TMEM201

Summary

TMEM201 (transmembrane protein 201, HGNC:33719) is a protein-coding gene on chromosome 1p36.22, encoding Transmembrane protein 201 (Q5SNT2). Critical regulator of angiogenesis and endothelial cell (EC) migration.

Predicted to enable actin filament binding activity and lamin binding activity. Involved in several processes, including centrosome localization; positive regulation of endothelial cell migration; and protein localization to nuclear envelope. Located in cortical endoplasmic reticulum; nuclear inner membrane; and spindle pole centrosome.

Source: NCBI Gene 199953 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 121 total
• MANE Select transcript: NM_001130924

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:33719
Approved symbol	TMEM201
Name	transmembrane protein 201
Location	1p36.22
Locus type	gene with protein product
Status	Approved
Aliases	RP13-15M17.2, NET5, Ima1, SAMP1
Ensembl gene	ENSG00000188807
Ensembl biotype	protein_coding
Entrez	199953

Gene structure

Transcript identifiers

Ensembl transcripts: 8 — 6 protein_coding, 1 nonsense_mediated_decay, 1 protein_coding_CDS_not_defined

ENST00000340305, ENST00000340381, ENST00000416541, ENST00000508400, ENST00000510900, ENST00000857597, ENST00000928149, ENST00000928150

RefSeq mRNA: 2 — MANE Select: NM_001130924 NM_001010866, NM_001130924

CCDS: CCDS30579, CCDS44055

Canonical transcript exons

ENST00000340381 — 11 exons

Exon	Start	End
ENSE00001365697	9601105	9601454
ENSE00001375118	9607557	9607789
ENSE00001378492	9610506	9610805
ENSE00001378607	9598449	9598625
ENSE00001385916	9602069	9602272
ENSE00001388240	9596859	9597053
ENSE00001473754	9609840	9609911
ENSE00001680944	9595890	9596010
ENSE00001854997	9612986	9614877
ENSE00003502159	9611753	9611890
ENSE00003847294	9588911	9589043

Expression profiles

Bgee: expression breadth ubiquitous, 218 present calls, max score 95.97.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 10.9933 / max 100.8374, expressed in 1684 samples.

FANTOM5 promoters (5 alternative TSS)

Promoter ID	TPM avg	Samples expressed
524	5.8849	1484
522	2.5597	1103
521	2.2924	1025
523	0.2379	109
525	0.0184	5

Top tissues by expression

244 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
cardiac muscle of right atrium	UBERON:0003379	95.97	silver quality
left ventricle myocardium	UBERON:0006566	95.73	silver quality
quadriceps femoris	UBERON:0001377	92.58	gold quality
vastus lateralis	UBERON:0001379	92.24	gold quality
kidney epithelium	UBERON:0004819	91.85	silver quality
gastrocnemius	UBERON:0001388	91.09	gold quality
deltoid	UBERON:0001476	90.31	silver quality
skeletal muscle tissue	UBERON:0001134	90.27	gold quality
skeletal muscle tissue of biceps brachii	UBERON:0004502	90.19	gold quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	90.19	silver quality
hindlimb stylopod muscle	UBERON:0004252	90.05	gold quality
myocardium	UBERON:0002349	89.71	silver quality
muscle of leg	UBERON:0001383	89.70	gold quality
body of tongue	UBERON:0011876	89.58	gold quality
biceps brachii	UBERON:0001507	89.49	gold quality
muscle tissue	UBERON:0002385	89.08	gold quality
tibialis anterior	UBERON:0001385	88.10	silver quality
secondary oocyte	CL:0000655	88.04	gold quality
oocyte	CL:0000023	87.85	gold quality
epithelial cell of pancreas	CL:0000083	87.65	gold quality
tongue	UBERON:0001723	87.13	silver quality
cerebellar vermis	UBERON:0004720	86.86	gold quality
substantia nigra pars reticulata	UBERON:0001966	86.47	silver quality
ventral tegmental area	UBERON:0002691	86.46	silver quality
apex of heart	UBERON:0002098	86.40	gold quality
vena cava	UBERON:0004087	85.48	silver quality
buccal mucosa cell	CL:0002336	85.43	silver quality
inferior vagus X ganglion	UBERON:0005363	85.38	silver quality
heart right ventricle	UBERON:0002080	85.21	gold quality
superior surface of tongue	UBERON:0007371	84.95	silver quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ENAD-17	no	93.59
E-ANND-3	no	1.91

