TMEM131

Summary

TMEM131 (transmembrane protein 131, HGNC:30366) is a protein-coding gene on chromosome 2q11.2, encoding Transmembrane protein 131 (Q92545). Collagen binding transmembrane protein involved in collagen secretion by recruiting the ER-to-Golgi transport complex TRAPPIII.

Enables collagen binding activity. Involved in collagen biosynthetic process. Predicted to be active in membrane.

Source: NCBI Gene 23505 — RefSeq curated summary.

At a glance

• GWAS associations: 18
• Clinical variants (ClinVar): 274 total
• MANE Select transcript: NM_015348

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:30366
Approved symbol	TMEM131
Name	transmembrane protein 131
Location	2q11.2
Locus type	gene with protein product
Status	Approved
Aliases	CC28, YR-23, RW1, KIAA0257, PRO1048
Ensembl gene	ENSG00000075568
Ensembl biotype	protein_coding
OMIM	615659
Entrez	23505

Gene structure

Transcript identifiers

Ensembl transcripts: 13 — 7 protein_coding, 5 retained_intron, 1 nonsense_mediated_decay

ENST00000186436, ENST00000409721, ENST00000418629, ENST00000438715, ENST00000465767, ENST00000469447, ENST00000480724, ENST00000485245, ENST00000489507, ENST00000913347, ENST00000913348, ENST00000913349, ENST00000962018

RefSeq mRNA: 1 — MANE Select: NM_015348 NM_015348

CCDS: CCDS46368

Canonical transcript exons

ENST00000186436 — 41 exons

Exon	Start	End
ENSE00000771460	97796844	97796986
ENSE00000771462	97801895	97801961
ENSE00000771463	97802428	97802537
ENSE00000804175	97775843	97776018
ENSE00000921818	97792386	97792984
ENSE00000921819	97793395	97793553
ENSE00000964033	97859304	97859427
ENSE00000964034	97844145	97844261
ENSE00000964036	97837077	97837157
ENSE00000964037	97834775	97834925
ENSE00000964038	97834621	97834677
ENSE00000964039	97833365	97833426
ENSE00000964040	97818613	97818721
ENSE00000964042	97814235	97814388
ENSE00000964043	97813971	97814141
ENSE00000964044	97812639	97812749
ENSE00000964045	97812421	97812555
ENSE00000964046	97811128	97811232
ENSE00000964047	97809688	97809774
ENSE00000964048	97805551	97805703
ENSE00000964049	97805376	97805451
ENSE00000964050	97805088	97805205
ENSE00000964051	97802652	97802790
ENSE00000964052	97797365	97797516
ENSE00000964055	97766478	97766602
ENSE00000964056	97766114	97766263
ENSE00000964061	97758893	97759053
ENSE00001072171	97772297	97772424
ENSE00001153481	97756336	97757383
ENSE00001308864	97762035	97762200
ENSE00001313123	97759652	97759749
ENSE00001326908	97760793	97760914
ENSE00002299854	97995476	97995948
ENSE00003472628	97815199	97815307
ENSE00003529444	97927426	97927487
ENSE00003539574	97796218	97796404
ENSE00003615875	97908658	97908698
ENSE00003626896	97794930	97795115
ENSE00003632122	97888052	97888120
ENSE00003654587	97760593	97760689
ENSE00003785318	97841815	97841937

Expression profiles

Bgee: expression breadth ubiquitous, 295 present calls, max score 97.99.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 17.0996 / max 146.6726, expressed in 1810 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
29831	15.2173	1804
29832	1.8716	1070
29822	0.0107	2

