TMEM161A

Summary

TMEM161A (transmembrane protein 161A, HGNC:26020) is a protein-coding gene on chromosome 19p13.11, encoding Transmembrane protein 161A (Q9NX61). May play a role in protection against oxidative stress.

Involved in several processes, including cellular response to UV; regulation of cellular response to stress; and response to retinoic acid. Predicted to be located in membrane.

Source: NCBI Gene 54929 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 99 total
• Druggable target: yes
• MANE Select transcript: NM_017814

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:26020
Approved symbol	TMEM161A
Name	transmembrane protein 161A
Location	19p13.11
Locus type	gene with protein product
Status	Approved
Aliases	FLJ39645, FLJ20422
Ensembl gene	ENSG00000064545
Ensembl biotype	protein_coding
OMIM	618966
Entrez	54929

Gene structure

Transcript identifiers

Ensembl transcripts: 27 — 19 protein_coding, 5 retained_intron, 2 nonsense_mediated_decay, 1 protein_coding_CDS_not_defined

ENST00000162044, ENST00000450333, ENST00000586357, ENST00000587096, ENST00000587406, ENST00000587583, ENST00000587915, ENST00000587925, ENST00000587985, ENST00000589448, ENST00000590216, ENST00000591031, ENST00000591443, ENST00000592147, ENST00000592369, ENST00000877799, ENST00000877800, ENST00000877801, ENST00000877802, ENST00000877803, ENST00000877804, ENST00000877805, ENST00000913781, ENST00000913782, ENST00000913783, ENST00000913784, ENST00000913785

RefSeq mRNA: 3 — MANE Select: NM_017814 NM_001256766, NM_001411131, NM_017814

CCDS: CCDS12393, CCDS58656, CCDS92570

Canonical transcript exons

ENST00000162044 — 12 exons

Exon	Start	End
ENSE00002268059	19119169	19120183
ENSE00003462582	19121525	19121668
ENSE00003509977	19134784	19134887
ENSE00003560868	19121308	19121421
ENSE00003660377	19120765	19120861
ENSE00003663140	19138426	19138478
ENSE00003695939	19121759	19121819
ENSE00003696172	19130156	19130307
ENSE00003696662	19132657	19132754
ENSE00003701044	19133130	19133210
ENSE00003701576	19132352	19132508
ENSE00003786553	19120992	19121166

Expression profiles

Bgee: expression breadth ubiquitous, 272 present calls, max score 96.22.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 17.8843 / max 173.8431, expressed in 1792 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
180123	17.8843	1792

Top tissues by expression

285 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
pancreatic ductal cell	CL:0002079	96.22	gold quality
gastrocnemius	UBERON:0001388	92.82	gold quality
hindlimb stylopod muscle	UBERON:0004252	92.15	gold quality
muscle of leg	UBERON:0001383	91.75	gold quality
tibialis anterior	UBERON:0001385	91.02	silver quality
right lobe of liver	UBERON:0001114	90.99	gold quality
left adrenal gland	UBERON:0001234	90.70	gold quality
right adrenal gland cortex	UBERON:0035827	90.70	gold quality
right adrenal gland	UBERON:0001233	90.67	gold quality
left adrenal gland cortex	UBERON:0035825	90.57	gold quality
muscle organ	UBERON:0001630	90.39	gold quality
skeletal muscle organ	UBERON:0014892	90.39	gold quality
right lobe of thyroid gland	UBERON:0001119	90.29	gold quality
apex of heart	UBERON:0002098	90.29	gold quality
body of uterus	UBERON:0009853	89.98	gold quality
stromal cell of endometrium	CL:0002255	89.84	gold quality
adrenal cortex	UBERON:0001235	89.84	gold quality
left lobe of thyroid gland	UBERON:0001120	89.54	gold quality
thyroid gland	UBERON:0002046	89.23	gold quality
right ovary	UBERON:0002118	89.03	gold quality
mucosa of transverse colon	UBERON:0004991	88.93	gold quality
left uterine tube	UBERON:0001303	88.86	gold quality
endocervix	UBERON:0000458	88.77	gold quality
adrenal gland	UBERON:0002369	88.57	gold quality
ectocervix	UBERON:0012249	88.54	gold quality
left ovary	UBERON:0002119	88.42	gold quality
muscle layer of sigmoid colon	UBERON:0035805	88.08	gold quality
lower esophagus mucosa	UBERON:0035834	87.91	gold quality
body of stomach	UBERON:0001161	87.79	gold quality
right atrium auricular region	UBERON:0006631	87.54	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	4.30

