TMEM131L

Summary

TMEM131L (transmembrane 131 like, HGNC:29146) is a protein-coding gene on chromosome 4q31.3, encoding Transmembrane protein 131-like (A2VDJ0). Membrane-associated form that antagonizes canonical Wnt signaling by triggering lysosome-dependent degradation of Wnt-activated LRP6.

Involved in negative regulation of canonical Wnt signaling pathway and negative regulation of immature T cell proliferation in thymus. Located in cytoplasm and plasma membrane.

Source: NCBI Gene 23240 — RefSeq curated summary.

At a glance

• GWAS associations: 26
• Clinical variants (ClinVar): 277 total
• MANE Select transcript: NM_001131007

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:29146
Approved symbol	TMEM131L
Name	transmembrane 131 like
Location	4q31.3
Locus type	gene with protein product
Status	Approved
Aliases	DKFZp586H1322
Ensembl gene	ENSG00000121210
Ensembl biotype	protein_coding
OMIM	616243
Entrez	23240

Gene structure

Transcript identifiers

Ensembl transcripts: 28 — 23 protein_coding, 4 retained_intron, 1 nonsense_mediated_decay

ENST00000240487, ENST00000409663, ENST00000409959, ENST00000445960, ENST00000462540, ENST00000478919, ENST00000497247, ENST00000509565, ENST00000886543, ENST00000886548, ENST00000886549, ENST00000886550, ENST00000886551, ENST00000886552, ENST00000939903, ENST00000939904, ENST00000939905, ENST00000939906, ENST00000939907, ENST00000939908, ENST00000939909, ENST00000939910, ENST00000939911, ENST00000939912, ENST00000971909, ENST00000971910, ENST00000971911, ENST00000971912

RefSeq mRNA: 2 — MANE Select: NM_001131007 NM_001131007, NM_015196

CCDS: CCDS3783, CCDS47148

Canonical transcript exons

ENST00000409959 — 35 exons

Exon	Start	End
ENSE00000740002	153620756	153620880
ENSE00000740004	153612252	153612400
ENSE00000740007	153603802	153604430
ENSE00000740010	153603303	153603452
ENSE00000821100	153621683	153621849
ENSE00000821101	153622898	153623083
ENSE00000821102	153626147	153626225
ENSE00000821103	153627605	153627687
ENSE00000821104	153632718	153632838
ENSE00000821105	153634192	153634280
ENSE00000821106	153635432	153635571
ENSE00000927455	153586209	153586379
ENSE00000927456	153587742	153587811
ENSE00000927457	153588890	153589007
ENSE00000927458	153591053	153591194
ENSE00000927459	153592475	153592584
ENSE00000927460	153593799	153593871
ENSE00000927461	153596258	153596385
ENSE00000927462	153598590	153598732
ENSE00000927463	153602152	153602338
ENSE00001334339	153583564	153583672
ENSE00001334341	153583190	153583248
ENSE00001334343	153581407	153581560
ENSE00001334344	153580826	153580903
ENSE00001334345	153558258	153558368
ENSE00001588844	153636301	153636711
ENSE00001713308	153467211	153467281
ENSE00001765859	153473845	153473888
ENSE00001922965	153466360	153466521
ENSE00003466099	153585458	153585611
ENSE00003473785	153584835	153584931
ENSE00003525201	153556966	153557082
ENSE00003544801	153555787	153555910
ENSE00003571772	153602542	153602727
ENSE00003589831	153550073	153550141

Expression profiles

Bgee: expression breadth ubiquitous, 236 present calls, max score 98.46.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 21.8315 / max 907.3634, expressed in 1783 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
50071	21.6936	1783
50072	0.1379	73

