TMEM132B

Summary

TMEM132B (transmembrane protein 132B, HGNC:29397) is a protein-coding gene on chromosome 12q24.31, encoding Transmembrane protein 132B (Q14DG7).

Predicted to be located in membrane.

Source: NCBI Gene 114795 — RefSeq curated summary.

At a glance

• GWAS associations: 9
• Clinical variants (ClinVar): 137 total
• MANE Select transcript: NM_001366854

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:29397
Approved symbol	TMEM132B
Name	transmembrane protein 132B
Location	12q24.31
Locus type	gene with protein product
Status	Approved
Aliases	KIAA1906, KIAA1786
Ensembl gene	ENSG00000139364
Ensembl biotype	protein_coding
OMIM	620260
Entrez	114795

Gene structure

Transcript identifiers

Ensembl transcripts: 6 — 3 protein_coding, 2 protein_coding_CDS_not_defined, 1 retained_intron

ENST00000299308, ENST00000534945, ENST00000535330, ENST00000535886, ENST00000613307, ENST00000682704

RefSeq mRNA: 3 — MANE Select: NM_001366854 NM_001286219, NM_001366854, NM_052907

CCDS: CCDS41859, CCDS66501, CCDS91772

Canonical transcript exons

ENST00000682704 — 9 exons

Exon	Start	End
ENSE00001101304	125349452	125350343
ENSE00001254522	125583851	125583994
ENSE00002234349	125186386	125186866
ENSE00003546515	125644076	125644281
ENSE00003629411	125519439	125519625
ENSE00003662689	125415531	125415677
ENSE00003726916	125650683	125650953
ENSE00003752526	125652441	125652632
ENSE00003917517	125653565	125662369

Expression profiles

Bgee: expression breadth ubiquitous, 181 present calls, max score 98.77.

FANTOM5 (CAGE): breadth broad, TPM avg 7.4828 / max 386.5458, expressed in 754 samples.

FANTOM5 promoters (6 alternative TSS)

Promoter ID	TPM avg	Samples expressed
128669	6.7867	739
128668	0.2012	117
128676	0.1888	95
128671	0.1296	64
128670	0.1269	57
128667	0.0496	27

Top tissues by expression

247 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
ventricular zone	UBERON:0003053	98.77	gold quality
ganglionic eminence	UBERON:0004023	96.83	gold quality
endothelial cell	CL:0000115	91.94	gold quality
middle temporal gyrus	UBERON:0002771	91.80	gold quality
Brodmann (1909) area 23	UBERON:0013554	90.85	gold quality
Brodmann (1909) area 46	UBERON:0006483	88.83	gold quality
sural nerve	UBERON:0015488	87.99	gold quality
superior frontal gyrus	UBERON:0002661	87.28	gold quality
prefrontal cortex	UBERON:0000451	86.96	gold quality
primary visual cortex	UBERON:0002436	86.04	gold quality
frontal cortex	UBERON:0001870	85.45	gold quality
neocortex	UBERON:0001950	85.34	gold quality
postcentral gyrus	UBERON:0002581	85.24	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	85.04	gold quality
cerebral cortex	UBERON:0000956	84.48	gold quality
parietal lobe	UBERON:0001872	84.38	gold quality
occipital lobe	UBERON:0002021	84.12	gold quality
entorhinal cortex	UBERON:0002728	83.98	gold quality
anterior cingulate cortex	UBERON:0009835	83.91	gold quality
stromal cell of endometrium	CL:0002255	83.31	gold quality
Brodmann (1909) area 9	UBERON:0013540	82.81	gold quality
cortical plate	UBERON:0005343	82.51	gold quality
temporal lobe	UBERON:0001871	82.45	gold quality
right frontal lobe	UBERON:0002810	82.08	gold quality
secondary oocyte	CL:0000655	81.61	gold quality
nucleus accumbens	UBERON:0001882	81.60	gold quality
caudate nucleus	UBERON:0001873	81.45	gold quality
amygdala	UBERON:0001876	81.17	gold quality
Ammon’s horn	UBERON:0001954	80.40	gold quality
tibial nerve	UBERON:0001323	80.09	gold quality

Single-cell (SCXA)

Detected in 5 experiment(s), a significant marker in 3.

