TMEM156

Summary

TMEM156 (transmembrane protein 156, HGNC:26260) is a protein-coding gene on chromosome 4p14, encoding Transmembrane protein 156 (Q8N614).

Predicted to be located in membrane.

Source: NCBI Gene 80008 — RefSeq curated summary.

At a glance

• GWAS associations: 6
• Clinical variants (ClinVar): 49 total
• MANE Select transcript: NM_024943

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:26260
Approved symbol	TMEM156
Name	transmembrane protein 156
Location	4p14
Locus type	gene with protein product
Status	Approved
Aliases	FLJ23235
Ensembl gene	ENSG00000121895
Ensembl biotype	protein_coding
Entrez	80008

Gene structure

Transcript identifiers

Ensembl transcripts: 9 — 7 protein_coding, 2 protein_coding_CDS_not_defined

ENST00000344606, ENST00000372489, ENST00000381938, ENST00000495029, ENST00000850870, ENST00000877062, ENST00000877063, ENST00000877064, ENST00000877065

RefSeq mRNA: 2 — MANE Select: NM_024943 NM_001303228, NM_024943

CCDS: CCDS3448

Canonical transcript exons

ENST00000381938 — 7 exons

Exon	Start	End
ENSE00000826436	38986336	38986419
ENSE00000826437	38988851	38988970
ENSE00000826438	38993738	38993998
ENSE00000826439	38998640	38998909
ENSE00001077183	38971032	38971137
ENSE00001490341	39032226	39032409
ENSE00004282576	38966744	38967641

Expression profiles

Bgee: expression breadth ubiquitous, 175 present calls, max score 97.05.

FANTOM5 (CAGE): breadth broad, TPM avg 4.2234 / max 211.8160, expressed in 570 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
51821	4.0731	555
51822	0.0966	53
51823	0.0537	18

Top tissues by expression

275 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
buccal mucosa cell	CL:0002336	97.05	gold quality
granulocyte	CL:0000094	86.98	gold quality
lymph node	UBERON:0000029	85.10	gold quality
spleen	UBERON:0002106	83.94	gold quality
bone marrow cell	CL:0002092	82.73	gold quality
vermiform appendix	UBERON:0001154	80.58	gold quality
colonic epithelium	UBERON:0000397	76.37	gold quality
caecum	UBERON:0001153	75.93	gold quality
bone marrow	UBERON:0002371	75.40	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	74.36	gold quality
blood	UBERON:0000178	73.81	gold quality
superficial temporal artery	UBERON:0001614	72.54	gold quality
tonsil	UBERON:0002372	72.51	gold quality
rectum	UBERON:0001052	72.44	gold quality
small intestine Peyer’s patch	UBERON:0003454	72.39	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	72.19	gold quality
leukocyte	CL:0000738	72.17	gold quality
monocyte	CL:0000576	71.11	gold quality
mononuclear cell	CL:0000842	70.92	gold quality
mucosa of transverse colon	UBERON:0004991	70.43	gold quality
gall bladder	UBERON:0002110	69.88	gold quality
spinal cord	UBERON:0002240	69.26	gold quality
small intestine	UBERON:0002108	69.03	gold quality
epithelium of nasopharynx	UBERON:0001951	68.84	gold quality
adrenal tissue	UBERON:0018303	65.56	gold quality
parotid gland	UBERON:0001831	64.50	gold quality
transverse colon	UBERON:0001157	61.85	gold quality
substantia nigra	UBERON:0002038	61.72	gold quality
right lobe of liver	UBERON:0001114	61.68	gold quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	61.20	gold quality

Single-cell (SCXA)

Detected in 4 experiment(s), a significant marker in 3.