Top tissues by expression

298 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
bronchial epithelial cell	CL:0002328	97.99	gold quality
mucosa of sigmoid colon	UBERON:0004993	96.88	gold quality
epithelium of bronchus	UBERON:0002031	96.61	gold quality
colonic mucosa	UBERON:0000317	96.54	gold quality
jejunal mucosa	UBERON:0000399	96.52	gold quality
bronchus	UBERON:0002185	96.46	gold quality
tibia	UBERON:0000979	95.82	gold quality
mucosa of paranasal sinus	UBERON:0005030	95.58	gold quality
jejunum	UBERON:0002115	95.20	gold quality
skin of hip	UBERON:0001554	95.01	gold quality
upper leg skin	UBERON:0004262	94.89	gold quality
trabecular bone tissue	UBERON:0002483	94.59	gold quality
blood vessel layer	UBERON:0004797	94.48	gold quality
pylorus	UBERON:0001166	94.36	gold quality
hair follicle	UBERON:0002073	94.26	gold quality
oral cavity	UBERON:0000167	94.25	gold quality
vastus lateralis	UBERON:0001379	94.10	gold quality
cardia of stomach	UBERON:0001162	93.76	gold quality
superficial temporal artery	UBERON:0001614	93.73	gold quality
bone marrow cell	CL:0002092	93.66	gold quality
secondary oocyte	CL:0000655	93.57	gold quality
quadriceps femoris	UBERON:0001377	93.54	gold quality
upper arm skin	UBERON:0004263	93.51	gold quality
seminal vesicle	UBERON:0000998	93.36	gold quality
superior surface of tongue	UBERON:0007371	93.19	gold quality
penis	UBERON:0000989	93.12	gold quality
parietal pleura	UBERON:0002400	93.00	gold quality
rectum	UBERON:0001052	92.99	gold quality
epithelium of nasopharynx	UBERON:0001951	92.98	gold quality
nasopharynx	UBERON:0001728	92.97	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	6.49
E-GEOD-124858	no	165.33

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

79 targeting TMEM131, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4262	100.00	73.26	3931
HSA-MIR-5692B	100.00	71.32	2622
HSA-MIR-5692C	100.00	71.32	2622
HSA-LET-7A-3P	100.00	74.03	3932
HSA-LET-7B-3P	100.00	74.08	3913
HSA-LET-7F-1-3P	100.00	74.02	3928
HSA-MIR-98-3P	100.00	74.08	3907
HSA-MIR-181A-5P	99.99	72.96	2995
HSA-MIR-181B-5P	99.99	72.97	2996
HSA-MIR-181C-5P	99.99	72.95	2996
HSA-MIR-181D-5P	99.99	73.04	2997
HSA-MIR-8068	99.98	73.85	2376
HSA-MIR-607	99.97	73.62	5593
HSA-MIR-3658	99.96	73.87	4379
HSA-MIR-4725-3P	99.96	69.53	2520
HSA-MIR-6780B-5P	99.96	69.60	2562
HSA-MIR-548AA	99.96	70.64	3753
HSA-MIR-548AP-3P	99.96	70.64	3753
HSA-MIR-548T-3P	99.96	70.64	3753
HSA-MIR-548AJ-3P	99.96	73.38	5345
HSA-MIR-548X-3P	99.96	73.38	5345
HSA-MIR-6825-5P	99.96	69.81	3431
HSA-MIR-548J-3P	99.94	72.61	4881
HSA-MIR-539-5P	99.93	70.30	2855
HSA-MIR-6835-3P	99.93	70.49	2904
HSA-MIR-548AE-3P	99.93	72.66	4867
HSA-MIR-548AH-3P	99.93	72.54	4872
HSA-MIR-548AM-3P	99.93	72.54	4872
HSA-MIR-548AQ-3P	99.93	72.66	4867
HSA-MIR-450B-5P	99.92	71.48	3175

Literature-anchored findings (GeneRIF, showing 1)

• A statistically significant loss of methylation at CpG dinucleotide sites within the non-syntenic TMEM131 gene is observed in individuals with free trisomy 21 (Down syndrome) compared with control disomic samples. The loss is independent of the maternal or the paternal origin of the chromosome 21 nondisjunction event. (PMID:27100087)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	tmem131	ENSDARG00000056259
mus_musculus	Tmem131	ENSMUSG00000026116
rattus_norvegicus	Tmem131	ENSRNOG00000017265
drosophila_melanogaster	Tmem131	FBGN0034060
caenorhabditis_elegans		WBGENE00016170

Paralogs (1): TMEM131L (ENSG00000121210)

Protein

Protein identifiers

Transmembrane protein 131 — Q92545 (reviewed: Q92545)

Alternative names: Protein RW1

All UniProt accessions (4): Q92545, C9J6W0, H7BZ05, H7BZV0

UniProt curated annotations — full annotation on UniProt →

Function. Collagen binding transmembrane protein involved in collagen secretion by recruiting the ER-to-Golgi transport complex TRAPPIII. May play a role in the immune response to viral infection.