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

87 targeting TMEM201, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-5692A	100.00	74.40	6850
HSA-MIR-6856-5P	100.00	65.47	1298
HSA-MIR-8485	100.00	77.57	4731
HSA-MIR-6758-5P	100.00	66.21	1470
HSA-MIR-4283	100.00	66.42	2097
HSA-MIR-4481	100.00	66.42	1669
HSA-MIR-3605-5P	99.96	67.12	932
HSA-MIR-185-3P	99.95	67.01	1743
HSA-MIR-6721-5P	99.93	68.92	2981
HSA-MIR-6783-3P	99.89	67.92	2059
HSA-MIR-1343-3P	99.89	66.78	1815
HSA-MIR-4492	99.87	68.25	3611
HSA-MIR-221-5P	99.86	65.45	1052
HSA-MIR-8073	99.86	65.21	1118
HSA-MIR-4728-5P	99.85	69.39	4718
HSA-MIR-6785-5P	99.82	68.68	4428
HSA-MIR-6756-5P	99.82	67.97	2466
HSA-MIR-6842-5P	99.80	67.54	1587
HSA-MIR-7110-5P	99.80	67.84	1712
HSA-MIR-92A-2-5P	99.75	67.01	2164
HSA-MIR-149-3P	99.72	68.22	3963
HSA-MIR-4524A-3P	99.72	66.85	2406
HSA-MIR-6883-5P	99.69	68.05	3785
HSA-MIR-4729	99.69	72.18	4233
HSA-MIR-6766-5P	99.68	67.70	2325
HSA-MIR-4470	99.66	69.35	1767
HSA-MIR-3158-5P	99.65	67.51	1763
HSA-MIR-6132	99.60	65.83	1554
HSA-MIR-6836-5P	99.60	65.62	1538
HSA-MIR-6752-5P	99.59	67.32	1243

Literature-anchored findings (GeneRIF, showing 8)

• characterization of a transmembrane protein of the nuclear envelope that we name spindle-associated membrane protein 1 (Samp1); Samp1 defines a specific membrane domain associated with the mitotic spindle (PMID:19494128)
• the nucleoplasmic domains of Samp1 and Emerin can bind directly to each other. (PMID:24950247)
• Samp1 is involved in early differentiation of induced pluripotent stem cells. (PMID:28668644)
• the mobility of YFP-Emerin was higher in Samp1 knock out cells and lower in cells overexpressing Samp1, suggesting that Samp1 significantly attenuates the mobility of Emerin in the nuclear envelope. The affinity between Samp1 and Emerin is decreased in the presence of Ran, suggesting that Ran attenuates the interaction between Samp1 and Emerin. (PMID:29510091)
• Authors show that Samp1 is involved in the recruitment of HAUS6 and gamma-tubulin to the mitotic spindle. Samp1 is the first inner nuclear membrane protein shown to have a function in mitotic spindle assembly. (PMID:29514856)
• We also found that peripheral heterochromatin depended on the levels of the inner nuclear membrane protein Samp1, suggesting an important role in promoting peripheral heterochromatin. Taken together, FRIC is a powerful and robust new tool to study dynamic chromatin redistribution in live cells. (PMID:30793190)
• Inner nuclear membrane protein TMEM201 maintains endothelial cell migration and angiogenesis by interacting with the LINC complex. (PMID:35311970)
• Characterization of the Clinical Significance and Immunological Landscapes of a Novel TMEMs Signature in Hepatocellular Carcinoma and the Contribution of TMEM201 to Hepatocarcinogenesis. (PMID:37373430)

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Tmem201	ENSMUSG00000044700
rattus_norvegicus	Tmem201	ENSRNOG00000023152

