TMEM147

Summary

TMEM147 (transmembrane protein 147, HGNC:30414) is a protein-coding gene on chromosome 19q13.12, encoding BOS complex subunit TMEM147 (Q9BVK8). Component of the multi-pass translocon (MPT) complex that mediates insertion of multi-pass membrane proteins into the lipid bilayer of membranes.

Enables ribosome binding activity. Involved in multi-pass transmembrane protein insertion into ER membrane and protein localization to nuclear inner membrane. Located in nuclear membrane. Part of multi-pass translocon complex. Is active in endoplasmic reticulum membrane.

Source: NCBI Gene 10430 — RefSeq curated summary.

At a glance

• Gene–disease (curated): neurodevelopmental disorder with facial dysmorphism, absent language, and pseudo-pelger-huet anomaly (Strong, GenCC) — +1 more curated relationship
• GWAS associations: 2
• Clinical variants (ClinVar): 67 total — 10 pathogenic, 1 likely-pathogenic
• Phenotypes (HPO): 44
• MANE Select transcript: NM_032635

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:30414
Approved symbol	TMEM147
Name	transmembrane protein 147
Location	19q13.12
Locus type	gene with protein product
Status	Approved
Aliases	NIFIE14, MGC1936
Ensembl gene	ENSG00000105677
Ensembl biotype	protein_coding
OMIM	613585
Entrez	10430

Gene structure

Transcript identifiers

Ensembl transcripts: 16 — 10 protein_coding, 5 retained_intron, 1 nonsense_mediated_decay

ENST00000222284, ENST00000392204, ENST00000392205, ENST00000477168, ENST00000593027, ENST00000595180, ENST00000595467, ENST00000596232, ENST00000599895, ENST00000909147, ENST00000909148, ENST00000909149, ENST00000928928, ENST00000928929, ENST00000928930, ENST00000928931

RefSeq mRNA: 3 — MANE Select: NM_032635 NM_001242597, NM_001242598, NM_032635

CCDS: CCDS12466, CCDS56091

Canonical transcript exons

ENST00000222284 — 7 exons

Exon	Start	End
ENSE00000700065	35546945	35547029
ENSE00000700066	35546672	35546808
ENSE00003105979	35545626	35545816
ENSE00003620791	35547119	35547240
ENSE00003651027	35547324	35547526
ENSE00003669239	35545888	35545957
ENSE00003754992	35546526	35546585

Expression profiles

Bgee: expression breadth ubiquitous, 293 present calls, max score 98.44.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 63.9178 / max 340.2157, expressed in 1822 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
175346	60.6523	1822
175347	1.6615	1065
175345	1.2514	760
175348	0.3526	136

Top tissues by expression

295 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right adrenal gland	UBERON:0001233	98.44	gold quality
left adrenal gland	UBERON:0001234	98.34	gold quality
right adrenal gland cortex	UBERON:0035827	98.25	gold quality
stromal cell of endometrium	CL:0002255	98.24	gold quality
left adrenal gland cortex	UBERON:0035825	98.24	gold quality
apex of heart	UBERON:0002098	98.01	gold quality
adrenal cortex	UBERON:0001235	97.99	gold quality
lower esophagus mucosa	UBERON:0035834	97.91	gold quality
body of pancreas	UBERON:0001150	97.88	gold quality
skin of leg	UBERON:0001511	97.76	gold quality
right lobe of thyroid gland	UBERON:0001119	97.73	gold quality
left lobe of thyroid gland	UBERON:0001120	97.62	gold quality
skin of abdomen	UBERON:0001416	97.58	gold quality
adrenal gland	UBERON:0002369	97.47	gold quality
zone of skin	UBERON:0000014	97.16	gold quality
mucosa of transverse colon	UBERON:0004991	97.13	gold quality
left coronary artery	UBERON:0001626	97.12	gold quality
thyroid gland	UBERON:0002046	97.08	gold quality
right atrium auricular region	UBERON:0006631	97.04	gold quality
body of stomach	UBERON:0001161	97.02	gold quality
islet of Langerhans	UBERON:0000006	96.99	gold quality
gastrocnemius	UBERON:0001388	96.99	gold quality
adenohypophysis	UBERON:0002196	96.97	gold quality
heart left ventricle	UBERON:0002084	96.96	gold quality
pancreas	UBERON:0001264	96.88	gold quality
ascending aorta	UBERON:0001496	96.85	gold quality
thoracic aorta	UBERON:0001515	96.85	gold quality
right coronary artery	UBERON:0001625	96.82	gold quality
right testis	UBERON:0004534	96.81	gold quality
metanephros cortex	UBERON:0010533	96.81	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 2.

