TMEM147-AS1

Summary

TMEM147-AS1 (TMEM147 antisense RNA 1, HGNC:51273) is a long non-coding RNA gene on chromosome 19q13.12.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:51273
Approved symbol	TMEM147-AS1
Name	TMEM147 antisense RNA 1
Location	19q13.12
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000236144
Ensembl biotype	lncRNA
Entrez	100506469
RNAcentral	URS000075D776 — lncRNA, 1651 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 14 — 14 lncRNA

ENST00000444728, ENST00000588286, ENST00000589137, ENST00000590125, ENST00000590717, ENST00000654809, ENST00000660248, ENST00000660839, ENST00000667891, ENST00000670097, ENST00000750094, ENST00000750095, ENST00000750096, ENST00000750097

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000444728 — 4 exons

Exon	Start	End
ENSE00001704792	35542911	35543097
ENSE00002754548	35540738	35541584
ENSE00002950955	35541751	35542074
ENSE00003986966	35545319	35545515

Expression profiles

Bgee: expression breadth ubiquitous, 232 present calls, max score 93.39.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 5.9680 / max 96.2539, expressed in 1636 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
180534	5.0124	1591
180535	0.6446	315
180536	0.3109	147

Top tissues by expression

271 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
pancreatic ductal cell	CL:0002079	93.39	gold quality
buccal mucosa cell	CL:0002336	92.89	silver quality
right lobe of thyroid gland	UBERON:0001119	87.40	gold quality
left lobe of thyroid gland	UBERON:0001120	87.20	gold quality
right uterine tube	UBERON:0001302	86.98	gold quality
thyroid gland	UBERON:0002046	86.65	gold quality
corpus epididymis	UBERON:0004359	84.39	gold quality
oviduct epithelium	UBERON:0004804	83.59	silver quality
tongue squamous epithelium	UBERON:0006919	83.36	silver quality
caput epididymis	UBERON:0004358	83.35	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	82.14	gold quality
body of pancreas	UBERON:0001150	82.05	gold quality
spleen	UBERON:0002106	81.88	gold quality
inferior olivary complex	UBERON:0002127	81.60	gold quality
apex of heart	UBERON:0002098	81.41	gold quality
right hemisphere of cerebellum	UBERON:0014890	81.30	gold quality
fallopian tube	UBERON:0003889	81.19	gold quality
prostate gland	UBERON:0002367	80.94	gold quality
skin of leg	UBERON:0001511	80.82	gold quality
adenohypophysis	UBERON:0002196	80.75	gold quality
cerebellar hemisphere	UBERON:0002245	80.70	gold quality
tibialis anterior	UBERON:0001385	80.65	silver quality
left ovary	UBERON:0002119	80.62	gold quality
cerebellar cortex	UBERON:0002129	80.58	gold quality
left uterine tube	UBERON:0001303	80.48	gold quality
right ovary	UBERON:0002118	80.37	gold quality
pituitary gland	UBERON:0000007	80.31	gold quality
ovary	UBERON:0000992	80.25	gold quality
cerebellar vermis	UBERON:0004720	80.25	silver quality
left adrenal gland cortex	UBERON:0035825	80.06	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.53

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• The long non-sacoding RNA TMEM147-AS1/miR-133b/ZNF587 axis regulates the Warburg effect and promotes prostatic carcinoma invasion and proliferation. (PMID:36181243)
• Long noncoding RNA TMEM147-AS1 serves as a microRNA-326 sponge to aggravate the malignancy of gastric cancer by upregulating SMAD5. (PMID:37303938)
• Long non-coding RNA TMEM147 antisense RNA 1/microRNA-124/signal transducer and activator of transcription 3 axis in estrogen receptor-positive breast cancer. (PMID:39113102)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.