Top tissues by expression

287 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
secondary oocyte	CL:0000655	98.46	gold quality
oocyte	CL:0000023	96.59	gold quality
body of pancreas	UBERON:0001150	91.57	gold quality
leukocyte	CL:0000738	91.43	gold quality
monocyte	CL:0000576	91.37	gold quality
granulocyte	CL:0000094	91.36	gold quality
mononuclear cell	CL:0000842	91.34	gold quality
bone marrow	UBERON:0002371	90.73	gold quality
blood	UBERON:0000178	90.24	gold quality
spleen	UBERON:0002106	89.71	gold quality
trabecular bone tissue	UBERON:0002483	89.63	gold quality
lymph node	UBERON:0000029	89.53	gold quality
ganglionic eminence	UBERON:0004023	89.41	gold quality
vermiform appendix	UBERON:0001154	89.39	gold quality
bone marrow cell	CL:0002092	89.30	gold quality
popliteal artery	UBERON:0002250	89.15	gold quality
tibial artery	UBERON:0007610	89.14	gold quality
ventricular zone	UBERON:0003053	88.66	gold quality
thymus	UBERON:0002370	88.37	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	87.53	gold quality
hindlimb stylopod muscle	UBERON:0004252	86.47	gold quality
tonsil	UBERON:0002372	86.37	gold quality
pancreas	UBERON:0001264	85.99	gold quality
blood vessel layer	UBERON:0004797	85.81	gold quality
aorta	UBERON:0000947	85.67	gold quality
right lobe of liver	UBERON:0001114	85.25	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	84.31	gold quality
caecum	UBERON:0001153	84.30	gold quality
muscle of leg	UBERON:0001383	84.23	gold quality
superficial temporal artery	UBERON:0001614	84.16	gold quality

Single-cell (SCXA)

Detected in 6 experiment(s), a significant marker in 4.

Experiment	Marker?	Max mean expression
E-CURD-119	yes	16.14
E-MTAB-9067	yes	13.36
E-ANND-3	yes	13.19
E-CURD-122	yes	6.32
E-ENAD-17	no	775.02
E-MTAB-8060	no	33.75

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): ELK1, ETS1

miRNA regulators (miRDB)

21 targeting TMEM131L, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-4282	99.99	75.36	6408
HSA-MIR-548N	99.98	71.94	4170
HSA-MIR-23A-3P	99.95	74.24	3163
HSA-MIR-23B-3P	99.95	74.24	3163
HSA-MIR-23C	99.95	73.92	3192
HSA-MIR-335-3P	99.93	73.36	4958
HSA-MIR-106A-5P	99.90	73.94	2683
HSA-MIR-17-5P	99.89	73.83	2665
HSA-MIR-106B-5P	99.88	74.72	2795
HSA-MIR-20A-5P	99.88	74.76	2769
HSA-MIR-20B-5P	99.88	74.01	2621
HSA-MIR-519D-3P	99.88	73.97	2607
HSA-MIR-526B-3P	99.88	74.06	2587
HSA-MIR-93-5P	99.88	73.98	2606
HSA-MIR-548AZ-5P	99.83	69.94	3230
HSA-MIR-548T-5P	99.83	69.91	3220
HSA-MIR-12123	99.52	71.79	2990
HSA-MIR-628-3P	99.04	68.37	814
HSA-MIR-4704-5P	96.13	68.67	608
HSA-MIR-5092	93.86	62.63	151

Literature-anchored findings (GeneRIF, showing 2)

• these data indicate that, during thymopoiesis, stage-specific surface translocation of TMEM131L may regulate immature single-positive thymocyte proliferation arrest (PMID:23690469)
• These results show that TMEM131L corresponds to an evolutionary conserved regulator of the Notch signaling pathway. (PMID:28347816)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	tmem131l	ENSDARG00000079434
mus_musculus	Tmem131l	ENSMUSG00000033767
rattus_norvegicus	Tmem131l	ENSRNOG00000009837
drosophila_melanogaster	Tmem131	FBGN0034060
caenorhabditis_elegans		WBGENE00016170

Paralogs (1): TMEM131 (ENSG00000075568)

Protein

Protein identifiers

Transmembrane protein 131-like — A2VDJ0 (reviewed: A2VDJ0)

All UniProt accessions (3): A2VDJ0, F8WEQ2, H0Y2M0

UniProt curated annotations — full annotation on UniProt →

Function. Membrane-associated form that antagonizes canonical Wnt signaling by triggering lysosome-dependent degradation of Wnt-activated LRP6. Regulates thymocyte proliferation.

Subcellular location. Cell membrane. Cytoplasm Endoplasmic reticulum Cytoplasm.

Tissue specificity. Expressed in thymocytes.

Similarity. Belongs to the TMEM131 family.

