75988148
ENSE00003591049	75987538	75987602
ENSE00003625553	75989165	75989224
ENSE00003637287	75987923	75987984
ENSE00003665679	75992144	75992260
ENSE00003671990	75988421	75988516
ENSE00003677659	75992439	75992557
ENSE00003718578	75987718	75987810

Expression profiles

Bgee: expression breadth ubiquitous, 238 present calls, max score 99.17.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 30.3801 / max 429.3022, expressed in 1814 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
84393	29.6119	1814
84392	0.7682	495

Top tissues by expression

252 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right testis	UBERON:0004534	99.17	gold quality
left testis	UBERON:0004533	99.00	gold quality
right adrenal gland cortex	UBERON:0035827	98.79	gold quality
right adrenal gland	UBERON:0001233	98.78	gold quality
left adrenal gland	UBERON:0001234	98.59	gold quality
left adrenal gland cortex	UBERON:0035825	98.59	gold quality
right ovary	UBERON:0002118	98.54	gold quality
left ovary	UBERON:0002119	98.39	gold quality
apex of heart	UBERON:0002098	98.38	gold quality
mucosa of transverse colon	UBERON:0004991	98.17	gold quality
ileal mucosa	UBERON:0000331	97.96	gold quality
right lobe of liver	UBERON:0001114	97.76	gold quality
heart left ventricle	UBERON:0002084	97.75	gold quality
lower esophagus mucosa	UBERON:0035834	97.60	gold quality
hindlimb stylopod muscle	UBERON:0004252	97.58	gold quality
adrenal gland	UBERON:0002369	97.54	gold quality
testis	UBERON:0000473	97.50	gold quality
adrenal cortex	UBERON:0001235	97.49	gold quality
right coronary artery	UBERON:0001625	97.40	gold quality
cardiac ventricle	UBERON:0002082	97.40	gold quality
ascending aorta	UBERON:0001496	97.39	gold quality
thoracic aorta	UBERON:0001515	97.38	gold quality
left coronary artery	UBERON:0001626	97.35	gold quality
small intestine Peyer’s patch	UBERON:0003454	97.31	gold quality
descending thoracic aorta	UBERON:0002345	97.27	gold quality
popliteal artery	UBERON:0002250	97.21	gold quality
tibial artery	UBERON:0007610	97.20	gold quality
endocervix	UBERON:0000458	97.19	gold quality
aorta	UBERON:0000947	97.14	gold quality
metanephros cortex	UBERON:0010533	97.09	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-MTAB-6379	no	191.33
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

15 targeting TMEM120A, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-6768-5P	99.92	67.36	1942
HSA-MIR-3686	99.90	70.53	2432
HSA-MIR-4743-3P	99.62	68.12	2095
HSA-MIR-4652-3P	99.33	70.02	2742
HSA-MIR-548AS-3P	99.12	69.12	2294
HSA-MIR-6814-5P	99.03	66.68	1273
HSA-MIR-6760-5P	98.87	66.73	1515
HSA-MIR-4742-3P	98.73	69.82	1803
HSA-MIR-6878-5P	98.49	67.91	2142
HSA-MIR-6818-5P	97.50	67.10	1167
HSA-MIR-6874-3P	97.29	66.34	975
HSA-MIR-148B-5P	97.29	66.30	992
HSA-MIR-1226-5P	96.50	65.28	643
HSA-MIR-3918	96.13	64.65	1300
HSA-MIR-5681B	94.82	69.30	514

Literature-anchored findings (GeneRIF, showing 3)

• TMEM120A is a coenzyme A-binding membrane protein with structural similarities to ELOVL fatty acid elongase. (PMID:34374645)
• Gain-of-function genetic screening identifies the antiviral function of TMEM120A via STING activation. (PMID:35013224)
• Cryo-EM structure of the human TACAN in a closed state. (PMID:35235791)

Cross-species orthologs

6 orthologs

Organism	Symbol	Gene ID
danio_rerio	tmem120aa	ENSDARG00000030914
danio_rerio	tmem120ab	ENSDARG00000042379
mus_musculus	Tmem120a	ENSMUSG00000039886
rattus_norvegicus	Tmem120a	ENSRNOG00000001441
drosophila_melanogaster	CG32795	FBGN0040384
caenorhabditis_elegans		WBGENE00019716

Paralogs (1): TMEM120B (ENSG00000188735)

Protein

Protein identifiers

Transmembrane protein 120A — Q9BXJ8 (reviewed: Q9BXJ8)

