TMEM139-AS1

Summary

TMEM139-AS1 (TMEM139 antisense RNA 1, HGNC:40988) is a long non-coding RNA gene on chromosome 7q34.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:40988
Approved symbol	TMEM139-AS1
Name	TMEM139 antisense RNA 1
Location	7q34
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000231840
Ensembl biotype	lncRNA
Entrez	105375545
RNAcentral	URS0000A772E8 — lncRNA, 602 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 7 — 7 lncRNA

ENST00000427392, ENST00000446192, ENST00000729203, ENST00000729204, ENST00000729205, ENST00000729206, ENST00000729207

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000427392 — 4 exons

Exon	Start	End
ENSE00001623783	143285718	143285838
ENSE00001636759	143286546	143286663
ENSE00001710341	143255264	143255421
ENSE00001782513	143285977	143286171

Expression profiles

Bgee: expression breadth ubiquitous, 122 present calls, max score 80.43.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.5741 / max 84.0440, expressed in 77 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
86654	0.5216	75
86655	0.0525	26

Top tissues by expression

122 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	80.43	gold quality
corpus callosum	UBERON:0002336	76.63	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	73.35	gold quality
colonic epithelium	UBERON:0000397	70.41	silver quality
cortical plate	UBERON:0005343	68.45	gold quality
right testis	UBERON:0004534	67.18	gold quality
left testis	UBERON:0004533	66.96	gold quality
testis	UBERON:0000473	66.77	gold quality
substantia nigra	UBERON:0002038	64.63	gold quality
sural nerve	UBERON:0015488	64.47	silver quality
mucosa of transverse colon	UBERON:0004991	62.62	gold quality
ganglionic eminence	UBERON:0004023	61.20	gold quality
Ammon’s horn	UBERON:0001954	61.05	gold quality
temporal lobe	UBERON:0001871	60.57	gold quality
amygdala	UBERON:0001876	60.54	gold quality
prefrontal cortex	UBERON:0000451	59.33	gold quality
metanephros cortex	UBERON:0010533	59.25	gold quality
skeletal muscle tissue	UBERON:0001134	58.60	gold quality
primary visual cortex	UBERON:0002436	58.57	gold quality
putamen	UBERON:0001874	58.28	gold quality
duodenum	UBERON:0002114	57.71	gold quality
hypothalamus	UBERON:0001898	55.51	gold quality
lymph node	UBERON:0000029	55.49	gold quality
cortex of kidney	UBERON:0001225	55.19	gold quality
frontal cortex	UBERON:0001870	54.86	gold quality
cerebral cortex	UBERON:0000956	54.71	gold quality
hindlimb stylopod muscle	UBERON:0004252	54.63	gold quality
monocyte	CL:0000576	54.45	gold quality
bone marrow	UBERON:0002371	54.37	silver quality
placenta	UBERON:0001987	54.12	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.13

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.