TMEM151B

Summary

TMEM151B (transmembrane protein 151B, HGNC:21315) is a protein-coding gene on chromosome 6p21.1, encoding Transmembrane protein 151B (Q8IW70).

Predicted to be active in membrane.

Source: NCBI Gene 441151 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 88 total
• MANE Select transcript: NM_001137560

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:21315
Approved symbol	TMEM151B
Name	transmembrane protein 151B
Location	6p21.1
Locus type	gene with protein product
Status	Approved
Aliases	bA444E17.5
Ensembl gene	ENSG00000178233
Ensembl biotype	protein_coding
Entrez	441151

Gene structure

Transcript identifiers

Ensembl transcripts: 2 — 2 protein_coding

ENST00000438774, ENST00000451188

RefSeq mRNA: 1 — MANE Select: NM_001137560 NM_001137560

CCDS: CCDS47437

Canonical transcript exons

ENST00000451188 — 3 exons

Exon	Start	End
ENSE00001414560	44270450	44270877
ENSE00001625170	44275403	44279444
ENSE00003707422	44273066	44273506

Expression profiles

Bgee: expression breadth ubiquitous, 181 present calls, max score 98.43.

FANTOM5 (CAGE): breadth broad, TPM avg 3.0052 / max 254.0776, expressed in 262 samples.

FANTOM5 promoters (6 alternative TSS)

Promoter ID	TPM avg	Samples expressed
68019	2.6434	217
68020	0.2124	78
204006	0.0489	18
68023	0.0397	15
68021	0.0394	16
68018	0.0214	8

Top tissues by expression

281 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
paraflocculus	UBERON:0005351	98.43	gold quality
right hemisphere of cerebellum	UBERON:0014890	97.65	gold quality
cerebellar hemisphere	UBERON:0002245	97.49	gold quality
cerebellar cortex	UBERON:0002129	97.48	gold quality
cerebellum	UBERON:0002037	97.42	gold quality
frontal pole	UBERON:0002795	97.27	gold quality
cerebellar vermis	UBERON:0004720	97.05	gold quality
Brodmann (1909) area 10	UBERON:0013541	96.24	gold quality
cortical plate	UBERON:0005343	95.60	gold quality
right frontal lobe	UBERON:0002810	94.99	gold quality
prefrontal cortex	UBERON:0000451	94.66	gold quality
frontal cortex	UBERON:0001870	94.59	gold quality
middle temporal gyrus	UBERON:0002771	94.50	gold quality
orbitofrontal cortex	UBERON:0004167	94.44	gold quality
Brodmann (1909) area 46	UBERON:0006483	94.32	gold quality
superior frontal gyrus	UBERON:0002661	94.30	gold quality
parietal lobe	UBERON:0001872	94.19	gold quality
postcentral gyrus	UBERON:0002581	94.13	gold quality
neocortex	UBERON:0001950	94.07	gold quality
endothelial cell	CL:0000115	93.97	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	93.54	gold quality
cingulate cortex	UBERON:0003027	93.36	gold quality
cerebral cortex	UBERON:0000956	93.34	gold quality
anterior cingulate cortex	UBERON:0009835	93.33	gold quality
occipital lobe	UBERON:0002021	93.06	gold quality
primary visual cortex	UBERON:0002436	93.04	gold quality
CA1 field of hippocampus	UBERON:0003881	93.04	gold quality
Brodmann (1909) area 9	UBERON:0013540	92.41	gold quality
ganglionic eminence	UBERON:0004023	91.91	gold quality
entorhinal cortex	UBERON:0002728	91.73	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.46

Regulation

Is transcription factor: no

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	tmem151ba	ENSDARG00000060034
danio_rerio	tmem151bb	ENSDARG00000079878
mus_musculus	Tmem151b	ENSMUSG00000096847
rattus_norvegicus	Tmem151b	ENSRNOG00000019961
caenorhabditis_elegans		WBGENE00014210

Paralogs (1): TMEM151A (ENSG00000179292)

Protein

Protein identifiers

Transmembrane protein 151B — Q8IW70 (reviewed: Q8IW70)

Alternative names: Transmembrane protein 193

All UniProt accessions (1): Q8IW70

UniProt curated annotations — full annotation on UniProt →

Subcellular location. Membrane.

