TMEM210

Summary

TMEM210 (transmembrane protein 210, HGNC:34059) is a protein-coding gene on chromosome 9q34.3, encoding Transmembrane protein 210 (A6NLX4).

Located in acrosomal vesicle.

Source: NCBI Gene 100505993 — RefSeq curated summary.

At a glance

• MANE Select transcript: NM_001282477

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:34059
Approved symbol	TMEM210
Name	transmembrane protein 210
Location	9q34.3
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000185863
Ensembl biotype	protein_coding
Entrez	100505993

Gene structure

Transcript identifiers

Ensembl transcripts: 4 — 1 protein_coding, 1 retained_intron, 1 protein_coding_CDS_not_defined, 1 nonsense_mediated_decay

ENST00000413619, ENST00000427366, ENST00000430332, ENST00000535352

RefSeq mRNA: 1 — MANE Select: NM_001282477 NM_001282477

CCDS: CCDS65197

Canonical transcript exons

ENST00000413619 — 4 exons

Exon	Start	End
ENSE00001699715	137171940	137172056
ENSE00003460194	137171414	137171443
ENSE00003534205	137170858	137171164
ENSE00003539221	137171641	137171776

Expression profiles

Bgee: expression breadth broad, 85 present calls, max score 95.19.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.0143 / max 13.0815, expressed in 3 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
103325	0.0057	3
103324	0.0044	3
103323	0.0043	3

Top tissues by expression

113 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right testis	UBERON:0004534	95.19	gold quality
left testis	UBERON:0004533	95.18	gold quality
testis	UBERON:0000473	94.35	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	89.86	gold quality
saliva-secreting gland	UBERON:0001044	64.45	gold quality
minor salivary gland	UBERON:0001830	62.87	gold quality
mucosa of transverse colon	UBERON:0004991	60.74	gold quality
tonsil	UBERON:0002372	55.09	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	54.73	gold quality
granulocyte	CL:0000094	54.28	gold quality
right hemisphere of cerebellum	UBERON:0014890	52.14	gold quality
cerebellar hemisphere	UBERON:0002245	51.42	gold quality
cerebellum	UBERON:0002037	51.40	gold quality
cerebellar cortex	UBERON:0002129	51.33	gold quality
prostate gland	UBERON:0002367	49.96	gold quality
lower esophagus mucosa	UBERON:0035834	49.52	gold quality
right coronary artery	UBERON:0001625	48.64	gold quality
transverse colon	UBERON:0001157	44.19	gold quality
right uterine tube	UBERON:0001302	41.22	silver quality
thoracic mammary gland	UBERON:0005200	39.48	gold quality
metanephros cortex	UBERON:0010533	38.69	silver quality
bone marrow cell	CL:0002092	38.62	gold quality
lymph node	UBERON:0000029	38.23	gold quality
rectum	UBERON:0001052	37.88	gold quality
small intestine Peyer’s patch	UBERON:0003454	37.27	gold quality
colonic epithelium	UBERON:0000397	37.20	gold quality
hindlimb stylopod muscle	UBERON:0004252	37.11	silver quality
bone marrow	UBERON:0002371	36.77	silver quality
fundus of stomach	UBERON:0001160	36.70	gold quality
small intestine	UBERON:0002108	36.56	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.50

Regulation

Is transcription factor: no

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Tmem210	ENSMUSG00000026963
rattus_norvegicus	Tmem210	ENSRNOG00000040275

Protein

Protein identifiers

Transmembrane protein 210 — A6NLX4 (reviewed: A6NLX4)

All UniProt accessions (2): A6NLX4, H3BNS5

UniProt curated annotations — full annotation on UniProt →

Subcellular location. Membrane. Cytoplasmic vesicle. Secretory vesicle. Acrosome.

RefSeq proteins (1): NP_001269406* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR028123	TMEM210	Family

Pfam: PF15195

UniProt features (7 total): topological domain 2, signal peptide 1, chain 1, transmembrane region 1, region of interest 1, compositionally biased region 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-A6NLX4-F1	60.60	0.08

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 13 (showing top): GOCC_SECRETORY_GRANULE, GOCC_SECRETORY_VESICLE, GOCC_ACROSOMAL_VESICLE, GSE13762_CTRL_VS_125_VITAMIND_DAY5_DC_UP, chr9q34, GSE13522_CTRL_VS_T_CRUZI_BRAZIL_STRAIN_INF_SKIN_UP, GSE14415_NATURAL_TREG_VS_FOXP3_KO_NATURAL_TREG_DN, GSE13547_2H_VS_12_H_ANTI_IGM_STIM_BCELL_UP, GSE13547_WT_VS_ZFX_KO_BCELL_ANTI_IGM_STIM_12H_UP, GREB1_TARGET_GENES, HAY_BONE_MARROW_DENDRITIC_CELL, ZAK_PBMC_MRKAD5_HIV_1_GAG_POL_NEF_AGE_20_50YO_CORRELATED_WITH_CD8_T_CELL_RESPONSE_3DY_NEGATIVE, GSE25123_ROSIGLITAZONE_VS_IL4_AND_ROSIGLITAZONE_STIM_MACROPHAGE_DAY10_DN

GO Biological Process (0):

GO Molecular Function (0):

GO Cellular Component (3): acrosomal vesicle (GO:0001669), membrane (GO:0016020), cytoplasmic vesicle (GO:0031410)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
secretory granule	1
cellular anatomical structure	1
cytoplasm	1
intracellular vesicle	1