Alternative names: Protein TACAN, Transmembrane protein induced by tumor necrosis factor alpha

All UniProt accessions (7): A0A024R4K9, A0A087WV11, A0A087WWH9, A0A087WZA9, A0A087WZF4, A0A087X266, Q9BXJ8

UniProt curated annotations — full annotation on UniProt →

Function. Multifunctional protein involved in mechanosensation, and plays an essential role in lipid metabolism and adipocyte differentiation. May function as a potential ion channel involved in sensing mechanical stimuli. Mediates the mechanosensitivity of the PKD2-TMEM120A channel complex through direct physical interaction. TMEM120A seems to affect mechanosensation by inhibiting PIEZO2 channels, possibly by altering cellular lipid content. TMEM120A is structurally similar to a lipid-modifying enzyme, ELOVL7, and contains a bound coenzyme A molecule, which suggests it might function as an enzyme in lipid metabolism. Additionally, implicated in innate immune response against Zika virus. Acts as a key activator of the antiviral signaling involving STING1.

Subunit / interactions. Homodimer. Forms heterooligomer with TMEM120B. Interacts with PKD2; TMEM120A inhibits PKD2 channel activity through the physical association of PKD2 with TMEM120A. Interacts (via C-terminal domain) with STING1; regulates the trafficking of STING1 from the ER to the ER-Golgi intermediate compartment to elicit antiviral effects.

Subcellular location. Cell membrane. Nucleus inner membrane. Endoplasmic reticulum.

Tissue specificity. Expressed in nociceptors.

Domain organisation. The transmembrane domain (TMD) has structural homology to the very long chain fatty acid elongase 7, ELOVL7, despite low sequence homology between them.

Miscellaneous. TACAN means movement in Farsi.

Similarity. Belongs to the TMEM120 family.

Isoforms (2)

UniProt ID	Names	Canonical?
Q9BXJ8-1	1	yes
Q9BXJ8-2	2

RefSeq proteins (3): NP_001304732, NP_001350391, NP_114131* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR012926	TMEM120A/B	Family

Pfam: PF07851

UniProt features (37 total): helix 9, binding site 8, topological domain 7, transmembrane region 6, sequence variant 2, mutagenesis site 2, chain 1, splice variant 1, strand 1

Structure

Experimental structures (PDB)

5 structures.

PDB	Method	Resolution (Å)
7N7P	ELECTRON MICROSCOPY	3.24
7CXR	ELECTRON MICROSCOPY	3.4
7F6V	ELECTRON MICROSCOPY	3.66
7F3T	ELECTRON MICROSCOPY	3.69
7F3U	ELECTRON MICROSCOPY	4

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9BXJ8-F1	89.40	0.66

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Ligand- & substrate-binding residues (8): 130; 187; 188; 237; 240; 241; 283; 332

Mutagenesis-validated functional residues (2):

Position	Phenotype
193	decreases the binding affinity with coa.
207	increases membrane pressure-activated current.

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 132 (showing top): GCM_GSPT1, MODULE_255, GOBP_SENSORY_PERCEPTION_OF_MECHANICAL_STIMULUS, GOBP_DETECTION_OF_MECHANICAL_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, MODULE_317, LINDGREN_BLADDER_CANCER_CLUSTER_3_DN, GCM_BCL2L1, GOBP_DETECTION_OF_MECHANICAL_STIMULUS, GOBP_SENSORY_PERCEPTION_OF_PAIN, GOBP_DEFENSE_RESPONSE_TO_OTHER_ORGANISM, HNF4_01, PPAR_DR1_Q2, GOBP_FAT_CELL_DIFFERENTIATION, GOBP_RESPONSE_TO_ABIOTIC_STIMULUS, GOBP_DEFENSE_RESPONSE_TO_VIRUS

GO Biological Process (8): monoatomic ion transmembrane transport (GO:0034220), fat cell differentiation (GO:0045444), detection of mechanical stimulus involved in sensory perception of pain (GO:0050966), protein homooligomerization (GO:0051260), protein heterooligomerization (GO:0051291), antiviral innate immune response (GO:0140374), immune system process (GO:0002376), innate immune response (GO:0045087)

GO Molecular Function (3): monoatomic ion channel activity (GO:0005216), coenzyme A binding (GO:0120225), protein binding (GO:0005515)

