TMEM144

Summary

TMEM144 (transmembrane protein 144, HGNC:25633) is a protein-coding gene on chromosome 4q32.1, encoding Transmembrane protein 144 (Q7Z5S9).

Predicted to enable carbohydrate transmembrane transporter activity. Predicted to be involved in carbohydrate transmembrane transport. Predicted to be located in membrane.

Source: NCBI Gene 55314 — RefSeq curated summary.

At a glance

• GWAS associations: 2
• Clinical variants (ClinVar): 67 total
• MANE Select transcript: NM_018342

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:25633
Approved symbol	TMEM144
Name	transmembrane protein 144
Location	4q32.1
Locus type	gene with protein product
Status	Approved
Aliases	FLJ11155, SLC35G7
Ensembl gene	ENSG00000164124
Ensembl biotype	protein_coding
OMIM	620325
Entrez	55314

Gene structure

Transcript identifiers

Ensembl transcripts: 38 — 33 protein_coding, 3 protein_coding_CDS_not_defined, 1 nonsense_mediated_decay, 1 retained_intron

ENST00000296529, ENST00000502698, ENST00000503200, ENST00000503404, ENST00000504569, ENST00000505049, ENST00000505189, ENST00000508243, ENST00000509278, ENST00000511038, ENST00000511532, ENST00000512272, ENST00000512481, ENST00000513744, ENST00000514346, ENST00000514558, ENST00000514971, ENST00000908630, ENST00000908631, ENST00000908632, ENST00000908633, ENST00000908634, ENST00000908635, ENST00000908636, ENST00000908637, ENST00000908638, ENST00000908639, ENST00000908640, ENST00000908641, ENST00000908642, ENST00000908643, ENST00000908644, ENST00000908645, ENST00000908646, ENST00000908647, ENST00000908648, ENST00000908649, ENST00000971428

RefSeq mRNA: 1 — MANE Select: NM_018342 NM_018342

CCDS: CCDS3799

Canonical transcript exons

ENST00000296529 — 13 exons

Exon	Start	End
ENSE00001081687	158232901	158232982
ENSE00001081690	158235438	158235505
ENSE00001081693	158212608	158212776
ENSE00001305326	158211453	158211574
ENSE00002037073	158210486	158210586
ENSE00002045356	158253444	158255416
ENSE00003459421	158240299	158240418
ENSE00003477783	158237525	158237643
ENSE00003482684	158244296	158244349
ENSE00003606277	158241509	158241606
ENSE00003784946	158217321	158217420
ENSE00003790557	158219310	158219390
ENSE00003791233	158215191	158215313

Expression profiles

Bgee: expression breadth ubiquitous, 244 present calls, max score 99.33.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 17.5876 / max 2225.2403, expressed in 1194 samples.

FANTOM5 promoters (12 alternative TSS)

Promoter ID	TPM avg	Samples expressed
50278	8.0026	249
50279	4.0805	420
50277	2.4406	265
50280	1.5519	633
50274	0.4347	243
50275	0.3103	161
50276	0.2507	112
50273	0.1772	88
50281	0.1289	51
50271	0.1222	28

Top tissues by expression

282 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
corpus callosum	UBERON:0002336	99.33	gold quality
inferior vagus X ganglion	UBERON:0005363	99.20	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	98.96	gold quality
substantia nigra pars reticulata	UBERON:0001966	98.85	gold quality
subthalamic nucleus	UBERON:0001906	98.84	gold quality
lateral globus pallidus	UBERON:0002476	98.83	gold quality
pons	UBERON:0000988	98.66	gold quality
spinal cord	UBERON:0002240	98.48	gold quality
globus pallidus	UBERON:0001875	98.30	gold quality
medial globus pallidus	UBERON:0002477	98.12	gold quality
superior vestibular nucleus	UBERON:0007227	98.07	gold quality
substantia nigra pars compacta	UBERON:0001965	97.91	gold quality
ventral tegmental area	UBERON:0002691	97.28	gold quality
medulla oblongata	UBERON:0001896	96.36	gold quality
lateral nuclear group of thalamus	UBERON:0002736	95.64	gold quality
dorsal plus ventral thalamus	UBERON:0001897	95.48	gold quality
putamen	UBERON:0001874	95.42	gold quality
Ammon’s horn	UBERON:0001954	94.88	gold quality
caudate nucleus	UBERON:0001873	94.61	gold quality
amygdala	UBERON:0001876	94.31	gold quality
midbrain	UBERON:0001891	94.07	gold quality
substantia nigra	UBERON:0002038	93.66	gold quality
parietal lobe	UBERON:0001872	93.48	gold quality
postcentral gyrus	UBERON:0002581	93.47	gold quality
endothelial cell	CL:0000115	92.69	gold quality
occipital lobe	UBERON:0002021	92.31	gold quality
temporal lobe	UBERON:0001871	92.13	gold quality
nucleus accumbens	UBERON:0001882	91.73	gold quality
primary visual cortex	UBERON:0002436	91.73	gold quality
jejunal mucosa	UBERON:0000399	91.43	gold quality

Single-cell (SCXA)

Detected in 5 experiment(s), a significant marker in 4.

