TMEM145

Summary

TMEM145 (transmembrane protein 145, HGNC:26912) is a protein-coding gene on chromosome 19q13.2, encoding Transmembrane protein 145 (Q8NBT3).

Predicted to be involved in G protein-coupled receptor signaling pathway and response to pheromone. Predicted to be located in membrane.

Source: NCBI Gene 284339 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 75 total
• MANE Select transcript: NM_173633

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:26912
Approved symbol	TMEM145
Name	transmembrane protein 145
Location	19q13.2
Locus type	gene with protein product
Status	Approved
Aliases	FLJ90805
Ensembl gene	ENSG00000167619
Ensembl biotype	protein_coding
Entrez	284339

Gene structure

Transcript identifiers

Ensembl transcripts: 7 — 5 protein_coding, 1 retained_intron, 1 protein_coding_CDS_not_defined

ENST00000301204, ENST00000595775, ENST00000598766, ENST00000601020, ENST00000601644, ENST00000673187, ENST00000673205

RefSeq mRNA: 2 — MANE Select: NM_173633 NM_001366910, NM_173633

CCDS: CCDS12603, CCDS92635

Canonical transcript exons

ENST00000301204 — 15 exons

Exon	Start	End
ENSE00001115001	42316662	42316740
ENSE00001115003	42315372	42315440
ENSE00001115005	42316870	42316963
ENSE00001115006	42314993	42315077
ENSE00001115008	42315188	42315259
ENSE00001115009	42316481	42316561
ENSE00001115010	42317709	42317881
ENSE00001115013	42314792	42314851
ENSE00001162782	42320317	42320437
ENSE00001162844	42323583	42323789
ENSE00001315878	42324737	42325064
ENSE00003084464	42313309	42313496
ENSE00003592173	42314451	42314528
ENSE00003620462	42314272	42314346
ENSE00003630018	42314613	42314699

Expression profiles

Bgee: expression breadth ubiquitous, 129 present calls, max score 98.90.

FANTOM5 (CAGE): breadth broad, TPM avg 2.5875 / max 253.6505, expressed in 359 samples.

FANTOM5 promoters (8 alternative TSS)

Promoter ID	TPM avg	Samples expressed
176145	1.3595	274
176148	0.2948	112
176149	0.2819	118
176150	0.2599	121
176146	0.1604	81
176147	0.1038	58
176151	0.0926	49
176152	0.0347	10

Top tissues by expression

132 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right hemisphere of cerebellum	UBERON:0014890	98.90	gold quality
cerebellar hemisphere	UBERON:0002245	98.89	gold quality
cerebellum	UBERON:0002037	98.88	gold quality
cerebellar cortex	UBERON:0002129	98.88	gold quality
primary visual cortex	UBERON:0002436	95.56	gold quality
right frontal lobe	UBERON:0002810	92.70	gold quality
cortical plate	UBERON:0005343	92.21	gold quality
superior frontal gyrus	UBERON:0002661	90.58	gold quality
frontal cortex	UBERON:0001870	90.27	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	90.10	gold quality
Brodmann (1909) area 9	UBERON:0013540	90.05	gold quality
hypothalamus	UBERON:0001898	89.62	gold quality
brain	UBERON:0000955	89.58	gold quality
cerebral cortex	UBERON:0000956	89.31	gold quality
anterior cingulate cortex	UBERON:0009835	89.12	gold quality
prefrontal cortex	UBERON:0000451	88.74	gold quality
putamen	UBERON:0001874	88.38	gold quality
temporal lobe	UBERON:0001871	87.95	gold quality
amygdala	UBERON:0001876	87.83	gold quality
pituitary gland	UBERON:0000007	87.49	gold quality
caudate nucleus	UBERON:0001873	86.97	gold quality
nucleus accumbens	UBERON:0001882	85.90	gold quality
ganglionic eminence	UBERON:0004023	85.78	gold quality
adenohypophysis	UBERON:0002196	85.30	gold quality
Ammon’s horn	UBERON:0001954	85.01	gold quality
substantia nigra	UBERON:0002038	84.42	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	82.49	gold quality
ventricular zone	UBERON:0003053	81.81	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	81.18	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	73.14	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	2.91
E-GEOD-109979	no	26.20