Subunit / interactions. Interacts (via PapD-L domain) with COL1A2 (via C-terminus); the interaction is direct, may occur with other collagen proteins, and is involved in assembly and TRAPPIII ER-to-Golgi transport complex-dependent secretion of collagen. Interacts (via C-terminus) with TRAPPC8 (via C-terminus); the interaction is direct.

Subcellular location. Membrane.

Domain organisation. Possesses a PapD-like (PapD-L) domain similar to PapD domains involved in assembly and secretion of bacterial pilus components. The PapD-L domain can bind collagens and is probably involved in collagen assembly and secretion.

Similarity. Belongs to the TMEM131 family.

RefSeq proteins (1): NP_056163* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR013783	Ig-like_fold	Homologous_superfamily
IPR022113	TMEM131L_N	Domain
IPR039877	TMEM131-like	Family
IPR045695	TMEM131-like_Ig_dom2	Domain
IPR055435	Ig_TMEM131L_3	Domain
IPR055436	Ig_TMEM131L_4	Domain
IPR055437	TMEM131L_Ig_5	Domain
IPR056311	TMEM131_Ig_2	Domain

Pfam: PF12371, PF19532, PF24495, PF24498, PF24499, PF24501

UniProt features (38 total): compositionally biased region 15, region of interest 6, modified residue 6, mutagenesis site 5, topological domain 2, signal peptide 1, chain 1, transmembrane region 1, glycosylation site 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q92545-F1	60.28	0.09

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (6): 803, 1322, 1342, 1375, 1863, 1871

Glycosylation sites (1): 300

Mutagenesis-validated functional residues (5):

Position	Phenotype
1533	does not affect trappc8 binding.
1564	does not affect trappc8 binding. abrogates interaction with trappc8; when associated with a-1707.
1577	does not affect trappc8 binding.
1590	does not affect trappc8 binding.
1707	does not affect trappc8 binding. abrogates interaction with trappc8; when associated with a-1564.

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 158 (showing top): DACOSTA_UV_RESPONSE_VIA_ERCC3_COMMON_DN, ZHAN_MULTIPLE_MYELOMA_SUBGROUPS, chr2q11, CASORELLI_ACUTE_PROMYELOCYTIC_LEUKEMIA_UP, WANG_RESPONSE_TO_GSK3_INHIBITOR_SB216763_UP, GOBP_COLLAGEN_METABOLIC_PROCESS, GOBP_COLLAGEN_BIOSYNTHETIC_PROCESS, WAKABAYASHI_ADIPOGENESIS_PPARG_RXRA_BOUND_8D, FOSTER_KDM1A_TARGETS_DN, GOMF_PROTEIN_CONTAINING_COMPLEX_BINDING, SHEN_SMARCA2_TARGETS_UP, GSE14415_ACT_TCONV_VS_ACT_NATURAL_TREG_UP, SESTO_RESPONSE_TO_UV_C8, CIITA_TARGET_GENES, DIDO1_TARGET_GENES

GO Biological Process (1): collagen biosynthetic process (GO:0032964)

GO Molecular Function (1): collagen binding (GO:0005518)

GO Cellular Component (1): membrane (GO:0016020)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
biosynthetic process	1
collagen metabolic process	1
protein-containing complex binding	1
cellular anatomical structure	1