GO Cellular Component (5): nuclear inner membrane (GO:0005637), endoplasmic reticulum (GO:0005783), plasma membrane (GO:0005886), membrane (GO:0016020), nucleus (GO:0005634)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
protein complex oligomerization	2
intracellular membrane-bounded organelle	2
monoatomic ion transport	1
transmembrane transport	1
cell differentiation	1
sensory perception of pain	1
detection of mechanical stimulus involved in sensory perception	1
innate immune response	1
defense response to virus	1
biological_process	1
immune response	1
defense response to symbiont	1
monoatomic ion transmembrane transporter activity	1
channel activity	1
anion binding	1
nucleoside phosphate binding	1
heterocyclic compound binding	1
sulfur compound binding	1
binding	1
organelle inner membrane	1
nuclear membrane	1
cytoplasm	1
endomembrane system	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

436 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
TMEM120A	PLPP7	Q8NBV4	642
TMEM120A	TMEM150C	B9EJG8	542
TMEM120A	TM7SF2	O76062	507
TMEM120A	TMEM60	Q9H2L4	506
TMEM120A	TMEM38A	Q9H6F2	488
TMEM120A	TMEM63A	O94886	461
TMEM120A	TMEM63C	Q9P1W3	444
TMEM120A	PIEZO1	Q92508	435
TMEM120A	ZBED11	P0CF97	429
TMEM120A	ZNF775	Q96BV0	425
TMEM120A	TMEM63B	Q5T3F8	405
TMEM120A	ELOVL7	A1L3X0	404
TMEM120A	TMEM87A	Q8NBN3	402
TMEM120A	TMC1	Q8TDI8	402
TMEM120A	TMC2	Q8TDI7	399

IntAct

132 interactions, top by confidence:

A	B	Type	Score
ATP5F1B	ATP5PD	psi-mi:“MI:0914”(association)	0.670
ATP5PF	ATP5PD	psi-mi:“MI:0914”(association)	0.670
TRDN	TMEM223	psi-mi:“MI:0914”(association)	0.640
TMEM120A	SPAG4	psi-mi:“MI:0915”(physical association)	0.560
TMEM120A	BIK	psi-mi:“MI:0915”(physical association)	0.560
TMEM120A	EBP	psi-mi:“MI:0915”(physical association)	0.560
DHRS7	TMEM120A	psi-mi:“MI:0915”(physical association)	0.560
TMEM120A	ZDHHC15	psi-mi:“MI:0915”(physical association)	0.560
TMEM120A	REEP4	psi-mi:“MI:0915”(physical association)	0.560
TMEM120A	TMEM88	psi-mi:“MI:0915”(physical association)	0.560
TMEM120A	DHRS7	psi-mi:“MI:0915”(physical association)	0.560
TMEM120A	SCN3B	psi-mi:“MI:0915”(physical association)	0.560
TMEM120A	HSD17B13	psi-mi:“MI:0915”(physical association)	0.560
TMEM120A	TMEM14B	psi-mi:“MI:0915”(physical association)	0.560
TMEM120A	TMX2	psi-mi:“MI:0915”(physical association)	0.560
BIK	TMEM120A	psi-mi:“MI:0915”(physical association)	0.560
EBP	TMEM120A	psi-mi:“MI:0915”(physical association)	0.560
ZDHHC15	TMEM120A	psi-mi:“MI:0915”(physical association)	0.560

BioGRID (83): SNAP29 (Affinity Capture-MS), TMEM120A (Affinity Capture-MS), TMEM120A (Affinity Capture-MS), TMEM120A (Affinity Capture-MS), TMEM120A (Affinity Capture-MS), TMEM120A (Affinity Capture-MS), TMEM120A (Affinity Capture-MS), TMEM120A (Affinity Capture-MS), TMEM120A (Affinity Capture-MS), TMEM120A (Affinity Capture-MS), TMEM120A (Affinity Capture-MS), TMEM120A (Affinity Capture-MS), TMEM120A (Affinity Capture-MS), TMEM120A (Affinity Capture-MS), TMEM120A (Reconstituted Complex)

ESM2 similar proteins: A0PK00, A1L2R7, A2BIE7, A2VE61, A3KNK1, A6QPF8, A7XZ53, A8DZH4, B1AZA5, D3ZEH5, D3ZXD8, E1BD52, O35052, P58749, P98191, Q05B45, Q0VFK3, Q15035, Q17QL9, Q1LY80, Q3TA38, Q3UMR5, Q5EAX9, Q5EAY8, Q5FWV6, Q5HZE2, Q5R7B1, Q5U239, Q5ZMP3, Q63ZG0, Q68EY2, Q6DE21, Q6ZMG9, Q8BXA5, Q8C172, Q8C1E7, Q8CIF6, Q8N5B7, Q8NBJ9, Q8WVP7