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

31 targeting TMEM145, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4534	99.99	66.58	1907
HSA-MIR-548AJ-3P	99.96	73.38	5345
HSA-MIR-548X-3P	99.96	73.38	5345
HSA-MIR-96-5P	99.95	72.80	2140
HSA-MIR-548J-3P	99.94	72.61	4881
HSA-MIR-548AE-3P	99.93	72.66	4867
HSA-MIR-548AH-3P	99.93	72.54	4872
HSA-MIR-548AM-3P	99.93	72.54	4872
HSA-MIR-548AQ-3P	99.93	72.66	4867
HSA-MIR-12133	99.92	71.82	2006
HSA-MIR-1271-5P	99.91	71.99	1972
HSA-MIR-182-5P	99.87	74.03	2589
HSA-MIR-548D-3P	99.87	70.67	4362
HSA-MIR-548BB-3P	99.86	70.58	4354
HSA-MIR-548AC	99.84	70.77	4351
HSA-MIR-548H-3P	99.84	70.80	4349
HSA-MIR-548Z	99.84	70.80	4349
HSA-MIR-577	99.78	69.13	2479
HSA-MIR-370-5P	99.78	66.81	706
HSA-MIR-4727-5P	99.23	67.55	1154
HSA-MIR-6809-5P	99.13	68.45	1223
HSA-MIR-4254	99.11	65.15	1315
HSA-MIR-6738-3P	99.03	67.14	1326
HSA-MIR-31-5P	98.58	68.35	1239
HSA-MIR-6838-3P	98.40	65.88	559
HSA-MIR-3179	98.22	65.90	1445
HSA-MIR-6881-5P	98.16	67.38	665
HSA-MIR-3690	96.44	65.18	737
HSA-MIR-548AD-3P	94.39	66.04	350
HSA-MIR-6820-5P	94.04	61.13	161

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
danio_rerio	tmem145	ENSDARG00000088342
mus_musculus	Tmem145	ENSMUSG00000043843
rattus_norvegicus	Tmem145	ENSRNOG00000020489
caenorhabditis_elegans		WBGENE00007595

Paralogs (1): GPR180 (ENSG00000152749)

Protein

Protein identifiers

Transmembrane protein 145 — Q8NBT3 (reviewed: Q8NBT3)

All UniProt accessions (5): A0A5F9ZGX1, A0A5F9ZH48, M0QZK1, M0QZX2, Q8NBT3

UniProt curated annotations — full annotation on UniProt →

Subcellular location. Membrane.

RefSeq proteins (2): NP_001353839, NP_775904* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR019336	GPR180/TMEM145_TM	Domain
IPR047831	GPR180/TMEM145	Family
IPR053880	GPR180-like_N	Domain

Pfam: PF10192, PF21892

UniProt features (15 total): transmembrane region 8, glycosylation site 2, sequence conflict 2, chain 1, sequence variant 1, region of interest 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8NBT3-F1	79.18	0.42

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Glycosylation sites (2): 35, 444

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 32 (showing top): AACTTT_UNKNOWN, PR_Q2, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_RESPONSE_TO_PHEROMONE, ZWANG_TRANSIENTLY_UP_BY_2ND_EGF_PULSE_ONLY, E2F5_TARGET_GENES, MIER1_TARGET_GENES, ZFP91_TARGET_GENES, ZNF282_TARGET_GENES, ZNF766_TARGET_GENES, MIR182_5P, MIR6809_5P, MIR31_5P, MIR3179, MIR6820_5P

GO Biological Process (2): G protein-coupled receptor signaling pathway (GO:0007186), response to pheromone (GO:0019236)

GO Molecular Function (0):

GO Cellular Component (1): membrane (GO:0016020)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
G protein-coupled receptor activity	1
signal transduction	1
response to chemical	1
cellular anatomical structure	1

Protein interactions and networks

STRING

534 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
TMEM145	PRR19	A6NJB7	656
TMEM145	PGBD5	Q8N414	585
TMEM145	ZNF574	Q6ZN55	582
TMEM145	PAFAH1B3	Q15102	580
TMEM145	RUNDC3A	Q59EK9	531
TMEM145	TTYH3	Q9C0H2	518
TMEM145	TRAPPC11	Q7Z392	514
TMEM145	CARMIL3	Q8ND23	509
TMEM145	CDKN2AIP	Q9NXV6	499
TMEM145	STOX2	Q9P2F5	497
TMEM145	PELO	Q9BRX2	485
TMEM145	CNFN	Q9BYD5	480
TMEM145	MEGF8	Q7Z7M0	480
TMEM145	SLC25A28	Q96A46	472
TMEM145	B9D2	Q9BPU9	469
TMEM145	TMEM278	A6NKF7	469

IntAct

2 interactions, top by confidence:

A	B	Type	Score
INSR	ATOX1	psi-mi:“MI:0914”(association)	0.350

BioGRID (1): TMEM145 (Negative Genetic)

ESM2 similar proteins: A4IFN5, A6NDV4, B1AWJ5, B1AZA5, B2LYG4, P59266, Q05B45, Q0VCJ8, Q3KRC4, Q3UMZ3, Q5EA70, Q5H8A4, Q5QJU3, Q5RBJ7, Q5U3C3, Q5VTY9, Q5ZMH6, Q6PHN7, Q6TCH4, Q6W5G4, Q6ZVK1, Q7Z7J7, Q865K8, Q86WK9, Q8BHH9, Q8BMT9, Q8BWB6, Q8C1E7, Q8K3J9, Q8N6M3, Q8NBT3, Q8NEB5, Q8NFT2, Q8VCW4, Q8VCY8, Q8VD53, Q8VDI9, Q96GM1, Q9BSA9, Q9BXJ8