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

9 targeting TMEM161A, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-6715B-5P	99.64	69.63	1420
HSA-MIR-1827	99.63	68.57	3265
HSA-MIR-4649-3P	99.56	66.90	1783
HSA-MIR-4269	99.55	69.89	1373
HSA-MIR-6840-3P	98.68	65.95	1923
HSA-MIR-4448	97.04	66.22	752
HSA-MIR-6772-3P	97.04	65.89	784
HSA-MIR-5091	92.36	64.51	99
HSA-MIR-4304	90.01	61.07	99

Literature-anchored findings (GeneRIF, showing 1)

• adaptive response to oxidative stress (AROS)-29 gene has a functional role in the protection against oxidative stress. (PMID:16551573)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	tmem161a	ENSDARG00000012790
mus_musculus	Tmem161a	ENSMUSG00000002342
rattus_norvegicus	Tmem161a	ENSRNOG00000020390
drosophila_melanogaster	emei	FBGN0036133
caenorhabditis_elegans	Y87G2A.13	WBGENE00013601

Paralogs (1): TMEM161B (ENSG00000164180)

Protein

Protein identifiers

Transmembrane protein 161A — Q9NX61 (reviewed: Q9NX61)

Alternative names: Adaptive response to oxidative stress protein 29

All UniProt accessions (8): Q9NX61, K7EJK6, K7EKY7, K7EPA3, K7EQ34, K7EQE7, U3KQT6, V9GYP8

UniProt curated annotations — full annotation on UniProt →

Function. May play a role in protection against oxidative stress. Overexpression leads to reduced levels of oxidant-induced DNA damage and apoptosis.

Subcellular location. Membrane.

Induction. Up-regulated in cells which display transient adaptation to mild oxidative stress by treatment with diethylmaleate, a glutathione-depleting agent. Also induced by retinoic acid.

Similarity. Belongs to the TMEM161 family.

Isoforms (2)

UniProt ID	Names	Canonical?
Q9NX61-1	1	yes
Q9NX61-2	2

RefSeq proteins (3): NP_001243695, NP_001398060, NP_060284* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR019395	Transmembrane_161A/B	Family

Pfam: PF10268

UniProt features (24 total): topological domain 9, transmembrane region 8, signal peptide 1, chain 1, modified residue 1, glycosylation site 1, splice variant 1, sequence variant 1, sequence conflict 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9NX61-F1	85.72	0.55

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (1): 69

Glycosylation sites (1): 34

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 109 (showing top): GOBP_CELLULAR_RESPONSE_TO_UV, MODULE_255, GOBP_CELLULAR_RESPONSE_TO_LIGHT_STIMULUS, GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN, GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_DN, MODULE_317, GOBP_NEGATIVE_REGULATION_OF_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_RESPONSE_TO_DNA_DAMAGE, GOBP_REGULATION_OF_DNA_REPAIR, GOBP_NEGATIVE_REGULATION_OF_INTRACELLULAR_SIGNAL_TRANSDUCTION, GOBP_NEGATIVE_REGULATION_OF_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY, GOBP_APOPTOTIC_SIGNALING_PATHWAY, GOBP_REGULATION_OF_RESPONSE_TO_STRESS, GOBP_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_RESPONSE_TO_DNA_DAMAGE, GOBP_RESPONSE_TO_OXYGEN_CONTAINING_COMPOUND, GOBP_RESPONSE_TO_UV

GO Biological Process (5): response to retinoic acid (GO:0032526), cellular response to oxidative stress (GO:0034599), cellular response to UV (GO:0034644), positive regulation of DNA repair (GO:0045739), negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage (GO:1902230)

GO Molecular Function (1): protein binding (GO:0005515)

GO Cellular Component (1): membrane (GO:0016020)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
response to lipid	1
response to oxygen-containing compound	1
response to oxidative stress	1
cellular response to chemical stress	1
response to UV	1
cellular response to light stimulus	1
DNA repair	1
regulation of DNA repair	1
positive regulation of response to stimulus	1
positive regulation of DNA metabolic process	1
intrinsic apoptotic signaling pathway in response to DNA damage	1
regulation of intrinsic apoptotic signaling pathway in response to DNA damage	1
negative regulation of intrinsic apoptotic signaling pathway	1
binding	1
cellular anatomical structure	1