Isoforms (5)

UniProt ID	Names	Canonical?
A2VDJ0-1	1, L	yes
A2VDJ0-2	2
A2VDJ0-3	3
A2VDJ0-5	4
A2VDJ0-6	5, S

RefSeq proteins (2): NP_001124479, NP_056011 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR013783	Ig-like_fold	Homologous_superfamily
IPR022113	TMEM131L_N	Domain
IPR039877	TMEM131-like	Family
IPR045695	TMEM131-like_Ig_dom2	Domain
IPR055435	Ig_TMEM131L_3	Domain
IPR055436	Ig_TMEM131L_4	Domain
IPR055437	TMEM131L_Ig_5	Domain

Pfam: PF12371, PF19532, PF24498, PF24499, PF24501

UniProt features (32 total): region of interest 6, glycosylation site 6, splice variant 5, sequence variant 5, compositionally biased region 3, topological domain 2, signal peptide 1, chain 1, modified residue 1, transmembrane region 1, sequence conflict 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-A2VDJ0-F1	53.30	0.08

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (1): 1122

Glycosylation sites (6): 343, 439, 522, 593, 709, 846

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 258 (showing top): GOBP_REGULATION_OF_CELL_ACTIVATION, E2F_Q4_01, GOBP_REGULATION_OF_LEUKOCYTE_PROLIFERATION, GOBP_NEGATIVE_REGULATION_OF_CELL_DEVELOPMENT, DACOSTA_UV_RESPONSE_VIA_ERCC3_XPCS_DN, GOBP_NEGATIVE_REGULATION_OF_LEUKOCYTE_PROLIFERATION, BASSO_HAIRY_CELL_LEUKEMIA_DN, LFA1_Q6, GOBP_NEGATIVE_REGULATION_OF_CELL_CELL_ADHESION, TAL1ALPHAE47_01, GOBP_REGULATION_OF_WNT_SIGNALING_PATHWAY, SP1_Q2_01, PUJANA_CHEK2_PCC_NETWORK, SENESE_HDAC1_AND_HDAC2_TARGETS_DN, GOBP_CELL_CELL_ADHESION

GO Biological Process (3): Wnt signaling pathway (GO:0016055), negative regulation of immature T cell proliferation in thymus (GO:0033088), negative regulation of canonical Wnt signaling pathway (GO:0090090)

GO Molecular Function (0):

GO Cellular Component (4): cytoplasm (GO:0005737), endoplasmic reticulum (GO:0005783), plasma membrane (GO:0005886), membrane (GO:0016020)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	2
cell surface receptor signaling pathway	1
immature T cell proliferation in thymus	1
regulation of immature T cell proliferation in thymus	1
negative regulation of T cell differentiation in thymus	1
negative regulation of immature T cell proliferation	1
negative regulation of Wnt signaling pathway	1
canonical Wnt signaling pathway	1
regulation of canonical Wnt signaling pathway	1
intracellular anatomical structure	1
cytoplasm	1
endomembrane system	1
intracellular membrane-bounded organelle	1
membrane	1
cell periphery	1

Protein interactions and networks

STRING

424 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
TMEM131L	TMEM229B	Q8NBD8	666
TMEM131L	TIGD4	Q8IY51	572
TMEM131L	SMIM14	Q96QK8	540
TMEM131L	COMMD8	Q9NX08	526
TMEM131L	RNF150	Q9ULK6	517
TMEM131L	OCIAD2	Q56VL3	504
TMEM131L	APBA2	Q99767	498
TMEM131L	ARFIP1	P53367	492
TMEM131L	C1orf21	Q9H246	477
TMEM131L	TMEM62	Q0P6H9	468
TMEM131L	LIAS	O43766	458
TMEM131L	SYNPO2	Q9UMS6	449
TMEM131L	GON7	Q9BXV9	446
TMEM131L	ETFDH	Q16134	443
TMEM131L	GABRB1	P18505	439

IntAct

75 interactions, top by confidence:

A	B	Type	Score
FBXO2	TMEM131L	psi-mi:“MI:0914”(association)	0.530
CSNK1D	TMEM131L	psi-mi:“MI:0914”(association)	0.350
MYC		psi-mi:“MI:0914”(association)	0.350
HLA-DQB1	ESYT2	psi-mi:“MI:0914”(association)	0.350
PCDHA4	TMEM223	psi-mi:“MI:0914”(association)	0.350
APOA2	TMEM131L	psi-mi:“MI:0914”(association)	0.350
LRCH1	TMEM131L	psi-mi:“MI:0914”(association)	0.350
CGRRF1	TMEM131L	psi-mi:“MI:0914”(association)	0.350
BTNL8	TMEM131L	psi-mi:“MI:0914”(association)	0.350
TCTN2	TMEM131L	psi-mi:“MI:0914”(association)	0.350
NLGN3	TMEM131L	psi-mi:“MI:0914”(association)	0.350
TMPRSS3	TMEM131L	psi-mi:“MI:0914”(association)	0.350
CHRNB2	TMEM131L	psi-mi:“MI:0914”(association)	0.350
TENT5A	TMEM131L	psi-mi:“MI:0914”(association)	0.350
IL17RC	TMEM131L	psi-mi:“MI:0914”(association)	0.350
LRP3	TMEM131L	psi-mi:“MI:0914”(association)	0.350
PDE3A	TMEM131L	psi-mi:“MI:0914”(association)	0.350
PCDHB3	ESYT2	psi-mi:“MI:0914”(association)	0.350
CLEC2D	ESYT2	psi-mi:“MI:0914”(association)	0.350
GP9	ESYT2	psi-mi:“MI:0914”(association)	0.350
APOM	ESYT2	psi-mi:“MI:0914”(association)	0.350
PIGH	ILVBL	psi-mi:“MI:0914”(association)	0.350
HLA-DQB1	PIPSL	psi-mi:“MI:0914”(association)	0.350
TMEM106A	TMEM131L	psi-mi:“MI:0914”(association)	0.350
PCDHA8	TMEM131L	psi-mi:“MI:0914”(association)	0.350
CCDC107	TMEM131L	psi-mi:“MI:0914”(association)	0.350
HLA-C	TMEM131L	psi-mi:“MI:0914”(association)	0.350
HLA-DPB1	TMEM131L	psi-mi:“MI:0914”(association)	0.350

BioGRID (130): KIAA0922 (Affinity Capture-MS), KIAA0922 (Affinity Capture-MS), KIAA0922 (Affinity Capture-MS), KIAA0922 (Affinity Capture-MS), KIAA0922 (Affinity Capture-MS), KIAA0922 (Affinity Capture-MS), KIAA0922 (Affinity Capture-MS), KIAA0922 (Affinity Capture-MS), KIAA0922 (Synthetic Lethality), KIAA0922 (Affinity Capture-MS), KIAA0922 (Affinity Capture-MS), KIAA0922 (Affinity Capture-MS), KIAA0922 (Affinity Capture-RNA), KIAA0922 (Affinity Capture-MS), KIAA0922 (Affinity Capture-MS)

ESM2 similar proteins: A2VDJ0, A5D791, A9CB18, D3YYM4, D5K8A9, E7FKV8, F1LW30, M0R2J8, O60383, O70173, O75747, Q07105, Q08DV9, Q2F7Z7, Q3MJ13, Q3SXY7, Q3T0Q2, Q3U3D7, Q3U3S3, Q4R8C8, Q5F479, Q5R800, Q5RFQ4, Q5SUS0, Q5XX13, Q6IRU7, Q6P4T1, Q6UXZ4, Q7TP65, Q8BLA1, Q8K1S2, Q8NDB2, Q8NEM2, Q8QHJ9, Q8R526, Q8TDX9, Q920I9, Q96KN7, Q9BXS4, Q9D0L6

Diamond homologs: A2VDJ0, Q08DV9, Q3U3D7, O70472, Q92545

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 77 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Translocation of ZAP-70 to Immunological synapse	5	55.6×	3e-06
Phosphorylation of CD3 and TCR zeta chains	5	47.7×	3e-06
Co-inhibition by PD-1	5	45.5×	3e-06
Generation of second messenger molecules	5	30.4×	2e-05
Interferon gamma signaling	7	15.4×	1e-05
R-HSA-425393	6	13.7×	1e-04
Downstream TCR signaling	5	11.3×	2e-03
SLC-mediated transmembrane transport	10	10.4×	3e-06

GO biological processes:

GO term	Partners	Fold	FDR
peptide antigen assembly with MHC class II protein complex	5	77.4×	2e-06
sodium ion import across plasma membrane	5	45.9×	9e-06
regulation of intracellular pH	5	44.2×	9e-06
antigen processing and presentation of exogenous peptide antigen via MHC class II	5	40.0×	1e-05
positive regulation of immune response	5	35.4×	2e-05
positive regulation of T cell activation	5	32.6×	3e-05
sodium ion transport	5	20.0×	3e-04
T cell receptor signaling pathway	8	17.9×	3e-06

Disease & clinical

Clinical variants and AI predictions

ClinVar

277 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	235
Likely benign	16
Benign	2

Top pathogenic / likely-pathogenic (0)

SpliceAI

5492 predictions. Top by Δscore:

Variant	Effect	Δscore
4:153467197:T:TA	acceptor_gain	1.0000
4:153467198:G:A	acceptor_gain	1.0000
4:153467200:T:TA	acceptor_gain	1.0000
4:153467206:T:A	acceptor_gain	1.0000
4:153467206:TGCA:T	acceptor_loss	1.0000
4:153467207:GCAGC:G	acceptor_loss	1.0000
4:153467209:A:AG	acceptor_gain	1.0000
4:153467209:AG:A	acceptor_loss	1.0000
4:153467209:AGC:A	acceptor_gain	1.0000
4:153467210:G:GA	acceptor_gain	1.0000
4:153467210:GC:G	acceptor_gain	1.0000
4:153467210:GCG:G	acceptor_gain	1.0000
4:153467210:GCGA:G	acceptor_gain	1.0000
4:153467210:GCGAT:G	acceptor_gain	1.0000
4:153467280:AG:A	donor_loss	1.0000
4:153467281:GG:G	donor_loss	1.0000
4:153467283:T:G	donor_loss	1.0000
4:153473886:GAG:G	donor_gain	1.0000
4:153473889:GT:G	donor_loss	1.0000
4:153473890:T:A	donor_loss	1.0000
4:153550068:TTTA:T	acceptor_loss	1.0000
4:153550069:TTAGC:T	acceptor_loss	1.0000
4:153550070:TA:T	acceptor_loss	1.0000
4:153550071:A:AG	acceptor_gain	1.0000
4:153550071:AGCT:A	acceptor_loss	1.0000
4:153550072:G:A	acceptor_loss	1.0000
4:153550072:G:GA	acceptor_gain	1.0000
4:153550072:GC:G	acceptor_gain	1.0000
4:153550137:ATACA:A	donor_gain	1.0000
4:153550138:TACA:T	donor_gain	1.0000

AlphaMissense

10689 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
4:153598694:T:C	F742S	1.000
4:153602274:T:C	F796L	1.000
4:153602275:T:C	F796S	1.000
4:153602276:C:A	F796L	1.000
4:153602276:C:G	F796L	1.000
4:153602544:T:C	F818S	1.000
4:153602625:T:C	L845P	1.000
4:153598693:T:C	F742L	0.999
4:153598695:T:A	F742L	0.999
4:153598695:T:G	F742L	0.999
4:153602194:T:C	F769S	0.999
4:153602200:T:A	V771D	0.999
4:153602275:T:G	F796C	0.999
4:153602335:T:A	I816N	0.999
4:153602543:T:C	F818L	0.999
4:153602545:C:A	F818L	0.999
4:153602545:C:G	F818L	0.999
4:153602569:G:C	W826C	0.999
4:153602569:G:T	W826C	0.999
4:153602583:T:C	L831P	0.999
4:153602619:T:C	F843S	0.999
4:153602625:T:A	L845H	0.999
4:153602637:T:A	L849H	0.999
4:153602637:T:C	L849P	0.999
4:153602649:T:C	L853P	0.999
4:153602652:T:C	L854S	0.999
4:153602660:T:C	C857R	0.999
4:153602661:G:A	C857Y	0.999
4:153602662:T:G	C857W	0.999
4:153598649:T:C	L727S	0.998

dbSNP variants (sampled 300 via entrez): RS1000032399 (4:153553990 A>G), RS1000038167 (4:153561391 A>G,T), RS1000046089 (4:153477588 G>A), RS1000071128 (4:153517269 C>A,T), RS1000071667 (4:153489704 C>G,T), RS10000932 (4:153599409 A>G), RS1000094204 (4:153523142 T>C), RS1000099680 (4:153613157 T>A), RS1000100313 (4:153482971 T>C), RS10001174 (4:153553113 T>A), RS1000129727 (4:153561357 T>C), RS10001304 (4:153539656 A>G), RS1000150344 (4:153534317 C>G,T), RS1000152569 (4:153483226 G>T), RS1000157873 (4:153522533 T>G)