Protein

Protein identifiers

Transmembrane protein 201 — Q5SNT2 (reviewed: Q5SNT2)

Alternative names: Spindle-associated membrane protein 1

All UniProt accessions (3): Q5SNT2, H0Y4R5, H0Y994

UniProt curated annotations — full annotation on UniProt →

Function. Critical regulator of angiogenesis and endothelial cell (EC) migration. Promotes the migration of endothelial cells, which is essential for angiogenesis. Interacts with the linker of nucleoskeleton and cytoskeleton (LINC) complex, which plays a vital role in connecting the cell’s cytoskeleton to the nuclear envelope. This interaction is essential for maintaining cellular structure and facilitating the movement of endothelial cells, which is critical for proper vascular development. Involved in nuclear movement during fibroblast polarization and migration. Overexpression can recruit Ran GTPase to the nuclear periphery. May define a distinct membrane domain in the vicinity of the mitotic spindle. Involved in the organization of the nuclear envelope implicating EMD, SUN1 and A-type lamina.

Subunit / interactions. Interacts with SUN2 and LMNA. May bind to Ran GTPase; has a greater affinity for Ran-GTP over Ran-GDP. Interacts with EMD.

Subcellular location. Nucleus inner membrane Nucleus inner membrane. Cytoplasm. Cytoskeleton. Spindle pole.

Similarity. Belongs to the TMEM201 family.

Isoforms (2)

UniProt ID	Names	Canonical?
Q5SNT2-1	1	yes
Q5SNT2-2	2, SAMP1

RefSeq proteins (2): NP_001010866, NP_001124396* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR018617	Ima1_N	Domain
IPR018861	TMEM201_C	Domain
IPR040041	TMEM201	Family

Pfam: PF09779, PF10476

UniProt features (27 total): modified residue 9, topological domain 6, transmembrane region 5, splice variant 2, mutagenesis site 2, chain 1, region of interest 1, compositionally biased region 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q5SNT2-F1	59.86	0.22

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (9): 1, 441, 444, 450, 454, 466, 477, 480, 529

Mutagenesis-validated functional residues (2):

Position	Phenotype
48	impairs organization of the nuclear envelope; abolishes its localization to the nuclear envelope; impairs localization o
121	abolishes localization to the nuclear envelopee; abolishes its localization to the nuclear envelope; impairs localizatio

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 139 (showing top): GOBP_ORGANELLE_TRANSPORT_ALONG_MICROTUBULE, GOCC_MICROTUBULE_ORGANIZING_CENTER, GOBP_AMEBOIDAL_TYPE_CELL_MIGRATION, GOBP_POSITIVE_REGULATION_OF_ENDOTHELIAL_CELL_MIGRATION, GOBP_REGULATION_OF_ENDOTHELIAL_CELL_MIGRATION, GOBP_NUCLEUS_ORGANIZATION, GOCC_CENTROSOME, GOBP_BLOOD_VESSEL_MORPHOGENESIS, GOBP_NUCLEUS_LOCALIZATION, LIAO_METASTASIS, GOBP_ENDOMEMBRANE_SYSTEM_ORGANIZATION, LASTOWSKA_NEUROBLASTOMA_COPY_NUMBER_DN, GOBP_PROTEIN_LOCALIZATION_TO_ORGANELLE, GOMF_ACTIN_BINDING, GOBP_NUCLEAR_ENVELOPE_ORGANIZATION

GO Biological Process (8): angiogenesis (GO:0001525), nuclear envelope organization (GO:0006998), positive regulation of endothelial cell migration (GO:0010595), fibroblast migration (GO:0010761), nuclear migration along microtubule (GO:0030473), centrosome localization (GO:0051642), protein localization to nuclear envelope (GO:0090435), nuclear migration (GO:0007097)

GO Molecular Function (3): lamin binding (GO:0005521), actin filament binding (GO:0051015), protein binding (GO:0005515)