Protein interactions and networks

STRING

584 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
TMEM161A	TMEM94	Q12767	612
TMEM161A	SLC25A42	Q86VD7	591
TMEM161A	POPDC2	Q9HBU9	520
TMEM161A	TMEM38A	Q9H6F2	506
TMEM161A	CFAP68	Q9H5F2	502
TMEM161A	KLHL31	Q9H511	491
TMEM161A	CASKIN2	Q8WXE0	483
TMEM161A	ASB14	A6NK59	478
TMEM161A	TMEM174	Q8WUU8	471
TMEM161A	RSAD1	Q9HA92	449
TMEM161A	ARMC6	Q6NXE6	432
TMEM161A	APPL2	Q8NEU8	419
TMEM161A	TMEM214	Q6NUQ4	418
TMEM161A	NFATC4	Q14934	417
TMEM161A	MANEAL	Q5VSG8	414
TMEM161A	TMX4	Q9H1E5	414

IntAct

99 interactions, top by confidence:

A	B	Type	Score
TMED9	TMED10	psi-mi:“MI:0914”(association)	0.730
CFTR	ESYT2	psi-mi:“MI:0914”(association)	0.710
RAF1	CALU	psi-mi:“MI:0914”(association)	0.640
TMEM161A	GPR35	psi-mi:“MI:0915”(physical association)	0.550
SLC30A2	ESYT2	psi-mi:“MI:0914”(association)	0.530
SLC6A8	ILVBL	psi-mi:“MI:0914”(association)	0.530
UNC93B1	GPR89A	psi-mi:“MI:0914”(association)	0.530
STOM	EI24	psi-mi:“MI:0914”(association)	0.510
GPR37	TMEM161A	psi-mi:“MI:0915”(physical association)	0.510
TMEM161A	GPR37	psi-mi:“MI:0915”(physical association)	0.510
NRAS	ESYT2	psi-mi:“MI:2364”(proximity)	0.480
TMEM161A	AGTR1	psi-mi:“MI:0915”(physical association)	0.370
TMEM161A	CCR2	psi-mi:“MI:0915”(physical association)	0.370
TMEM161A	F2RL1	psi-mi:“MI:0915”(physical association)	0.370
TMEM161A	GNRHR	psi-mi:“MI:0915”(physical association)	0.370
TMEM161A	CHRM5	psi-mi:“MI:0915”(physical association)	0.370
TMEM161A	OXTR	psi-mi:“MI:0915”(physical association)	0.370
TMEM161A	PTGER4	psi-mi:“MI:0915”(physical association)	0.370
Cdc16	ANAPC15	psi-mi:“MI:0914”(association)	0.350
Atp2a2	ESYT2	psi-mi:“MI:0914”(association)	0.350
Smn1	CLNS1A	psi-mi:“MI:0914”(association)	0.350
ARMC6		psi-mi:“MI:0914”(association)	0.350
ATL3	SNX14	psi-mi:“MI:0914”(association)	0.350
MYO5C	CLIC1	psi-mi:“MI:0914”(association)	0.350
Ktn1	ESYT2	psi-mi:“MI:0914”(association)	0.350
MYC	TARS3	psi-mi:“MI:0914”(association)	0.350
LGALS3BP	CEP290	psi-mi:“MI:0914”(association)	0.350
HDAC6	GLOD5	psi-mi:“MI:0914”(association)	0.350

BioGRID (116): TMEM161A (Proximity Label-MS), TMEM161A (Affinity Capture-MS), TMEM161A (Affinity Capture-MS), TMEM161A (Affinity Capture-MS), TMEM161A (Affinity Capture-MS), TMEM161A (Affinity Capture-MS), TMEM161A (Affinity Capture-MS), TMEM161A (Affinity Capture-MS), TMEM161A (Affinity Capture-MS), TMEM161A (Affinity Capture-MS), TMEM161A (Affinity Capture-MS), TMEM161A (Affinity Capture-MS), TMEM161A (Affinity Capture-MS), STOM (Affinity Capture-MS), TMEM161A (Affinity Capture-RNA)

ESM2 similar proteins: A0A140LIJ0, A1L3G9, A4IFL1, B9X187, O18968, O70491, P08033, P08034, P28230, P35212, P36380, P51915, P60572, Q02738, Q059Y8, Q0V8E7, Q1LXZ7, Q28FG4, Q29559, Q4QR83, Q5E9Z5, Q5FVF4, Q5FWS4, Q5JW98, Q5R7B4, Q5T197, Q5T1A1, Q60HF7, Q640M6, Q6GMB1, Q6WGK6, Q7SY10, Q7TNJ0, Q8BXV2, Q8C2L6, Q8C9E8, Q8CE93, Q8CEG0, Q8N5C1, Q8NDZ6

