TMEM202

Summary

TMEM202 (transmembrane protein 202, HGNC:33733) is a protein-coding gene on chromosome 15q23-q24.1, encoding Transmembrane protein 202 (A6NGA9).

Predicted to be located in membrane. Predicted to be active in plasma membrane.

Source: NCBI Gene 338949 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 36 total
• MANE Select transcript: NM_001080462

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:33733
Approved symbol	TMEM202
Name	transmembrane protein 202
Location	15q23-q24.1
Locus type	gene with protein product
Status	Approved
Aliases	FLJ27523
Ensembl gene	ENSG00000187806
Ensembl biotype	protein_coding
Entrez	338949

Gene structure

Transcript identifiers

Ensembl transcripts: 4 — 3 protein_coding, 1 nonsense_mediated_decay

ENST00000341689, ENST00000567679, ENST00000568167, ENST00000649825

RefSeq mRNA: 1 — MANE Select: NM_001080462 NM_001080462

CCDS: CCDS32287

Canonical transcript exons

ENST00000341689 — 5 exons

Exon	Start	End
ENSE00001366392	72398653	72398908
ENSE00002577537	72398305	72398407
ENSE00003463669	72406602	72406751
ENSE00003521149	72407691	72408367
ENSE00003660338	72407086	72407217

Expression profiles

Bgee: expression breadth broad, 23 present calls, max score 94.76.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.0236 / max 23.0053, expressed in 3 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
147577	0.0236	3

Top tissues by expression

107 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	94.76	gold quality
left testis	UBERON:0004533	85.94	gold quality
testis	UBERON:0000473	85.41	gold quality
right testis	UBERON:0004534	84.32	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	78.55	gold quality
quadriceps femoris	UBERON:0001377	77.26	gold quality
thymus	UBERON:0002370	56.63	silver quality
hindlimb stylopod muscle	UBERON:0004252	40.84	gold quality
colonic epithelium	UBERON:0000397	37.20	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
sural nerve	UBERON:0015488	36.26	gold quality
bone marrow cell	CL:0002092	36.16	gold quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
skeletal muscle tissue	UBERON:0001134	33.70	gold quality
monocyte	CL:0000576	32.22	gold quality
bone marrow	UBERON:0002371	32.02	gold quality
leukocyte	CL:0000738	31.80	gold quality
muscle tissue	UBERON:0002385	31.31	gold quality
stromal cell of endometrium	CL:0002255	29.87	gold quality
prefrontal cortex	UBERON:0000451	29.85	gold quality
liver	UBERON:0002107	29.37	gold quality
ectocervix	UBERON:0012249	28.45	silver quality
duodenum	UBERON:0002114	28.14	gold quality
placenta	UBERON:0001987	28.05	silver quality
superior frontal gyrus	UBERON:0002661	27.69	gold quality
lymph node	UBERON:0000029	27.57	gold quality
blood	UBERON:0000178	27.52	silver quality
tonsil	UBERON:0002372	27.05	gold quality
vermiform appendix	UBERON:0001154	26.42	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.94

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

26 targeting TMEM202, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-499A-5P	99.98	70.79	1323
HSA-MIR-7152-3P	99.97	67.47	849
HSA-MIR-3658	99.96	73.87	4379
HSA-MIR-5680	99.91	69.83	3421
HSA-MIR-1297	99.91	73.41	3162
HSA-MIR-8076	99.78	68.52	1170
HSA-MIR-3617-5P	99.75	69.41	1968
HSA-MIR-641	99.75	69.35	1975
HSA-MIR-4699-3P	99.71	70.15	3142
HSA-MIR-7159-5P	99.53	72.12	2472
HSA-MIR-155-5P	99.35	70.16	1509
HSA-MIR-4279	99.19	66.70	2437
HSA-MIR-5583-3P	99.06	65.68	1018
HSA-MIR-10B-3P	99.04	66.98	988
HSA-MIR-421	98.90	67.04	1883
HSA-MIR-3145-3P	98.85	69.07	2031
HSA-MIR-7977	98.65	66.18	2590
HSA-MIR-4709-5P	98.51	67.25	1335
HSA-MIR-4490	98.51	68.47	943
HSA-MIR-6801-3P	98.04	64.64	805
HSA-MIR-6810-3P	97.96	64.57	1023
HSA-MIR-5000-5P	97.40	66.11	1055
HSA-MIR-3663-5P	97.01	64.84	713
HSA-MIR-10525-3P	96.32	68.04	699
HSA-MIR-208A-3P	95.87	66.51	397
HSA-MIR-208B-3P	95.87	66.56	396

Cross-species orthologs

0 orthologs

Paralogs (10): LIM2 (ENSG00000105370), NKG7 (ENSG00000105374), PMP22 (ENSG00000109099), GSG1 (ENSG00000111305), EMP1 (ENSG00000134531), EMP3 (ENSG00000142227), CLDND2 (ENSG00000160318), GSG1L (ENSG00000169181), EMP2 (ENSG00000213853), GSG1L2 (ENSG00000214978)

Protein

Protein identifiers

Transmembrane protein 202 — A6NGA9 (reviewed: A6NGA9)

All UniProt accessions (3): A6NGA9, A0A3B3ITB0, H3BUG9

UniProt curated annotations — full annotation on UniProt →

Subcellular location. Membrane.