Experiment	Marker?	Max mean expression
E-MTAB-8271	yes	7.04
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 5)

• TMEM147 is a novel core component of the Nicalin-NOMO complex, further emphasizing its similarity with gamma-secretase. (PMID:20538592)
• Regulation of ER Composition and Extent, and Putative Action in Protein Networks by ER/NE Protein TMEM147. (PMID:34638576)
• Bi-allelic loss-of-function variants in TMEM147 cause moderate to profound intellectual disability with facial dysmorphism and pseudo-Pelger-Huet anomaly. (PMID:36044892)
• TMEM147 Correlates with Immune Infiltration and Serve as a Potential Prognostic Biomarker in Hepatocellular Carcinoma. (PMID:37305689)
• A biallelic loss-of-function variant in TMEM147 causes profound intellectual disability and spasticity. (PMID:37668766)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	tmem147	ENSDARG00000039913
mus_musculus	Tmem147	ENSMUSG00000006315
rattus_norvegicus	Tmem147	ENSRNOG00000021006
drosophila_melanogaster	CG5861	FBGN0015338
caenorhabditis_elegans		WBGENE00022734

Protein

Protein identifiers

BOS complex subunit TMEM147 — Q9BVK8 (reviewed: Q9BVK8)

Alternative names: Protein NIFIE 14, Transmembrane protein 147

All UniProt accessions (3): Q9BVK8, A8MU21, K7ELX3

UniProt curated annotations — full annotation on UniProt →

Function. Component of the multi-pass translocon (MPT) complex that mediates insertion of multi-pass membrane proteins into the lipid bilayer of membranes. The MPT complex takes over after the SEC61 complex: following membrane insertion of the first few transmembrane segments of proteins by the SEC61 complex, the MPT complex occludes the lateral gate of the SEC61 complex to promote insertion of subsequent transmembrane regions. Also acts as a negative regulator of CHRM3 function, most likely by interfering with its trafficking to the cell membrane. Negatively regulates CHRM3-mediated calcium mobilization and activation of RPS6KA1/p90RSK activity. Regulates LBR localization to the nucleus inner membrane.

Subunit / interactions. Component of the back of Sec61 (BOS) complex, composed of NCLN/Nicalin, NOMO (NOMO1, NOMO2 or NOMO3) and TMEM147. The BOS complex is part of the multi-pass translocon (MPT) complex, composed of three subcomplexes, the GEL complex (composed of RAB5IF/OPTI and TMCO1), the BOS complex (composed of NCLN/Nicalin, NOMO and TMEM147) and the PAT complex (composed of WDR83OS/Asterix and CCDC47). The MPT complex associates with the SEC61 complex. Interacts with CHRM3, CHRM1 and AVPR2. Interacts with LBR; promoting LBR localization to the nucleus inner membrane. Interacts with DHCR7.

Subcellular location. Endoplasmic reticulum membrane. Nucleus membrane. Cell membrane.

Disease relevance. Neurodevelopmental disorder with facial dysmorphism, absent language, and pseudo-Pelger-Huet anomaly (NEDFLPH) [MIM:620075] An autosomal recessive disorder with onset in infancy and characterized by global developmental delay, intellectual disability, dysmorphic facial features, coarse facies, and behavioral problems. Affected individuals may have variable findings on brain imaging, such as cortical atrophy, thin corpus callosum and enlarged ventricles. Laboratory studies show nuclear lobulation defects in a subset of neutrophils, indicating a pseudo-Pelger-Huet anomaly. The disease is caused by variants affecting the gene represented in this entry.