Protein interactions and networks

STRING

758 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
TMEM131	AMIGO3	Q86WK7	535
TMEM131	TRAPPC8	Q9Y2L5	523
TMEM131	SH3BP2	P78314	494
TMEM131	ERICH1	Q86X53	488
TMEM131	ZDHHC14	Q8IZN3	483
TMEM131	ST20	Q9HBF5	446
TMEM131	MIA3	Q5JRA6	445
TMEM131	RALGAPB	Q86X10	429
TMEM131	NAA30	Q147X3	418
TMEM131	ZNF510	Q9Y2H8	413
TMEM131	SLC24A5	Q71RS6	412
TMEM131	LRRC24	Q50LG9	405
TMEM131	SCGB1A1	P11684	399
TMEM131	SLC45A2	Q9UMX9	388
TMEM131	NHLRC2	Q8NBF2	386

IntAct

127 interactions, top by confidence:

A	B	Type	Score
PIGS	GPAA1	psi-mi:“MI:0914”(association)	0.760
B3GNT3	PGRMC1	psi-mi:“MI:0914”(association)	0.670
TNFSF13B	IPO8	psi-mi:“MI:0914”(association)	0.640
TMEM131		psi-mi:“MI:0915”(physical association)	0.550
PLXDC2	UPK3BL1	psi-mi:“MI:0914”(association)	0.530
MCOLN3	UPK3BL1	psi-mi:“MI:0914”(association)	0.530
DEFA1	MANBA	psi-mi:“MI:0914”(association)	0.530
OS9	AGRN	psi-mi:“MI:0914”(association)	0.530
GABRD	ATF6	psi-mi:“MI:0914”(association)	0.530
FBXO2	TMEM131L	psi-mi:“MI:0914”(association)	0.530
LRRTM1	UPK3BL1	psi-mi:“MI:0914”(association)	0.530
GABRA3	HLA-C	psi-mi:“MI:0914”(association)	0.530
C1orf54	EXTL3	psi-mi:“MI:0914”(association)	0.530
FKBP2	TTC13	psi-mi:“MI:0914”(association)	0.530
SIDT2	AP3D1	psi-mi:“MI:0914”(association)	0.530
PIP	TBKBP1	psi-mi:“MI:0914”(association)	0.530
THOC2		psi-mi:“MI:0914”(association)	0.350
CTR9	POLR2B	psi-mi:“MI:0914”(association)	0.350
Kcnk1	TRAPPC13	psi-mi:“MI:0914”(association)	0.350
Tubgcp5	TUBG1	psi-mi:“MI:0914”(association)	0.350
Csde1	TXNDC9	psi-mi:“MI:0914”(association)	0.350
EGLN3	FAM168B	psi-mi:“MI:0914”(association)	0.350
LRRTM1	TMEM223	psi-mi:“MI:0914”(association)	0.350

BioGRID (217): TMEM131 (Affinity Capture-MS), TMEM131 (Affinity Capture-MS), TMEM131 (Affinity Capture-MS), TMEM131 (Affinity Capture-MS), TMEM131 (Affinity Capture-MS), TMEM131 (Affinity Capture-MS), TMEM131 (Affinity Capture-MS), TMEM131 (Affinity Capture-MS), TMEM131 (Affinity Capture-MS), TMEM131 (Affinity Capture-MS), TMEM131 (Affinity Capture-MS), TMEM131 (Affinity Capture-MS), TMEM131 (Affinity Capture-MS), TMEM131 (Synthetic Lethality), TMEM131 (Affinity Capture-MS)

ESM2 similar proteins: A2AFS3, B2RY83, O70472, O95803, P35790, P52848, P61812, P78539, Q01134, Q02353, Q08DW9, Q09LZ8, Q0VCJ8, Q38L25, Q3UHN9, Q4R5H6, Q4R766, Q5F450, Q5H8A4, Q5RES2, Q5RKN4, Q5U4X8, Q5VU57, Q5VV63, Q5XIC4, Q5ZIN0, Q5ZMH6, Q63769, Q6A051, Q6AYT7, Q6PC62, Q6UXG2, Q86W50, Q8BG28, Q8BWB6, Q8MJJ1, Q8N2K0, Q8NCR0, Q8WWQ2, Q92545

