TMEM161B-DT

Summary

TMEM161B-DT (TMEM161B divergent transcript, HGNC:43839) is a long non-coding RNA gene on chromosome 5q14.3.

Predicted to be a structural constituent of ribosome. Predicted to be located in ribosome.

Source: NCBI Gene 100505894 — RefSeq curated summary.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:43839
Approved symbol	TMEM161B-DT
Name	TMEM161B divergent transcript
Location	5q14.3
Locus type	RNA, long non-coding
Status	Approved
Aliases	uc.165, linc-POLR3G-8
Ensembl gene	ENSG00000247828
Ensembl biotype	lncRNA
Entrez	100505894
RNAcentral	URS000075D38C — lncRNA, 739 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 117 — 117 lncRNA

ENST00000496733, ENST00000501715, ENST00000501869, ENST00000504636, ENST00000504769, ENST00000504922, ENST00000506584, ENST00000507736, ENST00000508015, ENST00000510087, ENST00000512724, ENST00000513011, ENST00000513694, ENST00000653183, ENST00000653898, ENST00000653918, ENST00000654762, ENST00000655966, ENST00000656152, ENST00000656195, ENST00000656903, ENST00000657491, ENST00000657617, ENST00000657972, ENST00000658094, ENST00000658478, ENST00000658611, ENST00000659005, ENST00000659093, ENST00000659215, ENST00000659938, ENST00000660783, ENST00000661351, ENST00000661377, ENST00000661627, ENST00000662970, ENST00000663476, ENST00000663490, ENST00000664347, ENST00000664462, ENST00000664546, ENST00000665319, ENST00000665517, ENST00000665926, ENST00000666577, ENST00000666808, ENST00000667127, ENST00000667139, ENST00000667511, ENST00000668037, ENST00000668128, ENST00000668471, ENST00000669353, ENST00000669465, ENST00000669796, ENST00000670030, ENST00000670451, ENST00000670873, ENST00000671394, ENST00000684909, ENST00000685962, ENST00000686847, ENST00000686930, ENST00000688087, ENST00000688118, ENST00000688398, ENST00000688523, ENST00000689901, ENST00000692797, ENST00000693402, ENST00000702628, ENST00000787430, ENST00000787431, ENST00000787432, ENST00000787433, ENST00000787434, ENST00000787435, ENST00000787436, ENST00000787437, ENST00000787438, ENST00000787439, ENST00000787440, ENST00000787441, ENST00000787442, ENST00000787443, ENST00000787444, ENST00000787445, ENST00000787446, ENST00000787447, ENST00000787448, ENST00000787449, ENST00000787450, ENST00000787451, ENST00000787452, ENST00000787453, ENST00000787454, ENST00000787455, ENST00000787456, ENST00000787457, ENST00000787458, ENST00000787459, ENST00000787460, ENST00000787461, ENST00000787462, ENST00000787463, ENST00000787464, ENST00000787465, ENST00000787466, ENST00000787467, ENST00000787468, ENST00000787469, ENST00000787470, ENST00000787471, ENST00000787472, ENST00000787473, ENST00000787474, ENST00000787475

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000496733 — 3 exons

Exon	Start	End
ENSE00001991171	88270526	88270585
ENSE00002044834	88269039	88269075
ENSE00002085384	88275911	88276222

Expression profiles

Bgee: expression breadth ubiquitous, 234 present calls, max score 99.25.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 15.3893 / max 387.5476, expressed in 1771 samples.

FANTOM5 promoters (7 alternative TSS)

Promoter ID	TPM avg	Samples expressed
57481	7.0127	1605
57480	6.9085	1564
57482	0.5431	279
203619	0.3877	192
57487	0.3117	41
57488	0.1707	32
57483	0.0548	25

Top tissues by expression

252 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
cortical plate	UBERON:0005343	99.25	gold quality
ventricular zone	UBERON:0003053	99.15	gold quality
ganglionic eminence	UBERON:0004023	98.97	gold quality
tendon of biceps brachii	UBERON:0008188	96.81	gold quality
cerebellar hemisphere	UBERON:0002245	96.17	gold quality
right hemisphere of cerebellum	UBERON:0014890	96.10	gold quality
cerebellar cortex	UBERON:0002129	96.07	gold quality
cerebellum	UBERON:0002037	95.25	gold quality
nucleus accumbens	UBERON:0001882	94.05	gold quality
caudate nucleus	UBERON:0001873	93.56	gold quality
right frontal lobe	UBERON:0002810	93.37	gold quality
anterior cingulate cortex	UBERON:0009835	93.25	gold quality
Brodmann (1909) area 9	UBERON:0013540	93.23	gold quality
putamen	UBERON:0001874	93.22	gold quality
amygdala	UBERON:0001876	92.76	gold quality
medial globus pallidus	UBERON:0002477	92.44	gold quality
right uterine tube	UBERON:0001302	92.18	gold quality
hypothalamus	UBERON:0001898	91.74	gold quality
tendon	UBERON:0000043	91.37	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	91.28	gold quality
primary visual cortex	UBERON:0002436	91.21	gold quality
brain	UBERON:0000955	90.82	gold quality
neocortex	UBERON:0001950	90.58	gold quality
colonic epithelium	UBERON:0000397	90.55	gold quality
forebrain	UBERON:0001890	90.54	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	90.33	gold quality
adenohypophysis	UBERON:0002196	90.01	gold quality
globus pallidus	UBERON:0001875	89.98	gold quality
cerebral cortex	UBERON:0000956	89.96	gold quality
vastus lateralis	UBERON:0001379	89.84	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	5.90

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• TMEM161B-AS1 suppresses proliferation, invasion and glycolysis by targeting miR-23a-3p/HIF1AN signal axis in oesophageal squamous cell carcinoma. (PMID:34046994)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.