Similarity. Belongs to the TMEM147 family.

Isoforms (2)

UniProt ID	Names	Canonical?
Q9BVK8-1	1	yes
Q9BVK8-2	2

RefSeq proteins (3): NP_001229526, NP_001229527, NP_116024* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR019164	TMEM147	Family

Pfam: PF09767

UniProt features (28 total): transmembrane region 7, topological domain 7, sequence variant 7, sequence conflict 5, chain 1, splice variant 1

Structure

Experimental structures (PDB)

3 structures.

PDB	Method	Resolution (Å)
9C7U	ELECTRON MICROSCOPY	3.65
6W6L	ELECTRON MICROSCOPY	3.84
9C7V	ELECTRON MICROSCOPY	6.6

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9BVK8-F1	92.38	0.74

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 288 (showing top): FAELT_B_CLL_WITH_VH_REARRANGEMENTS_DN, KAAB_FAILED_HEART_ATRIUM_DN, STARK_PREFRONTAL_CORTEX_22Q11_DELETION_DN, CREB_Q4, MORF_ATOX1, ATF1_Q6, WTGAAAT_UNKNOWN, LUI_TARGETS_OF_PAX8_PPARG_FUSION, GOBP_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_MEMBRANE, MORF_PPP2R4, GOBP_ENDOMEMBRANE_SYSTEM_ORGANIZATION, ATF3_Q6, MORF_GPX4, HFH1_01, FREAC4_01

GO Biological Process (2): protein localization to nuclear inner membrane (GO:0036228), multi-pass transmembrane protein insertion into ER membrane (GO:0160063)

GO Molecular Function (2): ribosome binding (GO:0043022), protein binding (GO:0005515)

GO Cellular Component (8): endoplasmic reticulum membrane (GO:0005789), plasma membrane (GO:0005886), nuclear membrane (GO:0031965), protein-containing complex (GO:0032991), multi-pass translocon complex (GO:0160064), nucleus (GO:0005634), endoplasmic reticulum (GO:0005783), membrane (GO:0016020)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
organelle membrane	2
intracellular membrane-bounded organelle	2
protein localization to membrane	1
protein localization to nuclear envelope	1
protein insertion into ER membrane	1
ribonucleoprotein complex binding	1
binding	1
nuclear outer membrane-endoplasmic reticulum membrane network	1
endoplasmic reticulum subcompartment	1
membrane	1
cell periphery	1
nucleus	1
nuclear envelope	1
cellular_component	1
ER membrane insertion complex	1
cytoplasm	1
endomembrane system	1
cellular anatomical structure	1

Protein interactions and networks

STRING

1308 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
TMEM147	NCLN	Q969V3	991
TMEM147	NOMO2	Q5JPE7	986
TMEM147	NOMO3	P69849	718
TMEM147	TMEM63A	O94886	651
TMEM147	ERG28	Q9UKR5	624
TMEM147	NOMO1	P78421	611
TMEM147	YIPF6	Q96EC8	593
TMEM147	EMC7	Q9NPA0	587
TMEM147	GALM	Q96C23	578
TMEM147	IER3IP1	Q9Y5U9	573
TMEM147	TMEM53	Q6P2H8	556
TMEM147	XYLT1	Q86Y38	549
TMEM147	TMEM223	A0PJW6	540
TMEM147	CCDC47	Q96A33	534
TMEM147	KRTCAP2	Q8N6L1	477

IntAct

177 interactions, top by confidence:

A	B	Type	Score
LDLRAD1	TMEM147	psi-mi:“MI:0915”(physical association)	0.780
CREB3L1	TMEM147	psi-mi:“MI:0915”(physical association)	0.780
TMEM147	LDLRAD1	psi-mi:“MI:0915”(physical association)	0.780
TMEM147	CREB3L1	psi-mi:“MI:0915”(physical association)	0.780
TMEM147	PACC1	psi-mi:“MI:0915”(physical association)	0.740
HTR2C	TMEM147	psi-mi:“MI:0915”(physical association)	0.740
ABHD16A	TMEM147	psi-mi:“MI:0915”(physical association)	0.670
TMEM147	SYNE4	psi-mi:“MI:0915”(physical association)	0.560
SYNE4	TMEM147	psi-mi:“MI:0915”(physical association)	0.560
TMEM147	GPR37L1	psi-mi:“MI:0915”(physical association)	0.560
TMEM147	CLRN1	psi-mi:“MI:0915”(physical association)	0.560
TMEM147	SHISA3	psi-mi:“MI:0915”(physical association)	0.560
TMEM147	SLC10A1	psi-mi:“MI:0915”(physical association)	0.560
TMEM147	LHFPL2	psi-mi:“MI:0915”(physical association)	0.560
TMEM147	PVR	psi-mi:“MI:0915”(physical association)	0.560
TMEM147		psi-mi:“MI:0915”(physical association)	0.560
TMEM147	TEX29	psi-mi:“MI:0915”(physical association)	0.560
TMEM147	IL3RA	psi-mi:“MI:0915”(physical association)	0.560

BioGRID (104): CREB3L1 (Two-hybrid), SYNE4 (Two-hybrid), LDLRAD1 (Two-hybrid), TMEM147 (Two-hybrid), ABI3 (Two-hybrid), TMEM147 (Affinity Capture-MS), TMEM147 (Affinity Capture-MS), TMEM147 (Positive Genetic), TMEM147 (Two-hybrid), TMEM147 (Two-hybrid), TMEM147 (Two-hybrid), TMEM147 (Two-hybrid), TMEM147 (Two-hybrid), TMEM147 (Two-hybrid), TSPAN12 (Two-hybrid)

ESM2 similar proteins: A0A078H868, A0A8I3MKU8, A1C7T5, A1DIF7, A2R616, A6S950, B0XUW3, B2B2N5, B6HJA3, B8N6H2, B9RK42, C0NLX2, C0RZV6, C1G565, C1GZK1, C4JDF8, C5FZ62, C5GN10, C5JCV0, C5PEI5, C6H4B5, C7Z7C3, D1ZIW5, D4AT37, D4DGR3, I6VSD2, O94673, O96005, Q0CVD7, Q0IJ20, Q28FY5, Q29BL9, Q2H0U8, Q2TA63, Q2UDE5, Q3SZR6, Q4WZS1, Q5BBC6, Q5BIY5, Q6DFI2

Diamond homologs: A0A8I3MKU8, I6VSD2, Q28FY5, Q2TA63, Q3SZR6, Q6DFI2, Q6DGL7, Q9BVK8, Q9CQG6

SIGNOR signaling

3 interactions.

A	Effect	B	Mechanism
TMEM147	“form complex”	“BOS complex, NOMO1 variant”	binding
TMEM147	“form complex”	“BOS complex, NOMO2 variant”	binding
TMEM147	“form complex”	“BOS complex, NOMO3 variant”	binding

Disease & clinical

Clinical variants and AI predictions

ClinVar

67 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	10
Likely pathogenic	1
Uncertain significance	37
Likely benign	4
Benign	1

Top pathogenic / likely-pathogenic (11)

Variant ID	HGVS	Classification
1708019	NM_032635.4(TMEM147):c.100_118del (p.Lys34fs)	Pathogenic
1708020	NM_032635.4(TMEM147):c.419dup (p.Asn140fs)	Pathogenic
1708024	NM_032635.4(TMEM147):c.345-1G>T	Pathogenic
1708025	NM_032635.4(TMEM147):c.390G>A (p.Trp130Ter)	Pathogenic
1708026	NM_032635.4(TMEM147):c.540_543dup (p.Val182fs)	Pathogenic
1708028	NM_032635.4(TMEM147):c.486C>G (p.Tyr162Ter)	Pathogenic
1711114	NM_032635.4(TMEM147):c.169_172del (p.Phe57fs)	Pathogenic
1712322	NM_032635.4(TMEM147):c.163_172del (p.Thr55fs)	Pathogenic
3602549	NM_032635.4(TMEM147):c.429+2T>C	Pathogenic
3778700	NM_032635.4(TMEM147):c.208-8_222delinsCT	Pathogenic
3374729	NM_032635.4(TMEM147):c.430-2A>T	Likely pathogenic