Diamond homologs: Q0V947, Q28FG4, Q6GMB1, Q7SY10, Q8C2L6, Q8NDZ6, Q8VCA6, Q9NX61

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 128 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
CD209 (DC-SIGN) signaling	5	31.3×	3e-05
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	5	31.3×	3e-05
DAP12 signaling	5	22.2×	1e-04
Signaling by high-kinase activity BRAF mutants	5	19.1×	2e-04
MAP2K and MAPK activation	5	17.2×	3e-04
Signaling by RAF1 mutants	5	16.8×	3e-04
R-HSA-425366	7	15.3×	3e-05
Signaling by moderate kinase activity BRAF mutants	5	15.3×	4e-04

GO biological processes:

GO term	Partners	Fold	FDR
intracellular zinc ion homeostasis	5	21.9×	9e-04
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	6	11.9×	2e-03
positive regulation of cytosolic calcium ion concentration	9	9.6×	4e-04
G protein-coupled receptor signaling pathway	14	4.6×	9e-04

Disease & clinical

Clinical variants and AI predictions

ClinVar

99 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	77
Likely benign	2
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

2308 predictions. Top by Δscore:

Variant	Effect	Δscore
19:19120759:TCTCA:T	donor_loss	1.0000
19:19120760:CTCAC:C	donor_loss	1.0000
19:19120761:TCACC:T	donor_loss	1.0000
19:19120762:CACCC:C	donor_loss	1.0000
19:19120763:A:AC	donor_gain	1.0000
19:19120763:AC:A	donor_gain	1.0000
19:19120763:ACCCA:A	donor_loss	1.0000
19:19120764:C:CC	donor_gain	1.0000
19:19120764:C:CG	donor_loss	1.0000
19:19120764:CC:C	donor_gain	1.0000
19:19120764:CCCAG:C	donor_gain	1.0000
19:19120768:G:C	donor_gain	1.0000
19:19120858:CCAC:C	acceptor_gain	1.0000
19:19120859:CAC:C	acceptor_gain	1.0000
19:19120859:CACC:C	acceptor_gain	1.0000
19:19120861:CCTG:C	acceptor_loss	1.0000
19:19120862:C:T	acceptor_loss	1.0000
19:19120989:TACC:T	donor_loss	1.0000
19:19120990:A:AC	donor_gain	1.0000
19:19120990:AC:A	donor_gain	1.0000
19:19120991:C:CC	donor_gain	1.0000
19:19120991:C:G	donor_loss	1.0000
19:19120991:CC:C	donor_gain	1.0000
19:19120991:CCCT:C	donor_gain	1.0000
19:19121163:CAGC:C	acceptor_gain	1.0000
19:19121164:AGC:A	acceptor_gain	1.0000
19:19121164:AGCCT:A	acceptor_loss	1.0000
19:19121165:GC:G	acceptor_gain	1.0000
19:19121165:GCCTG:G	acceptor_loss	1.0000
19:19121166:CC:C	acceptor_gain	1.0000

AlphaMissense

3020 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
19:19120826:G:C	S375R	0.996
19:19120826:G:T	S375R	0.996
19:19120828:T:G	S375R	0.996
19:19121403:G:C	S273R	0.989
19:19121403:G:T	S273R	0.989
19:19121405:T:G	S273R	0.989
19:19132380:A:G	W139R	0.987
19:19132380:A:T	W139R	0.987
19:19121372:A:G	W284R	0.986
19:19121372:A:T	W284R	0.986
19:19121559:C:G	A256P	0.985
19:19121593:G:C	F244L	0.985
19:19121593:G:T	F244L	0.985
19:19121595:A:G	F244L	0.985
19:19120172:A:G	W400R	0.984
19:19120172:A:T	W400R	0.984
19:19120001:A:G	W457R	0.983
19:19120001:A:T	W457R	0.983
19:19134847:G:T	A15D	0.983
19:19120004:A:G	W456R	0.982
19:19120004:A:T	W456R	0.982
19:19132473:C:G	D108H	0.982
19:19120772:C:A	K393N	0.981
19:19120772:C:G	K393N	0.981
19:19120809:G:C	P381R	0.981
19:19121610:C:G	G239R	0.981
19:19134808:G:T	A28E	0.980
19:19121609:C:T	G239D	0.979
19:19132468:A:C	F109L	0.979
19:19132468:A:T	F109L	0.979

dbSNP variants (sampled 300 via entrez): RS1000273895 (19:19137825 TAA>T), RS1000352558 (19:19133062 C>A), RS1000385418 (19:19131578 T>C), RS1000390681 (19:19122384 T>G), RS1000394652 (19:19139680 C>T), RS1000466897 (19:19139460 T>C), RS1000565023 (19:19125717 G>A), RS1000991243 (19:19121172 C>T), RS1001499764 (19:19138374 C>A,T), RS1001678450 (19:19138802 C>T), RS1001738643 (19:19126244 T>C), RS1001782222 (19:19137959 G>C), RS1001907072 (19:19119429 G>A,C), RS1002087340 (19:19126629 G>A), RS1002210999 (19:19120498 C>G,T)