Experiment	Marker?	Max mean expression
E-GEOD-93593	yes	255.95
E-HCAD-35	yes	63.71
E-HCAD-25	yes	36.11
E-MTAB-7008	no	66.97
E-ANND-3	no	5.50

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

304 targeting TMEM132B, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-8485	100.00	77.57	4731
HSA-LET-7A-3P	100.00	74.03	3932
HSA-LET-7B-3P	100.00	74.08	3913
HSA-LET-7F-1-3P	100.00	74.02	3928
HSA-MIR-98-3P	100.00	74.08	3907
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-4476	100.00	68.18	2030
HSA-MIR-6876-5P	100.00	67.68	2126
HSA-MIR-5692A	100.00	74.40	6850
HSA-MIR-4533	100.00	69.48	2758
HSA-MIR-4668-3P	100.00	68.74	2635
HSA-MIR-4673	100.00	66.64	1490
HSA-MIR-7110-3P	100.00	73.18	2486
HSA-MIR-5692B	100.00	71.32	2622
HSA-MIR-5692C	100.00	71.32	2622
HSA-MIR-4455	100.00	65.48	1587
HSA-MIR-6867-5P	100.00	82.21	3464
HSA-MIR-548C-3P	99.99	74.01	7587
HSA-MIR-1184	99.99	68.19	1458
HSA-MIR-186-5P	99.99	70.83	3707
HSA-MIR-196A-1-3P	99.99	72.15	2772
HSA-MIR-3662	99.99	73.82	5684
HSA-LET-7F-2-3P	99.98	70.98	2588
HSA-MIR-1185-1-3P	99.98	71.04	2593
HSA-MIR-1185-2-3P	99.98	71.04	2593
HSA-MIR-4789-5P	99.98	70.76	2721
HSA-MIR-4775	99.98	75.00	6394
HSA-MIR-568	99.98	69.86	2084
HSA-MIR-433-3P	99.98	69.37	1203

Literature-anchored findings (GeneRIF, showing 1)

• TMEM132B is differentially expressed in intracranial aneurysm samples as compared to controls. (PMID:25803036)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	si:dkey-1d7.3	ENSDARG00000075837
mus_musculus	Tmem132b	ENSMUSG00000070498
rattus_norvegicus	Tmem132b	ENSRNOG00000038406
drosophila_melanogaster	dtn	FBGN0262730
caenorhabditis_elegans		WBGENE00022175

Paralogs (4): TMEM132A (ENSG00000006118), TMEM132D (ENSG00000151952), TMEM132C (ENSG00000181234), TMEM132E (ENSG00000181291)

Protein

Protein identifiers

Transmembrane protein 132B — Q14DG7 (reviewed: Q14DG7)

All UniProt accessions (2): A0A804HK64, Q14DG7

UniProt curated annotations — full annotation on UniProt →

Subcellular location. Membrane.

Similarity. Belongs to the TMEM132 family.

Isoforms (3)

UniProt ID	Names	Canonical?
Q14DG7-1	1	yes
Q14DG7-2	2
Q14DG7-3	3

RefSeq proteins (3): NP_001273148, NP_001353783, NP_443139 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR026307	TMEM132	Family
IPR031435	TMEM132_N	Domain
IPR031436	TMEM132_C	Domain
IPR031437	Ig_TMEM132_4th	Domain
IPR055421	TMEM132_3rd	Domain
IPR055422	Ig_TMEM132_2nd	Domain
IPR055423	Ig_TMEM132_5th	Domain
IPR055424	Ig_TMEM132_6th	Domain

Pfam: PF15705, PF15706, PF16070, PF23039, PF23481, PF23486, PF23487

UniProt features (15 total): splice variant 3, glycosylation site 3, topological domain 2, sequence conflict 2, chain 1, sequence variant 1, transmembrane region 1, region of interest 1, compositionally biased region 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q14DG7-F1	69.84	0.34

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Glycosylation sites (3): 343, 366, 381

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 108 (showing top): RIGGI_EWING_SARCOMA_PROGENITOR_UP, chr12q24, MODULE_49, MYC_UP.V1_UP, SOX3_TARGET_GENES, ZNF513_TARGET_GENES, ZNF596_TARGET_GENES, ZSCAN30_TARGET_GENES, MIR8485, LET_7A_3P, MIR98_3P, LET_7F_1_3P, LET_7B_3P, MIR4729, MIR4659A_3P_MIR4659B_3P