RefSeq proteins (1): NP_001073931* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR050579	PMP-22/EMP/MP20-like	Family

UniProt features (8 total): transmembrane region 4, chain 1, region of interest 1, compositionally biased region 1, sequence variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-A6NGA9-F1	74.13	0.38

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 0 (showing top):

GO Biological Process (0):

GO Molecular Function (0):

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

142 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
TMEM202	FAM221B	A6H8Z2	646
TMEM202	SPATA31D1	Q6ZQQ2	580
TMEM202	OR4D10	Q8NGI6	553
TMEM202	NT5C1B	Q96P26	516
TMEM202	FNDC8	Q8TC99	480
TMEM202	SPACA1	Q9HBV2	478
TMEM202	CFAP45	Q9UL16	457
TMEM202	CABYR	O75952	455
TMEM202	SPEM3	A0A1B0GUW6	445
TMEM202	SPATA18	Q8TC71	435
TMEM202	SPATA31F1	Q6ZU69	415
TMEM202	DNAH8	Q96JB1	409
TMEM202	ADPGK	Q9BRR6	407
TMEM202	PARP6	Q2NL67	402
TMEM202	GARIN3	Q8TC56	386

IntAct

0 interactions, top by confidence:

BioGRID (1): TMEM202 (Positive Genetic)

ESM2 similar proteins: A2BGS3, A6NGA9, E7F594, O36364, O60478, O60883, O95800, O95838, P03208, P16849, P31389, P34590, P35367, P49219, Q03613, Q09351, Q09964, Q09965, Q14439, Q16950, Q16951, Q2KI97, Q3U3F9, Q5FVG1, Q5IXF8, Q5UAW9, Q60755, Q64017, Q66615, Q66H29, Q6P7G9, Q6SW98, Q6X632, Q7TSN5, Q7TSN6, Q80W35, Q80WT4, Q8BNQ3, Q8C206, Q8CIM5

Diamond homologs: A6NGA9, Q80W35

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

36 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	32
Likely benign	3
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

701 predictions. Top by Δscore:

Variant	Effect	Δscore
15:72406598:GCAG:G	acceptor_loss	1.0000
15:72406599:CA:C	acceptor_loss	1.0000
15:72406600:A:AG	acceptor_gain	1.0000
15:72406601:G:GG	acceptor_gain	1.0000
15:72406601:GATT:G	acceptor_gain	1.0000
15:72405968:A:AG	acceptor_gain	0.9900
15:72405969:G:GG	acceptor_gain	0.9900
15:72406601:GAT:G	acceptor_gain	0.9900
15:72406698:G:GT	donor_gain	0.9900
15:72407077:T:TA	acceptor_gain	0.9900
15:72406596:AT:A	acceptor_gain	0.9800
15:72406597:T:G	acceptor_gain	0.9800
15:72406601:GA:G	acceptor_gain	0.9800
15:72406601:GATTA:G	acceptor_gain	0.9800
15:72407191:GC:G	donor_gain	0.9800
15:72407686:CGTA:C	acceptor_loss	0.9800
15:72407687:GTA:G	acceptor_loss	0.9800
15:72407688:TA:T	acceptor_loss	0.9800
15:72407689:A:AG	acceptor_gain	0.9800
15:72407689:AG:A	acceptor_gain	0.9800
15:72407689:AGG:A	acceptor_gain	0.9800
15:72407690:G:GG	acceptor_gain	0.9800
15:72407690:GG:G	acceptor_gain	0.9800
15:72407690:GGG:G	acceptor_gain	0.9800
15:72406596:A:AG	acceptor_gain	0.9700
15:72406747:CTCAG:C	donor_loss	0.9700
15:72406748:TCAG:T	donor_loss	0.9700
15:72406750:AGG:A	donor_loss	0.9700
15:72406751:GGTA:G	donor_loss	0.9700
15:72406752:GTACA:G	donor_loss	0.9700

AlphaMissense

1787 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
15:72398770:A:C	S67R	0.987
15:72398772:C:A	S67R	0.987
15:72398772:C:G	S67R	0.987
15:72398857:T:A	W96R	0.981
15:72398857:T:C	W96R	0.981
15:72398886:G:C	W105C	0.974
15:72398886:G:T	W105C	0.974
15:72407115:T:C	F173L	0.972
15:72407117:T:A	F173L	0.972
15:72407117:T:G	F173L	0.972
15:72398755:A:C	S62R	0.970
15:72398757:C:A	S62R	0.970
15:72398757:C:G	S62R	0.970
15:72398764:A:C	S65R	0.969
15:72398766:T:A	S65R	0.969
15:72398766:T:G	S65R	0.969
15:72398806:T:A	W79R	0.967
15:72398806:T:C	W79R	0.967
15:72406739:A:C	S159R	0.966
15:72406741:C:A	S159R	0.966
15:72406741:C:G	S159R	0.966
15:72407091:T:C	C165R	0.966
15:72407217:G:A	G207R	0.966
15:72407217:G:C	G207R	0.966
15:72407103:T:C	C169R	0.962
15:72398859:G:C	W96C	0.960
15:72398859:G:T	W96C	0.960
15:72407217:G:T	G207W	0.958
15:72398808:G:C	W79C	0.957
15:72398808:G:T	W79C	0.957

dbSNP variants (sampled 300 via entrez): RS1000487867 (15:72399018 C>T), RS1000801066 (15:72407209 T>A,C), RS1000884392 (15:72406865 A>C,G), RS1000955948 (15:72407523 T>C), RS1001084125 (15:72400566 A>C), RS1001105446 (15:72400439 A>G), RS1001313847 (15:72400203 G>T), RS1001832848 (15:72405014 A>G), RS1001928757 (15:72400088 A>G), RS1002212855 (15:72406057 G>C), RS1002242592 (15:72399166 T>C), RS1002432128 (15:72406484 C>G), RS1002573728 (15:72402437 C>T), RS1002671301 (15:72402730 A>G), RS1003088080 (15:72403271 C>T)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

3 total (human), top 3 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
MT19c compound	decreases expression	1
Air Pollutants	increases expression	1
Benzo(a)pyrene	increases methylation	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.