GO Cellular Component (10): spindle pole (GO:0000922), nuclear envelope (GO:0005635), nuclear inner membrane (GO:0005637), nuclear membrane (GO:0031965), nucleus (GO:0005634), cytoplasm (GO:0005737), cytoskeleton (GO:0005856), membrane (GO:0016020), spindle pole centrosome (GO:0031616), cortical endoplasmic reticulum (GO:0032541)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	3
nucleus	2
blood vessel morphogenesis	1
anatomical structure formation involved in morphogenesis	1
nucleus organization	1
endomembrane system organization	1
membrane organization	1
regulation of endothelial cell migration	1
positive regulation of cell migration	1
endothelial cell migration	1
ameboidal-type cell migration	1
nuclear migration	1
organelle transport along microtubule	1
microtubule organizing center localization	1
protein localization to nucleus	1
intracellular transport	1
nucleus localization	1
establishment of organelle localization	1
protein binding	1
actin binding	1
protein-containing complex binding	1
binding	1
spindle	1
endomembrane system	1
organelle envelope	1
organelle inner membrane	1
nuclear membrane	1
nuclear envelope	1
organelle membrane	1
intracellular membrane-bounded organelle	1
intracellular anatomical structure	1
intracellular membraneless organelle	1
spindle pole	1
centrosome	1
cell cortex	1
endoplasmic reticulum tubular network	1

Protein interactions and networks

STRING

744 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
TMEM201	SUN1	O94901	950
TMEM201	EMD	P50402	816
TMEM201	SUN2	Q9UH99	808
TMEM201	LMNB1	P20700	723
TMEM201	BANF1	O75531	640
TMEM201	FHOD1	Q9Y613	634
TMEM201	LEMD3	Q9Y2U8	578
TMEM201	TOR1A	O14656	563
TMEM201	PLPP7	Q8NBV4	525
TMEM201	TMEM38A	Q9H6F2	517
TMEM201	TMEM214	Q6NUQ4	480
TMEM201	SUN3	Q8TAQ9	450
TMEM201	MADCAM1	Q13477	446
TMEM201	SYNE2	Q8WXH0	436
TMEM201	LEMD2	Q8NC56	434

IntAct

81 interactions, top by confidence:

A	B	Type	Score
STX18	NBAS	psi-mi:“MI:0914”(association)	0.810
CFTR	ESYT2	psi-mi:“MI:2364”(proximity)	0.710
B3GNT3	PGRMC1	psi-mi:“MI:0914”(association)	0.670
SLC39A4	TMEM120B	psi-mi:“MI:0914”(association)	0.530
APLNR	SLC33A1	psi-mi:“MI:0914”(association)	0.530
CXCR4	FANCA	psi-mi:“MI:0914”(association)	0.530
APBA3	CLSTN1	psi-mi:“MI:0914”(association)	0.530
Tax	TAX1BP3	psi-mi:“MI:0914”(association)	0.520
ALK	PIK3R2	psi-mi:“MI:0914”(association)	0.420
GPC1	SNAP23	psi-mi:“MI:0915”(physical association)	0.400
GPC1	GANAB	psi-mi:“MI:0915”(physical association)	0.400
Rab5b	BLTP3B	psi-mi:“MI:0914”(association)	0.350
SYNPO	LMO7	psi-mi:“MI:0914”(association)	0.350
RIPK4	VWA8	psi-mi:“MI:0914”(association)	0.350
UBAC2	TUB4q	psi-mi:“MI:0914”(association)	0.350
SLC16A11	ESYT2	psi-mi:“MI:0914”(association)	0.350
NUAK1	ZSWIM8	psi-mi:“MI:0914”(association)	0.350
STYK1	XPO1	psi-mi:“MI:0914”(association)	0.350
CANX	HLA-A	psi-mi:“MI:0914”(association)	0.350
TTMP	TMEM223	psi-mi:“MI:0914”(association)	0.350
CRELD1	TMEM223	psi-mi:“MI:0914”(association)	0.350
TEX28	NBAS	psi-mi:“MI:0914”(association)	0.350
GPR182	SLC12A8	psi-mi:“MI:0914”(association)	0.350
PCDHB3	ESYT2	psi-mi:“MI:0914”(association)	0.350
GP9	ESYT2	psi-mi:“MI:0914”(association)	0.350
CHRNA1	ESYT2	psi-mi:“MI:0914”(association)	0.350
TSPAN15	TMEM223	psi-mi:“MI:0914”(association)	0.350
PIGH	ILVBL	psi-mi:“MI:0914”(association)	0.350
TTMP	NBAS	psi-mi:“MI:0914”(association)	0.350
PCDHB7	TMEM131L	psi-mi:“MI:0914”(association)	0.350