Experiment	Marker?	Max mean expression
E-MTAB-8142	yes	22.87
E-ANND-3	yes	13.36
E-MTAB-10553	yes	8.77
E-CURD-112	no	2.86

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

46 targeting TMEM156, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-5692A	100.00	74.40	6850
HSA-MIR-495-3P	99.96	72.81	4197
HSA-MIR-5688	99.96	73.23	4504
HSA-MIR-335-3P	99.93	73.36	4958
HSA-MIR-4496	99.88	68.89	2236
HSA-MIR-659-3P	99.85	70.69	1620
HSA-MIR-5010-3P	99.83	70.60	2357
HSA-MIR-204-5P	99.79	71.62	2439
HSA-MIR-211-5P	99.79	71.65	2440
HSA-MIR-623	99.76	68.16	1170
HSA-MIR-4524A-3P	99.72	66.85	2406
HSA-MIR-4755-5P	99.71	70.34	2716
HSA-MIR-5006-3P	99.71	70.26	2728
HSA-MIR-12124	99.68	69.17	2700
HSA-MIR-548AV-5P	99.60	70.84	2107
HSA-MIR-548K	99.60	70.84	2107
HSA-MIR-4261	99.59	70.30	3415
HSA-MIR-4310	99.59	68.84	2527
HSA-MIR-3136-3P	99.57	66.59	781
HSA-MIR-7155-3P	99.57	66.48	794
HSA-MIR-6758-3P	99.57	67.55	1078
HSA-MIR-6832-3P	99.52	70.44	1726
HSA-MIR-6727-3P	99.49	65.92	1333
HSA-MIR-8054	99.48	70.81	2084
HSA-MIR-147B-5P	99.45	70.62	2432
HSA-MIR-4999-5P	99.35	69.15	926
HSA-MIR-4722-3P	99.35	65.22	1099
HSA-MIR-6744-3P	99.22	64.41	972
HSA-MIR-6780B-3P	99.13	67.18	622
HSA-MIR-4757-5P	99.12	64.51	981

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Tmem156	ENSMUSG00000037913
rattus_norvegicus	Tmem156	ENSRNOG00000026518

Protein

Protein identifiers

Transmembrane protein 156 — Q8N614 (reviewed: Q8N614)

All UniProt accessions (2): J3KNV8, Q8N614

UniProt curated annotations — full annotation on UniProt →

Subcellular location. Membrane.

RefSeq proteins (2): NP_001290157, NP_079219* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR029374	TMEM156	Family

Pfam: PF15106

UniProt features (11 total): topological domain 3, sequence variant 3, transmembrane region 2, glycosylation site 2, chain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8N614-F1	43.22	0.00

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Glycosylation sites (2): 45, 156

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 96 (showing top): IVANOVA_HEMATOPOIESIS_LATE_PROGENITOR, ODONNELL_TARGETS_OF_MYC_AND_TFRC_UP, TGANTCA_AP1_C, SENESE_HDAC1_TARGETS_UP, FOXJ2_02, CERVERA_SDHB_TARGETS_1_UP, MODULE_277, AP1FJ_Q2, LEE_RECENT_THYMIC_EMIGRANT, MGGAAGTG_GABP_B, MISHRA_CARCINOMA_ASSOCIATED_FIBROBLAST_UP, TCANNTGAY_SREBP1_01, DODD_NASOPHARYNGEAL_CARCINOMA_DN, AP1_Q6_01, PEDERSEN_METASTASIS_BY_ERBB2_ISOFORM_7

GO Biological Process (0):

GO Molecular Function (0):

GO Cellular Component (1): membrane (GO:0016020)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	1

Protein interactions and networks

STRING

598 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
TMEM156	KLHL5	Q96PQ7	636
TMEM156	RFC1	P35251	576
TMEM156	RPL9	P32969	522
TMEM156	LIAS	O43766	514
TMEM156	SMIM14	Q96QK8	508
TMEM156	WDR19	Q8NEZ3	504
TMEM156	RBM47	A0AV96	467
TMEM156	ASZ1	Q8WWH4	460
TMEM156	N4BP2	Q86UW6	453
TMEM156	LRRC66	Q68CR7	435
TMEM156	PDS5A	Q29RF7	427
TMEM156	KLF3	P57682	425
TMEM156	TLR10	Q9BXR5	424
TMEM156	UBE2K	P27924	414
TMEM156	APBB2	Q92870	412