Experiment	Marker?	Max mean expression
E-HCAD-35	yes	2652.06
E-HCAD-25	yes	75.33
E-GEOD-84465	yes	14.12
E-ANND-3	yes	7.22
E-GEOD-86618	no	118.17

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

102 targeting TMEM144, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4262	100.00	73.26	3931
HSA-MIR-8485	100.00	77.57	4731
HSA-MIR-432-3P	100.00	67.86	705
HSA-MIR-3924	100.00	72.09	2394
HSA-MIR-4747-5P	100.00	67.90	2681
HSA-MIR-5196-5P	100.00	67.98	2761
HSA-MIR-3662	99.99	73.82	5684
HSA-MIR-181A-5P	99.99	72.96	2995
HSA-MIR-181B-5P	99.99	72.97	2996
HSA-MIR-181C-5P	99.99	72.95	2996
HSA-MIR-181D-5P	99.99	73.04	2997
HSA-MIR-4789-3P	99.99	70.75	2484
HSA-MIR-4282	99.99	75.36	6408
HSA-MIR-4500	99.99	72.72	2367
HSA-MIR-3617-3P	99.98	67.86	918
HSA-MIR-5696	99.98	72.36	4487
HSA-LET-7A-5P	99.98	72.29	1790
HSA-LET-7B-5P	99.98	72.31	1790
HSA-LET-7C-5P	99.98	72.29	1790
HSA-LET-7E-5P	99.98	72.29	1790
HSA-LET-7F-5P	99.98	72.56	1784
HSA-LET-7G-5P	99.98	72.37	1784
HSA-LET-7I-5P	99.98	72.37	1788
HSA-MIR-98-5P	99.98	72.33	1787
HSA-MIR-302C-5P	99.97	72.56	3642
HSA-MIR-1229-3P	99.97	66.49	906
HSA-MIR-2110	99.96	66.68	1930
HSA-MIR-9-3P	99.96	70.88	2068
HSA-MIR-1250-3P	99.96	70.04	4038
HSA-MIR-493-5P	99.96	72.47	2382

Cross-species orthologs

10 orthologs

Organism	Symbol	Gene ID
danio_rerio	tmem144b	ENSDARG00000036247
danio_rerio	tmem144a	ENSDARG00000037409
mus_musculus	Tmem144	ENSMUSG00000027956
rattus_norvegicus	Tmem144	ENSRNOG00000010081
caenorhabditis_elegans		WBGENE00009876
caenorhabditis_elegans		WBGENE00010637
caenorhabditis_elegans	T19A6.4	WBGENE00011829
caenorhabditis_elegans		WBGENE00012293
caenorhabditis_elegans		WBGENE00020096
caenorhabditis_elegans	W02D3.4	WBGENE00020933

Protein

Protein identifiers

Transmembrane protein 144 — Q7Z5S9 (reviewed: Q7Z5S9)

All UniProt accessions (10): A0A1D5RMR6, D6R9I0, D6R9U5, D6RAX5, D6RCA2, D6RDF9, D6RDI4, D6RDN8, Q7Z5S9, D6RIX5

UniProt curated annotations — full annotation on UniProt →

Subcellular location. Membrane.

Similarity. Belongs to the TMEM144 family.

Isoforms (2)

UniProt ID	Names	Canonical?
Q7Z5S9-1	1	yes
Q7Z5S9-2	2

RefSeq proteins (1): NP_060812* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR010651	Sugar_transport	Family
IPR012435	TMEM144	Family
IPR037185	EmrE-like	Homologous_superfamily

Pfam: PF07857

UniProt features (16 total): transmembrane region 10, splice variant 2, sequence conflict 2, chain 1, sequence variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q7Z5S9-F1	88.14	0.64

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 118 (showing top): GSE45365_NK_CELL_VS_CD11B_DC_UP, GOBP_CARBOHYDRATE_TRANSPORT, chr4q32, MODULE_255, GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN, MODULE_317, DARWICHE_SKIN_TUMOR_PROMOTER_DN, DARWICHE_PAPILLOMA_RISK_LOW_DN, DARWICHE_PAPILLOMA_RISK_HIGH_DN, DARWICHE_SQUAMOUS_CELL_CARCINOMA_DN, ACEVEDO_LIVER_CANCER_WITH_H3K27ME3_UP, DOUGLAS_BMI1_TARGETS_DN, MODULE_207, GOBP_TRANSMEMBRANE_TRANSPORT, IVANOVA_HEMATOPOIESIS_STEM_CELL_LONG_TERM