Similarity. Belongs to the TMEM151 family.

Isoforms (2)

UniProt ID	Names	Canonical?
Q8IW70-1	1	yes
Q8IW70-2	2

RefSeq proteins (1): NP_001131032* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR026767	Tmem151	Family

Pfam: PF14857

UniProt features (11 total): compositionally biased region 4, transmembrane region 2, splice variant 2, region of interest 2, chain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8IW70-F1	66.75	0.36

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 53 (showing top): KIM_GASTRIC_CANCER_CHEMOSENSITIVITY, CUI_TCF21_TARGETS_2_UP, MEISSNER_BRAIN_HCP_WITH_H3K4ME3_AND_H3K27ME3, MEISSNER_NPC_HCP_WITH_H3K4ME2, MIKKELSEN_MCV6_HCP_WITH_H3K27ME3, KIM_ALL_DISORDERS_OLIGODENDROCYTE_NUMBER_CORR_UP, PTEN_DN.V1_UP, MIR6867_5P, MIR6833_3P, GSE10239_MEMORY_VS_KLRG1HIGH_EFF_CD8_TCELL_UP, MIR4492, MIR4768_5P, MIR1303, MIR4753_5P, MIR3663_3P

GO Biological Process (0):

GO Molecular Function (0):

GO Cellular Component (1): membrane (GO:0016020)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	1

Protein interactions and networks

STRING

908 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
TMEM151B	TMEM253	P0C7T8	621
TMEM151B	SPATS1	Q496A3	479
TMEM151B	TMEM235	A6NFC5	445
TMEM151B	TMEM116	Q8NCL8	419
TMEM151B	TMEM109	Q9BVC6	408
TMEM151B	ACBD7	Q8N6N7	364
TMEM151B	TTC9	Q92623	355
TMEM151B	DRC5	Q5JU00	348
TMEM151B	SLC35B2	Q8TB61	344
TMEM151B	TMEM114	B3SHH9	328
TMEM151B	ATP13A4	Q4VNC1	316
TMEM151B	RAB40A	Q8WXH6	311
TMEM151B	MIGA2	Q7L4E1	307
TMEM151B	RIMS3	Q9UJD0	306
TMEM151B	TRPC4AP	Q8TEL6	305
TMEM151B	RASGEF1A	Q8N9B8	305

IntAct

120 interactions, top by confidence:

A	B	Type	Score
YAP1	TMEM151B	psi-mi:“MI:0407”(direct interaction)	0.440
TMEM151B	MAST2	psi-mi:“MI:0407”(direct interaction)	0.440
TMEM151B	SNX27	psi-mi:“MI:0407”(direct interaction)	0.440
TMEM151B	SCRIB	psi-mi:“MI:0407”(direct interaction)	0.440
TMEM151B	PDZK1	psi-mi:“MI:0407”(direct interaction)	0.440
TMEM151B	PDZRN4	psi-mi:“MI:0407”(direct interaction)	0.440
TMEM151B	PDZRN3	psi-mi:“MI:0407”(direct interaction)	0.440
TMEM151B	MAST1	psi-mi:“MI:0407”(direct interaction)	0.440
TMEM151B	SYNJ2BP	psi-mi:“MI:0407”(direct interaction)	0.440
TMEM151B	ARHGEF12	psi-mi:“MI:0407”(direct interaction)	0.440
TMEM151B	RHPN1	psi-mi:“MI:0407”(direct interaction)	0.440
TMEM151B	PTPN3	psi-mi:“MI:0407”(direct interaction)	0.440
TMEM151B	DLG1	psi-mi:“MI:0407”(direct interaction)	0.440
TMEM151B	SNTB1	psi-mi:“MI:0407”(direct interaction)	0.440
TMEM151B	SNTA1	psi-mi:“MI:0407”(direct interaction)	0.440
TMEM151B	TAX1BP3	psi-mi:“MI:0407”(direct interaction)	0.440
TMEM151B	SNTG2	psi-mi:“MI:0407”(direct interaction)	0.440
TMEM151B	NHERF2	psi-mi:“MI:0407”(direct interaction)	0.440
TMEM151B	SHANK1	psi-mi:“MI:0407”(direct interaction)	0.440
TMEM151B	WHRN	psi-mi:“MI:0407”(direct interaction)	0.440
TMEM151B	DLG4	psi-mi:“MI:0407”(direct interaction)	0.440
TMEM151B	DLG3	psi-mi:“MI:0407”(direct interaction)	0.440
TMEM151B	FRMPD4	psi-mi:“MI:0407”(direct interaction)	0.440
TMEM151B	NHERF4	psi-mi:“MI:0407”(direct interaction)	0.440
TMEM151B	PDZD7	psi-mi:“MI:0407”(direct interaction)	0.440
TMEM151B	LIN7B	psi-mi:“MI:0407”(direct interaction)	0.440
TMEM151B	SNTG1	psi-mi:“MI:0407”(direct interaction)	0.440
LIN7C	TMEM151B	psi-mi:“MI:0407”(direct interaction)	0.440