Diamond homologs: A2VDJ0, O70472, Q3U3D7, Q92545, Q08DV9

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 158 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Neutrophil degranulation	14	3.2×	5e-03

GO biological processes:

GO term	Partners	Fold	FDR
synaptic transmission, cholinergic	5	30.9×	2e-04
acetylcholine receptor signaling pathway	5	24.0×	5e-04
membrane depolarization	5	19.6×	1e-03
ERAD pathway	7	9.8×	1e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

274 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	239
Likely benign	9
Benign	1

Top pathogenic / likely-pathogenic (0)

SpliceAI

7303 predictions. Top by Δscore:

Variant	Effect	Δscore
2:97757380:CCGA:C	acceptor_gain	1.0000
2:97757381:CGAC:C	acceptor_gain	1.0000
2:97758889:TCA:T	donor_loss	1.0000
2:97758890:CA:C	donor_loss	1.0000
2:97758891:A:AC	donor_gain	1.0000
2:97758891:A:T	donor_loss	1.0000
2:97758892:C:CA	donor_gain	1.0000
2:97758892:CT:C	donor_gain	1.0000
2:97758892:CTG:C	donor_gain	1.0000
2:97758892:CTGT:C	donor_gain	1.0000
2:97758892:CTGTG:C	donor_gain	1.0000
2:97759049:AACTT:A	acceptor_gain	1.0000
2:97759050:ACTT:A	acceptor_loss	1.0000
2:97759050:ACTTC:A	acceptor_gain	1.0000
2:97759051:CTT:C	acceptor_gain	1.0000
2:97759051:CTTC:C	acceptor_loss	1.0000
2:97759051:CTTCT:C	acceptor_gain	1.0000
2:97759052:TT:T	acceptor_gain	1.0000
2:97759052:TTCTG:T	acceptor_loss	1.0000
2:97759054:C:CC	acceptor_gain	1.0000
2:97759054:C:T	acceptor_loss	1.0000
2:97759055:T:A	acceptor_loss	1.0000
2:97760910:GGTCA:G	acceptor_gain	1.0000
2:97760912:TCAC:T	acceptor_loss	1.0000
2:97760913:CA:C	acceptor_gain	1.0000
2:97760913:CACT:C	acceptor_gain	1.0000
2:97760914:ACT:A	acceptor_loss	1.0000
2:97760915:C:CC	acceptor_gain	1.0000
2:97760915:CTTGA:C	acceptor_loss	1.0000
2:97760916:T:C	acceptor_gain	1.0000

AlphaMissense

12330 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
2:97793513:C:G	A1143P	1.000
2:97795074:A:G	L1081P	1.000
2:97796281:A:G	F1046S	1.000
2:97815221:A:C	Y424D	1.000
2:97815262:A:T	V410D	1.000
2:97815268:A:C	I408R	1.000
2:97815268:A:T	I408K	1.000
2:97818630:G:T	A389E	1.000
2:97818631:C:G	A389P	1.000
2:97818633:A:T	V388D	1.000
2:97818717:A:T	V360D	1.000
2:97833369:A:C	I357R	1.000
2:97833369:A:T	I357K	1.000
2:97833392:A:C	N349K	1.000
2:97833392:A:T	N349K	1.000
2:97833405:A:G	L345P	1.000
2:97834666:A:C	Y323D	1.000
2:97834789:A:T	V314D	1.000
2:97834795:A:T	V312D	1.000
2:97834801:A:G	L310P	1.000
2:97834840:A:T	I297K	1.000
2:97834846:A:C	I295R	1.000
2:97834846:A:T	I295K	1.000
2:97834848:G:C	F294L	1.000
2:97834848:G:T	F294L	1.000
2:97834850:A:G	F294L	1.000
2:97834853:C:G	A293P	1.000
2:97834888:G:T	A281D	1.000
2:97837077:C:A	W268C	1.000
2:97837077:C:G	W268C	1.000