SpliceAI

642 predictions. Top by Δscore:

Variant	Effect	Δscore
19:35545812:GGCCT:G	donor_gain	1.0000
19:35545813:GCCT:G	donor_gain	1.0000
19:35545813:GCCTG:G	donor_gain	1.0000
19:35545817:G:GG	donor_gain	1.0000
19:35545956:AGGT:A	donor_loss	1.0000
19:35545959:T:A	donor_loss	1.0000
19:35546670:A:AG	acceptor_gain	1.0000
19:35546670:AG:A	acceptor_gain	1.0000
19:35546671:G:GG	acceptor_gain	1.0000
19:35546671:GG:G	acceptor_gain	1.0000
19:35546671:GGA:G	acceptor_gain	1.0000
19:35546749:A:T	donor_gain	1.0000
19:35546805:CCCGG:C	donor_loss	1.0000
19:35546807:CGG:C	donor_loss	1.0000
19:35546809:G:GA	donor_loss	1.0000
19:35546809:G:GG	donor_gain	1.0000
19:35547025:GTCTG:G	donor_gain	1.0000
19:35547227:GCC:G	donor_gain	1.0000
19:35547238:GGA:G	donor_gain	1.0000
19:35547239:GAG:G	donor_gain	1.0000
19:35547241:G:GG	donor_gain	1.0000
19:35546583:GGG:G	donor_gain	0.9900
19:35546584:GG:G	donor_gain	0.9900
19:35546584:GGG:G	donor_gain	0.9900
19:35546585:GG:G	donor_gain	0.9900
19:35546585:GGTGA:G	donor_loss	0.9900
19:35546586:G:GA	donor_loss	0.9900
19:35546587:T:A	donor_loss	0.9900
19:35546671:GGAGT:G	acceptor_gain	0.9900
19:35546747:G:GT	donor_gain	0.9900

AlphaMissense

1466 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
19:35545925:G:A	G39R	1.000
19:35545925:G:C	G39R	1.000
19:35546777:G:C	G105R	1.000
19:35546780:T:A	W106R	1.000
19:35546780:T:C	W106R	1.000
19:35546782:G:C	W106C	1.000
19:35546782:G:T	W106C	1.000
19:35546958:T:A	W120R	1.000
19:35546958:T:C	W120R	1.000
19:35546982:T:C	F128L	1.000
19:35546983:T:C	F128S	1.000
19:35546983:T:G	F128C	1.000
19:35546984:T:A	F128L	1.000
19:35546984:T:G	F128L	1.000
19:35546988:T:A	W130R	1.000
19:35546988:T:C	W130R	1.000
19:35545759:G:A	G7E	0.999
19:35545763:C:A	N8K	0.999
19:35545763:C:G	N8K	0.999
19:35545764:T:C	C9R	0.999
19:35545765:G:A	C9Y	0.999
19:35545766:C:G	C9W	0.999
19:35545771:C:A	A11D	0.999
19:35545774:T:A	L12H	0.999
19:35545786:C:A	P16H	0.999
19:35545800:T:G	Y21D	0.999
19:35545917:T:A	V36D	0.999
19:35545926:G:A	G39E	0.999
19:35545950:T:C	L47P	0.999
19:35545952:T:C	C48R	0.999

dbSNP variants (sampled 300 via entrez): RS1000513581 (19:35546017 G>A), RS1001088815 (19:35544644 C>T), RS1001207725 (19:35547327 C>A,T), RS1002625632 (19:35547908 G>C), RS1003549329 (19:35546066 C>T), RS1003653580 (19:35546700 C>G), RS1005633805 (19:35547079 C>G), RS1005727157 (19:35546790 C>T), RS1006746426 (19:35545442 C>T), RS1007107284 (19:35545363 C>T), RS1007615253 (19:35544424 G>A,C), RS1007858150 (19:35546408 A>G), RS1008108980 (19:35543642 G>A), RS1009845012 (19:35544442 T>G), RS1010161018 (19:35544575 T>C)