Protein interactions and networks

STRING

50 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
TMEM210	SMIM9	A6NGZ8	787
TMEM210	SMIM8	Q96KF7	656
TMEM210	SLC25A41	Q8N5S1	626
TMEM210	TOMM20L	Q6UXN7	598
TMEM210	CBY2	Q8NA61	559
TMEM210	SLC25A2	Q9BXI2	494
TMEM210	RASEF	Q8IZ41	493
TMEM210	PLCH1	Q4KWH8	447
TMEM210	THEMIS2	Q5TEJ8	447
TMEM210	PDZD8	Q8NEN9	433
TMEM210	PLEKHB1	Q9UF11	400
TMEM210	ZMYND8	Q9ULU4	370
TMEM210	PSMD12	O00232	367
TMEM210	LDHAL6B	Q9BYZ2	353
TMEM210	C1orf141	Q5JVX7	349
TMEM210	CTXND2	A0A1B0GV90	349

IntAct

0 interactions, top by confidence:

ESM2 similar proteins: A0A1B0GU29, A6NLX4, A6QNY1, A9CBA0, B7ZWI3, O14669, O88472, P14784, P16297, P25918, P26896, Q0VFL4, Q13651, Q32M26, Q38J84, Q38J85, Q3SYS8, Q58CT8, Q5BK39, Q5EAA5, Q5HZE8, Q5NCP0, Q5RCL0, Q64322, Q68DV7, Q6AXS2, Q6AXU5, Q6NUJ2, Q6UWV7, Q86UW2, Q8BHB3, Q8BLR5, Q8BSU2, Q8C353, Q8C708, Q8K1T1, Q8MII8, Q8N6P7, Q8NET5, Q8R182

Diamond homologs: A6NLX4, Q9D2F0

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

0 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

602 predictions. Top by Δscore:

Variant	Effect	Δscore
9:137170969:AGC:A	donor_gain	1.0000
9:137170977:A:AC	donor_gain	1.0000
9:137170978:C:CC	donor_gain	1.0000
9:137170981:A:AC	donor_gain	1.0000
9:137170982:G:C	donor_gain	1.0000
9:137171009:T:TA	donor_gain	1.0000
9:137171444:C:CC	acceptor_gain	1.0000
9:137171639:ACC:A	donor_gain	1.0000
9:137171640:CCC:C	donor_gain	1.0000
9:137171010:C:CA	donor_gain	0.9900
9:137171024:T:TA	donor_gain	0.9900
9:137171078:T:TA	donor_gain	0.9900
9:137171160:CCAAC:C	acceptor_gain	0.9900
9:137171161:CAACC:C	acceptor_gain	0.9900
9:137171166:T:C	acceptor_loss	0.9900
9:137171440:TTCA:T	acceptor_gain	0.9900
9:137171442:CA:C	acceptor_gain	0.9900
9:137171636:CGCA:C	donor_loss	0.9900
9:137171637:GCA:G	donor_loss	0.9900
9:137171639:A:AC	donor_gain	0.9900
9:137171640:C:CC	donor_gain	0.9900
9:137171641:C:A	donor_gain	0.9900
9:137171773:CCAG:C	acceptor_gain	0.9900
9:137171774:CAG:C	acceptor_gain	0.9900
9:137171774:CAGC:C	acceptor_gain	0.9900
9:137171777:C:CC	acceptor_gain	0.9900
9:137171161:CAAC:C	acceptor_gain	0.9800
9:137171163:ACC:A	acceptor_loss	0.9800
9:137171164:CCTG:C	acceptor_loss	0.9800
9:137171165:C:A	acceptor_loss	0.9800

AlphaMissense

935 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
9:137171691:G:C	S58R	0.994
9:137171691:G:T	S58R	0.994
9:137171693:T:G	S58R	0.994
9:137171697:A:C	S56R	0.990
9:137171697:A:T	S56R	0.990
9:137171699:T:G	S56R	0.990
9:137171690:A:G	C59R	0.989
9:137171705:C:G	G54R	0.969
9:137171704:C:T	G54D	0.957
9:137171742:G:C	S41R	0.956
9:137171742:G:T	S41R	0.956
9:137171744:T:G	S41R	0.956
9:137171684:A:G	C61R	0.955
9:137171677:A:T	L63H	0.952
9:137171743:C:A	S41I	0.949
9:137171680:G:T	A62D	0.937
9:137171722:A:T	L48H	0.931
9:137171695:G:T	A57D	0.925
9:137171677:A:C	L63R	0.921
9:137171710:A:C	L52R	0.917
9:137171668:A:T	V66E	0.909
9:137171722:A:C	L48R	0.909
9:137171722:A:G	L48P	0.908
9:137171725:G:T	A47D	0.906
9:137171674:A:T	V64D	0.903
9:137171746:A:T	L40H	0.902
9:137171688:G:C	C59W	0.900
9:137171659:C:T	G69D	0.899
9:137171660:C:G	G69R	0.887
9:137171716:A:T	V50E	0.883

dbSNP variants (sampled 300 via entrez): RS1000093890 (9:137171173 C>A,G,T), RS1000146335 (9:137170959 A>G), RS1001159501 (9:137171962 G>A), RS1001720589 (9:137173919 CCAGGCGCAGCTCA>C), RS1002489842 (9:137173114 C>T), RS1002664885 (9:137172279 G>A), RS1002712150 (9:137171930 G>A), RS1002868670 (9:137172905 G>A), RS1003231422 (9:137172215 G>A), RS1004179331 (9:137173504 T>G), RS1005843039 (9:137172380 T>A,C), RS1006268517 (9:137173100 T>G), RS1006676878 (9:137170713 G>A), RS1006972093 (9:137170496 G>A), RS1008408215 (9:137173715 G>A,T)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

3 total (human), top 3 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
benzo(e)pyrene	decreases methylation	1
Benzo(a)pyrene	affects methylation	1
Methapyrilene	decreases methylation	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.