TMEM132D-AS1

Summary

TMEM132D-AS1 (TMEM132D antisense RNA 1, HGNC:27466) is a long non-coding RNA gene on chromosome 12q24.33.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:27466
Approved symbol	TMEM132D-AS1
Name	TMEM132D antisense RNA 1
Location	12q24.33
Locus type	RNA, long non-coding
Status	Approved
Aliases	LOC283352, RP11-669N7.2
Ensembl gene	ENSG00000249196
Ensembl biotype	lncRNA
Entrez	283352
RNAcentral	URS0000CCDFBD — lncRNA, 560 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 9 — 6 lncRNA, 3 retained_intron

ENST00000508925, ENST00000510001, ENST00000512133, ENST00000537367, ENST00000540739, ENST00000541320, ENST00000542535, ENST00000747530, ENST00000747531

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000508925 — 4 exons

Exon	Start	End
ENSE00002037456	129111420	129111669
ENSE00002055813	129110993	129111139
ENSE00004089434	129109660	129109757
ENSE00004089437	129113065	129113303

Expression profiles

Bgee: expression breadth ubiquitous, 106 present calls, max score 84.22.

Top tissues by expression

210 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	84.22	gold quality
calcaneal tendon	UBERON:0003701	67.53	gold quality
right testis	UBERON:0004534	66.69	gold quality
left testis	UBERON:0004533	66.37	gold quality
testis	UBERON:0000473	65.18	gold quality
monocyte	CL:0000576	58.03	gold quality
lower lobe of lung	UBERON:0008949	56.46	silver quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	56.14	gold quality
gastrocnemius	UBERON:0001388	54.10	gold quality
islet of Langerhans	UBERON:0000006	53.29	gold quality
body of pancreas	UBERON:0001150	52.94	gold quality
right adrenal gland	UBERON:0001233	52.65	gold quality
adrenal tissue	UBERON:0018303	52.39	gold quality
pancreas	UBERON:0001264	51.92	gold quality
left adrenal gland cortex	UBERON:0035825	51.25	gold quality
left adrenal gland	UBERON:0001234	50.29	gold quality
adrenal gland	UBERON:0002369	50.10	gold quality
skin of hip	UBERON:0001554	49.82	silver quality
blood	UBERON:0000178	49.63	gold quality
heart left ventricle	UBERON:0002084	49.39	gold quality
adrenal cortex	UBERON:0001235	49.04	gold quality
right lobe of liver	UBERON:0001114	48.56	silver quality
cardiac ventricle	UBERON:0002082	48.41	gold quality
mucosa of stomach	UBERON:0001199	48.23	gold quality
ascending aorta	UBERON:0001496	47.97	gold quality
cortex of kidney	UBERON:0001225	47.88	gold quality
thoracic aorta	UBERON:0001515	47.80	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	47.62	gold quality
tibial artery	UBERON:0007610	47.38	gold quality
buccal mucosa cell	CL:0002336	47.28	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.78

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Lnc-TMEM132D-AS1 as a potential therapeutic target for acquired resistance to osimertinib in non-small-cell lung cancer. (PMID:36651104)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.