IntAct

4 interactions, top by confidence:

A	B	Type	Score
	SHTN1	psi-mi:“MI:0914”(association)	0.350
	TMEM223	psi-mi:“MI:0914”(association)	0.350

BioGRID (6): TMEM156 (Affinity Capture-MS), TMEM156 (Affinity Capture-MS), TMEM156 (Affinity Capture-MS), TMEM156 (Proximity Label-MS), TMEM156 (Proximity Label-MS), TMEM156 (Protein-peptide)

ESM2 similar proteins: A0A1B0GTR0, A0A1B0GTY4, A0A1B0GVD1, A7WNB0, A8R0V4, E9Q7F5, O55779, O70552, O75818, O93036, P01586, P03212, P03319, P03321, P04823, P0DOE0, P10260, P13206, P16837, P20880, P28907, P36340, P47939, P47940, Q02484, Q03233, Q1HVF6, Q2HRD2, Q3KSS3, Q3TTJ4, Q5BK38, Q5QR91, Q5VAN0, Q64277, Q66669, Q66672, Q6GQU0, Q6GVM5, Q6UWF9, Q86WR6

Diamond homologs: Q5BK38, Q8N614

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

49 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	39
Likely benign	5
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1423 predictions. Top by Δscore:

Variant	Effect	Δscore
4:38967649:T:TC	acceptor_gain	1.0000
4:38967650:T:C	acceptor_gain	1.0000
4:38971133:CTCTG:C	acceptor_gain	1.0000
4:38971138:C:CC	acceptor_gain	1.0000
4:38993999:C:CC	acceptor_gain	1.0000
4:38967638:TATT:T	acceptor_gain	0.9900
4:38967640:TTC:T	acceptor_loss	0.9900
4:38967641:TC:T	acceptor_loss	0.9900
4:38967642:C:CC	acceptor_gain	0.9900
4:38967642:CTGA:C	acceptor_loss	0.9900
4:38967650:T:TC	acceptor_gain	0.9900
4:38967654:A:AC	acceptor_gain	0.9900
4:38971025:CACT:C	donor_loss	0.9900
4:38971026:ACTC:A	donor_loss	0.9900
4:38971027:CT:C	donor_loss	0.9900
4:38971028:T:TA	donor_loss	0.9900
4:38971029:C:CG	donor_loss	0.9900
4:38971030:ACC:A	donor_loss	0.9900
4:38971135:CTG:C	acceptor_gain	0.9900
4:38971136:TG:T	acceptor_gain	0.9900
4:38986417:GACC:G	acceptor_loss	0.9900
4:38986418:ACC:A	acceptor_loss	0.9900
4:38986421:T:G	acceptor_loss	0.9900
4:38986427:C:T	acceptor_gain	0.9900
4:38988849:A:AC	donor_gain	0.9900
4:38988850:C:CC	donor_gain	0.9900
4:38988850:CT:C	donor_gain	0.9900
4:38988850:CTCTG:C	donor_gain	0.9900
4:38993736:A:AC	donor_gain	0.9900
4:38993737:C:CC	donor_gain	0.9900