GO Biological Process (1): biological_process (GO:0008150)

GO Molecular Function (1): molecular_function (GO:0003674)

GO Cellular Component (2): membrane (GO:0016020), cellular_component (GO:0005575)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	1

Protein interactions and networks

STRING

744 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
TMEM132B	LYST	Q99698	427
TMEM132B	ARRDC4	Q8NCT1	401
TMEM132B	ERO1B	Q86YB8	397
TMEM132B	POLN	Q7Z5Q5	375
TMEM132B	HPS6	Q86YV9	374
TMEM132B	ZBTB37	Q5TC79	364
TMEM132B	SIX6	O95475	353
TMEM132B	HHLA1	C9JL84	336
TMEM132B	THSD1	Q9NS62	328
TMEM132B	ANKRD34A	Q69YU3	325
TMEM132B	CCDC150	Q8NCX0	323
TMEM132B	SLC35F1	Q5T1Q4	322
TMEM132B	ANXA13	P27216	318
TMEM132B	LRRC55	Q6ZSA7	315
TMEM132B	WDR27	A2RRH5	312

IntAct

0 interactions, top by confidence:

BioGRID (3): TMEM132B (Affinity Capture-MS), PPIA (Cross-Linking-MS (XL-MS)), TMEM132B (Protein-peptide)

ESM2 similar proteins: A0A8M2B818, A0A8M9PFP2, A1XQX3, A1XQY0, A1XQY3, B0S5G3, D0PRN4, F1N4M2, L7VG99, O35158, O35464, O61307, Q01083, Q14DG7, Q24322, Q3KN41, Q3UHK6, Q3UN70, Q568T5, Q58EG3, Q5R7F5, Q62765, Q62889, Q66IV1, Q76KF0, Q7T2X6, Q8BMA3, Q8N2Q7, Q8NFY4, Q8VDA1, Q90Z04, Q91713, Q96LU7, Q9DER5, Q9ER65, Q9H2E6, Q9H4D0, Q9HDB5, Q9NT68, Q9NZ94

Diamond homologs: L7VG99, Q14C87, Q14DG7, Q24JP5, Q6IEE6, Q6IEE7, Q76HP2, Q76HP3, Q80WF4, Q8CEF9, Q8N3T6, Q922P8

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

137 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	122
Likely benign	7
Benign	2

Top pathogenic / likely-pathogenic (0)

SpliceAI

3387 predictions. Top by Δscore:

Variant	Effect	Δscore
12:125349447:T:TA	acceptor_gain	1.0000
12:125349447:TGCA:T	acceptor_loss	1.0000
12:125349449:CAGT:C	acceptor_loss	1.0000
12:125349450:A:AG	acceptor_gain	1.0000
12:125349450:A:C	acceptor_loss	1.0000
12:125349451:G:GT	acceptor_gain	1.0000
12:125349451:GT:G	acceptor_gain	1.0000
12:125415674:GCAG:G	donor_gain	1.0000
12:125415675:CAGGT:C	donor_loss	1.0000
12:125415677:GGT:G	donor_loss	1.0000
12:125415678:G:GG	donor_gain	1.0000
12:125415678:GT:G	donor_loss	1.0000
12:125415679:T:G	donor_loss	1.0000
12:125519437:A:AG	acceptor_gain	1.0000
12:125519437:AG:A	acceptor_gain	1.0000
12:125519437:AGG:A	acceptor_gain	1.0000
12:125519438:G:GC	acceptor_gain	1.0000
12:125519438:GG:G	acceptor_gain	1.0000
12:125519438:GGG:G	acceptor_gain	1.0000
12:125519438:GGGT:G	acceptor_gain	1.0000
12:125519438:GGGTA:G	acceptor_gain	1.0000
12:125519623:ATGG:A	donor_loss	1.0000
12:125519625:GGTG:G	donor_loss	1.0000
12:125519627:T:A	donor_loss	1.0000
12:125583991:TAAGG:T	donor_loss	1.0000
12:125583992:AAGG:A	donor_loss	1.0000
12:125583993:AGG:A	donor_loss	1.0000
12:125583994:GGTAA:G	donor_loss	1.0000
12:125583995:G:C	donor_loss	1.0000
12:125583996:T:A	donor_loss	1.0000

