TMEM18-DT

Summary

TMEM18-DT (TMEM18 divergent transcript, HGNC:54481) is a long non-coding RNA gene on chromosome 2p25.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:54481
Approved symbol	TMEM18-DT
Name	TMEM18 divergent transcript
Location	2p25.3
Locus type	RNA, long non-coding
Status	Approved
Aliases	AC092159.2
Ensembl gene	ENSG00000233296
Ensembl biotype	lncRNA
Entrez	105373354
RNAcentral	URS00026A2105 — lncRNA, 1831 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 5 — 5 lncRNA

ENST00000435573, ENST00000445418, ENST00000668697, ENST00000783571, ENST00000783572

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000435573 — 3 exons

Exon	Start	End
ENSE00001617995	696541	696670
ENSE00001697394	697147	697371
ENSE00001747060	680081	680151

Expression profiles

Bgee: expression breadth ubiquitous, 131 present calls, max score 79.54.

FANTOM5 (CAGE): breadth broad, TPM avg 1.7152 / max 27.6263, expressed in 789 samples.

FANTOM5 promoters (5 alternative TSS)

Promoter ID	TPM avg	Samples expressed
18542	0.8054	416
18543	0.7982	362
18546	0.0610	19
18545	0.0439	16
18544	0.0066	3

Top tissues by expression

131 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	79.54	gold quality
colonic epithelium	UBERON:0000397	70.63	silver quality
bone marrow cell	CL:0002092	68.39	silver quality
sural nerve	UBERON:0015488	66.27	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	65.39	gold quality
smooth muscle tissue	UBERON:0001135	63.82	gold quality
testis	UBERON:0000473	62.74	gold quality
muscle tissue	UBERON:0002385	62.41	gold quality
left testis	UBERON:0004533	62.00	gold quality
popliteal artery	UBERON:0002250	61.70	gold quality
tibial artery	UBERON:0007610	61.63	gold quality
skeletal muscle tissue	UBERON:0001134	61.29	gold quality
left uterine tube	UBERON:0001303	61.26	gold quality
right testis	UBERON:0004534	61.14	gold quality
stromal cell of endometrium	CL:0002255	60.55	gold quality
bone marrow	UBERON:0002371	60.16	silver quality
body of uterus	UBERON:0009853	59.20	gold quality
ventricular zone	UBERON:0003053	59.11	silver quality
hindlimb stylopod muscle	UBERON:0004252	59.10	gold quality
myometrium	UBERON:0001296	58.84	gold quality
ganglionic eminence	UBERON:0004023	58.38	silver quality
cortical plate	UBERON:0005343	58.21	silver quality
lymph node	UBERON:0000029	57.79	gold quality
calcaneal tendon	UBERON:0003701	57.05	gold quality
tonsil	UBERON:0002372	56.75	gold quality
monocyte	CL:0000576	55.76	gold quality
right ovary	UBERON:0002118	54.93	gold quality
ovary	UBERON:0000992	54.88	gold quality
prefrontal cortex	UBERON:0000451	54.65	gold quality
endometrium	UBERON:0001295	54.63	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.04

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.