Disease associations

OMIM: gene MIM:618966 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL6066277 (SINGLE PROTEIN)

PharmGKB: 1 entry (VIP=true, CPIC=false)

ChEMBL bioactivities

4 potent at pChembl≥5 of 4 total, top 4 by pChembl (potency: 10 = 0.1 nM, 6 = 1 µM).

pChembl	Type	Value	Unit	Molecule
7.36	Kd	44.02	nM	CHEMBL3752910
7.36	ED50	44.02	nM	CHEMBL3752910
6.36	Kd	434.3	nM	CHEMBL5653589
6.36	ED50	434.3	nM	CHEMBL5653589

PubChem BioAssay actives

2 with measured affinity, of 4 total; 2 most potent distinct compounds. Largely complementary to BindingDB; screening values are coarse (µM, 4 dp), so sub-nM hits tie at the floor.

Compound	Assay	Type	Value	Unit
4-methyl-3-[(1-methyl-6-pyridin-3-ylpyrazolo[3,4-d]pyrimidin-4-yl)amino]-N-[3-(trifluoromethyl)phenyl]benzamide	2149609: Binding affinity to human TMEM161A incubated for 45 mins by Kinobead based pull down assay	kd	0.0440	uM
4-methyl-3-[(2-methyl-6-pyridin-3-ylpyrazolo[3,4-d]pyrimidin-4-yl)amino]-N-[3-(trifluoromethyl)phenyl]benzamide	2149609: Binding affinity to human TMEM161A incubated for 45 mins by Kinobead based pull down assay	kd	0.4343	uM

CTD chemical–gene interactions

30 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Arsenic	affects cotreatment, increases abundance, increases expression, affects methylation	2
alpha-pinene	affects cotreatment, increases oxidation, increases abundance	1
pirinixic acid	affects binding, increases activity, increases expression	1
arsenite	affects binding, increases reaction	1
sodium arsenite	affects cotreatment, increases abundance, increases expression	1
manganese chloride	affects cotreatment, increases abundance, increases expression	1
benzo(e)pyrene	increases methylation	1
methacrylaldehyde	increases abundance, affects cotreatment, increases oxidation	1
di-n-butylphosphoric acid	affects expression	1
2-palmitoylglycerol	increases expression	1
2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	decreases expression, decreases reaction	1
jinfukang	affects cotreatment, increases expression	1
MT19c compound	decreases expression	1
Acrolein	affects cotreatment, increases oxidation, increases abundance	1
Air Pollutants	increases oxidation, affects cotreatment, increases abundance	1
Vehicle Emissions	decreases expression, decreases reaction	1
Benzo(a)pyrene	affects methylation	1
Cisplatin	affects cotreatment, increases expression	1
Manganese	affects cotreatment, increases abundance, increases expression	1
Methapyrilene	increases methylation	1
Ozone	affects cotreatment, increases oxidation, increases abundance	1
Smoke	decreases expression	1
Tetrachlorodibenzodioxin	affects expression	1
Thiram	decreases expression	1
Valproic Acid	affects expression	1
1-Methyl-4-phenylpyridinium	increases expression	1
Aflatoxin B1	increases methylation	1
Okadaic Acid	decreases expression	1
Particulate Matter	decreases expression, decreases reaction	1
Volatile Organic Compounds	affects cotreatment, increases oxidation	1

ChEMBL screening assays

1 unique, capped per target: 1 binding

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL5652651	Binding	Binding affinity to human TMEM161A incubated for 45 mins by Kinobead based pull down assay	NVP-BHG712: Effects of Regioisomers on the Affinity and Selectivity toward the EPHrin Family. — ChemMedChem

Cellosaurus cell lines

2 cell lines: 2 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_D8CL	Ubigene A-549 TMEM161A KO	Cancer cell line	Male
CVCL_E0R7	Ubigene HeLa TMEM161A KO	Cancer cell line	Female

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.