Diamond homologs: A0PK00, A1L2R7, A3KNK1, A6QPF8, Q05B45, Q1LY80, Q3TA38, Q54IK2, Q5EAX9, Q5FWV6, Q5HZE2, Q63ZG0, Q6DE21, Q8C1E7, Q9BXJ8, Q9U1M2

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 97 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Formation of ATP by chemiosmotic coupling	6	60.1×	1e-07
Cristae formation	6	36.4×	1e-06
Mitochondrial biogenesis	6	17.7×	8e-05
Aerobic respiration and respiratory electron transport	7	10.9×	2e-04
Organelle biogenesis and maintenance	6	7.0×	7e-03

GO biological processes:

GO term	Partners	Fold	FDR
proton motive force-driven ATP synthesis	6	54.7×	5e-07
proton motive force-driven mitochondrial ATP synthesis	5	15.0×	6e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

84 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	51
Likely benign	2
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1484 predictions. Top by Δscore:

Variant	Effect	Δscore
7:75987429:C:CC	acceptor_gain	1.0000
7:75987716:AC:A	donor_gain	1.0000
7:75987717:CC:C	donor_gain	1.0000
7:75987717:CCCA:C	donor_gain	1.0000
7:75987808:AGC:A	acceptor_gain	1.0000
7:75987811:C:CA	acceptor_loss	1.0000
7:75987811:C:CC	acceptor_gain	1.0000
7:75987817:C:CT	acceptor_gain	1.0000
7:75987817:C:T	acceptor_gain	1.0000
7:75987818:G:T	acceptor_gain	1.0000
7:75987821:C:CT	acceptor_gain	1.0000
7:75987822:G:T	acceptor_gain	1.0000
7:75987921:A:AC	donor_gain	1.0000
7:75987922:C:CC	donor_gain	1.0000
7:75987922:CT:C	donor_gain	1.0000
7:75988082:CCA:C	donor_gain	1.0000
7:75988247:CCCA:C	donor_loss	1.0000
7:75988248:CCA:C	donor_loss	1.0000
7:75988249:CACCG:C	donor_loss	1.0000
7:75988250:ACCG:A	donor_loss	1.0000
7:75988251:C:G	donor_loss	1.0000
7:75988279:T:A	donor_gain	1.0000
7:75988280:C:CA	donor_gain	1.0000
7:75988337:TCACC:T	acceptor_gain	1.0000
7:75988338:CACC:C	acceptor_gain	1.0000
7:75988338:CACCC:C	acceptor_gain	1.0000
7:75988339:ACC:A	acceptor_gain	1.0000
7:75988340:CC:C	acceptor_gain	1.0000
7:75988340:CCC:C	acceptor_gain	1.0000
7:75988340:CCCT:C	acceptor_loss	1.0000

AlphaMissense

2272 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
7:75987595:G:C	F264L	1.000
7:75987595:G:T	F264L	1.000
7:75987597:A:G	F264L	1.000
7:75987759:A:G	L248P	1.000
7:75988133:C:A	W193C	1.000
7:75988133:C:G	W193C	1.000
7:75988138:A:G	W192R	1.000
7:75988138:A:T	W192R	1.000
7:75988260:G:C	N185K	1.000
7:75988260:G:T	N185K	1.000
7:75988270:A:G	L182P	1.000
7:75988270:A:T	L182H	1.000
7:75988279:T:A	E179V	1.000
7:75988291:A:G	L175P	1.000
7:75988307:A:G	W170R	1.000
7:75988307:A:T	W170R	1.000
7:75988483:C:A	K137N	1.000
7:75988483:C:G	K137N	1.000
7:75988497:A:G	Y133H	1.000
7:75988504:C:A	K130N	1.000
7:75988504:C:G	K130N	1.000
7:75988506:T:C	K130E	1.000
7:75989201:C:T	G114E	1.000
7:75987241:A:C	N321K	0.999
7:75987241:A:T	N321K	0.999
7:75987583:C:A	M268I	0.999
7:75987583:C:G	M268I	0.999
7:75987583:C:T	M268I	0.999
7:75987586:C:A	W267C	0.999
7:75987586:C:G	W267C	0.999