AlphaMissense

1956 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
4:38988944:A:G	W216R	0.937
4:38988944:A:T	W216R	0.937
4:38998889:A:G	C37R	0.903
4:39032239:G:C	F25L	0.893
4:39032239:G:T	F25L	0.893
4:39032241:A:G	F25L	0.893
4:38998691:A:G	C103R	0.864
4:38998887:A:C	C37W	0.853
4:39032290:T:A	K8N	0.853
4:39032290:T:G	K8N	0.853
4:38998690:C:G	C103S	0.842
4:38998691:A:T	C103S	0.842
4:38998888:C:G	C37S	0.841
4:38998889:A:T	C37S	0.841
4:39032279:G:T	A12E	0.841
4:39032267:G:T	T16K	0.823
4:38998888:C:T	C37Y	0.800
4:38998690:C:T	C103Y	0.792
4:38998894:A:G	L35P	0.783
4:38998689:A:C	C103W	0.755
4:38988918:A:C	F224L	0.754
4:38988918:A:T	F224L	0.754
4:38988920:A:G	F224L	0.754
4:39032276:A:T	I13K	0.753
4:38988931:A:T	V220D	0.751
4:39032267:G:C	T16R	0.751
4:38988942:C:A	W216C	0.740
4:38988942:C:G	W216C	0.740
4:39032249:G:T	P22Q	0.731
4:39032292:T:C	K8E	0.728

dbSNP variants (sampled 300 via entrez): RS1000032425 (4:39008669 A>C), RS1000040262 (4:38984521 G>A,T), RS10001298 (4:39005146 C>G,T), RS1000140782 (4:39019692 ATTATATATATAT>A), RS1000146074 (4:39031776 C>T), RS1000187432 (4:38978738 T>A), RS1000187892 (4:38980204 A>C), RS1000255284 (4:38983341 G>A,C), RS1000347136 (4:38971938 C>A), RS1000371390 (4:39019256 T>C), RS10003755 (4:38966352 T>C,G), RS1000397350 (4:39025453 C>G,T), RS1000408947 (4:38973747 G>T), RS1000423415 (4:38989863 G>A), RS1000435074 (4:38984337 C>G)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

6 associations (top):

Study	Trait	p-value
GCST012490_624	Femur bone mineral density x serum urate levels interaction	7.000000e-09
GCST012490_71	Femur bone mineral density x serum urate levels interaction	9.000000e-11
GCST90002381_205	Eosinophil count	3.000000e-18
GCST90002382_595	Eosinophil percentage of white cells	2.000000e-13
GCST90002393_220	Monocyte count	8.000000e-25
GCST90002394_54	Monocyte percentage of white cells	2.000000e-15

EFO canonical traits (5, from GWAS)

EFO ID	Trait name
EFO:0004531	urate measurement
EFO:0004842	eosinophil count
EFO:0007991	eosinophil percentage of leukocytes
EFO:0005091	monocyte count
EFO:0007989	monocyte percentage of leukocytes

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

53 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Tetrachlorodibenzodioxin	affects cotreatment, decreases expression, increases expression	4
Particulate Matter	increases expression, increases abundance	4
(+)-JQ1 compound	decreases expression, affects cotreatment	3
Benzo(a)pyrene	affects methylation, increases expression	3
sodium arsenite	increases expression	2
Air Pollutants	increases abundance, increases expression	2
Silicon Dioxide	increases expression	2
Smoke	increases expression	2
Aflatoxin B1	increases methylation, increases expression	2
sotorasib	affects cotreatment, decreases expression	1
methyleugenol	increases expression	1
triphenyl phosphate	affects expression	1
2-methyl-4-isothiazolin-3-one	increases expression	1
hydroxyhydroquinone	increases expression	1
methylparaben	decreases expression	1
sulforaphane	increases expression	1
tris(1,3-dichloro-2-propyl)phosphate	increases expression	1
didecyldimethylammonium	increases expression	1
potassium chromate(VI)	decreases expression	1
S-(1,2-dichlorovinyl)cysteine	affects response to substance, increases expression, affects cotreatment, decreases expression	1
di-n-butylphosphoric acid	affects expression	1
perfluorooctane sulfonic acid	increases expression	1
perfluoro-n-nonanoic acid	increases expression	1
2-palmitoylglycerol	increases expression	1
abrine	increases expression	1
mirdametinib	affects cotreatment, decreases expression	1
2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	affects cotreatment, decreases expression	1
bisphenol S	affects cotreatment, increases methylation	1
jinfukang	decreases expression	1
NSC 689534	affects binding, increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.