BioGRID (3): TMEM151B (Positive Genetic), TMEM151B (Protein-peptide), TMEM151B (Affinity Capture-RNA)

ESM2 similar proteins: A1A4M2, A4IFG4, A5D8P8, A6NKD9, A7E2M3, B4F7F3, E9Q6B2, F1MX48, F1SAM7, O97676, P18065, P36956, P47877, P49705, P56720, P56873, Q00709, Q00973, Q09200, Q0IHY5, Q15465, Q24JP5, Q2YD98, Q3TAS6, Q58CS8, Q5QQ49, Q5UCC4, Q60416, Q60698, Q641Q3, Q68FE7, Q6AYH6, Q6DVA0, Q6P7K5, Q6UKI2, Q6WVG3, Q80WF4, Q8IW70, Q8JGM4, Q8K064

Diamond homologs: A3KN95, A4IFG4, A7E2I7, Q23387, Q626N3, Q68FE7, Q6GQT5, Q8IW70, Q8N4L1

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 79 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Ras activation upon Ca2+ influx through NMDA receptor	5	54.9×	1e-06
Unblocking of NMDA receptors, glutamate binding and activation	5	52.3×	1e-06
Negative regulation of NMDA receptor-mediated neuronal transmission	5	52.3×	1e-06
Assembly and cell surface presentation of NMDA receptors	10	48.8×	5e-13
Dopamine Neurotransmitter Release Cycle	5	47.7×	2e-06
Long-term potentiation	5	45.8×	2e-06
Neurexins and neuroligins	11	41.6×	2e-13
Protein-protein interactions at synapses	7	35.8×	6e-08

GO biological processes:

GO term	Partners	Fold	FDR
establishment or maintenance of epithelial cell apical/basal polarity	10	75.5×	2e-14
protein localization to synapse	6	59.7×	7e-08
receptor clustering	7	56.7×	7e-09
regulation of postsynaptic membrane neurotransmitter receptor levels	7	45.1×	3e-08
protein-containing complex assembly	9	13.3×	2e-06
cell-cell adhesion	10	13.2×	3e-07
regulation of small GTPase mediated signal transduction	5	9.3×	4e-03
chemical synaptic transmission	7	7.0×	2e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

88 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	86
Likely benign	1
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

4568 predictions. Top by Δscore:

Variant	Effect	Δscore
6:44280386:CCGTC:C	acceptor_gain	1.0000
6:44280387:CGTC:C	acceptor_gain	1.0000
6:44280387:CGTCC:C	acceptor_gain	1.0000
6:44280388:GTC:G	acceptor_gain	1.0000
6:44280388:GTCC:G	acceptor_loss	1.0000
6:44280389:TC:T	acceptor_gain	1.0000
6:44280390:CC:C	acceptor_gain	1.0000
6:44280391:C:CC	acceptor_gain	1.0000
6:44280391:C:CG	acceptor_loss	1.0000
6:44280391:C:T	acceptor_gain	1.0000
6:44280392:T:C	acceptor_loss	1.0000
6:44280402:G:C	acceptor_gain	1.0000
6:44280402:G:GC	acceptor_gain	1.0000
6:44285960:GTA:G	donor_loss	1.0000
6:44285961:TAC:T	donor_loss	1.0000
6:44285962:A:AT	donor_loss	1.0000
6:44285963:C:CT	donor_loss	1.0000
6:44301273:C:CT	acceptor_gain	1.0000
6:44301376:CTCA:C	donor_gain	1.0000
6:44301377:TCACT:T	donor_loss	1.0000
6:44301378:CAC:C	donor_loss	1.0000
6:44301379:A:AC	donor_gain	1.0000
6:44301379:AC:A	donor_loss	1.0000
6:44301380:C:CA	donor_gain	1.0000
6:44301380:CT:C	donor_gain	1.0000
6:44301380:CTG:C	donor_gain	1.0000
6:44301380:CTGA:C	donor_gain	1.0000
6:44301380:CTGAG:C	donor_gain	1.0000
6:44301393:AG:A	donor_gain	1.0000
6:44301394:G:C	donor_gain	1.0000

AlphaMissense

3654 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
6:44273174:T:C	C82R	1.000
6:44273274:T:A	I115N	1.000
6:44273405:G:C	A159P	1.000
6:44273412:C:A	P161H	1.000
6:44273412:C:G	P161R	1.000
6:44273418:T:A	I163N	1.000
6:44273420:T:A	W164R	1.000
6:44273420:T:C	W164R	1.000
6:44273422:G:C	W164C	1.000
6:44273422:G:T	W164C	1.000
6:44273423:T:A	W165R	1.000
6:44273423:T:C	W165R	1.000
6:44273424:G:C	W165S	1.000
6:44273425:G:C	W165C	1.000
6:44273425:G:T	W165C	1.000
6:44273429:G:C	A167P	1.000
6:44273430:C:A	A167D	1.000
6:44273435:A:C	S169R	1.000
6:44273437:C:A	S169R	1.000
6:44273437:C:G	S169R	1.000
6:44273438:T:A	Y170N	1.000
6:44273438:T:C	Y170H	1.000
6:44273438:T:G	Y170D	1.000
6:44273441:C:G	H171D	1.000
6:44273443:C:A	H171Q	1.000
6:44273443:C:G	H171Q	1.000
6:44273450:C:A	R174S	1.000
6:44273453:C:A	R175S	1.000
6:44273454:G:C	R175P	1.000
6:44273459:C:A	R177S	1.000

dbSNP variants (sampled 300 via entrez): RS1000558130 (6:44273400 A>G), RS1000632111 (6:44279795 G>T), RS1000930193 (6:44273657 A>G), RS1001462628 (6:44273755 C>T), RS1001508219 (6:44279933 A>G), RS1001578906 (6:44273393 C>A,T), RS1001799850 (6:44271889 T>G), RS1001915938 (6:44271463 CAA>C), RS1001969490 (6:44274404 G>C), RS1002071047 (6:44278343 G>A), RS1002359513 (6:44278628 AGGGGGAC>A), RS1002444827 (6:44274082 G>A,C,T), RS1002602668 (6:44269067 G>T), RS1002631762 (6:44277121 G>A), RS1002706702 (6:44276855 T>C)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

7 total (human), top 7 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
bisphenol A	increases expression	1
ethyl-p-hydroxybenzoate	decreases expression	1
Amphotericin B	increases expression	1
Benzo(a)pyrene	increases methylation	1
Lead	decreases expression	1
Niclosamide	increases expression	1
Tobacco Smoke Pollution	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.