TMEM184C

Summary

TMEM184C (transmembrane protein 184C, HGNC:25587) is a protein-coding gene on chromosome 4q31.23, encoding Transmembrane protein 184C (Q9NVA4). Possible tumor suppressor which may play a role in cell growth.

Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be active in membrane.

Source: NCBI Gene 55751 — RefSeq curated summary.

At a glance

• GWAS associations: 1
• Clinical variants (ClinVar): 46 total
• MANE Select transcript: NM_018241

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:25587
Approved symbol	TMEM184C
Name	transmembrane protein 184C
Location	4q31.23
Locus type	gene with protein product
Status	Approved
Aliases	FLJ10846, SLC51C3
Ensembl gene	ENSG00000164168
Ensembl biotype	protein_coding
OMIM	613937
Entrez	55751

Gene structure

Transcript identifiers

Ensembl transcripts: 5 — 3 protein_coding, 1 nonsense_mediated_decay, 1 retained_intron

ENST00000296582, ENST00000505999, ENST00000506826, ENST00000508208, ENST00000880769

RefSeq mRNA: 1 — MANE Select: NM_018241 NM_018241

CCDS: CCDS3770

Canonical transcript exons

ENST00000296582 — 10 exons

Exon	Start	End
ENSE00001082022	147623834	147623964
ENSE00001082023	147634169	147636721
ENSE00001082024	147631393	147631505
ENSE00001082025	147632903	147633002
ENSE00001082026	147624062	147624098
ENSE00001082027	147628361	147628435
ENSE00001082028	147629599	147629692
ENSE00001082029	147624804	147625009
ENSE00002064092	147617397	147618079
ENSE00003635781	147633765	147633936

Expression profiles

Bgee: expression breadth ubiquitous, 259 present calls, max score 95.20.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 15.4916 / max 99.0617, expressed in 1804 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
49935	14.1120	1800
49936	1.1802	718
49937	0.1340	35
49938	0.0653	23

Top tissues by expression

277 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
parotid gland	UBERON:0001831	95.20	silver quality
endothelial cell	CL:0000115	94.80	silver quality
hair follicle	UBERON:0002073	94.37	silver quality
buccal mucosa cell	CL:0002336	94.25	gold quality
mammary duct	UBERON:0001765	92.39	silver quality
adrenal tissue	UBERON:0018303	92.09	gold quality
heart right ventricle	UBERON:0002080	91.76	silver quality
epithelium of mammary gland	UBERON:0003244	91.63	silver quality
calcaneal tendon	UBERON:0003701	91.37	gold quality
lateral nuclear group of thalamus	UBERON:0002736	91.03	silver quality
stromal cell of endometrium	CL:0002255	90.85	gold quality
Brodmann (1909) area 23	UBERON:0013554	90.77	silver quality
mucosa of sigmoid colon	UBERON:0004993	90.57	gold quality
colonic mucosa	UBERON:0000317	90.37	gold quality
biceps brachii	UBERON:0001507	90.34	silver quality
CA1 field of hippocampus	UBERON:0003881	90.25	silver quality
middle temporal gyrus	UBERON:0002771	90.19	gold quality
rectum	UBERON:0001052	89.13	gold quality
oviduct epithelium	UBERON:0004804	88.90	gold quality
oocyte	CL:0000023	88.72	silver quality
corpus callosum	UBERON:0002336	88.69	gold quality
islet of Langerhans	UBERON:0000006	88.61	gold quality
smooth muscle tissue	UBERON:0001135	88.59	gold quality
thoracic mammary gland	UBERON:0005200	88.57	gold quality
mammary gland	UBERON:0001911	88.53	gold quality
placenta	UBERON:0001987	88.53	gold quality
thyroid gland	UBERON:0002046	88.45	gold quality
seminal vesicle	UBERON:0000998	88.31	gold quality
left lobe of thyroid gland	UBERON:0001120	88.21	gold quality
secondary oocyte	CL:0000655	88.18	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	5.16
E-MTAB-6386	no	109.85