Disease associations

OMIM: gene MIM:613585 | disease phenotypes: MIM:620075

GenCC curated gene-disease

Disease	Classification	Inheritance
neurodevelopmental disorder with facial dysmorphism, absent language, and pseudo-pelger-huet anomaly	Strong	Autosomal recessive
complex neurodevelopmental disorder	Moderate	Autosomal recessive

Mondo (2): neurodevelopmental disorder with facial dysmorphism, absent language, and pseudo-pelger-huet anomaly (MONDO:0859298), complex neurodevelopmental disorder (MONDO:0100038)

Orphanet (1): Global developmental delay-intellectual disability-facial dysmorphism-pseudo-Pelger-Huët anomaly syndrome (Orphanet:698085)

HPO phenotypes

44 total (30 of 44 shown, HPO-id order):

HPO	Term
HP:0000007	Autosomal recessive inheritance
HP:0000154	Wide mouth
HP:0000179	Thick lower lip vermilion
HP:0000219	Thin upper lip vermilion
HP:0000232	Everted lower lip vermilion
HP:0000276	Long face
HP:0000280	Coarse facial features
HP:0000286	Epicanthus
HP:0000316	Hypertelorism
HP:0000319	Smooth philtrum
HP:0000343	Long philtrum
HP:0000369	Low-set ears
HP:0000407	Sensorineural hearing impairment
HP:0000494	Downslanted palpebral fissures
HP:0000664	Synophrys
HP:0000718	Aggressive behavior
HP:0000739	Anxiety
HP:0000750	Delayed speech and language development
HP:0000752	Hyperactivity
HP:0000954	Single transverse palmar crease
HP:0001249	Intellectual disability
HP:0001252	Hypotonia
HP:0001270	Motor delay
HP:0001335	Bimanual synkinesia
HP:0001344	Absent speech
HP:0001631	Atrial septal defect
HP:0001655	Patent foramen ovale
HP:0002188	Delayed CNS myelination
HP:0002212	Curly hair
HP:0002751	Kyphoscoliosis

GWAS associations

2 associations (top):

Study	Trait	p-value
GCST90011898_58	Alanine aminotransferase levels	6.000000e-12
GCST90013405_116	Liver enzyme levels (alanine transaminase)	2.000000e-16

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

20 total (human), top 20 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	increases expression, increases methylation	3
sodium arsenite	decreases expression	2
bisphenol A	affects expression	1
beta-lapachone	decreases expression	1
arsenite	affects binding, increases reaction	1
di-n-butylphosphoric acid	affects expression	1
perfluorooctane sulfonic acid	increases expression	1
Diazinon	increases methylation	1
Diuron	decreases expression	1
Doxorubicin	increases expression	1
Ethyl Methanesulfonate	decreases expression	1
Hydrogen Peroxide	affects expression	1
Methyl Methanesulfonate	decreases expression	1
Smoke	decreases expression	1
Thiram	decreases expression	1
Tobacco Smoke Pollution	increases expression	1
Cyclosporine	increases expression	1
Aflatoxin B1	increases methylation	1
Copper Sulfate	decreases expression	1
Lactic Acid	decreases expression	1

Cellosaurus cell lines

1 cell lines: 1 transformed cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_B3JI	Abcam HEK293T TMEM147 KO	Transformed cell line	Female

Clinical trials (associated diseases)

2 trials via MONDO — disease-level, not drug-specific.

Trial	Phase	Status	Title
NCT06310681	Not specified	COMPLETED	Pilot Testing of a Co-adapted Group Programme for Parents/Carers of Children With Complex Neurodisability
NCT07303049	Not specified	NOT_YET_RECRUITING	Cognitive Benefit of Intensive Rehabilitation Using Rhythmic Music Training in Children With Complex Neurodevelopmental Disorder