Diamond homologs: Q5U239, Q8C4U2, Q8NBT3

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

75 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	69
Likely benign	1
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

2525 predictions. Top by Δscore:

Variant	Effect	Δscore
19:42313466:G:GG	donor_gain	1.0000
19:42313493:GGAG:G	donor_gain	1.0000
19:42313494:G:GT	donor_gain	1.0000
19:42314306:C:A	acceptor_gain	1.0000
19:42314307:G:A	acceptor_gain	1.0000
19:42314313:C:CA	acceptor_gain	1.0000
19:42314609:CCAG:C	acceptor_loss	1.0000
19:42314611:A:AG	acceptor_gain	1.0000
19:42314611:A:AT	acceptor_loss	1.0000
19:42314612:G:GA	acceptor_gain	1.0000
19:42314612:GGACT:G	acceptor_gain	1.0000
19:42314678:G:GG	donor_gain	1.0000
19:42314852:G:GG	donor_gain	1.0000
19:42314991:AG:A	acceptor_gain	1.0000
19:42314992:GG:G	acceptor_gain	1.0000
19:42315073:GTTTG:G	donor_gain	1.0000
19:42315256:GGAT:G	donor_gain	1.0000
19:42315257:GAT:G	donor_gain	1.0000
19:42315257:GATG:G	donor_gain	1.0000
19:42315260:G:GG	donor_gain	1.0000
19:42316479:A:AG	acceptor_gain	1.0000
19:42316480:G:GA	acceptor_gain	1.0000
19:42316480:GTCCT:G	acceptor_gain	1.0000
19:42316508:ACTG:A	acceptor_gain	1.0000
19:42316508:ACTGG:A	acceptor_gain	1.0000
19:42316510:T:A	acceptor_gain	1.0000
19:42316753:G:GT	donor_gain	1.0000
19:42316855:A:AG	acceptor_gain	1.0000
19:42316855:AT:A	acceptor_gain	1.0000
19:42316855:ATG:A	acceptor_gain	1.0000

AlphaMissense

3166 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
19:42314293:T:C	F48L	1.000
19:42314295:T:A	F48L	1.000
19:42314295:T:G	F48L	1.000
19:42314499:T:A	W82R	1.000
19:42314499:T:C	W82R	1.000
19:42314501:G:C	W82C	1.000
19:42314501:G:T	W82C	1.000
19:42315034:T:A	N154K	1.000
19:42315034:T:G	N154K	1.000
19:42316724:G:A	G264R	1.000
19:42316724:G:C	G264R	1.000
19:42316725:G:A	G264E	1.000
19:42320371:G:C	W376C	1.000
19:42320371:G:T	W376C	1.000
19:42320436:T:C	L398P	1.000
19:42323616:T:C	F410L	1.000
19:42323617:T:C	F410S	1.000
19:42323617:T:G	F410C	1.000
19:42323618:C:A	F410L	1.000
19:42323618:C:G	F410L	1.000
19:42314277:G:C	W42C	0.999
19:42314277:G:T	W42C	0.999
19:42314294:T:C	F48S	0.999
19:42314297:G:A	C49Y	0.999
19:42314298:T:G	C49W	0.999
19:42314299:T:C	F50L	0.999
19:42314300:T:C	F50S	0.999
19:42314300:T:G	F50C	0.999
19:42314301:C:A	F50L	0.999
19:42314301:C:G	F50L	0.999

dbSNP variants (sampled 300 via entrez): RS1000167014 (19:42311744 C>A,T), RS1000198515 (19:42311431 A>G), RS1000419722 (19:42317527 T>A), RS1000730640 (19:42313129 A>G), RS1001525024 (19:42321124 A>C,G), RS1001684260 (19:42312757 A>G), RS1002005268 (19:42314663 C>T), RS1002359302 (19:42323136 T>C), RS1002695275 (19:42313954 T>G), RS1002898784 (19:42319911 C>T), RS1003204250 (19:42318596 A>G), RS1003642965 (19:42318379 A>C), RS1003710078 (19:42322435 G>A), RS1003750052 (19:42316082 G>C), RS1004220309 (19:42321059 C>G,T)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

14 total (human), top 14 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects expression, increases methylation	2
tris(2-butoxyethyl) phosphate	affects expression	1
tris(1,3-dichloro-2-propyl)phosphate	decreases expression	1
butyraldehyde	increases expression	1
aflatoxin B2	decreases methylation	1
abrine	decreases expression	1
jinfukang	affects cotreatment, increases expression	1
(+)-JQ1 compound	decreases expression	1
Resveratrol	decreases expression, affects cotreatment	1
Benzo(a)pyrene	affects methylation	1
Cisplatin	affects cotreatment, increases expression	1
Plant Extracts	affects cotreatment, decreases expression	1
Rifampin	increases expression	1
Acrylamide	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.