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

64 targeting TMEM184C, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-3120-5P	100.00	65.56	965
HSA-MIR-3163	100.00	77.23	8605
HSA-LET-7A-3P	100.00	74.03	3932
HSA-LET-7B-3P	100.00	74.08	3913
HSA-LET-7F-1-3P	100.00	74.02	3928
HSA-MIR-98-3P	100.00	74.08	3907
HSA-MIR-371B-5P	99.99	75.34	4759
HSA-MIR-373-5P	99.98	75.36	4753
HSA-MIR-616-5P	99.98	75.58	4775
HSA-MIR-12136	99.98	72.81	5713
HSA-MIR-8068	99.98	73.85	2376
HSA-MIR-6499-3P	99.90	66.38	1212
HSA-MIR-6780A-5P	99.88	66.69	2776
HSA-MIR-4728-5P	99.85	69.39	4718
HSA-MIR-544A	99.84	68.66	1965
HSA-MIR-5010-3P	99.83	70.60	2357
HSA-MIR-6785-5P	99.82	68.68	4428
HSA-MIR-1273H-5P	99.77	66.32	2471
HSA-MIR-3617-5P	99.75	69.41	1968
HSA-MIR-641	99.75	69.35	1975
HSA-MIR-149-3P	99.72	68.22	3963
HSA-MIR-33A-3P	99.70	70.27	3362
HSA-MIR-30B-3P	99.70	65.76	2325
HSA-MIR-3689A-3P	99.70	65.73	2306
HSA-MIR-3689B-3P	99.70	65.71	2311
HSA-MIR-3689C	99.70	65.71	2311
HSA-MIR-6779-5P	99.70	65.76	2363
HSA-MIR-6883-5P	99.69	68.05	3785
HSA-MIR-12124	99.68	69.17	2700

Literature-anchored findings (GeneRIF, showing 1)

• Recently, by cDNA microarray anal., we identified transmembrane protein 34 (TMEM34) that down-regulated in anaplastic thyroid cancer cell lines as compared to normal thyroid tissues. Transfection of TMEM34 into KTA2 cells led to inhibition of cell growth (PMID:17072649)

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
danio_rerio	tmem184c	ENSDARG00000078789
mus_musculus	Tmem184c	ENSMUSG00000031617
rattus_norvegicus	Tmem184c	ENSRNOG00000012860
drosophila_melanogaster	CG5850	FBGN0032172

Paralogs (3): SLC51A (ENSG00000163959), TMEM184A (ENSG00000164855), TMEM184B (ENSG00000198792)

Protein

Protein identifiers

Transmembrane protein 184C — Q9NVA4 (reviewed: Q9NVA4)

Alternative names: Transmembrane protein 34

All UniProt accessions (3): A0A0C4DGC8, Q9NVA4, H0Y8I5

UniProt curated annotations — full annotation on UniProt →

Function. Possible tumor suppressor which may play a role in cell growth.

Subcellular location. Membrane.

Tissue specificity. Widely expressed with higher expression in lung, kidney, spleen, pancreas, thymus, prostate, testis, ovary, small intestine and thyroid.

Similarity. Belongs to the TMEM184 family.

Isoforms (2)

UniProt ID	Names	Canonical?
Q9NVA4-1	1	yes
Q9NVA4-2	2

RefSeq proteins (1): NP_060711* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR005178	Ostalpha/TMEM184C	Family

Pfam: PF03619

UniProt features (18 total): transmembrane region 7, sequence conflict 4, compositionally biased region 3, chain 1, modified residue 1, splice variant 1, region of interest 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9NVA4-F1	72.08	0.19

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (1): 422

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 93 (showing top): RUTELLA_RESPONSE_TO_CSF2RB_AND_IL4_UP, KINSEY_TARGETS_OF_EWSR1_FLII_FUSION_DN, GOBP_TRANSMEMBRANE_TRANSPORT, CAIRO_LIVER_DEVELOPMENT_UP, RUTELLA_RESPONSE_TO_HGF_UP, STEIN_ESRRA_TARGETS_UP, GOMF_TRANSPORTER_ACTIVITY, RUTELLA_RESPONSE_TO_HGF_VS_CSF2RB_AND_IL4_UP, GCM_RAB10, GSE14415_ACT_TCONV_VS_ACT_NATURAL_TREG_UP, CEBPZ_TARGET_GENES, DIDO1_TARGET_GENES, ELF2_TARGET_GENES, HDAC4_TARGET_GENES, ZNF350_TARGET_GENES

GO Biological Process (1): transmembrane transport (GO:0055085)

GO Molecular Function (1): transmembrane transporter activity (GO:0022857)

GO Cellular Component (1): membrane (GO:0016020)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transport	1
cellular process	1
transporter activity	1
transmembrane transport	1
cellular anatomical structure	1