AlphaMissense

7166 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
12:125644253:T:A	W534R	0.999
12:125644253:T:C	W534R	0.999
12:125644255:G:C	W534C	0.999
12:125644255:G:T	W534C	0.999
12:125652490:T:A	V650D	0.999
12:125654216:T:C	F915L	0.999
12:125654218:C:A	F915L	0.999
12:125654218:C:G	F915L	0.999
12:125654308:G:C	W945C	0.999
12:125654308:G:T	W945C	0.999
12:125654549:T:C	F1026L	0.999
12:125654551:C:A	F1026L	0.999
12:125654551:C:G	F1026L	0.999
12:125644257:G:C	R535T	0.998
12:125644258:G:C	R535S	0.998
12:125644258:G:T	R535S	0.998
12:125650735:T:A	C561S	0.998
12:125650735:T:C	C561R	0.998
12:125650736:G:C	C561S	0.998
12:125652471:G:C	A644P	0.998
12:125653778:T:A	C769S	0.998
12:125653778:T:C	C769R	0.998
12:125653779:G:C	C769S	0.998
12:125653795:G:C	R774S	0.998
12:125653795:G:T	R774S	0.998
12:125654195:T:C	F908L	0.998
12:125654197:C:A	F908L	0.998
12:125654197:C:G	F908L	0.998
12:125654550:T:C	F1026S	0.998
12:125644236:T:C	L528P	0.997

dbSNP variants (sampled 300 via entrez): RS1000002107 (12:125241287 C>T), RS1000006889 (12:125617872 T>G), RS1000009734 (12:125490256 C>G), RS1000019837 (12:125247978 C>G,T), RS1000020647 (12:125414654 G>A,T), RS1000030239 (12:125436722 G>A,C), RS1000034708 (12:125241590 A>G), RS1000041860 (12:125537628 G>A), RS1000042188 (12:125661875 C>T), RS1000043473 (12:125272374 G>T), RS1000046501 (12:125403961 G>A), RS1000050744 (12:125577075 C>T), RS1000056571 (12:125487909 G>A), RS1000056900 (12:125247698 A>G), RS1000060995 (12:125523072 C>T)

Disease associations

OMIM: gene MIM:620260 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

9 associations (top):

Study	Trait	p-value
GCST002306_19	Bipolar disorder (body mass index interaction)	4.000000e-06
GCST002337_97	Amyotrophic lateral sclerosis (sporadic)	2.000000e-06
GCST002875_89	Diisocyanate-induced asthma	1.000000e-06
GCST003979_10	Excessive daytime sleepiness	9.000000e-09
GCST006069_66	Time-dependent creatinine clearance change response to tenofovir treatment in HIV infection (time and treatment arm interaction)	5.000000e-06
GCST007327_77	Smoking status (ever vs never smokers)	4.000000e-08
GCST009363_42	Triglyceride levels x short total sleep time interaction (2df test)	9.000000e-11
GCST011741_59	LDL cholesterol levels in HIV infection	4.000000e-06
GCST90026414_6	Severe insulin-resistant type 2 diabetes	6.000000e-06

EFO canonical traits (7, from GWAS)

EFO ID	Trait name
EFO:0004340	body mass index
EFO:0006995	response to diisocyanate
EFO:0007875	excessive daytime sleepiness measurement
EFO:0007934	creatinine clearance measurement
EFO:0004318	smoking behavior
EFO:0004530	triglyceride measurement
EFO:0004611	low density lipoprotein cholesterol measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

19 total (human), top 19 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects expression, increases expression	5
Benzo(a)pyrene	affects methylation, decreases methylation, increases methylation	2
Phenylmercuric Acetate	affects cotreatment, increases expression	2
methylmercuric chloride	decreases expression	1
bisphenol A	increases expression	1
glycidyl methacrylate	increases expression	1
CGP 52608	affects binding, increases reaction	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, increases expression	1
2,2’,4,4’,5-brominated diphenyl ether	increases expression	1
abrine	increases expression	1
dorsomorphin	affects cotreatment, increases expression	1
(+)-JQ1 compound	increases expression	1
Diethylhexyl Phthalate	decreases expression	1
Diuron	increases expression	1
Estradiol	decreases expression	1
Polychlorinated Biphenyls	affects expression	1
Silicon Dioxide	increases expression	1
Tretinoin	decreases expression	1
Triclosan	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.