GO Biological Process (1): carbohydrate transmembrane transport (GO:0034219)

GO Molecular Function (2): carbohydrate transmembrane transporter activity (GO:0015144), protein binding (GO:0005515)

GO Cellular Component (1): membrane (GO:0016020)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
carbohydrate transport	1
transmembrane transport	1
transmembrane transporter activity	1
carbohydrate transmembrane transport	1
binding	1
cellular anatomical structure	1

Protein interactions and networks

STRING

338 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
TMEM144	LZIC	Q8WZA0	557
TMEM144	KTI12	Q96EK9	538
TMEM144	SLC35H1	Q9NQQ7	517
TMEM144	TMEM234	Q8WY98	507
TMEM144	SLC35B3	Q9H1N7	504
TMEM144	KCTD9	Q7L273	485
TMEM144	SLC35C1	Q96A29	470
TMEM144	ATF7IP2	Q5U623	433
TMEM144	NPAS4	Q8IUM7	418
TMEM144	SLC30A1	Q9Y6M5	418
TMEM144	GLRB	P48167	399
TMEM144	GNRHR	P30968	371
TMEM144	ENOSF1	Q7L5Y1	371
TMEM144	SLC39A2	Q9NP94	361
TMEM144	RANBP17	Q9H2T7	354

IntAct

20 interactions, top by confidence:

A	B	Type	Score
TMEM144	SSMEM1	psi-mi:“MI:0915”(physical association)	0.560
TMEM144	TMEM237	psi-mi:“MI:0915”(physical association)	0.560
TMEM144	HERPUD2	psi-mi:“MI:0915”(physical association)	0.560
TMEM144	TIMMDC1	psi-mi:“MI:0915”(physical association)	0.560
FFAR2	TMEM144	psi-mi:“MI:0915”(physical association)	0.560
AQP6	TMEM144	psi-mi:“MI:0915”(physical association)	0.560
TMEM144	ADRB2	psi-mi:“MI:0915”(physical association)	0.370
TMEM144	TMEM237	psi-mi:“MI:0915”(physical association)	0.000
TMEM144	HERPUD2	psi-mi:“MI:0915”(physical association)	0.000
TMEM144	AQP6	psi-mi:“MI:0915”(physical association)	0.000
TMEM144	TIMMDC1	psi-mi:“MI:0915”(physical association)	0.000
TMEM144	FFAR2	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (8): TMEM144 (Affinity Capture-RNA), TMEM144 (Two-hybrid), TMEM144 (Two-hybrid), TMEM144 (Two-hybrid), TMEM144 (Two-hybrid), TMEM144 (Two-hybrid), TMEM144 (Two-hybrid), TMEM144 (Affinity Capture-RNA)

ESM2 similar proteins: A6QQU6, A8MRY9, B3LFA3, B8AF63, F4JKQ7, O43934, O80605, P57057, P57758, Q03411, Q0D7E4, Q10R54, Q39231, Q39232, Q3TIT8, Q4R495, Q5F3N0, Q5M7K3, Q5RCQ5, Q5RD30, Q5RKH7, Q640L2, Q67YF8, Q6A329, Q6DIT7, Q6GPQ3, Q6P499, Q6PB15, Q6YK44, Q7Z5S9, Q8AVC3, Q8BGN5, Q8BJ51, Q8GWX2, Q8GYS1, Q8H4H5, Q8NCC5, Q8VE96, Q8VEH0, Q944N8

Diamond homologs: A6QQU6, Q10000, Q54V96, Q55FV8, Q7Z5S9, Q8VEH0

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

67 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	52
Likely benign	1
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

2184 predictions. Top by Δscore:

Variant	Effect	Δscore
4:158212137:A:AG	donor_gain	1.0000
4:158212606:A:AG	acceptor_gain	1.0000
4:158212607:G:GA	acceptor_gain	1.0000
4:158212607:GA:G	acceptor_gain	1.0000
4:158212607:GAA:G	acceptor_gain	1.0000
4:158219383:GTA:G	donor_gain	1.0000
4:158235512:A:T	donor_gain	1.0000
4:158237522:A:AG	acceptor_gain	1.0000
4:158237522:AAG:A	acceptor_gain	1.0000
4:158237522:AAGG:A	acceptor_gain	1.0000
4:158237522:AAGGG:A	acceptor_gain	1.0000
4:158237523:A:AG	acceptor_gain	1.0000
4:158237523:A:G	acceptor_loss	1.0000
4:158237523:AG:A	acceptor_gain	1.0000
4:158237523:AGG:A	acceptor_gain	1.0000
4:158237524:G:A	acceptor_gain	1.0000
4:158237524:G:GG	acceptor_gain	1.0000
4:158237524:GGG:G	acceptor_gain	1.0000
4:158237644:G:GG	donor_gain	1.0000
4:158239052:C:CA	acceptor_gain	1.0000
4:158241607:G:GG	donor_gain	1.0000
4:158210383:G:GT	donor_gain	0.9900
4:158210584:GCA:G	donor_gain	0.9900
4:158210587:G:GG	donor_gain	0.9900
4:158212153:G:GA	donor_gain	0.9900
4:158212601:A:AG	acceptor_gain	0.9900
4:158212602:T:G	acceptor_gain	0.9900
4:158212602:TTTCA:T	acceptor_loss	0.9900
4:158212603:TTCAG:T	acceptor_loss	0.9900
4:158212604:TCA:T	acceptor_loss	0.9900