Disease associations

OMIM: gene MIM:616243 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

26 associations (top):

Study	Trait	p-value
GCST002001_4	Adverse response to chemotherapy (neutropenia/leucopenia) (all antimicrotubule drugs)	9.000000e-06
GCST002927_11	Mercury levels	9.000000e-06
GCST004599_95	Mean platelet volume	4.000000e-14
GCST004611_119	High light scatter reticulocyte count	3.000000e-10
GCST004612_66	High light scatter reticulocyte percentage of red cells	2.000000e-09
GCST004616_4	Platelet distribution width	7.000000e-09
GCST004619_198	Reticulocyte fraction of red cells	1.000000e-10
GCST004622_170	Reticulocyte count	1.000000e-11
GCST008368_12	Plasma anti-thyroid peroxidase levels	1.000000e-06
GCST90002385_262	High light scatter reticulocyte count	5.000000e-18
GCST90002386_9	High light scatter reticulocyte percentage of red cells	5.000000e-15
GCST90002393_141	Monocyte count	4.000000e-11
GCST90002395_658	Mean platelet volume	1.000000e-12
GCST90002395_659	Mean platelet volume	7.000000e-27
GCST90002396_243	Mean reticulocyte volume	1.000000e-25
GCST90002397_27	Mean spheric corpuscular volume	6.000000e-18
GCST90002397_28	Mean spheric corpuscular volume	2.000000e-14
GCST90002400_674	Plateletcrit	6.000000e-09
GCST90002400_675	Plateletcrit	2.000000e-11
GCST90002401_155	Platelet distribution width	1.000000e-12
GCST90002402_754	Platelet count	6.000000e-11
GCST90002402_755	Platelet count	3.000000e-09
GCST90002405_48	Reticulocyte count	1.000000e-20
GCST90002405_49	Reticulocyte count	1.000000e-11
GCST90002406_153	Reticulocyte fraction of red cells	5.000000e-17
GCST90002406_154	Reticulocyte fraction of red cells	3.000000e-12

EFO canonical traits (7, from GWAS)

EFO ID	Trait name
EFO:0005260	response to antimicrotubule agent
EFO:0007986	reticulocyte count
EFO:0007984	platelet component distribution width
EFO:0005091	monocyte count
EFO:0010701	mean reticulocyte volume
EFO:0007985	platelet crit
EFO:0004309	platelet count

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

PharmGKB variants

1 variants.

Variant	Genes	Level	Score	#Clin annots	Drugs
rs117412990	TMEM131L		0.00	0

CTD chemical–gene interactions

39 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	decreases expression	3
Cisplatin	affects cotreatment, decreases expression	2
Nickel	increases expression	2
Valproic Acid	decreases expression, decreases methylation	2
aristolochic acid I	decreases expression	1
methylmercuric chloride	increases expression	1
triphenyl phosphate	affects expression	1
bisphenol A	affects methylation	1
trichostatin A	increases expression	1
beta-lapachone	decreases expression	1
potassium chromate(VI)	affects cotreatment, decreases expression	1
1-hydroxypyrene	affects cotreatment, increases methylation	1
epigallocatechin gallate	affects cotreatment, decreases expression	1
perfluorooctane sulfonic acid	decreases expression	1
ICG 001	decreases expression	1
abrine	decreases expression	1
jinfukang	affects cotreatment, decreases expression	1
Temozolomide	increases expression	1
Sunitinib	increases expression	1
Air Pollutants	decreases expression	1
Atrazine	decreases expression	1
Vehicle Emissions	decreases expression, increases abundance	1
Benzo(a)pyrene	increases methylation	1
Lead	affects expression	1
Melphalan	decreases expression	1
Polychlorinated Biphenyls	affects expression	1
Quercetin	increases expression	1
Ribonucleotides	affects binding	1
Dronabinol	increases expression	1
Thiram	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.