Protein interactions and networks

STRING

622 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
TMEM184C	PRMT9	Q6P2P2	716
TMEM184C	FAM204A	Q9H8W3	618
TMEM184C	EDNRA	P25101	530
TMEM184C	ACBD6	Q9BR61	512
TMEM184C	HSF2	Q03933	505
TMEM184C	ZCCHC9	Q8N567	476
TMEM184C	FAM13B	Q9NYF5	469
TMEM184C	TMEM207	Q6UWW9	465
TMEM184C	OR7E24	Q6IFN5	460
TMEM184C	RAB11FIP2	Q7L804	443
TMEM184C	PNISR	Q8TF01	435
TMEM184C	KIF6	Q6ZMV9	427
TMEM184C	TMEM214	Q6NUQ4	414
TMEM184C	SLC35A4	Q96G79	411
TMEM184C	COL23A1	Q86Y22	400

IntAct

13 interactions, top by confidence:

A	B	Type	Score
SGK1	TMEM184C	psi-mi:“MI:0915”(physical association)	0.370
	ESYT2	psi-mi:“MI:0914”(association)	0.350
E5	ESYT2	psi-mi:“MI:0914”(association)	0.350
Npc1	ESYT2	psi-mi:“MI:0914”(association)	0.350
LAMP1	DST	psi-mi:“MI:0914”(association)	0.350
LAMTOR2	SCAMP3	psi-mi:“MI:0914”(association)	0.350
MAPRE1	SCAMP1	psi-mi:“MI:0914”(association)	0.350
POLR1D	BDP1	psi-mi:“MI:0914”(association)	0.350
STX7	SCAMP1	psi-mi:“MI:0914”(association)	0.350
TNFRSF10C	PLPP3	psi-mi:“MI:0914”(association)	0.350
TCTN3	TMEM120B	psi-mi:“MI:2364”(proximity)	0.270

BioGRID (22): TMEM184C (Proximity Label-MS), TMEM184C (Synthetic Lethality), TMEM184C (Affinity Capture-MS), TMEM184C (Affinity Capture-MS), TMEM184C (Affinity Capture-MS), TMEM184C (Proximity Label-MS), TMEM184C (Affinity Capture-MS), TMEM184C (Affinity Capture-MS), TMEM184C (Affinity Capture-MS), TMEM184C (Affinity Capture-MS), TMEM184C (Affinity Capture-MS), TMEM184C (Affinity Capture-MS), TMEM184C (Cross-Linking-MS (XL-MS)), TMEM184C (Affinity Capture-MS), TMEM184C (Co-fractionation)

ESM2 similar proteins: A0JNC1, A0PK00, A1L2R7, A2BIE7, A3KNK1, A6QPF8, A7XZ53, A8DZH4, D3ZEH5, O35052, O95427, P98191, Q05B45, Q0VFK3, Q17QL9, Q1LY80, Q28CY9, Q3TA38, Q5BL21, Q5EAX9, Q5EAY8, Q5FWV6, Q5HZE2, Q5RET6, Q5U239, Q5ZMP3, Q63ZG0, Q68EY2, Q6DD44, Q6DE21, Q6ZMG9, Q7ZUA6, Q8BXA5, Q8C172, Q8C1E7, Q8CIF6, Q8NBJ9, Q8WVP7, Q91XU8, Q92903

Diamond homologs: A2VDL9, Q09906, Q17QL9, Q1RMW2, Q28CV2, Q3TPR7, Q3UFJ6, Q4QQS1, Q54PI4, Q54WM0, Q5BPZ5, Q5RET6, Q5ZMP3, Q6GQE1, Q6ZMB5, Q75JN3, Q810F5, Q8BG09, Q9NVA4, Q9Y519, F4JTN2, Q94CA0, P36142

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

46 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	30
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

2592 predictions. Top by Δscore:

Variant	Effect	Δscore
4:147623828:CTTAA:C	acceptor_loss	1.0000
4:147623829:TTAA:T	acceptor_loss	1.0000
4:147623832:A:G	acceptor_gain	1.0000
4:147623833:G:C	acceptor_loss	1.0000
4:147623962:AAGGT:A	donor_loss	1.0000
4:147623964:GGTA:G	donor_loss	1.0000
4:147624057:AATAG:A	acceptor_gain	1.0000
4:147624094:ATAGT:A	donor_gain	1.0000
4:147624095:TAGT:T	donor_gain	1.0000
4:147624097:GT:G	donor_gain	1.0000
4:147624099:G:GG	donor_gain	1.0000
4:147624800:ATAGT:A	acceptor_gain	1.0000
4:147624802:A:AG	acceptor_gain	1.0000
4:147624802:AGT:A	acceptor_gain	1.0000
4:147624802:AGTG:A	acceptor_gain	1.0000
4:147624803:G:GG	acceptor_gain	1.0000
4:147624803:GT:G	acceptor_gain	1.0000
4:147624803:GTG:G	acceptor_gain	1.0000
4:147624803:GTGG:G	acceptor_gain	1.0000
4:147625005:GGAGA:G	donor_gain	1.0000
4:147625006:GAGAG:G	donor_gain	1.0000
4:147625008:GA:G	donor_gain	1.0000
4:147625010:G:GG	donor_gain	1.0000
4:147628359:A:AG	acceptor_gain	1.0000
4:147628360:G:GG	acceptor_gain	1.0000
4:147628360:GA:G	acceptor_gain	1.0000
4:147628360:GAGT:G	acceptor_gain	1.0000
4:147628360:GAGTA:G	acceptor_gain	1.0000
4:147628431:GCTTT:G	donor_gain	1.0000
4:147628433:TTT:T	donor_gain	1.0000

AlphaMissense

2851 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
4:147623950:A:C	Q80H	0.999
4:147623950:A:T	Q80H	0.999
4:147624069:T:A	W88R	0.999
4:147624069:T:C	W88R	0.999
4:147624087:A:C	S94R	0.999
4:147624089:T:A	S94R	0.999
4:147624089:T:G	S94R	0.999
4:147624854:A:C	R114S	0.999
4:147624854:A:T	R114S	0.999
4:147631409:T:C	L228P	0.999
4:147631501:T:C	F259L	0.999
4:147631503:T:A	F259L	0.999
4:147631503:T:G	F259L	0.999
4:147633788:G:A	M301I	0.999
4:147633788:G:C	M301I	0.999
4:147633788:G:T	M301I	0.999
4:147633819:T:C	F312L	0.999
4:147633821:C:A	F312L	0.999
4:147633821:C:G	F312L	0.999
4:147623964:G:T	R85M	0.998
4:147624073:T:C	M89T	0.998
4:147624073:T:G	M89R	0.998
4:147624804:T:A	W98R	0.998
4:147624804:T:C	W98R	0.998
4:147624853:G:C	R114T	0.998
4:147624853:G:T	R114I	0.998
4:147624865:A:T	E118V	0.998
4:147624898:T:C	L129P	0.998
4:147628386:G:C	G175R	0.998
4:147628387:G:A	G175D	0.998

dbSNP variants (sampled 300 via entrez): RS1000551635 (4:147632078 CAGG>C), RS1000622543 (4:147630103 T>C), RS1000883621 (4:147636543 G>T), RS1000899940 (4:147632401 A>G), RS1000944682 (4:147630428 A>T), RS1001093606 (4:147618709 C>A,T), RS1001667848 (4:147631967 G>A), RS1001705919 (4:147635644 T>C,G), RS1001722009 (4:147631787 A>G), RS1002111023 (4:147621948 T>C), RS1002222701 (4:147629216 C>T), RS1002354024 (4:147621485 A>T), RS1002494302 (4:147629944 T>G), RS1002555319 (4:147635117 CG>C), RS1002858881 (4:147621196 T>C)

Disease associations

OMIM: gene MIM:613937 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST002960_3	Frontotemporal dementia	3.000000e-06

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

23 total (human), top 23 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	decreases expression, increases expression	2
Cadmium Chloride	increases abundance, increases palmitoylation, decreases expression, decreases reaction	2
aristolochic acid I	decreases expression	1
FR900359	increases phosphorylation	1
triphenyl phosphate	affects expression	1
2-bromopalmitate	decreases reaction, increases abundance, increases palmitoylation	1
N,N,N’,N’-tetrakis(2-pyridylmethyl)ethylenediamine	increases expression	1
di-n-butylphosphoric acid	affects expression	1
Temozolomide	decreases expression	1
Air Pollutants	decreases expression, increases abundance	1
Air Pollutants, Occupational	decreases expression	1
Cadmium	decreases reaction, increases abundance, increases palmitoylation	1
Formaldehyde	increases expression	1
Hydrogen Peroxide	decreases expression	1
Lead	increases expression	1
Nickel	decreases expression	1
Phthalic Acids	increases methylation	1
Smoke	decreases expression	1
Urethane	increases expression	1
Aflatoxin B1	increases methylation	1
Sodium Selenite	increases expression	1
Zinc Sulfate	decreases expression	1
Particulate Matter	decreases expression, increases abundance	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.