BioGRID (183): TMEM201 (Affinity Capture-MS), TMEM201 (Affinity Capture-MS), TMEM201 (Affinity Capture-MS), TMEM201 (Proximity Label-MS), TMEM201 (Proximity Label-MS), TMEM201 (Affinity Capture-MS), TMEM201 (Affinity Capture-MS), TMEM201 (Affinity Capture-MS), TMEM201 (Affinity Capture-MS), TMEM201 (Reconstituted Complex), TMEM201 (Two-hybrid), TMEM201 (Affinity Capture-MS), TMEM201 (Affinity Capture-MS), TMEM201 (Affinity Capture-MS), TMEM201 (Affinity Capture-MS)

ESM2 similar proteins: A0PJX4, A2A8U2, A4D2P6, A6QM06, D4A6L0, E1BBQ2, O15079, O60320, P12755, P49797, P97260, Q0D2I5, Q12770, Q15884, Q1RMB5, Q3TS39, Q3UPR0, Q4FZH1, Q5MNU5, Q5SNT2, Q5T848, Q5XKK7, Q60698, Q6A044, Q7T0Z7, Q7TMB0, Q7TPB0, Q810F0, Q86XR5, Q8BX43, Q8BXL9, Q8C419, Q8CA71, Q8K064, Q8K2Y3, Q8N114, Q8NDY8, Q8WV15, Q91WM6, Q92537

Diamond homologs: A2A8U2, A4IG66, Q22747, Q32PF0, Q5SNT2

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 125 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Metal ion SLC transporters	5	37.1×	7e-05
Downstream TCR signaling	6	9.5×	4e-03
Transport of small molecules	12	3.7×	6e-03

GO biological processes:

GO term	Partners	Fold	FDR
intracellular zinc ion homeostasis	5	22.3×	6e-04
potassium ion transmembrane transport	6	7.5×	8e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

121 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	93
Likely benign	7
Benign	7

Top pathogenic / likely-pathogenic (0)

SpliceAI

2064 predictions. Top by Δscore:

Variant	Effect	Δscore
1:9589040:GGAG:G	donor_gain	1.0000
1:9589041:GAG:G	donor_gain	1.0000
1:9589041:GAGG:G	donor_gain	1.0000
1:9589042:AGGT:A	donor_loss	1.0000
1:9589044:GT:G	donor_loss	1.0000
1:9589045:T:G	donor_loss	1.0000
1:9595885:CACA:C	acceptor_loss	1.0000
1:9595888:A:AG	acceptor_gain	1.0000
1:9595888:A:G	acceptor_loss	1.0000
1:9595888:AG:A	acceptor_gain	1.0000
1:9595888:AGGAT:A	acceptor_gain	1.0000
1:9595889:G:GA	acceptor_gain	1.0000
1:9595889:GG:G	acceptor_gain	1.0000
1:9595889:GGAT:G	acceptor_gain	1.0000
1:9595889:GGATG:G	acceptor_gain	1.0000
1:9595991:A:AG	donor_gain	1.0000
1:9595992:G:GG	donor_gain	1.0000
1:9596007:GGAG:G	donor_gain	1.0000
1:9596007:GGAGG:G	donor_loss	1.0000
1:9596008:G:GT	donor_gain	1.0000
1:9596008:GAGG:G	donor_loss	1.0000
1:9596009:AG:A	donor_loss	1.0000
1:9596857:AGAAC:A	acceptor_gain	1.0000
1:9596858:GAAC:G	acceptor_gain	1.0000
1:9596858:GAACG:G	acceptor_gain	1.0000
1:9597050:GGAG:G	donor_gain	1.0000
1:9597051:G:GT	donor_gain	1.0000
1:9597051:GAGG:G	donor_loss	1.0000
1:9597052:AGG:A	donor_loss	1.0000
1:9597053:GGTG:G	donor_loss	1.0000