dbSNP variants (sampled 300 via entrez): RS1000016619 (2:97912689 C>T), RS1000016983 (2:97832972 C>T), RS1000024284 (2:97924066 C>G,T), RS1000044029 (2:97773654 G>A,T), RS1000047958 (2:97832727 T>G), RS1000060622 (2:97788512 A>C), RS1000078518 (2:97832457 G>A), RS1000114065 (2:97817023 A>G), RS1000116838 (2:97919397 G>A,C), RS1000117354 (2:97910961 A>C), RS1000127638 (2:97807928 G>A,T), RS1000130474 (2:97786995 A>C), RS1000148170 (2:97963397 A>G), RS1000149668 (2:97965272 T>C), RS1000158669 (2:97807610 C>A)

Disease associations

OMIM: gene MIM:615659 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

18 associations (top):

Study	Trait	p-value
GCST007932_77	Medication use (thyroid preparations)	5.000000e-10
GCST008103_128	Bipolar disorder	2.000000e-06
GCST008310_6	Cardiac Troponin-T levels	5.000000e-07
GCST010697_1	Cortical surface area (min-P)	6.000000e-12
GCST010698_17	Subcortical volume (min-P)	9.000000e-09
GCST010699_105	Brain morphology (min-P)	2.000000e-11
GCST010700_9	Cortical thickness (MOSTest)	9.000000e-14
GCST010701_54	Cortical surface area (MOSTest)	2.000000e-16
GCST010702_79	Subcortical volume (MOSTest)	5.000000e-09
GCST010703_322	Brain morphology (MOSTest)	1.000000e-10
GCST90002381_36	Eosinophil count	6.000000e-11
GCST90002382_43	Eosinophil percentage of white cells	2.000000e-14
GCST90002385_135	High light scatter reticulocyte count	2.000000e-09
GCST90002386_251	High light scatter reticulocyte percentage of red cells	2.000000e-10
GCST90002397_810	Mean spheric corpuscular volume	1.000000e-13
GCST90002399_148	Neutrophil percentage of white cells	1.000000e-09
GCST90002405_131	Reticulocyte count	2.000000e-13
GCST90002406_24	Reticulocyte fraction of red cells	1.000000e-15

EFO canonical traits (8, from GWAS)

EFO ID	Trait name
EFO:0009933	Thyroid preparation use measurement
EFO:0005043	cardiac troponin T measurement
EFO:0004346	neuroimaging measurement
EFO:0004840	cortical thickness
EFO:0004842	eosinophil count
EFO:0007991	eosinophil percentage of leukocytes
EFO:0007986	reticulocyte count
EFO:0007990	neutrophil percentage of leukocytes

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

32 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Benzo(a)pyrene	increases methylation, increases mutagenesis	2
Cadmium Chloride	increases expression, decreases expression, increases abundance	2
aristolochic acid I	decreases expression	1
FR900359	affects phosphorylation	1
bisphenol F	affects cotreatment, decreases methylation	1
dicrotophos	increases expression	1
triphenyl phosphate	affects expression	1
sodium arsenite	increases expression	1
di-n-butylphosphoric acid	affects expression	1
chloropicrin	increases expression	1
K 7174	increases expression	1
bisphenol S	affects cotreatment, increases methylation, decreases methylation	1
Temozolomide	decreases expression	1
Fulvestrant	affects cotreatment, decreases methylation, increases methylation	1
Air Pollutants	increases abundance, increases expression	1
Cadmium	increases abundance, decreases expression	1
Caffeine	affects phosphorylation	1
Cisplatin	decreases expression	1
Doxorubicin	decreases expression	1
Ethyl Methanesulfonate	increases expression	1
Formaldehyde	increases expression	1
Hydrogen Peroxide	affects expression	1
Methotrexate	decreases expression	1
Methyl Methanesulfonate	increases expression	1
Ribonucleotides	affects binding	1
Dronabinol	increases expression	1
Tobacco Smoke Pollution	decreases expression	1
Tretinoin	increases expression	1
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	decreases expression	1
Cyclosporine	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.