dbSNP variants (sampled 300 via entrez): RS1000315250 (7:75990779 A>T), RS1000530798 (7:75989763 C>A,G,T), RS1000600168 (7:75991069 C>T), RS1000994194 (7:75989547 T>C), RS1001035226 (7:75994457 C>A,T), RS1001382738 (7:75986961 C>A,G,T), RS1001721711 (7:75992016 C>T), RS1002055716 (7:75995674 C>T), RS1003649195 (7:75987997 G>A), RS1003945756 (7:75993148 A>G), RS1004163099 (7:75992671 G>A,C,T), RS1004365572 (7:75987538 G>A), RS1005140821 (7:75993796 G>A), RS1005181364 (7:75992126 G>A), RS1005193330 (7:75994040 C>G,T)

Disease associations

OMIM: gene MIM:616550 | disease phenotypes: MIM:613571

GenCC curated gene-disease

Mondo (1): congenital adrenal hyperplasia due to cytochrome P450 oxidoreductase deficiency (MONDO:0013310)

Orphanet (1): Congenital adrenal hyperplasia due to cytochrome P450 oxidoreductase deficiency (Orphanet:95699)

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

3 associations (top):

Study	Trait	p-value
GCST002650_4	Coffee consumption (cups per day)	4.000000e-11
GCST002651_1	Coffee consumption	1.000000e-09
GCST011437_2	Sarcoidosis	1.000000e-10

EFO canonical traits (2, from GWAS)

EFO ID	Trait name
EFO:0004330	coffee consumption
EFO:0006782	cups of coffee per day measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL6066365 (SINGLE PROTEIN)

PharmGKB: 1 entry (VIP=true, CPIC=false)

ChEMBL bioactivities

2 potent at pChembl≥5 of 2 total, top 2 by pChembl (potency: 10 = 0.1 nM, 6 = 1 µM).

pChembl	Type	Value	Unit	Molecule
6.19	Kd	650.8	nM	CHEMBL5653589
5.88	ED50	1329	nM	CHEMBL5653589

PubChem BioAssay actives

1 with measured affinity, of 2 total; 1 most potent distinct compounds. Largely complementary to BindingDB; screening values are coarse (µM, 4 dp), so sub-nM hits tie at the floor.

Compound	Assay	Type	Value	Unit
4-methyl-3-[(2-methyl-6-pyridin-3-ylpyrazolo[3,4-d]pyrimidin-4-yl)amino]-N-[3-(trifluoromethyl)phenyl]benzamide	2149606: Binding affinity to human TMEM120A incubated for 45 mins by Kinobead based pull down assay	kd	0.6508	uM

CTD chemical–gene interactions

39 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
bisphenol A	increases methylation, increases expression, affects expression, affects cotreatment	3
Benzo(a)pyrene	affects methylation, decreases expression	2
Phenylmercuric Acetate	affects cotreatment, increases expression	2
Valproic Acid	affects expression, increases expression	2
Cyclosporine	decreases expression, increases expression	2
Aflatoxin B1	affects expression, increases methylation	2
aristolochic acid I	decreases expression	1
bisphenol F	increases expression	1
alpha phellandrene	decreases expression	1
triphenyl phosphate	affects expression	1
pirinixic acid	affects binding, decreases expression, increases activity	1
glycidyl methacrylate	decreases expression	1
beta-lapachone	decreases expression	1
sodium arsenite	increases abundance, increases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, increases expression	1
dorsomorphin	increases expression, affects cotreatment	1
bisphenol S	increases expression	1
jinfukang	affects cotreatment, increases expression	1
bisphenol AF	increases expression	1
4-(4-((5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl)methylene)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)benzoic acid	increases expression	1
Temozolomide	decreases expression	1
Sunitinib	decreases expression	1
Fulvestrant	affects cotreatment, increases methylation	1
Norethindrone Acetate	affects cotreatment, increases expression	1
Arsenic	increases abundance, increases expression	1
Benzene	increases expression	1
Cadmium	increases abundance, increases expression	1
Cisplatin	affects cotreatment, increases expression	1
Dichlorodiphenyl Dichloroethylene	decreases expression	1
Diethylstilbestrol	decreases expression	1

ChEMBL screening assays

1 unique, capped per target: 1 binding

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL5652648	Binding	Binding affinity to human TMEM120A incubated for 45 mins by Kinobead based pull down assay	NVP-BHG712: Effects of Regioisomers on the Affinity and Selectivity toward the EPHrin Family. — ChemMedChem

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.