AlphaMissense

4254 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
1:9595918:T:C	C48R	1.000
1:9595919:G:A	C48Y	1.000
1:9595920:C:G	C48W	1.000
1:9595924:T:C	F50L	1.000
1:9595926:C:A	F50L	1.000
1:9595926:C:G	F50L	1.000
1:9595969:T:A	W65R	1.000
1:9595969:T:C	W65R	1.000
1:9595971:G:C	W65C	1.000
1:9595971:G:T	W65C	1.000
1:9595975:T:C	C67R	1.000
1:9596002:T:C	F76L	1.000
1:9596003:T:C	F76S	1.000
1:9596004:C:A	F76L	1.000
1:9596004:C:G	F76L	1.000
1:9595918:T:A	C48S	0.999
1:9595919:G:C	C48S	0.999
1:9595919:G:T	C48F	0.999
1:9595921:T:A	W49R	0.999
1:9595921:T:C	W49R	0.999
1:9595923:G:C	W49C	0.999
1:9595923:G:T	W49C	0.999
1:9595925:T:C	F50S	0.999
1:9595925:T:G	F50C	0.999
1:9595927:T:A	C51S	0.999
1:9595927:T:C	C51R	0.999
1:9595928:G:A	C51Y	0.999
1:9595928:G:C	C51S	0.999
1:9595928:G:T	C51F	0.999
1:9595929:C:G	C51W	0.999

dbSNP variants (sampled 300 via entrez): RS1000135174 (1:9606119 G>A), RS1000199329 (1:9605107 G>A), RS1000203256 (1:9612361 C>A), RS1000252564 (1:9612756 C>T), RS1000313837 (1:9587806 C>T), RS1000393766 (1:9607147 G>A), RS1000608211 (1:9591932 G>A), RS1000682237 (1:9597309 G>A), RS1000687587 (1:9596778 G>A,C,T), RS1000768264 (1:9592688 C>A,T), RS1000841998 (1:9592857 G>A), RS1000870568 (1:9607356 C>T), RS1000943834 (1:9612587 G>T), RS1001114440 (1:9597533 G>C), RS1001241281 (1:9604518 C>G,T)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

42 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	affects cotreatment, increases abundance, increases expression, decreases expression	4
Acetaminophen	increases expression	2
Arsenic	affects methylation, affects cotreatment, increases abundance, increases expression	2
Estradiol	increases expression	2
Valproic Acid	increases expression, increases methylation	2
afuresertib	decreases expression	1
FR900359	affects phosphorylation	1
TAK-243	decreases sumoylation	1
dicrotophos	increases expression	1
bisphenol A	decreases expression	1
zinc chromate	decreases expression, increases abundance	1
manganese chloride	increases abundance, increases expression, affects cotreatment	1
benzo(e)pyrene	decreases methylation	1
potassium chromate(VI)	increases expression	1
aflatoxin B2	decreases methylation	1
chromium hexavalent ion	increases abundance, decreases expression	1
abrine	decreases expression	1
2,2’,4,4’-tetrabromodiphenyl ether	decreases expression	1
Grape Seed Proanthocyanidins	affects cotreatment, increases expression	1
NSC 689534	decreases expression, affects binding	1
Sunitinib	increases expression	1
Benzo(a)pyrene	increases expression	1
Caffeine	affects phosphorylation	1
Calcitriol	decreases expression, affects cotreatment	1
Catechin	affects cotreatment, increases expression	1
Copper	affects binding, decreases expression	1
Dichlorodiphenyl Dichloroethylene	increases expression	1
Doxorubicin	decreases expression	1
Formaldehyde	decreases expression	1
Ivermectin	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.