AlphaMissense

2270 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
4:158240343:A:C	S243R	0.996
4:158240345:T:A	S243R	0.996
4:158240345:T:G	S243R	0.996
4:158241586:A:C	S294R	0.994
4:158241588:T:A	S294R	0.994
4:158241588:T:G	S294R	0.994
4:158217407:T:A	W107R	0.993
4:158217407:T:C	W107R	0.993
4:158215205:T:A	W42R	0.991
4:158215205:T:C	W42R	0.991
4:158215304:T:A	W75R	0.990
4:158215304:T:C	W75R	0.990
4:158215313:G:T	G78W	0.990
4:158237551:G:A	G197E	0.989
4:158217380:T:A	W98R	0.988
4:158217380:T:C	W98R	0.988
4:158217325:C:A	N79K	0.987
4:158217325:C:G	N79K	0.987
4:158217413:A:C	S109R	0.987
4:158217415:C:A	S109R	0.987
4:158217415:C:G	S109R	0.987
4:158237539:C:A	A193E	0.986
4:158241589:T:C	F295L	0.986
4:158241591:T:A	F295L	0.986
4:158241591:T:G	F295L	0.986
4:158215313:G:A	G78R	0.985
4:158215313:G:C	G78R	0.985
4:158217368:G:A	G94R	0.985
4:158217368:G:C	G94R	0.985
4:158212735:G:A	G23D	0.984

dbSNP variants (sampled 300 via entrez): RS1000020619 (4:158219953 G>A,T), RS1000046253 (4:158249614 C>A), RS1000056559 (4:158220447 A>C), RS1000075169 (4:158214518 C>G), RS1000147629 (4:158242454 T>A), RS1000179576 (4:158236563 G>A), RS10002043 (4:158225305 G>T), RS1000268334 (4:158246495 A>G), RS1000299430 (4:158246755 G>A), RS1000326456 (4:158249022 T>G), RS1000454191 (4:158210566 C>A), RS1000592100 (4:158249243 G>A), RS1000665076 (4:158231655 A>G), RS1000708871 (4:158231019 G>C,T), RS1000737632 (4:158225193 C>A,G)

Disease associations

OMIM: gene MIM:620325 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

2 associations (top):

Study	Trait	p-value
GCST003979_4	Excessive daytime sleepiness	4.000000e-07
GCST007096_81	Pulse pressure	2.000000e-08

EFO canonical traits (2, from GWAS)

EFO ID	Trait name
EFO:0007875	excessive daytime sleepiness measurement
EFO:0005763	pulse pressure measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

43 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects expression, decreases methylation, affects cotreatment, increases expression	7
trichostatin A	affects cotreatment, increases expression	3
Cyclosporine	decreases expression, increases expression	3
mercuric bromide	increases expression, affects cotreatment	2
entinostat	increases expression, affects cotreatment	2
(+)-JQ1 compound	decreases expression	2
Vorinostat	affects cotreatment, increases expression	2
Panobinostat	affects cotreatment, increases expression	2
Phenylmercuric Acetate	affects cotreatment, increases expression	2
p-Chloromercuribenzoic Acid	increases expression, affects cotreatment	2
aristolochic acid I	decreases expression	1
sotorasib	affects cotreatment, decreases expression	1
bisphenol A	increases expression	1
tris(2-butoxyethyl) phosphate	affects expression	1
arsenite	affects binding, increases reaction	1
sodium arsenite	increases expression	1
potassium chromate(VI)	increases expression	1
perfluorooctane sulfonic acid	increases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, increases expression	1
ICG 001	increases expression	1
abrine	decreases expression	1
dorsomorphin	affects cotreatment, increases expression	1
jinfukang	increases expression	1
trametinib	affects cotreatment, decreases expression	1
NVP-BKM120	affects cotreatment, decreases expression	1
Resveratrol	affects cotreatment, increases expression	1
Temozolomide	decreases expression	1
Decitabine	affects expression	1
Sunitinib	decreases expression	1
Acetaminophen	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.